KU80 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

KU80 protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H820_LEIDO

TriTrypDb:

LdBPK_361560.1 , LdCL_360021100 , LDHU3_36.1990

Length:

948

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H820

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H820

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.590
CLV_C14_Caspase3-7	313	317	PF00656	0.724
CLV_C14_Caspase3-7	407	411	PF00656	0.621
CLV_C14_Caspase3-7	427	431	PF00656	0.600
CLV_C14_Caspase3-7	461	465	PF00656	0.570
CLV_C14_Caspase3-7	513	517	PF00656	0.628
CLV_C14_Caspase3-7	576	580	PF00656	0.499
CLV_C14_Caspase3-7	632	636	PF00656	0.721
CLV_C14_Caspase3-7	868	872	PF00656	0.744
CLV_C14_Caspase3-7	873	877	PF00656	0.748
CLV_NRD_NRD_1	298	300	PF00675	0.665
CLV_NRD_NRD_1	697	699	PF00675	0.573
CLV_NRD_NRD_1	754	756	PF00675	0.570
CLV_NRD_NRD_1	840	842	PF00675	0.662
CLV_NRD_NRD_1	887	889	PF00675	0.688
CLV_NRD_NRD_1	904	906	PF00675	0.573
CLV_PCSK_FUR_1	905	909	PF00082	0.540
CLV_PCSK_KEX2_1	262	264	PF00082	0.756
CLV_PCSK_KEX2_1	297	299	PF00082	0.669
CLV_PCSK_KEX2_1	697	699	PF00082	0.573
CLV_PCSK_KEX2_1	754	756	PF00082	0.570
CLV_PCSK_KEX2_1	862	864	PF00082	0.744
CLV_PCSK_KEX2_1	889	891	PF00082	0.761
CLV_PCSK_KEX2_1	903	905	PF00082	0.598
CLV_PCSK_KEX2_1	907	909	PF00082	0.544
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.756
CLV_PCSK_PC1ET2_1	862	864	PF00082	0.744
CLV_PCSK_PC1ET2_1	889	891	PF00082	0.781
CLV_PCSK_PC1ET2_1	903	905	PF00082	0.627
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.568
CLV_PCSK_SKI1_1	358	362	PF00082	0.573
CLV_PCSK_SKI1_1	404	408	PF00082	0.576
CLV_PCSK_SKI1_1	435	439	PF00082	0.508
CLV_PCSK_SKI1_1	53	57	PF00082	0.570
CLV_PCSK_SKI1_1	555	559	PF00082	0.629
CLV_PCSK_SKI1_1	660	664	PF00082	0.588
CLV_PCSK_SKI1_1	698	702	PF00082	0.681
CLV_PCSK_SKI1_1	842	846	PF00082	0.629
CLV_PCSK_SKI1_1	85	89	PF00082	0.665
DEG_APCC_DBOX_1	84	92	PF00400	0.652
DEG_SPOP_SBC_1	589	593	PF00917	0.692
DEG_SPOP_SBC_1	788	792	PF00917	0.681
DOC_CKS1_1	437	442	PF01111	0.528
DOC_CYCLIN_RxL_1	432	441	PF00134	0.540
DOC_CYCLIN_RxL_1	550	562	PF00134	0.603
DOC_CYCLIN_yClb5_NLxxxL_5	47	56	PF00134	0.364
DOC_CYCLIN_yClb5_NLxxxL_5	675	684	PF00134	0.567
DOC_MAPK_FxFP_2	545	548	PF00069	0.567
DOC_MAPK_gen_1	614	623	PF00069	0.676
DOC_MAPK_gen_1	82	91	PF00069	0.655
DOC_MAPK_gen_1	845	855	PF00069	0.678
DOC_MAPK_RevD_3	682	698	PF00069	0.623
DOC_PP1_RVXF_1	206	213	PF00149	0.541
DOC_PP1_SILK_1	201	206	PF00149	0.493
DOC_PP2B_LxvP_1	602	605	PF13499	0.699
DOC_PP4_FxxP_1	545	548	PF00568	0.524
DOC_PP4_FxxP_1	55	58	PF00568	0.500
DOC_USP7_MATH_1	155	159	PF00917	0.519
DOC_USP7_MATH_1	22	26	PF00917	0.582
DOC_USP7_MATH_1	315	319	PF00917	0.721
DOC_USP7_MATH_1	572	576	PF00917	0.632
DOC_USP7_MATH_1	589	593	PF00917	0.769
DOC_USP7_MATH_1	605	609	PF00917	0.664
DOC_USP7_MATH_1	616	620	PF00917	0.630
DOC_USP7_MATH_1	640	644	PF00917	0.740
DOC_USP7_MATH_1	70	74	PF00917	0.555
DOC_USP7_MATH_1	705	709	PF00917	0.718
DOC_USP7_MATH_1	718	722	PF00917	0.741
DOC_USP7_MATH_1	731	735	PF00917	0.595
DOC_USP7_MATH_1	762	766	PF00917	0.772
DOC_USP7_MATH_1	788	792	PF00917	0.761
DOC_USP7_UBL2_3	262	266	PF12436	0.762
DOC_USP7_UBL2_3	420	424	PF12436	0.564
DOC_USP7_UBL2_3	842	846	PF12436	0.651
DOC_USP7_UBL2_3	903	907	PF12436	0.636
DOC_USP7_UBL2_3	915	919	PF12436	0.606
DOC_WW_Pin1_4	11	16	PF00397	0.506
DOC_WW_Pin1_4	436	441	PF00397	0.513
DOC_WW_Pin1_4	504	509	PF00397	0.702
DOC_WW_Pin1_4	668	673	PF00397	0.615
DOC_WW_Pin1_4	734	739	PF00397	0.624
DOC_WW_Pin1_4	811	816	PF00397	0.736
DOC_WW_Pin1_4	926	931	PF00397	0.677
LIG_14-3-3_CanoR_1	251	256	PF00244	0.607
LIG_14-3-3_CanoR_1	518	527	PF00244	0.577
LIG_14-3-3_CanoR_1	543	548	PF00244	0.515
LIG_14-3-3_CanoR_1	614	623	PF00244	0.676
LIG_14-3-3_CanoR_1	697	703	PF00244	0.680
LIG_14-3-3_CanoR_1	848	855	PF00244	0.742
LIG_Actin_WH2_2	481	499	PF00022	0.484
LIG_BIR_III_2	470	474	PF00653	0.638
LIG_BIR_III_2	856	860	PF00653	0.692
LIG_CaM_IQ_9	834	850	PF13499	0.702
LIG_CtBP_PxDLS_1	724	728	PF00389	0.478
LIG_FHA_1	151	157	PF00498	0.509
LIG_FHA_1	378	384	PF00498	0.575
LIG_FHA_1	437	443	PF00498	0.625
LIG_FHA_1	44	50	PF00498	0.488
LIG_FHA_1	505	511	PF00498	0.709
LIG_FHA_1	591	597	PF00498	0.742
LIG_FHA_1	616	622	PF00498	0.640
LIG_FHA_1	629	635	PF00498	0.544
LIG_FHA_1	738	744	PF00498	0.688
LIG_FHA_2	213	219	PF00498	0.570
LIG_FHA_2	366	372	PF00498	0.664
LIG_FHA_2	405	411	PF00498	0.539
LIG_FHA_2	511	517	PF00498	0.592
LIG_FHA_2	871	877	PF00498	0.591
LIG_GBD_Chelix_1	190	198	PF00786	0.499
LIG_IBAR_NPY_1	126	128	PF08397	0.540
LIG_IRF3_LxIS_1	163	170	PF10401	0.532
LIG_LIR_Apic_2	542	548	PF02991	0.512
LIG_LIR_Gen_1	165	172	PF02991	0.391
LIG_LIR_Gen_1	34	43	PF02991	0.385
LIG_LIR_Gen_1	384	393	PF02991	0.435
LIG_LIR_Gen_1	5	11	PF02991	0.519
LIG_LIR_LC3C_4	851	855	PF02991	0.660
LIG_LIR_Nem_3	139	145	PF02991	0.398
LIG_LIR_Nem_3	165	169	PF02991	0.380
LIG_LIR_Nem_3	34	38	PF02991	0.387
LIG_LIR_Nem_3	413	418	PF02991	0.453
LIG_LIR_Nem_3	5	9	PF02991	0.491
LIG_PAM2_1	526	538	PF00658	0.494
LIG_PCNA_yPIPBox_3	614	627	PF02747	0.709
LIG_PTB_Apo_2	452	459	PF02174	0.477
LIG_PTB_Apo_2	487	494	PF02174	0.511
LIG_PTB_Phospho_1	487	493	PF10480	0.509
LIG_SH2_CRK	423	427	PF00017	0.618
LIG_SH2_CRK	493	497	PF00017	0.454
LIG_SH2_NCK_1	468	472	PF00017	0.614
LIG_SH2_NCK_1	646	650	PF00017	0.660
LIG_SH2_SRC	468	471	PF00017	0.609
LIG_SH2_SRC	747	750	PF00017	0.684
LIG_SH2_SRC	809	812	PF00017	0.617
LIG_SH2_STAP1	749	753	PF00017	0.573
LIG_SH2_STAT3	109	112	PF00017	0.484
LIG_SH2_STAT5	128	131	PF00017	0.547
LIG_SH2_STAT5	359	362	PF00017	0.571
LIG_SH2_STAT5	418	421	PF00017	0.453
LIG_SH2_STAT5	487	490	PF00017	0.418
LIG_SH2_STAT5	498	501	PF00017	0.468
LIG_SH2_STAT5	646	649	PF00017	0.662
LIG_SH2_STAT5	747	750	PF00017	0.684
LIG_SH3_3	394	400	PF00018	0.562
LIG_SH3_3	470	476	PF00018	0.695
LIG_SH3_3	812	818	PF00018	0.613
LIG_SH3_3	819	825	PF00018	0.645
LIG_SH3_3	936	942	PF00018	0.689
LIG_SxIP_EBH_1	773	783	PF03271	0.678
LIG_TRAF2_1	223	226	PF00917	0.584
LIG_TRAF2_1	269	272	PF00917	0.739
LIG_TRAF2_1	476	479	PF00917	0.554
LIG_WRC_WIRS_1	163	168	PF05994	0.453
LIG_WRC_WIRS_1	748	753	PF05994	0.631
MOD_CDK_SPK_2	811	816	PF00069	0.721
MOD_CDK_SPK_2	926	931	PF00069	0.677
MOD_CDK_SPxxK_3	504	511	PF00069	0.636
MOD_CK1_1	13	19	PF00069	0.537
MOD_CK1_1	158	164	PF00069	0.492
MOD_CK1_1	170	176	PF00069	0.387
MOD_CK1_1	189	195	PF00069	0.441
MOD_CK1_1	254	260	PF00069	0.688
MOD_CK1_1	375	381	PF00069	0.545
MOD_CK1_1	441	447	PF00069	0.613
MOD_CK1_1	483	489	PF00069	0.538
MOD_CK1_1	590	596	PF00069	0.751
MOD_CK1_1	619	625	PF00069	0.652
MOD_CK1_1	671	677	PF00069	0.636
MOD_CK1_1	683	689	PF00069	0.358
MOD_CK1_1	717	723	PF00069	0.711
MOD_CK1_1	734	740	PF00069	0.637
MOD_CK1_1	769	775	PF00069	0.740
MOD_CK1_1	786	792	PF00069	0.758
MOD_CK2_1	221	227	PF00069	0.574
MOD_CK2_1	23	29	PF00069	0.681
MOD_CK2_1	266	272	PF00069	0.734
MOD_CK2_1	344	350	PF00069	0.698
MOD_CK2_1	365	371	PF00069	0.694
MOD_CK2_1	589	595	PF00069	0.524
MOD_CK2_1	655	661	PF00069	0.656
MOD_CK2_1	787	793	PF00069	0.720
MOD_Cter_Amidation	859	862	PF01082	0.729
MOD_Cter_Amidation	905	908	PF01082	0.648
MOD_GlcNHglycan	131	134	PF01048	0.426
MOD_GlcNHglycan	15	18	PF01048	0.548
MOD_GlcNHglycan	157	160	PF01048	0.557
MOD_GlcNHglycan	362	366	PF01048	0.685
MOD_GlcNHglycan	410	413	PF01048	0.557
MOD_GlcNHglycan	482	485	PF01048	0.602
MOD_GlcNHglycan	530	533	PF01048	0.515
MOD_GlcNHglycan	561	564	PF01048	0.532
MOD_GlcNHglycan	565	568	PF01048	0.580
MOD_GlcNHglycan	631	634	PF01048	0.666
MOD_GlcNHglycan	638	641	PF01048	0.669
MOD_GlcNHglycan	64	67	PF01048	0.495
MOD_GlcNHglycan	642	645	PF01048	0.606
MOD_GlcNHglycan	652	655	PF01048	0.760
MOD_GlcNHglycan	716	719	PF01048	0.686
MOD_GlcNHglycan	720	723	PF01048	0.665
MOD_GlcNHglycan	76	80	PF01048	0.644
MOD_GlcNHglycan	774	777	PF01048	0.803
MOD_GlcNHglycan	793	797	PF01048	0.421
MOD_GlcNHglycan	850	853	PF01048	0.625
MOD_GlcNHglycan	863	866	PF01048	0.620
MOD_GSK3_1	158	165	PF00069	0.510
MOD_GSK3_1	254	261	PF00069	0.698
MOD_GSK3_1	273	280	PF00069	0.712
MOD_GSK3_1	281	288	PF00069	0.597
MOD_GSK3_1	328	335	PF00069	0.756
MOD_GSK3_1	361	368	PF00069	0.725
MOD_GSK3_1	373	380	PF00069	0.586
MOD_GSK3_1	404	411	PF00069	0.609
MOD_GSK3_1	444	451	PF00069	0.539
MOD_GSK3_1	479	486	PF00069	0.552
MOD_GSK3_1	506	513	PF00069	0.657
MOD_GSK3_1	514	521	PF00069	0.579
MOD_GSK3_1	539	546	PF00069	0.408
MOD_GSK3_1	559	566	PF00069	0.516
MOD_GSK3_1	587	594	PF00069	0.711
MOD_GSK3_1	615	622	PF00069	0.643
MOD_GSK3_1	636	643	PF00069	0.704
MOD_GSK3_1	714	721	PF00069	0.669
MOD_GSK3_1	734	741	PF00069	0.710
MOD_GSK3_1	762	769	PF00069	0.717
MOD_GSK3_1	783	790	PF00069	0.793
MOD_GSK3_1	805	812	PF00069	0.648
MOD_GSK3_1	891	898	PF00069	0.751
MOD_GSK3_1	941	948	PF00069	0.587
MOD_N-GLC_1	424	429	PF02516	0.601
MOD_N-GLC_1	572	577	PF02516	0.532
MOD_N-GLC_1	619	624	PF02516	0.715
MOD_N-GLC_1	628	633	PF02516	0.571
MOD_N-GLC_1	895	900	PF02516	0.804
MOD_NEK2_1	212	217	PF00069	0.525
MOD_NEK2_1	305	310	PF00069	0.648
MOD_NEK2_1	372	377	PF00069	0.608
MOD_NEK2_1	458	463	PF00069	0.430
MOD_NEK2_1	510	515	PF00069	0.665
MOD_NEK2_1	520	525	PF00069	0.501
MOD_NEK2_1	680	685	PF00069	0.368
MOD_PIKK_1	70	76	PF00454	0.531
MOD_PIKK_1	762	768	PF00454	0.694
MOD_PIKK_1	809	815	PF00454	0.551
MOD_PKA_1	861	867	PF00069	0.800
MOD_PKA_2	448	454	PF00069	0.516
MOD_PKA_2	616	622	PF00069	0.686
MOD_PKA_2	883	889	PF00069	0.620
MOD_PKB_1	75	83	PF00069	0.560
MOD_Plk_1	273	279	PF00069	0.734
MOD_Plk_1	619	625	PF00069	0.713
MOD_Plk_1	846	852	PF00069	0.577
MOD_Plk_4	158	164	PF00069	0.550
MOD_Plk_4	199	205	PF00069	0.448
MOD_Plk_4	398	404	PF00069	0.575
MOD_Plk_4	448	454	PF00069	0.461
MOD_Plk_4	458	464	PF00069	0.396
MOD_Plk_4	510	516	PF00069	0.613
MOD_Plk_4	683	689	PF00069	0.580
MOD_ProDKin_1	11	17	PF00069	0.499
MOD_ProDKin_1	436	442	PF00069	0.525
MOD_ProDKin_1	504	510	PF00069	0.706
MOD_ProDKin_1	668	674	PF00069	0.613
MOD_ProDKin_1	734	740	PF00069	0.622
MOD_ProDKin_1	811	817	PF00069	0.735
MOD_ProDKin_1	926	932	PF00069	0.680
MOD_SUMO_for_1	553	556	PF00179	0.593
MOD_SUMO_for_1	710	713	PF00179	0.563
MOD_SUMO_for_1	844	847	PF00179	0.627
MOD_SUMO_rev_2	139	145	PF00179	0.420
MOD_SUMO_rev_2	321	331	PF00179	0.735
MOD_SUMO_rev_2	350	360	PF00179	0.741
MOD_SUMO_rev_2	478	483	PF00179	0.590
TRG_DiLeu_BaEn_1	369	374	PF01217	0.720
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.588
TRG_ENDOCYTIC_2	142	145	PF00928	0.393
TRG_ENDOCYTIC_2	423	426	PF00928	0.555
TRG_ENDOCYTIC_2	493	496	PF00928	0.447
TRG_ER_diArg_1	296	299	PF00400	0.719
TRG_ER_diArg_1	696	698	PF00400	0.552
TRG_ER_diArg_1	753	755	PF00400	0.565
TRG_NLS_Bipartite_1	845	865	PF00514	0.672
TRG_NLS_Bipartite_1	888	907	PF00514	0.721
TRG_NLS_MonoCore_2	901	906	PF00514	0.710
TRG_NLS_MonoExtC_3	902	907	PF00514	0.685
TRG_NLS_MonoExtN_4	859	865	PF00514	0.688
TRG_NLS_MonoExtN_4	900	907	PF00514	0.687
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W5	Leptomonas seymouri	60%	98%
A0A0S4JFW1	Bodo saltans	32%	100%
A0A1X0P867	Trypanosomatidae	38%	100%
A4HP10	Leishmania braziliensis	69%	98%
A4IDB9	Leishmania infantum	99%	100%
D0A2Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ASS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1S6	Leishmania major	89%	100%