CS_domain_containing_protein_putative/Pfam:PF0496 9

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Co-chaperone protein P23

Species:

Leishmania donovani

UniProt:

A0A3S5H807_LEIDO

TriTrypDb:

LdBPK_354540.1 , LdCL_350050500 , LDHU3_35.5980

Length:

199

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Co-chaperone P23 |

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Phosphorylation

Amastigote: 48
Promastigote: 168

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H807

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H807

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0031072	heat shock protein binding	3	11
GO:0051087	protein-folding chaperone binding	3	1
GO:0051879	Hsp90 protein binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.755
CLV_NRD_NRD_1	10	12	PF00675	0.282
DOC_MAPK_gen_1	11	19	PF00069	0.468
DOC_MAPK_MEF2A_6	11	19	PF00069	0.468
DOC_MAPK_MEF2A_6	71	79	PF00069	0.468
DOC_USP7_MATH_1	122	126	PF00917	0.728
DOC_USP7_MATH_1	45	49	PF00917	0.499
DOC_USP7_MATH_1	65	69	PF00917	0.468
DOC_USP7_MATH_1	99	103	PF00917	0.666
DOC_WW_Pin1_4	20	25	PF00397	0.583

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JTH1	Bodo saltans	46%	100%
A0A1X0P6F3	Trypanosomatidae	67%	100%
A0A3Q8II57	Leishmania donovani	29%	95%
A0A3R7NTN0	Trypanosoma rangeli	61%	100%
A4HNB5	Leishmania braziliensis	82%	100%
A4I9J1	Leishmania infantum	29%	95%
A4IBY7	Leishmania infantum	100%	100%
C9ZYL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AFS4	Leishmania major	91%	100%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	95%

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