Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H809_LEIDO

TriTrypDb:

LdBPK_354960.1 , LdCL_350054600 , LDHU3_35.6490

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H809

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H809

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.579
CLV_NRD_NRD_1	39	41	PF00675	0.509
CLV_NRD_NRD_1	44	46	PF00675	0.552
CLV_PCSK_FUR_1	37	41	PF00082	0.456
CLV_PCSK_KEX2_1	39	41	PF00082	0.555
CLV_PCSK_PC7_1	35	41	PF00082	0.545
CLV_PCSK_SKI1_1	149	153	PF00082	0.452
DEG_SPOP_SBC_1	72	76	PF00917	0.617
DOC_PP2B_LxvP_1	62	65	PF13499	0.509
LIG_14-3-3_CanoR_1	3	11	PF00244	0.550
LIG_14-3-3_CterR_2	149	153	PF00244	0.450
LIG_BIR_III_4	55	59	PF00653	0.581
LIG_Clathr_ClatBox_1	120	124	PF01394	0.374
LIG_deltaCOP1_diTrp_1	143	148	PF00928	0.501
LIG_deltaCOP1_diTrp_1	98	107	PF00928	0.477
LIG_FHA_2	120	126	PF00498	0.319
LIG_FHA_2	50	56	PF00498	0.589
LIG_LIR_Gen_1	98	107	PF02991	0.418
LIG_LIR_Nem_3	130	136	PF02991	0.455
LIG_LIR_Nem_3	143	147	PF02991	0.396
LIG_LIR_Nem_3	98	103	PF02991	0.428
LIG_PDZ_Class_2	148	153	PF00595	0.396
LIG_Pex14_1	144	148	PF04695	0.436
LIG_SH2_STAT5	119	122	PF00017	0.449
LIG_SH2_STAT5	147	150	PF00017	0.490
LIG_SH3_3	89	95	PF00018	0.713
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.383
LIG_SUMO_SIM_par_1	118	126	PF11976	0.357
LIG_TRAF2_1	122	125	PF00917	0.411
MOD_CK2_1	119	125	PF00069	0.336
MOD_GlcNHglycan	41	44	PF01048	0.529
MOD_GlcNHglycan	51	55	PF01048	0.643
MOD_GlcNHglycan	75	78	PF01048	0.643
MOD_GSK3_1	50	57	PF00069	0.571
MOD_PK_1	7	13	PF00069	0.438
MOD_PKA_1	39	45	PF00069	0.477
MOD_PKA_2	2	8	PF00069	0.566
MOD_PKA_2	39	45	PF00069	0.498
MOD_PKB_1	37	45	PF00069	0.470
TRG_ER_diArg_1	33	36	PF00400	0.658
TRG_ER_diArg_1	39	41	PF00400	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I444	Leptomonas seymouri	55%	98%
A0A1X0P5P2	Trypanosomatidae	29%	100%
A4HNF4	Leishmania braziliensis	74%	100%
A4IC26	Leishmania infantum	100%	100%
E9AFW5	Leishmania major	91%	100%
E9B718	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%