Mitochondrial RNA binding complex 1 subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial ribosomal protein S18, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H825_LEIDO

TriTrypDb:

LdBPK_362440.1 , LdCL_360030100 , LDHU3_36.3250

Length:

325

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Mitochondrial ribosomal S18

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000314	organellar small ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005763	mitochondrial small ribosomal subunit	3	1
GO:0015935	small ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H825

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H825

PDB structure(s): 7ane_m

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	175	181	PF00089	0.380
CLV_NRD_NRD_1	237	239	PF00675	0.555
CLV_NRD_NRD_1	55	57	PF00675	0.468
CLV_PCSK_KEX2_1	237	239	PF00082	0.555
CLV_PCSK_KEX2_1	311	313	PF00082	0.475
CLV_PCSK_KEX2_1	57	59	PF00082	0.481
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.475
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.468
CLV_PCSK_SKI1_1	139	143	PF00082	0.369
CLV_PCSK_SKI1_1	164	168	PF00082	0.363
CLV_PCSK_SKI1_1	237	241	PF00082	0.593
CLV_PCSK_SKI1_1	281	285	PF00082	0.479
CLV_PCSK_SKI1_1	295	299	PF00082	0.462
DEG_Nend_UBRbox_3	1	3	PF02207	0.704
DOC_MAPK_gen_1	164	173	PF00069	0.363
DOC_MAPK_MEF2A_6	120	127	PF00069	0.449
DOC_MAPK_MEF2A_6	167	175	PF00069	0.367
DOC_PP4_FxxP_1	118	121	PF00568	0.521
DOC_PP4_FxxP_1	179	182	PF00568	0.363
DOC_PP4_FxxP_1	315	318	PF00568	0.428
DOC_USP7_MATH_1	239	243	PF00917	0.582
DOC_USP7_UBL2_3	128	132	PF12436	0.384
DOC_USP7_UBL2_3	295	299	PF12436	0.462
DOC_WW_Pin1_4	43	48	PF00397	0.494
LIG_14-3-3_CanoR_1	238	248	PF00244	0.606
LIG_BIR_III_2	39	43	PF00653	0.564
LIG_BRCT_BRCA1_1	186	190	PF00533	0.389
LIG_deltaCOP1_diTrp_1	61	65	PF00928	0.389
LIG_EH_1	180	184	PF12763	0.351
LIG_FHA_1	218	224	PF00498	0.393
LIG_FHA_1	317	323	PF00498	0.444
LIG_FHA_2	34	40	PF00498	0.451
LIG_FHA_2	44	50	PF00498	0.318
LIG_FHA_2	91	97	PF00498	0.418
LIG_LIR_Gen_1	124	134	PF02991	0.387
LIG_LIR_Gen_1	30	35	PF02991	0.437
LIG_LIR_Gen_1	79	90	PF02991	0.470
LIG_LIR_Nem_3	124	129	PF02991	0.395
LIG_LIR_Nem_3	30	34	PF02991	0.424
LIG_LIR_Nem_3	79	85	PF02991	0.459
LIG_LYPXL_S_1	175	179	PF13949	0.371
LIG_Pex14_2	179	183	PF04695	0.361
LIG_Pex14_2	213	217	PF04695	0.397
LIG_SH2_CRK	126	130	PF00017	0.388
LIG_SH2_CRK	131	135	PF00017	0.375
LIG_SH2_PTP2	31	34	PF00017	0.403
LIG_SH2_STAP1	14	18	PF00017	0.456
LIG_SH2_STAT5	226	229	PF00017	0.406
LIG_SH2_STAT5	31	34	PF00017	0.406
LIG_SH3_3	151	157	PF00018	0.385
LIG_SH3_3	283	289	PF00018	0.459
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.472
LIG_TRAF2_1	194	197	PF00917	0.473
LIG_TRAF2_1	46	49	PF00917	0.579
MOD_CDK_SPxxK_3	43	50	PF00069	0.581
MOD_CK1_1	306	312	PF00069	0.446
MOD_CK1_1	316	322	PF00069	0.442
MOD_CK1_1	33	39	PF00069	0.489
MOD_CK2_1	43	49	PF00069	0.581
MOD_Cter_Amidation	54	57	PF01082	0.453
MOD_GlcNHglycan	242	245	PF01048	0.593
MOD_GSK3_1	135	142	PF00069	0.366
MOD_GSK3_1	199	206	PF00069	0.455
MOD_GSK3_1	233	240	PF00069	0.557
MOD_GSK3_1	303	310	PF00069	0.440
MOD_N-GLC_1	262	267	PF02516	0.496
MOD_N-GLC_1	83	88	PF02516	0.414
MOD_NEK2_1	13	18	PF00069	0.620
MOD_NEK2_1	141	146	PF00069	0.397
MOD_NEK2_1	233	238	PF00069	0.574
MOD_NEK2_1	291	296	PF00069	0.455
MOD_NEK2_1	304	309	PF00069	0.446
MOD_NEK2_1	313	318	PF00069	0.434
MOD_NEK2_1	90	95	PF00069	0.526
MOD_PIKK_1	16	22	PF00454	0.525
MOD_PIKK_1	184	190	PF00454	0.385
MOD_PIKK_1	253	259	PF00454	0.551
MOD_PKA_1	237	243	PF00069	0.596
MOD_PKA_2	237	243	PF00069	0.594
MOD_Plk_1	262	268	PF00069	0.482
MOD_Plk_1	279	285	PF00069	0.545
MOD_Plk_1	83	89	PF00069	0.409
MOD_Plk_2-3	262	268	PF00069	0.579
MOD_ProDKin_1	43	49	PF00069	0.494
MOD_SUMO_rev_2	109	115	PF00179	0.428
TRG_AP2beta_CARGO_1	79	89	PF09066	0.468
TRG_DiLeu_BaEn_1	30	35	PF01217	0.424
TRG_ENDOCYTIC_2	126	129	PF00928	0.390
TRG_ENDOCYTIC_2	176	179	PF00928	0.370
TRG_ENDOCYTIC_2	215	218	PF00928	0.431
TRG_ENDOCYTIC_2	31	34	PF00928	0.425
TRG_ENDOCYTIC_2	73	76	PF00928	0.391
TRG_ER_diArg_1	53	56	PF00400	0.441
TRG_NES_CRM1_1	257	267	PF08389	0.542
TRG_NLS_MonoExtC_3	55	60	PF00514	0.471
TRG_NLS_MonoExtN_4	295	302	PF00514	0.461
TRG_NLS_MonoExtN_4	54	60	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD70	Leptomonas seymouri	90%	100%
A0A0S4JTC8	Bodo saltans	67%	100%
A0A422NIU3	Trypanosoma rangeli	84%	100%
A4HP99	Leishmania braziliensis	94%	100%
A4IDK5	Leishmania infantum	100%	100%
D0A3A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9AT08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q1J0	Leishmania major	98%	100%
V5BKY9	Trypanosoma cruzi	82%	100%