Enriched in surface-labeled proteome protein 9, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 9, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H803_LEIDO

TriTrypDb:

LdBPK_353820.1 , LdCL_350043200 , LDHU3_35.4980

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 4
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0005768	endosome	7	1
GO:0020023	kinetoplast	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S5H803

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H803

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.396
CLV_NRD_NRD_1	382	384	PF00675	0.680
CLV_NRD_NRD_1	394	396	PF00675	0.548
CLV_NRD_NRD_1	546	548	PF00675	0.592
CLV_PCSK_KEX2_1	394	396	PF00082	0.592
CLV_PCSK_KEX2_1	546	548	PF00082	0.592
CLV_PCSK_SKI1_1	384	388	PF00082	0.663
CLV_PCSK_SKI1_1	573	577	PF00082	0.672
DEG_SCF_FBW7_1	142	149	PF00400	0.314
DEG_SPOP_SBC_1	184	188	PF00917	0.365
DEG_SPOP_SBC_1	278	282	PF00917	0.541
DEG_SPOP_SBC_1	404	408	PF00917	0.346
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.445
DOC_MAPK_gen_1	250	259	PF00069	0.467
DOC_MAPK_gen_1	78	87	PF00069	0.323
DOC_MAPK_MEF2A_6	253	261	PF00069	0.447
DOC_MAPK_MEF2A_6	78	87	PF00069	0.380
DOC_MAPK_NFAT4_5	80	88	PF00069	0.349
DOC_PP1_RVXF_1	441	447	PF00149	0.296
DOC_PP2B_LxvP_1	165	168	PF13499	0.329
DOC_PP4_FxxP_1	369	372	PF00568	0.417
DOC_SPAK_OSR1_1	67	71	PF12202	0.344
DOC_USP7_MATH_1	146	150	PF00917	0.371
DOC_USP7_MATH_1	271	275	PF00917	0.539
DOC_USP7_MATH_1	370	374	PF00917	0.374
DOC_USP7_MATH_1	404	408	PF00917	0.343
DOC_USP7_MATH_1	50	54	PF00917	0.421
DOC_WW_Pin1_4	137	142	PF00397	0.351
DOC_WW_Pin1_4	144	149	PF00397	0.341
DOC_WW_Pin1_4	173	178	PF00397	0.301
DOC_WW_Pin1_4	198	203	PF00397	0.405
DOC_WW_Pin1_4	311	316	PF00397	0.446
DOC_WW_Pin1_4	411	416	PF00397	0.397
LIG_14-3-3_CanoR_1	139	148	PF00244	0.369
LIG_14-3-3_CanoR_1	250	260	PF00244	0.399
LIG_14-3-3_CanoR_1	3	11	PF00244	0.709
LIG_14-3-3_CanoR_1	405	411	PF00244	0.373
LIG_14-3-3_CanoR_1	443	447	PF00244	0.299
LIG_14-3-3_CanoR_1	477	481	PF00244	0.382
LIG_14-3-3_CanoR_1	60	70	PF00244	0.444
LIG_14-3-3_CanoR_1	616	620	PF00244	0.615
LIG_14-3-3_CterR_2	647	651	PF00244	0.660
LIG_AP2alpha_1	302	306	PF02296	0.279
LIG_APCC_ABBA_1	83	88	PF00400	0.410
LIG_BRCT_BRCA1_1	336	340	PF00533	0.412
LIG_BRCT_BRCA1_1	498	502	PF00533	0.334
LIG_Clathr_ClatBox_1	195	199	PF01394	0.435
LIG_Clathr_ClatBox_1	40	44	PF01394	0.373
LIG_deltaCOP1_diTrp_1	353	359	PF00928	0.385
LIG_FHA_1	116	122	PF00498	0.352
LIG_FHA_1	12	18	PF00498	0.272
LIG_FHA_1	2	8	PF00498	0.601
LIG_FHA_1	448	454	PF00498	0.401
LIG_FHA_1	471	477	PF00498	0.411
LIG_FHA_1	537	543	PF00498	0.341
LIG_FHA_1	574	580	PF00498	0.400
LIG_FHA_1	616	622	PF00498	0.637
LIG_FHA_1	633	639	PF00498	0.630
LIG_FHA_1	96	102	PF00498	0.397
LIG_FHA_2	54	60	PF00498	0.483
LIG_LIR_Apic_2	294	300	PF02991	0.423
LIG_LIR_Apic_2	367	372	PF02991	0.405
LIG_LIR_Apic_2	499	503	PF02991	0.312
LIG_LIR_Apic_2	549	553	PF02991	0.361
LIG_LIR_Gen_1	222	230	PF02991	0.352
LIG_LIR_Gen_1	307	316	PF02991	0.359
LIG_LIR_Gen_1	356	365	PF02991	0.401
LIG_LIR_Gen_1	470	480	PF02991	0.346
LIG_LIR_Gen_1	531	538	PF02991	0.374
LIG_LIR_Nem_3	169	174	PF02991	0.402
LIG_LIR_Nem_3	222	226	PF02991	0.305
LIG_LIR_Nem_3	307	313	PF02991	0.324
LIG_LIR_Nem_3	319	323	PF02991	0.377
LIG_LIR_Nem_3	325	330	PF02991	0.340
LIG_LIR_Nem_3	456	462	PF02991	0.373
LIG_LIR_Nem_3	470	475	PF02991	0.335
LIG_LIR_Nem_3	531	535	PF02991	0.320
LIG_LIR_Nem_3	539	544	PF02991	0.280
LIG_NRBOX	16	22	PF00104	0.375
LIG_Pex14_2	221	225	PF04695	0.367
LIG_Pex14_2	302	306	PF04695	0.323
LIG_PTB_Apo_2	215	222	PF02174	0.390
LIG_SH2_CRK	171	175	PF00017	0.447
LIG_SH2_CRK	297	301	PF00017	0.347
LIG_SH2_CRK	472	476	PF00017	0.381
LIG_SH2_CRK	500	504	PF00017	0.365
LIG_SH2_CRK	532	536	PF00017	0.324
LIG_SH2_CRK	550	554	PF00017	0.386
LIG_SH2_CRK	572	576	PF00017	0.449
LIG_SH2_GRB2like	100	103	PF00017	0.380
LIG_SH2_GRB2like	355	358	PF00017	0.270
LIG_SH2_NCK_1	297	301	PF00017	0.364
LIG_SH2_SRC	100	103	PF00017	0.380
LIG_SH2_STAP1	159	163	PF00017	0.380
LIG_SH2_STAP1	327	331	PF00017	0.330
LIG_SH2_STAP1	355	359	PF00017	0.368
LIG_SH2_STAP1	400	404	PF00017	0.364
LIG_SH2_STAP1	472	476	PF00017	0.350
LIG_SH2_STAP1	526	530	PF00017	0.413
LIG_SH2_STAP1	532	536	PF00017	0.317
LIG_SH2_STAP1	58	62	PF00017	0.504
LIG_SH2_STAT3	159	162	PF00017	0.349
LIG_SH2_STAT5	100	103	PF00017	0.290
LIG_SH2_STAT5	297	300	PF00017	0.398
LIG_SH2_STAT5	355	358	PF00017	0.300
LIG_SH2_STAT5	385	388	PF00017	0.345
LIG_SH2_STAT5	472	475	PF00017	0.342
LIG_SH2_STAT5	532	535	PF00017	0.296
LIG_SH2_STAT5	544	547	PF00017	0.315
LIG_SH2_STAT5	86	89	PF00017	0.344
LIG_SH2_STAT5	95	98	PF00017	0.297
LIG_SH3_1	297	303	PF00018	0.338
LIG_SH3_3	254	260	PF00018	0.462
LIG_SH3_3	297	303	PF00018	0.349
LIG_SH3_3	309	315	PF00018	0.305
LIG_SH3_3	412	418	PF00018	0.397
LIG_SH3_3	49	55	PF00018	0.455
LIG_SH3_3	491	497	PF00018	0.386
LIG_SH3_3	596	602	PF00018	0.367
LIG_SH3_3	78	84	PF00018	0.513
LIG_SUMO_SIM_anti_2	204	212	PF11976	0.305
LIG_SUMO_SIM_anti_2	42	47	PF11976	0.378
LIG_SUMO_SIM_par_1	16	22	PF11976	0.364
LIG_SUMO_SIM_par_1	201	206	PF11976	0.376
LIG_SUMO_SIM_par_1	9	14	PF11976	0.412
LIG_TRAF2_1	373	376	PF00917	0.346
LIG_UBA3_1	261	270	PF00899	0.394
LIG_WRC_WIRS_1	220	225	PF05994	0.354
LIG_WRC_WIRS_1	538	543	PF05994	0.279
LIG_WRC_WIRS_1	565	570	PF05994	0.416
MOD_CDC14_SPxK_1	314	317	PF00782	0.286
MOD_CDK_SPxK_1	311	317	PF00069	0.275
MOD_CDK_SPxxK_3	311	318	PF00069	0.337
MOD_CK1_1	133	139	PF00069	0.384
MOD_CK1_1	140	146	PF00069	0.365
MOD_CK1_1	176	182	PF00069	0.322
MOD_CK1_1	228	234	PF00069	0.444
MOD_CK1_1	236	242	PF00069	0.444
MOD_CK1_1	274	280	PF00069	0.542
MOD_CK1_1	282	288	PF00069	0.545
MOD_CK1_1	334	340	PF00069	0.331
MOD_CK1_1	406	412	PF00069	0.400
MOD_CK1_1	458	464	PF00069	0.537
MOD_CK1_1	467	473	PF00069	0.490
MOD_CK1_1	53	59	PF00069	0.456
MOD_CK1_1	564	570	PF00069	0.403
MOD_CK1_1	61	67	PF00069	0.381
MOD_CK1_1	73	79	PF00069	0.518
MOD_CK2_1	121	127	PF00069	0.400
MOD_CK2_1	241	247	PF00069	0.511
MOD_CK2_1	278	284	PF00069	0.588
MOD_CK2_1	370	376	PF00069	0.334
MOD_CK2_1	73	79	PF00069	0.409
MOD_GlcNHglycan	142	145	PF01048	0.577
MOD_GlcNHglycan	211	214	PF01048	0.635
MOD_GlcNHglycan	230	233	PF01048	0.533
MOD_GlcNHglycan	27	30	PF01048	0.445
MOD_GlcNHglycan	289	292	PF01048	0.760
MOD_GlcNHglycan	372	375	PF01048	0.581
MOD_GlcNHglycan	4	7	PF01048	0.499
MOD_GlcNHglycan	466	469	PF01048	0.675
MOD_GlcNHglycan	48	51	PF01048	0.631
MOD_GlcNHglycan	625	628	PF01048	0.452
MOD_GlcNHglycan	63	66	PF01048	0.499
MOD_GlcNHglycan	72	75	PF01048	0.676
MOD_GSK3_1	101	108	PF00069	0.335
MOD_GSK3_1	133	140	PF00069	0.346
MOD_GSK3_1	142	149	PF00069	0.373
MOD_GSK3_1	163	170	PF00069	0.455
MOD_GSK3_1	2	9	PF00069	0.712
MOD_GSK3_1	207	214	PF00069	0.452
MOD_GSK3_1	21	28	PF00069	0.304
MOD_GSK3_1	221	228	PF00069	0.334
MOD_GSK3_1	233	240	PF00069	0.355
MOD_GSK3_1	270	277	PF00069	0.534
MOD_GSK3_1	278	285	PF00069	0.534
MOD_GSK3_1	287	294	PF00069	0.596
MOD_GSK3_1	360	367	PF00069	0.363
MOD_GSK3_1	46	53	PF00069	0.482
MOD_GSK3_1	623	630	PF00069	0.620
MOD_GSK3_1	66	73	PF00069	0.468
MOD_N-GLC_1	101	106	PF02516	0.624
MOD_N-GLC_1	157	162	PF02516	0.576
MOD_N-GLC_1	163	168	PF02516	0.571
MOD_N-GLC_1	228	233	PF02516	0.600
MOD_N-GLC_1	242	247	PF02516	0.625
MOD_N-GLC_1	295	300	PF02516	0.547
MOD_N-GLC_1	423	428	PF02516	0.610
MOD_N-GLC_1	627	632	PF02516	0.458
MOD_N-GLC_1	70	75	PF02516	0.614
MOD_N-GLC_2	217	219	PF02516	0.587
MOD_N-GLC_2	391	393	PF02516	0.573
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	11	16	PF00069	0.252
MOD_NEK2_1	130	135	PF00069	0.333
MOD_NEK2_1	185	190	PF00069	0.365
MOD_NEK2_1	21	26	PF00069	0.233
MOD_NEK2_1	221	226	PF00069	0.361
MOD_NEK2_1	316	321	PF00069	0.347
MOD_NEK2_1	333	338	PF00069	0.237
MOD_NEK2_1	403	408	PF00069	0.382
MOD_NEK2_1	453	458	PF00069	0.408
MOD_NEK2_1	478	483	PF00069	0.377
MOD_NEK2_1	589	594	PF00069	0.407
MOD_NEK2_1	623	628	PF00069	0.613
MOD_NEK2_1	66	71	PF00069	0.388
MOD_NEK2_2	423	428	PF00069	0.399
MOD_PIKK_1	158	164	PF00454	0.330
MOD_PIKK_1	185	191	PF00454	0.363
MOD_PKA_2	2	8	PF00069	0.700
MOD_PKA_2	233	239	PF00069	0.485
MOD_PKA_2	274	280	PF00069	0.486
MOD_PKA_2	323	329	PF00069	0.388
MOD_PKA_2	404	410	PF00069	0.352
MOD_PKA_2	442	448	PF00069	0.351
MOD_PKA_2	476	482	PF00069	0.384
MOD_PKA_2	615	621	PF00069	0.606
MOD_PKA_2	66	72	PF00069	0.399
MOD_Plk_1	163	169	PF00069	0.360
MOD_Plk_1	228	234	PF00069	0.438
MOD_Plk_1	295	301	PF00069	0.398
MOD_Plk_1	423	429	PF00069	0.410
MOD_Plk_1	530	536	PF00069	0.342
MOD_Plk_1	58	64	PF00069	0.463
MOD_Plk_2-3	105	111	PF00069	0.341
MOD_Plk_4	130	136	PF00069	0.401
MOD_Plk_4	146	152	PF00069	0.350
MOD_Plk_4	274	280	PF00069	0.590
MOD_Plk_4	316	322	PF00069	0.348
MOD_Plk_4	325	331	PF00069	0.289
MOD_Plk_4	360	366	PF00069	0.335
MOD_Plk_4	406	412	PF00069	0.341
MOD_Plk_4	417	423	PF00069	0.321
MOD_Plk_4	442	448	PF00069	0.345
MOD_Plk_4	455	461	PF00069	0.444
MOD_Plk_4	53	59	PF00069	0.461
MOD_Plk_4	530	536	PF00069	0.378
MOD_Plk_4	537	543	PF00069	0.357
MOD_Plk_4	578	584	PF00069	0.398
MOD_ProDKin_1	137	143	PF00069	0.353
MOD_ProDKin_1	144	150	PF00069	0.343
MOD_ProDKin_1	173	179	PF00069	0.299
MOD_ProDKin_1	198	204	PF00069	0.400
MOD_ProDKin_1	311	317	PF00069	0.450
MOD_ProDKin_1	411	417	PF00069	0.399
MOD_SUMO_for_1	640	643	PF00179	0.693
TRG_DiLeu_BaEn_2	536	542	PF01217	0.311
TRG_ENDOCYTIC_2	171	174	PF00928	0.380
TRG_ENDOCYTIC_2	330	333	PF00928	0.409
TRG_ENDOCYTIC_2	400	403	PF00928	0.354
TRG_ENDOCYTIC_2	472	475	PF00928	0.388
TRG_ENDOCYTIC_2	532	535	PF00928	0.306
TRG_ENDOCYTIC_2	572	575	PF00928	0.449
TRG_ER_diArg_1	394	396	PF00400	0.313
TRG_ER_diArg_1	545	547	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH70	Leptomonas seymouri	45%	100%
A0A1X0NCX6	Trypanosomatidae	30%	100%
A4HN48	Leishmania braziliensis	62%	100%
A4IBR6	Leishmania infantum	100%	100%
C9ZYV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFK1	Leishmania major	88%	100%
E9B6Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%