CS_domain_containing_protein_putative/Pfam:PF0496 9

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Co-chaperone protein P23

Species:

Leishmania donovani

UniProt:

A0A3S5H807_LEIDO

TriTrypDb:

LdBPK_354540.1 , LdCL_350050500 , LDHU3_35.5980

Length:

199

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Co-chaperone P23 |

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 48
Promastigote: 168

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H807

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H807

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0031072	heat shock protein binding	3	11
GO:0051879	Hsp90 protein binding	4	11
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.755
CLV_NRD_NRD_1	10	12	PF00675	0.282
DOC_MAPK_gen_1	11	19	PF00069	0.468
DOC_MAPK_MEF2A_6	11	19	PF00069	0.468
DOC_MAPK_MEF2A_6	71	79	PF00069	0.468
DOC_USP7_MATH_1	122	126	PF00917	0.728
DOC_USP7_MATH_1	45	49	PF00917	0.499
DOC_USP7_MATH_1	65	69	PF00917	0.468
DOC_USP7_MATH_1	99	103	PF00917	0.666
DOC_WW_Pin1_4	20	25	PF00397	0.583
LIG_14-3-3_CanoR_1	14	20	PF00244	0.572
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_4	163	167	PF00653	0.544
LIG_deltaCOP1_diTrp_1	107	111	PF00928	0.545
LIG_FHA_1	33	39	PF00498	0.562
LIG_FHA_1	67	73	PF00498	0.520
LIG_FHA_2	184	190	PF00498	0.556
LIG_FHA_2	21	27	PF00498	0.510
LIG_LIR_Gen_1	13	24	PF02991	0.468
LIG_LIR_Nem_3	125	130	PF02991	0.614
LIG_LIR_Nem_3	13	19	PF02991	0.468
LIG_LIR_Nem_3	67	73	PF02991	0.473
LIG_PDZ_Class_2	194	199	PF00595	0.749
LIG_SH2_GRB2like	88	91	PF00017	0.539
LIG_SUMO_SIM_par_1	33	39	PF11976	0.502
LIG_TRAF2_1	186	189	PF00917	0.551
LIG_UBA3_1	156	162	PF00899	0.672
MOD_CK1_1	102	108	PF00069	0.620
MOD_CK1_1	22	28	PF00069	0.458
MOD_CK2_1	165	171	PF00069	0.698
MOD_CK2_1	183	189	PF00069	0.461
MOD_CMANNOS	108	111	PF00535	0.560
MOD_GlcNHglycan	104	107	PF01048	0.641
MOD_GlcNHglycan	38	41	PF01048	0.316
MOD_GSK3_1	15	22	PF00069	0.466
MOD_GSK3_1	152	159	PF00069	0.689
MOD_GSK3_1	32	39	PF00069	0.474
MOD_GSK3_1	41	48	PF00069	0.468
MOD_GSK3_1	93	100	PF00069	0.508
MOD_NEK2_1	156	161	PF00069	0.717
MOD_PIKK_1	45	51	PF00454	0.547
MOD_PK_1	34	40	PF00069	0.548
MOD_Plk_1	32	38	PF00069	0.471
MOD_Plk_1	65	71	PF00069	0.499
MOD_Plk_4	137	143	PF00069	0.673
MOD_Plk_4	152	158	PF00069	0.591
MOD_Plk_4	99	105	PF00069	0.623
MOD_ProDKin_1	20	26	PF00069	0.583
MOD_SUMO_for_1	53	56	PF00179	0.520
MOD_SUMO_for_1	82	85	PF00179	0.640
TRG_ENDOCYTIC_2	130	133	PF00928	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JTH1	Bodo saltans	46%	100%
A0A1X0P6F3	Trypanosomatidae	67%	100%
A0A3Q8II57	Leishmania donovani	29%	95%
A0A3R7NTN0	Trypanosoma rangeli	61%	100%
A4HNB5	Leishmania braziliensis	82%	100%
A4I9J1	Leishmania infantum	29%	95%
A4IBY7	Leishmania infantum	100%	100%
C9ZYL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AFS4	Leishmania major	91%	100%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	95%
E9B6X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
G1TGF1	Oryctolagus cuniculus	35%	100%
P0C8Z0	Oryza sativa subsp. indica	30%	95%
P83868	Rattus norvegicus	35%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q15185	Homo sapiens	35%	100%
Q3ZBF7	Bos taurus	35%	100%
Q4Q3I7	Leishmania major	28%	95%
Q5NVM4	Pongo abelii	35%	100%
Q6PWL5	Macaca fascicularis	35%	100%
Q6YYB0	Oryza sativa subsp. japonica	30%	93%
Q90955	Gallus gallus	34%	100%
Q9FR62	Brassica napus	31%	100%
Q9R0Q7	Mus musculus	35%	100%
Q9VH95	Drosophila melanogaster	29%	100%
V5BCP6	Trypanosoma cruzi	59%	100%