Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7Z5_LEIDO

TriTrypDb:

LdBPK_352580.1 , LdCL_350030700 , LDHU3_35.3330

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H7Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.728
CLV_PCSK_KEX2_1	180	182	PF00082	0.728
CLV_PCSK_SKI1_1	100	104	PF00082	0.778
CLV_PCSK_SKI1_1	141	145	PF00082	0.364
DEG_APCC_DBOX_1	86	94	PF00400	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.776
DOC_MAPK_gen_1	131	139	PF00069	0.763
DOC_MAPK_MEF2A_6	141	149	PF00069	0.530
DOC_USP7_MATH_1	59	63	PF00917	0.578
DOC_WW_Pin1_4	180	185	PF00397	0.447
DOC_WW_Pin1_4	206	211	PF00397	0.530
DOC_WW_Pin1_4	25	30	PF00397	0.530
LIG_14-3-3_CanoR_1	100	108	PF00244	0.259
LIG_14-3-3_CanoR_1	141	146	PF00244	0.469
LIG_14-3-3_CanoR_1	38	43	PF00244	0.521
LIG_14-3-3_CanoR_1	85	91	PF00244	0.615
LIG_BRCT_BRCA1_1	189	193	PF00533	0.435
LIG_FHA_1	101	107	PF00498	0.313
LIG_FHA_1	138	144	PF00498	0.580
LIG_FHA_1	14	20	PF00498	0.351
LIG_FHA_1	81	87	PF00498	0.511
LIG_GBD_Chelix_1	196	204	PF00786	0.355
LIG_LIR_Gen_1	103	113	PF02991	0.407
LIG_LIR_Gen_1	122	130	PF02991	0.432
LIG_LIR_Gen_1	13	22	PF02991	0.530
LIG_LIR_Gen_1	165	176	PF02991	0.550
LIG_LIR_Gen_1	190	201	PF02991	0.530
LIG_LIR_LC3C_4	6	9	PF02991	0.580
LIG_LIR_Nem_3	103	108	PF02991	0.407
LIG_LIR_Nem_3	13	17	PF02991	0.530
LIG_LIR_Nem_3	165	171	PF02991	0.547
LIG_LIR_Nem_3	190	196	PF02991	0.369
LIG_MLH1_MIPbox_1	189	193	PF16413	0.435
LIG_NRBOX	199	205	PF00104	0.433
LIG_SH2_CRK	14	18	PF00017	0.530
LIG_SH2_CRK	168	172	PF00017	0.546
LIG_SH2_CRK	49	53	PF00017	0.592
LIG_SH2_GRB2like	168	171	PF00017	0.546
LIG_SH2_NCK_1	49	53	PF00017	0.592
LIG_SH2_SRC	49	52	PF00017	0.440
LIG_SH2_STAP1	14	18	PF00017	0.389
LIG_SH2_STAT5	105	108	PF00017	0.530
LIG_SH2_STAT5	11	14	PF00017	0.501
LIG_SH2_STAT5	176	179	PF00017	0.554
LIG_SH3_3	142	148	PF00018	0.530
LIG_SH3_3	23	29	PF00018	0.384
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.530
LIG_SUMO_SIM_par_1	203	209	PF11976	0.452
LIG_UBA3_1	123	131	PF00899	0.617
MOD_CDK_SPxxK_3	180	187	PF00069	0.523
MOD_CDK_SPxxK_3	206	213	PF00069	0.452
MOD_CK1_1	183	189	PF00069	0.426
MOD_CK1_1	25	31	PF00069	0.530
MOD_CK1_1	64	70	PF00069	0.581
MOD_CK1_1	74	80	PF00069	0.502
MOD_CK1_1	96	102	PF00069	0.588
MOD_CK2_1	31	37	PF00069	0.565
MOD_GlcNHglycan	189	192	PF01048	0.636
MOD_GlcNHglycan	61	64	PF01048	0.692
MOD_GlcNHglycan	74	77	PF01048	0.658
MOD_GSK3_1	115	122	PF00069	0.290
MOD_GSK3_1	137	144	PF00069	0.714
MOD_GSK3_1	183	190	PF00069	0.546
MOD_GSK3_1	57	64	PF00069	0.589
MOD_GSK3_1	70	77	PF00069	0.420
MOD_GSK3_1	96	103	PF00069	0.482
MOD_N-GLC_1	38	43	PF02516	0.683
MOD_NEK2_1	10	15	PF00069	0.530
MOD_NEK2_1	119	124	PF00069	0.530
MOD_NEK2_1	192	197	PF00069	0.400
MOD_NEK2_1	22	27	PF00069	0.331
MOD_PK_1	38	44	PF00069	0.483
MOD_PKA_2	86	92	PF00069	0.607
MOD_Plk_1	38	44	PF00069	0.483
MOD_Plk_4	115	121	PF00069	0.522
MOD_Plk_4	13	19	PF00069	0.434
MOD_Plk_4	141	147	PF00069	0.355
MOD_Plk_4	22	28	PF00069	0.407
MOD_Plk_4	38	44	PF00069	0.407
MOD_Plk_4	52	58	PF00069	0.439
MOD_ProDKin_1	180	186	PF00069	0.449
MOD_ProDKin_1	206	212	PF00069	0.530
MOD_ProDKin_1	25	31	PF00069	0.530
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.680
TRG_ENDOCYTIC_2	105	108	PF00928	0.530
TRG_ENDOCYTIC_2	14	17	PF00928	0.465
TRG_ENDOCYTIC_2	168	171	PF00928	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HMS5	Leishmania braziliensis	67%	97%
A4IBG3	Leishmania infantum	100%	100%
E9AF77	Leishmania major	91%	100%
E9B6D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%