Splicing_factor_3B_subunit_10_(SF3b10)_putative/P fam:PF07189

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Splicing factor 3B subunit 10 (SF3b10), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H805_LEIDO

TriTrypDb:

LdBPK_354150.1 , LdCL_350046600 , LDHU3_35.5370

Length:

Annotations

Annotations by Jardim et al.

RNA Processing, Splicing factor 3B subunit 10 (SF3b10), putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A0A3S5H805

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H805

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	71	75	PF00082	0.266
DEG_APCC_DBOX_1	41	49	PF00400	0.321
DEG_APCC_DBOX_1	51	59	PF00400	0.310
DEG_APCC_DBOX_1	70	78	PF00400	0.274
DOC_CYCLIN_RxL_1	68	75	PF00134	0.260
DOC_PP4_FxxP_1	5	8	PF00568	0.504
LIG_AP2alpha_2	3	5	PF02296	0.500
LIG_FHA_1	24	30	PF00498	0.281
LIG_FHA_2	29	35	PF00498	0.296
LIG_FHA_2	45	51	PF00498	0.246

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K0	Leptomonas seymouri	89%	100%
A0A0S4IXB6	Bodo saltans	56%	83%
A4HN80	Leishmania braziliensis	95%	100%
A4IBU8	Leishmania infantum	100%	100%
C9ZYR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	94%
E9AFN5	Leishmania major	98%	100%
E9B6T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q56K13	Bos taurus	36%	98%
Q923D4	Mus musculus	37%	98%
Q9BWJ5	Homo sapiens	36%	98%

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