Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H810_LEIDO

TriTrypDb:

LdBPK_355370.1 , LdCL_350056000 , LDHU3_35.6690

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H810

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H810

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.641
CLV_C14_Caspase3-7	60	64	PF00656	0.549
CLV_NRD_NRD_1	19	21	PF00675	0.699
CLV_NRD_NRD_1	373	375	PF00675	0.683
CLV_NRD_NRD_1	377	379	PF00675	0.645
CLV_NRD_NRD_1	516	518	PF00675	0.700
CLV_NRD_NRD_1	520	522	PF00675	0.697
CLV_NRD_NRD_1	545	547	PF00675	0.711
CLV_NRD_NRD_1	583	585	PF00675	0.720
CLV_NRD_NRD_1	590	592	PF00675	0.648
CLV_PCSK_FUR_1	374	378	PF00082	0.636
CLV_PCSK_FUR_1	517	521	PF00082	0.667
CLV_PCSK_FUR_1	588	592	PF00082	0.715
CLV_PCSK_KEX2_1	19	21	PF00082	0.699
CLV_PCSK_KEX2_1	373	375	PF00082	0.683
CLV_PCSK_KEX2_1	376	378	PF00082	0.658
CLV_PCSK_KEX2_1	516	518	PF00082	0.701
CLV_PCSK_KEX2_1	519	521	PF00082	0.702
CLV_PCSK_KEX2_1	545	547	PF00082	0.711
CLV_PCSK_KEX2_1	583	585	PF00082	0.720
CLV_PCSK_KEX2_1	590	592	PF00082	0.648
CLV_PCSK_PC7_1	373	379	PF00082	0.636
CLV_PCSK_PC7_1	516	522	PF00082	0.694
CLV_PCSK_SKI1_1	190	194	PF00082	0.681
CLV_PCSK_SKI1_1	243	247	PF00082	0.563
CLV_PCSK_SKI1_1	36	40	PF00082	0.631
CLV_PCSK_SKI1_1	558	562	PF00082	0.648
CLV_PCSK_SKI1_1	72	76	PF00082	0.600
DEG_Nend_UBRbox_2	1	3	PF02207	0.638
DEG_SPOP_SBC_1	214	218	PF00917	0.664
DEG_SPOP_SBC_1	289	293	PF00917	0.656
DEG_SPOP_SBC_1	417	421	PF00917	0.583
DEG_SPOP_SBC_1	45	49	PF00917	0.685
DOC_CKS1_1	83	88	PF01111	0.721
DOC_CYCLIN_RxL_1	69	78	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	180	183	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	564	570	PF00134	0.642
DOC_MAPK_MEF2A_6	558	566	PF00069	0.647
DOC_MAPK_RevD_3	359	374	PF00069	0.658
DOC_MAPK_RevD_3	532	546	PF00069	0.615
DOC_PP2B_LxvP_1	180	183	PF13499	0.653
DOC_PP2B_LxvP_1	224	227	PF13499	0.719
DOC_PP2B_LxvP_1	265	268	PF13499	0.713
DOC_PP2B_LxvP_1	455	458	PF13499	0.670
DOC_PP2B_LxvP_1	564	567	PF13499	0.641
DOC_SPAK_OSR1_1	357	361	PF12202	0.677
DOC_USP7_MATH_1	127	131	PF00917	0.678
DOC_USP7_MATH_1	152	156	PF00917	0.688
DOC_USP7_MATH_1	192	196	PF00917	0.707
DOC_USP7_MATH_1	200	204	PF00917	0.649
DOC_USP7_MATH_1	214	218	PF00917	0.586
DOC_USP7_MATH_1	227	231	PF00917	0.558
DOC_USP7_MATH_1	275	279	PF00917	0.691
DOC_USP7_MATH_1	290	294	PF00917	0.610
DOC_USP7_MATH_1	313	317	PF00917	0.600
DOC_USP7_MATH_1	393	397	PF00917	0.668
DOC_USP7_MATH_1	418	422	PF00917	0.647
DOC_USP7_MATH_1	45	49	PF00917	0.652
DOC_USP7_MATH_1	464	468	PF00917	0.668
DOC_USP7_MATH_1	511	515	PF00917	0.717
DOC_USP7_MATH_1	601	605	PF00917	0.539
DOC_USP7_MATH_1	640	644	PF00917	0.636
DOC_USP7_MATH_2	445	451	PF00917	0.602
DOC_WW_Pin1_4	202	207	PF00397	0.710
DOC_WW_Pin1_4	219	224	PF00397	0.548
DOC_WW_Pin1_4	309	314	PF00397	0.638
DOC_WW_Pin1_4	335	340	PF00397	0.665
DOC_WW_Pin1_4	388	393	PF00397	0.654
DOC_WW_Pin1_4	441	446	PF00397	0.668
DOC_WW_Pin1_4	459	464	PF00397	0.556
DOC_WW_Pin1_4	509	514	PF00397	0.656
DOC_WW_Pin1_4	536	541	PF00397	0.611
DOC_WW_Pin1_4	558	563	PF00397	0.676
DOC_WW_Pin1_4	578	583	PF00397	0.540
DOC_WW_Pin1_4	58	63	PF00397	0.657
DOC_WW_Pin1_4	592	597	PF00397	0.558
DOC_WW_Pin1_4	621	626	PF00397	0.700
DOC_WW_Pin1_4	82	87	PF00397	0.717
LIG_14-3-3_CanoR_1	103	107	PF00244	0.651
LIG_14-3-3_CanoR_1	213	223	PF00244	0.644
LIG_14-3-3_CanoR_1	383	387	PF00244	0.634
LIG_14-3-3_CanoR_1	408	417	PF00244	0.649
LIG_BIR_III_2	639	643	PF00653	0.618
LIG_BRCT_BRCA1_1	337	341	PF00533	0.621
LIG_CtBP_PxDLS_1	206	210	PF00389	0.663
LIG_EVH1_1	265	269	PF00568	0.714
LIG_FHA_1	26	32	PF00498	0.688
LIG_FHA_1	283	289	PF00498	0.662
LIG_FHA_1	402	408	PF00498	0.574
LIG_FHA_1	559	565	PF00498	0.646
LIG_FHA_1	625	631	PF00498	0.674
LIG_FHA_2	398	404	PF00498	0.636
LIG_FHA_2	574	580	PF00498	0.666
LIG_LIR_Apic_2	595	601	PF02991	0.681
LIG_LIR_Gen_1	355	364	PF02991	0.665
LIG_LIR_Nem_3	218	224	PF02991	0.673
LIG_LIR_Nem_3	355	361	PF02991	0.668
LIG_MYND_1	476	480	PF01753	0.639
LIG_MYND_1	96	100	PF01753	0.698
LIG_RPA_C_Fungi	541	553	PF08784	0.706
LIG_SH2_CRK	598	602	PF00017	0.685
LIG_SH2_NCK_1	598	602	PF00017	0.685
LIG_SH2_SRC	322	325	PF00017	0.549
LIG_SH3_1	19	25	PF00018	0.680
LIG_SH3_1	263	269	PF00018	0.711
LIG_SH3_2	269	274	PF14604	0.590
LIG_SH3_3	121	127	PF00018	0.642
LIG_SH3_3	19	25	PF00018	0.680
LIG_SH3_3	263	269	PF00018	0.711
LIG_SH3_3	28	34	PF00018	0.603
LIG_SH3_3	328	334	PF00018	0.649
LIG_SH3_3	347	353	PF00018	0.531
LIG_SH3_3	361	367	PF00018	0.512
LIG_SH3_3	426	432	PF00018	0.623
LIG_SH3_3	627	633	PF00018	0.645
LIG_SH3_3	639	645	PF00018	0.518
LIG_SH3_3	77	83	PF00018	0.698
LIG_SH3_3	94	100	PF00018	0.527
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.631
MOD_CDC14_SPxK_1	581	584	PF00782	0.713
MOD_CDC14_SPxK_1	628	631	PF00782	0.695
MOD_CDK_SPK_2	578	583	PF00069	0.714
MOD_CDK_SPxK_1	578	584	PF00069	0.715
MOD_CDK_SPxK_1	625	631	PF00069	0.693
MOD_CDK_SPxxK_3	509	516	PF00069	0.640
MOD_CK1_1	105	111	PF00069	0.581
MOD_CK1_1	130	136	PF00069	0.734
MOD_CK1_1	167	173	PF00069	0.698
MOD_CK1_1	175	181	PF00069	0.631
MOD_CK1_1	205	211	PF00069	0.712
MOD_CK1_1	217	223	PF00069	0.596
MOD_CK1_1	231	237	PF00069	0.516
MOD_CK1_1	256	262	PF00069	0.666
MOD_CK1_1	293	299	PF00069	0.653
MOD_CK1_1	425	431	PF00069	0.676
MOD_CK1_1	495	501	PF00069	0.617
MOD_CK1_1	548	554	PF00069	0.670
MOD_CK1_1	594	600	PF00069	0.687
MOD_CK1_1	604	610	PF00069	0.582
MOD_CK1_1	624	630	PF00069	0.502
MOD_CK1_1	91	97	PF00069	0.686
MOD_CK2_1	157	163	PF00069	0.603
MOD_CK2_1	294	300	PF00069	0.667
MOD_CK2_1	322	328	PF00069	0.634
MOD_CK2_1	397	403	PF00069	0.636
MOD_CK2_1	441	447	PF00069	0.628
MOD_DYRK1A_RPxSP_1	441	445	PF00069	0.729
MOD_DYRK1A_RPxSP_1	558	562	PF00069	0.648
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.713
MOD_GlcNHglycan	159	162	PF01048	0.747
MOD_GlcNHglycan	177	180	PF01048	0.568
MOD_GlcNHglycan	277	280	PF01048	0.638
MOD_GlcNHglycan	297	300	PF01048	0.521
MOD_GlcNHglycan	317	320	PF01048	0.470
MOD_GlcNHglycan	367	370	PF01048	0.632
MOD_GlcNHglycan	41	44	PF01048	0.623
MOD_GlcNHglycan	420	423	PF01048	0.650
MOD_GlcNHglycan	424	427	PF01048	0.629
MOD_GlcNHglycan	48	51	PF01048	0.631
MOD_GlcNHglycan	494	497	PF01048	0.604
MOD_GlcNHglycan	513	516	PF01048	0.602
MOD_GlcNHglycan	521	524	PF01048	0.668
MOD_GlcNHglycan	548	551	PF01048	0.666
MOD_GlcNHglycan	611	615	PF01048	0.676
MOD_GlcNHglycan	90	93	PF01048	0.654
MOD_GSK3_1	102	109	PF00069	0.712
MOD_GSK3_1	125	132	PF00069	0.734
MOD_GSK3_1	188	195	PF00069	0.677
MOD_GSK3_1	198	205	PF00069	0.634
MOD_GSK3_1	213	220	PF00069	0.577
MOD_GSK3_1	227	234	PF00069	0.561
MOD_GSK3_1	289	296	PF00069	0.683
MOD_GSK3_1	309	316	PF00069	0.549
MOD_GSK3_1	32	39	PF00069	0.663
MOD_GSK3_1	393	400	PF00069	0.638
MOD_GSK3_1	41	48	PF00069	0.587
MOD_GSK3_1	418	425	PF00069	0.693
MOD_GSK3_1	447	454	PF00069	0.686
MOD_GSK3_1	53	60	PF00069	0.572
MOD_GSK3_1	568	575	PF00069	0.546
MOD_GSK3_1	617	624	PF00069	0.698
MOD_GSK3_1	78	85	PF00069	0.704
MOD_N-GLC_1	128	133	PF02516	0.674
MOD_N-GLC_1	36	41	PF02516	0.644
MOD_NEK2_1	164	169	PF00069	0.639
MOD_NEK2_1	253	258	PF00069	0.625
MOD_NEK2_1	27	32	PF00069	0.642
MOD_NEK2_1	314	319	PF00069	0.673
MOD_NEK2_1	38	43	PF00069	0.562
MOD_NEK2_1	397	402	PF00069	0.620
MOD_NEK2_1	439	444	PF00069	0.689
MOD_NEK2_2	393	398	PF00069	0.649
MOD_PIKK_1	322	328	PF00454	0.573
MOD_PIKK_1	456	462	PF00454	0.662
MOD_PIKK_1	551	557	PF00454	0.715
MOD_PKA_1	519	525	PF00069	0.665
MOD_PKA_1	545	551	PF00069	0.711
MOD_PKA_1	583	589	PF00069	0.667
MOD_PKA_2	102	108	PF00069	0.674
MOD_PKA_2	114	120	PF00069	0.608
MOD_PKA_2	167	173	PF00069	0.687
MOD_PKA_2	256	262	PF00069	0.581
MOD_PKA_2	32	38	PF00069	0.815
MOD_PKA_2	382	388	PF00069	0.630
MOD_PKA_2	407	413	PF00069	0.646
MOD_PKA_2	519	525	PF00069	0.665
MOD_PKA_2	545	551	PF00069	0.711
MOD_PKA_2	583	589	PF00069	0.667
MOD_PKB_1	517	525	PF00069	0.663
MOD_Plk_1	253	259	PF00069	0.571
MOD_Plk_1	304	310	PF00069	0.705
MOD_Plk_1	353	359	PF00069	0.665
MOD_Plk_1	464	470	PF00069	0.653
MOD_Plk_4	27	33	PF00069	0.659
MOD_Plk_4	393	399	PF00069	0.697
MOD_Plk_4	474	480	PF00069	0.667
MOD_Plk_4	538	544	PF00069	0.638
MOD_Plk_4	601	607	PF00069	0.680
MOD_ProDKin_1	202	208	PF00069	0.709
MOD_ProDKin_1	219	225	PF00069	0.548
MOD_ProDKin_1	309	315	PF00069	0.636
MOD_ProDKin_1	335	341	PF00069	0.665
MOD_ProDKin_1	388	394	PF00069	0.651
MOD_ProDKin_1	441	447	PF00069	0.670
MOD_ProDKin_1	459	465	PF00069	0.557
MOD_ProDKin_1	509	515	PF00069	0.654
MOD_ProDKin_1	536	542	PF00069	0.612
MOD_ProDKin_1	558	564	PF00069	0.676
MOD_ProDKin_1	578	584	PF00069	0.541
MOD_ProDKin_1	58	64	PF00069	0.654
MOD_ProDKin_1	592	598	PF00069	0.559
MOD_ProDKin_1	621	627	PF00069	0.699
MOD_ProDKin_1	82	88	PF00069	0.719
TRG_DiLeu_BaEn_1	207	212	PF01217	0.645
TRG_DiLeu_BaEn_1	474	479	PF01217	0.616
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.702
TRG_ER_diArg_1	18	20	PF00400	0.705
TRG_ER_diArg_1	373	376	PF00400	0.683
TRG_ER_diArg_1	516	519	PF00400	0.705
TRG_ER_diArg_1	582	584	PF00400	0.712
TRG_ER_diArg_1	588	591	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HNG7	Leishmania braziliensis	59%	100%
A4IC58	Leishmania infantum	99%	100%
E9AFX8	Leishmania major	86%	100%
E9B731	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%