Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H801_LEIDO

TriTrypDb:

LdBPK_353530.1 , LdCL_350040300 , LDHU3_35.4630

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H801

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H801

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.507
CLV_NRD_NRD_1	190	192	PF00675	0.756
CLV_NRD_NRD_1	225	227	PF00675	0.713
CLV_NRD_NRD_1	437	439	PF00675	0.783
CLV_PCSK_FUR_1	188	192	PF00082	0.748
CLV_PCSK_KEX2_1	11	13	PF00082	0.441
CLV_PCSK_KEX2_1	190	192	PF00082	0.763
CLV_PCSK_KEX2_1	225	227	PF00082	0.713
CLV_PCSK_KEX2_1	439	441	PF00082	0.780
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.441
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.738
CLV_PCSK_SKI1_1	325	329	PF00082	0.630
CLV_PCSK_SKI1_1	376	380	PF00082	0.531
CLV_PCSK_SKI1_1	704	708	PF00082	0.787
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DEG_SCF_FBW7_1	379	385	PF00400	0.574
DEG_SCF_FBW7_1	582	589	PF00400	0.764
DEG_SIAH_1	145	153	PF03145	0.791
DEG_SPOP_SBC_1	280	284	PF00917	0.617
DEG_SPOP_SBC_1	482	486	PF00917	0.727
DEG_SPOP_SBC_1	549	553	PF00917	0.811
DOC_CKS1_1	379	384	PF01111	0.529
DOC_CKS1_1	446	451	PF01111	0.729
DOC_CKS1_1	515	520	PF01111	0.809
DOC_CKS1_1	583	588	PF01111	0.769
DOC_CKS1_1	682	687	PF01111	0.745
DOC_CYCLIN_yCln2_LP_2	719	725	PF00134	0.776
DOC_MAPK_DCC_7	147	155	PF00069	0.670
DOC_MAPK_HePTP_8	29	41	PF00069	0.591
DOC_MAPK_MEF2A_6	147	155	PF00069	0.578
DOC_MAPK_MEF2A_6	175	183	PF00069	0.643
DOC_MAPK_MEF2A_6	299	307	PF00069	0.437
DOC_MAPK_MEF2A_6	32	41	PF00069	0.495
DOC_PP1_RVXF_1	30	37	PF00149	0.552
DOC_PP2B_LxvP_1	341	344	PF13499	0.495
DOC_PP2B_LxvP_1	456	459	PF13499	0.615
DOC_PP2B_LxvP_1	539	542	PF13499	0.696
DOC_PP2B_LxvP_1	670	673	PF13499	0.777
DOC_PP2B_LxvP_1	688	691	PF13499	0.628
DOC_PP2B_LxvP_1	719	722	PF13499	0.748
DOC_PP4_FxxP_1	602	605	PF00568	0.721
DOC_USP7_MATH_1	132	136	PF00917	0.405
DOC_USP7_MATH_1	146	150	PF00917	0.764
DOC_USP7_MATH_1	163	167	PF00917	0.745
DOC_USP7_MATH_1	213	217	PF00917	0.828
DOC_USP7_MATH_1	232	236	PF00917	0.581
DOC_USP7_MATH_1	275	279	PF00917	0.681
DOC_USP7_MATH_1	345	349	PF00917	0.536
DOC_USP7_MATH_1	382	386	PF00917	0.625
DOC_USP7_MATH_1	423	427	PF00917	0.688
DOC_USP7_MATH_1	464	468	PF00917	0.778
DOC_USP7_MATH_1	482	486	PF00917	0.690
DOC_USP7_MATH_1	520	524	PF00917	0.793
DOC_USP7_MATH_1	550	554	PF00917	0.815
DOC_USP7_MATH_1	572	576	PF00917	0.752
DOC_USP7_MATH_1	586	590	PF00917	0.625
DOC_USP7_MATH_1	595	599	PF00917	0.724
DOC_USP7_MATH_1	642	646	PF00917	0.799
DOC_USP7_UBL2_3	273	277	PF12436	0.716
DOC_WW_Pin1_4	267	272	PF00397	0.501
DOC_WW_Pin1_4	312	317	PF00397	0.621
DOC_WW_Pin1_4	378	383	PF00397	0.515
DOC_WW_Pin1_4	445	450	PF00397	0.732
DOC_WW_Pin1_4	501	506	PF00397	0.771
DOC_WW_Pin1_4	514	519	PF00397	0.781
DOC_WW_Pin1_4	555	560	PF00397	0.734
DOC_WW_Pin1_4	578	583	PF00397	0.760
DOC_WW_Pin1_4	591	596	PF00397	0.654
DOC_WW_Pin1_4	613	618	PF00397	0.699
DOC_WW_Pin1_4	626	631	PF00397	0.725
DOC_WW_Pin1_4	632	637	PF00397	0.798
DOC_WW_Pin1_4	681	686	PF00397	0.716
DOC_WW_Pin1_4	693	698	PF00397	0.750
LIG_14-3-3_CanoR_1	137	146	PF00244	0.578
LIG_14-3-3_CanoR_1	147	151	PF00244	0.670
LIG_14-3-3_CanoR_1	214	224	PF00244	0.777
LIG_14-3-3_CanoR_1	470	474	PF00244	0.763
LIG_14-3-3_CanoR_1	480	487	PF00244	0.694
LIG_14-3-3_CanoR_1	63	72	PF00244	0.601
LIG_14-3-3_CanoR_1	94	98	PF00244	0.588
LIG_BIR_III_2	162	166	PF00653	0.705
LIG_BRCT_BRCA1_1	652	656	PF00533	0.811
LIG_eIF4E_1	14	20	PF01652	0.513
LIG_EVH1_1	539	543	PF00568	0.678
LIG_FHA_1	24	30	PF00498	0.480
LIG_FHA_1	281	287	PF00498	0.563
LIG_FHA_1	403	409	PF00498	0.480
LIG_FHA_1	51	57	PF00498	0.459
LIG_FHA_2	113	119	PF00498	0.459
LIG_FHA_2	167	173	PF00498	0.761
LIG_FHA_2	321	327	PF00498	0.648
LIG_FXI_DFP_1	33	37	PF00024	0.533
LIG_LIR_Apic_2	600	605	PF02991	0.761
LIG_LIR_Apic_2	624	630	PF02991	0.719
LIG_LIR_Gen_1	128	139	PF02991	0.490
LIG_LIR_Gen_1	30	41	PF02991	0.469
LIG_LIR_Nem_3	115	119	PF02991	0.629
LIG_LIR_Nem_3	30	36	PF02991	0.470
LIG_LIR_Nem_3	471	476	PF02991	0.744
LIG_MYND_1	454	458	PF01753	0.622
LIG_MYND_1	668	672	PF01753	0.779
LIG_NRBOX	236	242	PF00104	0.585
LIG_SH2_CRK	355	359	PF00017	0.420
LIG_SH2_CRK	370	374	PF00017	0.395
LIG_SH2_CRK	627	631	PF00017	0.683
LIG_SH2_NCK_1	243	247	PF00017	0.478
LIG_SH2_NCK_1	545	549	PF00017	0.839
LIG_SH2_NCK_1	569	573	PF00017	0.763
LIG_SH2_SRC	119	122	PF00017	0.587
LIG_SH2_SRC	46	49	PF00017	0.571
LIG_SH2_STAP1	116	120	PF00017	0.614
LIG_SH2_STAP1	243	247	PF00017	0.478
LIG_SH2_STAP1	355	359	PF00017	0.498
LIG_SH2_STAP1	569	573	PF00017	0.763
LIG_SH2_STAT3	247	250	PF00017	0.509
LIG_SH2_STAT3	359	362	PF00017	0.498
LIG_SH2_STAT5	119	122	PF00017	0.524
LIG_SH2_STAT5	177	180	PF00017	0.643
LIG_SH2_STAT5	352	355	PF00017	0.475
LIG_SH2_STAT5	393	396	PF00017	0.605
LIG_SH2_STAT5	569	572	PF00017	0.838
LIG_SH2_STAT5	674	677	PF00017	0.720
LIG_SH3_2	192	197	PF14604	0.742
LIG_SH3_3	189	195	PF00018	0.733
LIG_SH3_3	313	319	PF00018	0.646
LIG_SH3_3	37	43	PF00018	0.501
LIG_SH3_3	425	431	PF00018	0.707
LIG_SH3_3	503	509	PF00018	0.744
LIG_SH3_3	512	518	PF00018	0.795
LIG_SH3_3	535	541	PF00018	0.790
LIG_SH3_3	556	562	PF00018	0.753
LIG_SH3_3	568	574	PF00018	0.603
LIG_SH3_3	602	608	PF00018	0.746
LIG_SH3_3	666	672	PF00018	0.714
LIG_SH3_3	675	681	PF00018	0.683
LIG_SH3_3	684	690	PF00018	0.546
LIG_SH3_3	692	698	PF00018	0.702
LIG_SH3_3	707	713	PF00018	0.572
LIG_SH3_3	722	728	PF00018	0.687
LIG_SH3_3	97	103	PF00018	0.604
LIG_SH3_CIN85_PxpxPR_1	724	729	PF14604	0.663
LIG_SUMO_SIM_par_1	25	30	PF11976	0.524
LIG_SUMO_SIM_par_1	80	86	PF11976	0.468
LIG_TRFH_1	14	18	PF08558	0.503
LIG_TYR_ITIM	353	358	PF00017	0.431
LIG_TYR_ITIM	368	373	PF00017	0.457
LIG_WRC_WIRS_1	473	478	PF05994	0.804
LIG_WRC_WIRS_1	599	604	PF05994	0.724
LIG_WW_1	542	545	PF00397	0.828
LIG_WW_1	566	569	PF00397	0.719
LIG_WW_2	559	562	PF00397	0.665
LIG_WW_3	194	198	PF00397	0.618
LIG_WW_3	222	226	PF00397	0.835
LIG_WW_3	317	321	PF00397	0.675
MOD_CDK_SPxK_1	267	273	PF00069	0.660
MOD_CDK_SPxK_1	582	588	PF00069	0.747
MOD_CK1_1	166	172	PF00069	0.729
MOD_CK1_1	22	28	PF00069	0.542
MOD_CK1_1	284	290	PF00069	0.604
MOD_CK1_1	445	451	PF00069	0.774
MOD_CK1_1	469	475	PF00069	0.717
MOD_CK1_1	478	484	PF00069	0.672
MOD_CK1_1	485	491	PF00069	0.589
MOD_CK1_1	554	560	PF00069	0.765
MOD_CK1_1	575	581	PF00069	0.739
MOD_CK1_1	598	604	PF00069	0.735
MOD_CK1_1	616	622	PF00069	0.526
MOD_CK1_1	635	641	PF00069	0.708
MOD_CK2_1	166	172	PF00069	0.773
MOD_CK2_1	248	254	PF00069	0.530
MOD_CK2_1	320	326	PF00069	0.661
MOD_CK2_1	80	86	PF00069	0.505
MOD_GlcNHglycan	276	280	PF01048	0.648
MOD_GlcNHglycan	480	483	PF01048	0.710
MOD_GlcNHglycan	574	577	PF01048	0.827
MOD_GlcNHglycan	602	605	PF01048	0.763
MOD_GlcNHglycan	691	694	PF01048	0.769
MOD_GSK3_1	19	26	PF00069	0.499
MOD_GSK3_1	228	235	PF00069	0.645
MOD_GSK3_1	248	255	PF00069	0.376
MOD_GSK3_1	275	282	PF00069	0.689
MOD_GSK3_1	378	385	PF00069	0.575
MOD_GSK3_1	412	419	PF00069	0.496
MOD_GSK3_1	438	445	PF00069	0.733
MOD_GSK3_1	464	471	PF00069	0.706
MOD_GSK3_1	472	479	PF00069	0.661
MOD_GSK3_1	481	488	PF00069	0.628
MOD_GSK3_1	510	517	PF00069	0.649
MOD_GSK3_1	550	557	PF00069	0.842
MOD_GSK3_1	572	579	PF00069	0.737
MOD_GSK3_1	582	589	PF00069	0.675
MOD_GSK3_1	591	598	PF00069	0.539
MOD_GSK3_1	622	629	PF00069	0.706
MOD_GSK3_1	631	638	PF00069	0.701
MOD_GSK3_1	648	655	PF00069	0.799
MOD_GSK3_1	689	696	PF00069	0.778
MOD_N-GLC_1	532	537	PF02516	0.741
MOD_N-GLC_2	55	57	PF02516	0.530
MOD_NEK2_1	19	24	PF00069	0.565
MOD_NEK2_1	252	257	PF00069	0.486
MOD_NEK2_1	411	416	PF00069	0.615
MOD_NEK2_1	468	473	PF00069	0.776
MOD_NEK2_1	476	481	PF00069	0.729
MOD_NEK2_1	487	492	PF00069	0.644
MOD_NEK2_1	643	648	PF00069	0.695
MOD_NEK2_2	132	137	PF00069	0.469
MOD_PIKK_1	137	143	PF00454	0.612
MOD_PIKK_1	190	196	PF00454	0.831
MOD_PIKK_1	442	448	PF00454	0.776
MOD_PIKK_1	521	527	PF00454	0.717
MOD_PIKK_1	533	539	PF00454	0.766
MOD_PIKK_1	551	557	PF00454	0.840
MOD_PIKK_1	560	566	PF00454	0.659
MOD_PIKK_1	606	612	PF00454	0.580
MOD_PIKK_1	704	710	PF00454	0.718
MOD_PIKK_1	712	718	PF00454	0.682
MOD_PKA_1	190	196	PF00069	0.784
MOD_PKA_1	438	444	PF00069	0.739
MOD_PKA_2	146	152	PF00069	0.662
MOD_PKA_2	166	172	PF00069	0.733
MOD_PKA_2	190	196	PF00069	0.784
MOD_PKA_2	213	219	PF00069	0.792
MOD_PKA_2	469	475	PF00069	0.749
MOD_PKA_2	62	68	PF00069	0.520
MOD_PKA_2	93	99	PF00069	0.574
MOD_PKB_1	188	196	PF00069	0.826
MOD_Plk_1	232	238	PF00069	0.552
MOD_Plk_4	146	152	PF00069	0.762
MOD_Plk_4	233	239	PF00069	0.482
MOD_Plk_4	281	287	PF00069	0.556
MOD_Plk_4	293	299	PF00069	0.558
MOD_Plk_4	423	429	PF00069	0.693
MOD_Plk_4	507	513	PF00069	0.749
MOD_Plk_4	616	622	PF00069	0.643
MOD_ProDKin_1	267	273	PF00069	0.513
MOD_ProDKin_1	312	318	PF00069	0.630
MOD_ProDKin_1	378	384	PF00069	0.525
MOD_ProDKin_1	445	451	PF00069	0.732
MOD_ProDKin_1	501	507	PF00069	0.773
MOD_ProDKin_1	514	520	PF00069	0.780
MOD_ProDKin_1	555	561	PF00069	0.735
MOD_ProDKin_1	578	584	PF00069	0.758
MOD_ProDKin_1	591	597	PF00069	0.655
MOD_ProDKin_1	613	619	PF00069	0.698
MOD_ProDKin_1	626	632	PF00069	0.728
MOD_ProDKin_1	681	687	PF00069	0.718
MOD_ProDKin_1	693	699	PF00069	0.749
MOD_SUMO_rev_2	324	330	PF00179	0.695
TRG_DiLeu_BaEn_1	233	238	PF01217	0.641
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.617
TRG_ENDOCYTIC_2	131	134	PF00928	0.452
TRG_ENDOCYTIC_2	355	358	PF00928	0.426
TRG_ENDOCYTIC_2	370	373	PF00928	0.433
TRG_ENDOCYTIC_2	473	476	PF00928	0.811
TRG_ER_diArg_1	188	191	PF00400	0.748
TRG_ER_diArg_1	224	226	PF00400	0.743
TRG_NLS_MonoExtC_3	437	442	PF00514	0.739
TRG_NLS_MonoExtN_4	436	443	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHM5	Leptomonas seymouri	49%	98%
A0A1X0P647	Trypanosomatidae	36%	100%
A4HN17	Leishmania braziliensis	74%	100%
A4IBN8	Leishmania infantum	100%	100%
E9AFH2	Leishmania major	92%	100%
E9B6M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%