PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H814_LEIDO

TriTrypDb:

LdBPK_360430.1 , LdCL_360009200 , LDHU3_36.0570

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H814

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H814

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.518
CLV_NRD_NRD_1	7	9	PF00675	0.421
CLV_NRD_NRD_1	88	90	PF00675	0.587
CLV_PCSK_KEX2_1	7	9	PF00082	0.495
CLV_PCSK_KEX2_1	88	90	PF00082	0.587
CLV_PCSK_SKI1_1	339	343	PF00082	0.545
CLV_PCSK_SKI1_1	439	443	PF00082	0.404
DEG_SPOP_SBC_1	325	329	PF00917	0.553
DEG_SPOP_SBC_1	63	67	PF00917	0.647
DOC_CKS1_1	408	413	PF01111	0.479
DOC_MIT_MIM_1	261	270	PF04212	0.543
DOC_PP2B_LxvP_1	335	338	PF13499	0.538
DOC_SPAK_OSR1_1	8	12	PF12202	0.472
DOC_USP7_MATH_1	118	122	PF00917	0.417
DOC_USP7_MATH_1	187	191	PF00917	0.408
DOC_USP7_MATH_1	255	259	PF00917	0.524
DOC_USP7_MATH_1	330	334	PF00917	0.767
DOC_USP7_MATH_1	63	67	PF00917	0.653
DOC_USP7_MATH_2	292	298	PF00917	0.524
DOC_WW_Pin1_4	280	285	PF00397	0.587
DOC_WW_Pin1_4	321	326	PF00397	0.688
DOC_WW_Pin1_4	347	352	PF00397	0.744
DOC_WW_Pin1_4	407	412	PF00397	0.422
LIG_14-3-3_CanoR_1	108	116	PF00244	0.472
LIG_14-3-3_CanoR_1	120	126	PF00244	0.365
LIG_14-3-3_CanoR_1	316	325	PF00244	0.626
LIG_14-3-3_CanoR_1	339	347	PF00244	0.613
LIG_14-3-3_CanoR_1	366	372	PF00244	0.395
LIG_14-3-3_CanoR_1	439	446	PF00244	0.428
LIG_14-3-3_CanoR_1	88	94	PF00244	0.573
LIG_Actin_WH2_2	233	250	PF00022	0.466
LIG_AP2alpha_2	432	434	PF02296	0.442
LIG_EVH1_1	354	358	PF00568	0.530
LIG_FHA_1	111	117	PF00498	0.573
LIG_FHA_1	124	130	PF00498	0.406
LIG_FHA_1	213	219	PF00498	0.494
LIG_FHA_1	326	332	PF00498	0.685
LIG_FHA_1	56	62	PF00498	0.514
LIG_FHA_2	122	128	PF00498	0.496
LIG_FHA_2	168	174	PF00498	0.472
LIG_FHA_2	254	260	PF00498	0.508
LIG_FHA_2	360	366	PF00498	0.541
LIG_FHA_2	427	433	PF00498	0.422
LIG_Integrin_isoDGR_2	435	437	PF01839	0.465
LIG_LIR_Gen_1	211	221	PF02991	0.452
LIG_LIR_Gen_1	232	242	PF02991	0.608
LIG_LIR_Nem_3	211	217	PF02991	0.402
LIG_LIR_Nem_3	232	237	PF02991	0.502
LIG_LIR_Nem_3	429	434	PF02991	0.430
LIG_PTB_Apo_2	3	10	PF02174	0.488
LIG_Rb_LxCxE_1	245	264	PF01857	0.493
LIG_RPA_C_Fungi	388	400	PF08784	0.416
LIG_SH2_STAP1	125	129	PF00017	0.397
LIG_SH2_STAP1	214	218	PF00017	0.495
LIG_SH2_STAT5	125	128	PF00017	0.451
LIG_SH2_STAT5	21	24	PF00017	0.428
LIG_SH2_STAT5	214	217	PF00017	0.445
LIG_SH3_3	297	303	PF00018	0.615
LIG_SH3_3	349	355	PF00018	0.584
LIG_SH3_3	405	411	PF00018	0.490
LIG_SH3_3	94	100	PF00018	0.518
LIG_SH3_CIN85_PxpxPR_1	351	356	PF14604	0.512
LIG_SUMO_SIM_anti_2	172	180	PF11976	0.431
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.394
LIG_SUMO_SIM_par_1	20	27	PF11976	0.395
LIG_TRAF2_1	170	173	PF00917	0.429
LIG_TRAF2_1	262	265	PF00917	0.522
LIG_TRAF2_1	307	310	PF00917	0.525
LIG_TRAF2_1	413	416	PF00917	0.414
LIG_TYR_ITIM	92	97	PF00017	0.582
MOD_CDK_SPK_2	321	326	PF00069	0.660
MOD_CK1_1	110	116	PF00069	0.502
MOD_CK1_1	121	127	PF00069	0.497
MOD_CK1_1	200	206	PF00069	0.591
MOD_CK1_1	212	218	PF00069	0.315
MOD_CK1_1	314	320	PF00069	0.686
MOD_CK1_1	345	351	PF00069	0.673
MOD_CK1_1	359	365	PF00069	0.347
MOD_CK1_1	70	76	PF00069	0.542
MOD_CK2_1	121	127	PF00069	0.497
MOD_CK2_1	167	173	PF00069	0.472
MOD_CK2_1	255	261	PF00069	0.639
MOD_CK2_1	304	310	PF00069	0.586
MOD_CK2_1	359	365	PF00069	0.673
MOD_DYRK1A_RPxSP_1	321	325	PF00069	0.623
MOD_GlcNHglycan	139	142	PF01048	0.486
MOD_GlcNHglycan	14	17	PF01048	0.431
MOD_GlcNHglycan	278	281	PF01048	0.480
MOD_GlcNHglycan	316	319	PF01048	0.666
MOD_GlcNHglycan	339	342	PF01048	0.666
MOD_GSK3_1	208	215	PF00069	0.498
MOD_GSK3_1	255	262	PF00069	0.492
MOD_GSK3_1	269	276	PF00069	0.481
MOD_GSK3_1	321	328	PF00069	0.729
MOD_GSK3_1	342	349	PF00069	0.800
MOD_GSK3_1	403	410	PF00069	0.608
MOD_GSK3_1	53	60	PF00069	0.699
MOD_GSK3_1	63	70	PF00069	0.617
MOD_N-GLC_1	314	319	PF02516	0.653
MOD_N-GLC_1	33	38	PF02516	0.415
MOD_NEK2_1	12	17	PF00069	0.406
MOD_NEK2_1	181	186	PF00069	0.486
MOD_NEK2_1	210	215	PF00069	0.495
MOD_NEK2_1	304	309	PF00069	0.599
MOD_NEK2_2	57	62	PF00069	0.555
MOD_OFUCOSY	13	18	PF10250	0.469
MOD_PIKK_1	148	154	PF00454	0.508
MOD_PIKK_1	200	206	PF00454	0.448
MOD_PIKK_1	304	310	PF00454	0.642
MOD_PIKK_1	319	325	PF00454	0.631
MOD_PIKK_1	356	362	PF00454	0.488
MOD_PIKK_1	87	93	PF00454	0.616
MOD_PKA_2	107	113	PF00069	0.515
MOD_PKA_2	345	351	PF00069	0.812
MOD_PKA_2	87	93	PF00069	0.646
MOD_PKB_1	437	445	PF00069	0.484
MOD_Plk_1	118	124	PF00069	0.405
MOD_Plk_2-3	259	265	PF00069	0.485
MOD_Plk_4	110	116	PF00069	0.502
MOD_Plk_4	162	168	PF00069	0.466
MOD_Plk_4	17	23	PF00069	0.389
MOD_Plk_4	24	30	PF00069	0.394
MOD_Plk_4	269	275	PF00069	0.486
MOD_ProDKin_1	280	286	PF00069	0.589
MOD_ProDKin_1	321	327	PF00069	0.687
MOD_ProDKin_1	347	353	PF00069	0.745
MOD_ProDKin_1	407	413	PF00069	0.420
MOD_SUMO_for_1	39	42	PF00179	0.475
MOD_SUMO_rev_2	127	132	PF00179	0.526
TRG_ENDOCYTIC_2	214	217	PF00928	0.470
TRG_ENDOCYTIC_2	234	237	PF00928	0.333
TRG_ENDOCYTIC_2	431	434	PF00928	0.442
TRG_ENDOCYTIC_2	94	97	PF00928	0.588
TRG_ER_diArg_1	437	440	PF00400	0.487
TRG_ER_diArg_1	7	9	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I6	Leptomonas seymouri	56%	94%
A0A1X0P8C3	Trypanosomatidae	30%	100%
A4HNP8	Leishmania braziliensis	76%	100%
A4ICU7	Leishmania infantum	100%	100%
E9ASF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q238	Leishmania major	91%	100%
V5DRR0	Trypanosoma cruzi	33%	100%