Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H822_LEIDO

TriTrypDb:

LdBPK_361880.1 , LdCL_360024300 , LDHU3_36.2440

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005882	intermediate filament	6	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H822

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H822

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.454
CLV_NRD_NRD_1	14	16	PF00675	0.620
CLV_NRD_NRD_1	179	181	PF00675	0.535
CLV_NRD_NRD_1	336	338	PF00675	0.564
CLV_PCSK_KEX2_1	103	105	PF00082	0.453
CLV_PCSK_KEX2_1	14	16	PF00082	0.653
CLV_PCSK_KEX2_1	151	153	PF00082	0.617
CLV_PCSK_KEX2_1	336	338	PF00082	0.546
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.603
CLV_PCSK_PC7_1	147	153	PF00082	0.610
CLV_PCSK_SKI1_1	165	169	PF00082	0.588
CLV_PCSK_SKI1_1	276	280	PF00082	0.582
CLV_PCSK_SKI1_1	336	340	PF00082	0.537
CLV_PCSK_SKI1_1	78	82	PF00082	0.593
DEG_APCC_DBOX_1	315	323	PF00400	0.561
DEG_Nend_UBRbox_4	1	3	PF02207	0.500
DEG_SPOP_SBC_1	65	69	PF00917	0.554
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.434
DOC_MAPK_gen_1	180	189	PF00069	0.559
DOC_USP7_MATH_1	118	122	PF00917	0.425
DOC_USP7_MATH_1	225	229	PF00917	0.619
DOC_USP7_MATH_1	4	8	PF00917	0.706
DOC_USP7_MATH_1	66	70	PF00917	0.700
DOC_WW_Pin1_4	27	32	PF00397	0.688
DOC_WW_Pin1_4	71	76	PF00397	0.543
LIG_14-3-3_CanoR_1	14	19	PF00244	0.574
LIG_14-3-3_CanoR_1	165	175	PF00244	0.524
LIG_14-3-3_CanoR_1	180	184	PF00244	0.313
LIG_14-3-3_CanoR_1	368	374	PF00244	0.586
LIG_14-3-3_CanoR_1	41	47	PF00244	0.626
LIG_APCC_ABBA_1	187	192	PF00400	0.487
LIG_APCC_ABBAyCdc20_2	186	192	PF00400	0.490
LIG_FHA_1	183	189	PF00498	0.493
LIG_FHA_1	89	95	PF00498	0.642
LIG_FHA_2	157	163	PF00498	0.616
LIG_FHA_2	373	379	PF00498	0.588
LIG_FHA_2	47	53	PF00498	0.528
LIG_PCNA_PIPBox_1	109	118	PF02747	0.570
LIG_PDZ_Class_3	381	386	PF00595	0.529
LIG_Pex14_2	179	183	PF04695	0.372
LIG_SH2_GRB2like	115	118	PF00017	0.562
LIG_SH2_NCK_1	351	355	PF00017	0.646
LIG_SH2_SRC	115	118	PF00017	0.562
LIG_SH2_STAP1	190	194	PF00017	0.470
LIG_SH2_STAP1	206	210	PF00017	0.415
LIG_SH2_STAT3	247	250	PF00017	0.472
LIG_SH2_STAT5	115	118	PF00017	0.467
LIG_SH2_STAT5	247	250	PF00017	0.447
LIG_SH3_3	376	382	PF00018	0.473
LIG_SH3_3	7	13	PF00018	0.472
LIG_TRAF2_1	216	219	PF00917	0.588
LIG_TRAF2_1	332	335	PF00917	0.571
LIG_UBA3_1	145	151	PF00899	0.440
LIG_WRC_WIRS_1	5	10	PF05994	0.503
MOD_CDK_SPxxK_3	71	78	PF00069	0.522
MOD_CK1_1	182	188	PF00069	0.349
MOD_CK1_1	232	238	PF00069	0.613
MOD_CK1_1	26	32	PF00069	0.725
MOD_CK1_1	43	49	PF00069	0.516
MOD_CK2_1	156	162	PF00069	0.381
MOD_CK2_1	261	267	PF00069	0.605
MOD_CK2_1	372	378	PF00069	0.573
MOD_GlcNHglycan	120	123	PF01048	0.526
MOD_GlcNHglycan	125	128	PF01048	0.554
MOD_GlcNHglycan	194	197	PF01048	0.503
MOD_GlcNHglycan	221	224	PF01048	0.637
MOD_GlcNHglycan	32	35	PF01048	0.654
MOD_GlcNHglycan	42	45	PF01048	0.515
MOD_GlcNHglycan	68	71	PF01048	0.697
MOD_GlcNHglycan	88	91	PF01048	0.736
MOD_GSK3_1	225	232	PF00069	0.670
MOD_GSK3_1	23	30	PF00069	0.701
MOD_GSK3_1	4	11	PF00069	0.502
MOD_GSK3_1	60	67	PF00069	0.695
MOD_N-GLC_1	192	197	PF02516	0.588
MOD_N-GLC_1	276	281	PF02516	0.621
MOD_NEK2_1	179	184	PF00069	0.445
MOD_NEK2_1	372	377	PF00069	0.612
MOD_NEK2_1	8	13	PF00069	0.672
MOD_PIKK_1	367	373	PF00454	0.581
MOD_PKA_1	14	20	PF00069	0.539
MOD_PKA_1	151	157	PF00069	0.376
MOD_PKA_2	13	19	PF00069	0.620
MOD_PKA_2	151	157	PF00069	0.579
MOD_PKA_2	179	185	PF00069	0.539
MOD_PKA_2	359	365	PF00069	0.620
MOD_PKA_2	367	373	PF00069	0.545
MOD_PKA_2	40	46	PF00069	0.612
MOD_Plk_1	192	198	PF00069	0.584
MOD_Plk_1	276	282	PF00069	0.532
MOD_Plk_2-3	156	162	PF00069	0.609
MOD_ProDKin_1	27	33	PF00069	0.688
MOD_ProDKin_1	71	77	PF00069	0.515
MOD_SUMO_for_1	291	294	PF00179	0.467
TRG_DiLeu_BaEn_1	170	175	PF01217	0.521
TRG_DiLeu_BaEn_3	334	340	PF01217	0.585
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.588
TRG_DiLeu_LyEn_5	170	175	PF01217	0.521
TRG_ER_diArg_1	103	105	PF00400	0.495
TRG_ER_diArg_1	13	15	PF00400	0.623
TRG_ER_diArg_1	336	338	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW3	Leptomonas seymouri	45%	95%
A0A0S4IWZ6	Bodo saltans	20%	100%
A0A1X0P838	Trypanosomatidae	24%	98%
A0A422NLC8	Trypanosoma rangeli	28%	100%
A4HP44	Leishmania braziliensis	67%	100%
E9ASV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q1P4	Leishmania major	90%	100%
V5B4D1	Trypanosoma cruzi	27%	100%