CRAL/TRIO domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sec14, cytosolic factor

Species:

Leishmania donovani

UniProt:

A0A3S5H815_LEIDO

TriTrypDb:

LdBPK_360640.1 , LdCL_360011300 , LDHU3_36.0800

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H815

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H815

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.548
CLV_C14_Caspase3-7	53	57	PF00656	0.421
CLV_MEL_PAP_1	98	104	PF00089	0.452
CLV_NRD_NRD_1	190	192	PF00675	0.347
CLV_NRD_NRD_1	305	307	PF00675	0.449
CLV_NRD_NRD_1	419	421	PF00675	0.745
CLV_NRD_NRD_1	67	69	PF00675	0.392
CLV_NRD_NRD_1	75	77	PF00675	0.330
CLV_PCSK_FUR_1	219	223	PF00082	0.407
CLV_PCSK_KEX2_1	221	223	PF00082	0.312
CLV_PCSK_KEX2_1	419	421	PF00082	0.745
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.312
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.674
CLV_PCSK_SKI1_1	105	109	PF00082	0.475
CLV_PCSK_SKI1_1	275	279	PF00082	0.319
CLV_PCSK_SKI1_1	79	83	PF00082	0.365
DEG_MDM2_SWIB_1	270	277	PF02201	0.336
DEG_SCF_FBW7_1	388	395	PF00400	0.670
DEG_SPOP_SBC_1	374	378	PF00917	0.768
DEG_SPOP_SBC_1	392	396	PF00917	0.567
DEG_SPOP_SBC_1	408	412	PF00917	0.779
DOC_MAPK_gen_1	191	197	PF00069	0.407
DOC_MAPK_gen_1	219	229	PF00069	0.304
DOC_MAPK_gen_1	76	83	PF00069	0.423
DOC_PP1_RVXF_1	132	139	PF00149	0.418
DOC_PP1_RVXF_1	285	292	PF00149	0.312
DOC_PP4_FxxP_1	291	294	PF00568	0.367
DOC_PP4_FxxP_1	380	383	PF00568	0.655
DOC_USP7_MATH_1	365	369	PF00917	0.737
DOC_USP7_MATH_1	392	396	PF00917	0.771
DOC_USP7_MATH_1	408	412	PF00917	0.564
DOC_USP7_MATH_1	58	62	PF00917	0.372
DOC_USP7_UBL2_3	41	45	PF12436	0.432
DOC_WW_Pin1_4	341	346	PF00397	0.597
DOC_WW_Pin1_4	35	40	PF00397	0.455
DOC_WW_Pin1_4	361	366	PF00397	0.718
DOC_WW_Pin1_4	388	393	PF00397	0.738
DOC_WW_Pin1_4	395	400	PF00397	0.673
LIG_14-3-3_CanoR_1	105	110	PF00244	0.474
LIG_14-3-3_CanoR_1	191	196	PF00244	0.325
LIG_APCC_ABBA_1	277	282	PF00400	0.293
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	386	390	PF00533	0.657
LIG_CtBP_PxDLS_1	255	259	PF00389	0.407
LIG_FHA_1	192	198	PF00498	0.407
LIG_FHA_1	376	382	PF00498	0.726
LIG_FHA_1	90	96	PF00498	0.516
LIG_FHA_2	106	112	PF00498	0.489
LIG_FHA_2	151	157	PF00498	0.465
LIG_FHA_2	164	170	PF00498	0.422
LIG_FHA_2	5	11	PF00498	0.525
LIG_Integrin_isoDGR_2	66	68	PF01839	0.345
LIG_LIR_Apic_2	341	346	PF02991	0.593
LIG_LIR_Apic_2	377	383	PF02991	0.658
LIG_LIR_Gen_1	108	117	PF02991	0.369
LIG_LIR_Gen_1	126	136	PF02991	0.390
LIG_LIR_Nem_3	108	112	PF02991	0.386
LIG_LIR_Nem_3	126	132	PF02991	0.390
LIG_LIR_Nem_3	43	49	PF02991	0.340
LIG_PCNA_PIPBox_1	143	152	PF02747	0.250
LIG_PCNA_yPIPBox_3	116	129	PF02747	0.448
LIG_PCNA_yPIPBox_3	139	150	PF02747	0.255
LIG_PCNA_yPIPBox_3	288	302	PF02747	0.423
LIG_Pex14_1	138	142	PF04695	0.364
LIG_Pex14_2	270	274	PF04695	0.293
LIG_SH2_CRK	193	197	PF00017	0.345
LIG_SH2_CRK	343	347	PF00017	0.606
LIG_SH2_NCK_1	343	347	PF00017	0.591
LIG_SH2_NCK_1	87	91	PF00017	0.528
LIG_SH2_SRC	87	90	PF00017	0.529
LIG_SH2_STAP1	168	172	PF00017	0.312
LIG_SH2_STAT3	149	152	PF00017	0.453
LIG_SH2_STAT5	149	152	PF00017	0.383
LIG_SH2_STAT5	162	165	PF00017	0.293
LIG_SH2_STAT5	174	177	PF00017	0.312
LIG_SH2_STAT5	193	196	PF00017	0.345
LIG_SH2_STAT5	70	73	PF00017	0.293
LIG_SH3_3	261	267	PF00018	0.312
LIG_SH3_3	396	402	PF00018	0.750
LIG_TRAF2_1	398	401	PF00917	0.684
LIG_UBA3_1	301	307	PF00899	0.438
MOD_CDC14_SPxK_1	364	367	PF00782	0.769
MOD_CDC14_SPxK_1	38	41	PF00782	0.455
MOD_CDK_SPxK_1	35	41	PF00069	0.423
MOD_CDK_SPxK_1	361	367	PF00069	0.755
MOD_CK1_1	344	350	PF00069	0.606
MOD_CK1_1	395	401	PF00069	0.669
MOD_CK1_1	411	417	PF00069	0.725
MOD_CK1_1	61	67	PF00069	0.407
MOD_CK2_1	150	156	PF00069	0.376
MOD_CK2_1	365	371	PF00069	0.705
MOD_CK2_1	395	401	PF00069	0.767
MOD_Cter_Amidation	416	419	PF01082	0.719
MOD_Cter_Amidation	66	69	PF01082	0.392
MOD_GlcNHglycan	415	418	PF01048	0.691
MOD_GSK3_1	213	220	PF00069	0.409
MOD_GSK3_1	355	362	PF00069	0.647
MOD_GSK3_1	384	391	PF00069	0.656
MOD_GSK3_1	403	410	PF00069	0.669
MOD_N-GLC_1	353	358	PF02516	0.675
MOD_N-GLC_1	61	66	PF02516	0.423
MOD_N-GLC_2	290	292	PF02516	0.407
MOD_N-GLC_2	312	314	PF02516	0.391
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	213	218	PF00069	0.299
MOD_NEK2_1	235	240	PF00069	0.307
MOD_NEK2_1	242	247	PF00069	0.270
MOD_NEK2_1	353	358	PF00069	0.607
MOD_NEK2_2	23	28	PF00069	0.423
MOD_NEK2_2	365	370	PF00069	0.755
MOD_PIKK_1	353	359	PF00454	0.679
MOD_PKA_1	191	197	PF00069	0.407
MOD_PKA_2	213	219	PF00069	0.393
MOD_ProDKin_1	341	347	PF00069	0.605
MOD_ProDKin_1	35	41	PF00069	0.455
MOD_ProDKin_1	361	367	PF00069	0.724
MOD_ProDKin_1	388	394	PF00069	0.738
MOD_ProDKin_1	395	401	PF00069	0.674
MOD_SUMO_for_1	348	351	PF00179	0.523
MOD_SUMO_rev_2	395	405	PF00179	0.765
MOD_SUMO_rev_2	9	13	PF00179	0.530
TRG_ENDOCYTIC_2	129	132	PF00928	0.378
TRG_ENDOCYTIC_2	87	90	PF00928	0.473
TRG_ER_diArg_1	138	141	PF00400	0.422
TRG_NLS_MonoCore_2	417	422	PF00514	0.671
TRG_NLS_MonoExtN_4	418	423	PF00514	0.672
TRG_NLS_MonoExtN_4	75	80	PF00514	0.345
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.775

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF64	Leptomonas seymouri	69%	99%
A0A0S4J1X8	Bodo saltans	47%	100%
A0A1X0P8J0	Trypanosomatidae	47%	100%
A0A3R7LCT9	Trypanosoma rangeli	48%	100%
A4ICS6	Leishmania infantum	99%	100%
E9ASH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
F4K6D3	Arabidopsis thaliana	27%	74%
P24859	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	100%
Q501H5	Arabidopsis thaliana	25%	68%
V5BZX6	Trypanosoma cruzi	50%	100%