EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7Z9_LEIDO

TriTrypDb:

LdCL_350037000 , LDHU3_35.4200

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Z9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.638
CLV_C14_Caspase3-7	166	170	PF00656	0.603
CLV_NRD_NRD_1	170	172	PF00675	0.419
CLV_PCSK_SKI1_1	135	139	PF00082	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.444
DEG_SCF_TRCP1_1	115	120	PF00400	0.493
DOC_CKS1_1	62	67	PF01111	0.431
DOC_PP4_FxxP_1	19	22	PF00568	0.463
DOC_PP4_FxxP_1	202	205	PF00568	0.349
DOC_USP7_MATH_1	157	161	PF00917	0.628
DOC_USP7_MATH_1	163	167	PF00917	0.548
DOC_USP7_MATH_1	24	28	PF00917	0.538
DOC_USP7_MATH_1	32	36	PF00917	0.536
DOC_USP7_MATH_1	63	67	PF00917	0.479
DOC_WW_Pin1_4	214	219	PF00397	0.544
DOC_WW_Pin1_4	225	230	PF00397	0.635
DOC_WW_Pin1_4	61	66	PF00397	0.485
DOC_WW_Pin1_4	73	78	PF00397	0.599
LIG_14-3-3_CanoR_1	135	140	PF00244	0.380
LIG_14-3-3_CanoR_1	180	186	PF00244	0.456
LIG_14-3-3_CanoR_1	84	89	PF00244	0.723
LIG_APCC_ABBA_1	16	21	PF00400	0.451
LIG_BIR_III_4	96	100	PF00653	0.690
LIG_BRCT_BRCA1_1	107	111	PF00533	0.622
LIG_BRCT_BRCA1_1	12	16	PF00533	0.389
LIG_BRCT_BRCA1_1	254	258	PF00533	0.424
LIG_CORNRBOX	240	248	PF00104	0.444
LIG_eIF4E_1	62	68	PF01652	0.473
LIG_FHA_1	39	45	PF00498	0.632
LIG_FHA_1	62	68	PF00498	0.489
LIG_FHA_2	38	44	PF00498	0.574
LIG_GBD_Chelix_1	240	248	PF00786	0.444
LIG_LIR_Apic_2	17	22	PF02991	0.417
LIG_LIR_Gen_1	13	24	PF02991	0.475
LIG_LIR_Gen_1	131	141	PF02991	0.380
LIG_LIR_Gen_1	255	265	PF02991	0.454
LIG_LIR_Nem_3	13	19	PF02991	0.470
LIG_LIR_Nem_3	131	136	PF02991	0.412
LIG_LIR_Nem_3	255	261	PF02991	0.438
LIG_LIR_Nem_3	4	8	PF02991	0.513
LIG_LIR_Nem_3	52	58	PF02991	0.462
LIG_LIR_Nem_3	70	75	PF02991	0.613
LIG_Pex14_1	178	182	PF04695	0.475
LIG_Pex14_2	202	206	PF04695	0.345
LIG_Pex14_2	55	59	PF04695	0.340
LIG_SH2_STAT5	133	136	PF00017	0.474
LIG_SH2_STAT5	264	267	PF00017	0.556
LIG_SH2_STAT5	56	59	PF00017	0.332
LIG_SH3_2	90	95	PF14604	0.621
LIG_SH3_3	182	188	PF00018	0.355
LIG_SH3_3	212	218	PF00018	0.429
LIG_SH3_3	87	93	PF00018	0.623
LIG_SUMO_SIM_par_1	211	217	PF11976	0.512
LIG_TRAF2_1	141	144	PF00917	0.492
MOD_CDK_SPK_2	225	230	PF00069	0.508
MOD_CDK_SPxxK_3	229	236	PF00069	0.410
MOD_CDK_SPxxK_3	77	84	PF00069	0.593
MOD_CK1_1	10	16	PF00069	0.390
MOD_CK1_1	107	113	PF00069	0.592
MOD_CK1_1	116	122	PF00069	0.492
MOD_CK1_1	222	228	PF00069	0.639
MOD_CK2_1	1	7	PF00069	0.398
MOD_Cter_Amidation	169	172	PF01082	0.512
MOD_GlcNHglycan	115	118	PF01048	0.546
MOD_GlcNHglycan	121	124	PF01048	0.448
MOD_GlcNHglycan	130	133	PF01048	0.445
MOD_GlcNHglycan	26	29	PF01048	0.561
MOD_GlcNHglycan	77	80	PF01048	0.501
MOD_GlcNHglycan	86	89	PF01048	0.606
MOD_GSK3_1	107	114	PF00069	0.639
MOD_GSK3_1	157	164	PF00069	0.600
MOD_GSK3_1	214	221	PF00069	0.553
MOD_GSK3_1	225	232	PF00069	0.683
MOD_GSK3_1	6	13	PF00069	0.502
MOD_GSK3_1	71	78	PF00069	0.531
MOD_LATS_1	104	110	PF00433	0.495
MOD_NEK2_1	1	6	PF00069	0.448
MOD_NEK2_1	105	110	PF00069	0.570
MOD_NEK2_1	128	133	PF00069	0.361
MOD_PIKK_1	32	38	PF00454	0.584
MOD_PKA_2	117	123	PF00069	0.643
MOD_PKA_2	83	89	PF00069	0.720
MOD_Plk_4	63	69	PF00069	0.417
MOD_ProDKin_1	214	220	PF00069	0.548
MOD_ProDKin_1	225	231	PF00069	0.635
MOD_ProDKin_1	61	67	PF00069	0.481
MOD_ProDKin_1	73	79	PF00069	0.601
TRG_DiLeu_BaEn_3	143	149	PF01217	0.542
TRG_ENDOCYTIC_2	133	136	PF00928	0.407
TRG_ENDOCYTIC_2	56	59	PF00928	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P561	Leptomonas seymouri	42%	95%
A0A3R7N8Q9	Trypanosoma rangeli	26%	100%
C9ZZ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
V5BY41	Trypanosoma cruzi	25%	89%