LeishMANIAdb
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Homeobox_associated_leucine_zipper_putative/Pfam: PF02183

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Homeobox_associated_leucine_zipper_putative/Pfam: PF02183
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H811_LEIDO
TriTrypDb:
LdBPK_355230.1 , LdCL_350058100 , LDHU3_35.6990
Length:
85

Annotations

Annotations by Jardim et al.

Transcription, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9
GO:0005815 microtubule organizing center 2 1
GO:0005930 axoneme 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

A0A3S5H811
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H811

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003677 DNA binding 4 2
GO:0003712 transcription coregulator activity 2 9
GO:0003713 transcription coactivator activity 3 9
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:0140110 transcription regulator activity 1 9
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 13 15 PF00675 0.425
CLV_PCSK_KEX2_1 48 50 PF00082 0.505
CLV_PCSK_PC1ET2_1 48 50 PF00082 0.505
CLV_PCSK_SKI1_1 48 52 PF00082 0.415
LIG_APCC_ABBA_1 31 36 PF00400 0.384
LIG_BIR_II_1 1 5 PF00653 0.485
LIG_FHA_1 18 24 PF00498 0.431
LIG_FHA_1 25 31 PF00498 0.388
LIG_GBD_Chelix_1 22 30 PF00786 0.459
LIG_LIR_Gen_1 56 67 PF02991 0.419
LIG_LIR_Nem_3 11 16 PF02991 0.386
LIG_LIR_Nem_3 56 62 PF02991 0.477
LIG_SH2_SRC 16 19 PF00017 0.408
LIG_SH2_STAT5 16 19 PF00017 0.373
LIG_SH2_STAT5 46 49 PF00017 0.489
LIG_SH3_3 37 43 PF00018 0.446
MOD_CK1_1 2 8 PF00069 0.437
MOD_GlcNHglycan 55 58 PF01048 0.544
MOD_GlcNHglycan 80 83 PF01048 0.563
MOD_NEK2_1 17 22 PF00069 0.435
MOD_PIKK_1 17 23 PF00454 0.461
MOD_PKA_2 3 9 PF00069 0.519
MOD_Plk_1 17 23 PF00069 0.462
MOD_SUMO_for_1 8 11 PF00179 0.368
MOD_SUMO_rev_2 35 40 PF00179 0.493
TRG_ENDOCYTIC_2 59 62 PF00928 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P616 Leptomonas seymouri 96% 100%
A0A0S4JQH9 Bodo saltans 73% 97%
A4HNI7 Leishmania braziliensis 96% 100%
A4IC44 Leishmania infantum 100% 100%
C9ZYD0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 80% 100%
E9AFZ9 Leishmania major 99% 100%
E9B752 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q2TBP7 Bos taurus 38% 83%
Q54I57 Dictyostelium discoideum 53% 94%
Q5R7A8 Pongo abelii 39% 83%
Q99417 Homo sapiens 39% 83%
Q9EQS3 Mus musculus 39% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS