Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H819_LEIDO

TriTrypDb:

LdBPK_361400.1 , LdCL_360019100 , LDHU3_36.1750

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0043233	organelle lumen	3	1

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Expansion

Sequence features

A0A3S5H819

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H819

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0016874	ligase activity	2	3
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.707
CLV_C14_Caspase3-7	262	266	PF00656	0.768
CLV_NRD_NRD_1	201	203	PF00675	0.761
CLV_NRD_NRD_1	283	285	PF00675	0.714
CLV_NRD_NRD_1	43	45	PF00675	0.513
CLV_PCSK_KEX2_1	195	197	PF00082	0.699
CLV_PCSK_KEX2_1	282	284	PF00082	0.665
CLV_PCSK_KEX2_1	42	44	PF00082	0.516
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.699
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.665

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA52	Leptomonas seymouri	73%	100%
A0A0S4J2P2	Bodo saltans	39%	100%
A0A1X0P7R0	Trypanosomatidae	42%	100%
A4HNZ2	Leishmania braziliensis	74%	100%
A4ICK1	Leishmania infantum	100%	100%
D0A369	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1U1	Leishmania major	90%	100%

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