Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7Z4_LEIDO

TriTrypDb:

LdBPK_352350.1 , LdCL_350028400 , LDHU3_35.2990

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.327
CLV_C14_Caspase3-7	55	59	PF00656	0.552
CLV_C14_Caspase3-7	72	76	PF00656	0.741
CLV_NRD_NRD_1	100	102	PF00675	0.517
CLV_NRD_NRD_1	103	105	PF00675	0.496
CLV_NRD_NRD_1	148	150	PF00675	0.532
CLV_NRD_NRD_1	237	239	PF00675	0.539
CLV_NRD_NRD_1	298	300	PF00675	0.397
CLV_NRD_NRD_1	320	322	PF00675	0.325
CLV_NRD_NRD_1	397	399	PF00675	0.447
CLV_NRD_NRD_1	45	47	PF00675	0.694
CLV_PCSK_FUR_1	103	107	PF00082	0.473
CLV_PCSK_FUR_1	395	399	PF00082	0.453
CLV_PCSK_FUR_1	97	101	PF00082	0.526
CLV_PCSK_KEX2_1	103	105	PF00082	0.495
CLV_PCSK_KEX2_1	136	138	PF00082	0.434
CLV_PCSK_KEX2_1	237	239	PF00082	0.537
CLV_PCSK_KEX2_1	298	300	PF00082	0.397
CLV_PCSK_KEX2_1	320	322	PF00082	0.325
CLV_PCSK_KEX2_1	397	399	PF00082	0.529
CLV_PCSK_KEX2_1	45	47	PF00082	0.709
CLV_PCSK_KEX2_1	99	101	PF00082	0.510
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.467
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.424
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.650
CLV_PCSK_PC7_1	99	105	PF00082	0.503
CLV_PCSK_SKI1_1	199	203	PF00082	0.684
CLV_PCSK_SKI1_1	226	230	PF00082	0.420
CLV_PCSK_SKI1_1	250	254	PF00082	0.442
CLV_PCSK_SKI1_1	373	377	PF00082	0.371
DEG_APCC_DBOX_1	297	305	PF00400	0.370
DEG_APCC_KENBOX_2	154	158	PF00400	0.578
DEG_MDM2_SWIB_1	303	311	PF02201	0.472
DEG_SCF_FBW7_1	17	24	PF00400	0.635
DOC_CKS1_1	18	23	PF01111	0.595
DOC_CKS1_1	200	205	PF01111	0.563
DOC_CYCLIN_RxL_1	169	179	PF00134	0.618
DOC_CYCLIN_RxL_1	296	306	PF00134	0.358
DOC_MAPK_gen_1	317	325	PF00069	0.478
DOC_PP2B_LxvP_1	217	220	PF13499	0.604
DOC_USP7_MATH_1	189	193	PF00917	0.607
DOC_USP7_MATH_1	2	6	PF00917	0.693
DOC_USP7_MATH_1	349	353	PF00917	0.505
DOC_USP7_MATH_1	357	361	PF00917	0.334
DOC_USP7_MATH_1	69	73	PF00917	0.743
DOC_USP7_MATH_1	92	96	PF00917	0.510
DOC_USP7_UBL2_3	32	36	PF12436	0.507
DOC_WW_Pin1_4	17	22	PF00397	0.743
DOC_WW_Pin1_4	199	204	PF00397	0.566
DOC_WW_Pin1_4	226	231	PF00397	0.504
DOC_WW_Pin1_4	64	69	PF00397	0.684
LIG_14-3-3_CanoR_1	103	112	PF00244	0.508
LIG_14-3-3_CanoR_1	298	302	PF00244	0.381
LIG_14-3-3_CanoR_1	359	369	PF00244	0.426
LIG_14-3-3_CanoR_1	370	380	PF00244	0.449
LIG_14-3-3_CanoR_1	381	387	PF00244	0.385
LIG_14-3-3_CanoR_1	397	402	PF00244	0.515
LIG_AP2alpha_2	221	223	PF02296	0.381
LIG_APCC_ABBA_1	174	179	PF00400	0.549
LIG_BIR_III_4	27	31	PF00653	0.530
LIG_BRCT_BRCA1_1	299	303	PF00533	0.539
LIG_BRCT_BRCA1_1	66	70	PF00533	0.534
LIG_eIF4E_1	281	287	PF01652	0.259
LIG_FHA_1	12	18	PF00498	0.603
LIG_FHA_1	59	65	PF00498	0.652
LIG_FHA_2	234	240	PF00498	0.574
LIG_FHA_2	381	387	PF00498	0.468
LIG_LIR_Gen_1	319	330	PF02991	0.469
LIG_LIR_Nem_3	278	284	PF02991	0.267
LIG_LIR_Nem_3	306	311	PF02991	0.318
LIG_LIR_Nem_3	319	325	PF02991	0.316
LIG_LIR_Nem_3	363	369	PF02991	0.379
LIG_LIR_Nem_3	389	393	PF02991	0.394
LIG_PDZ_Class_3	401	406	PF00595	0.435
LIG_Pex14_2	164	168	PF04695	0.534
LIG_Pex14_2	303	307	PF04695	0.502
LIG_SH2_CRK	308	312	PF00017	0.325
LIG_SH2_CRK	366	370	PF00017	0.384
LIG_SH2_PTP2	322	325	PF00017	0.466
LIG_SH2_SRC	354	357	PF00017	0.431
LIG_SH2_STAP1	143	147	PF00017	0.463
LIG_SH2_STAP1	207	211	PF00017	0.594
LIG_SH2_STAP1	215	219	PF00017	0.466
LIG_SH2_STAT5	207	210	PF00017	0.590
LIG_SH2_STAT5	322	325	PF00017	0.393
LIG_SH3_1	160	166	PF00018	0.483
LIG_SH3_3	15	21	PF00018	0.691
LIG_SH3_3	160	166	PF00018	0.470
LIG_SH3_3	197	203	PF00018	0.761
LIG_SH3_3	227	233	PF00018	0.533
LIG_SH3_3	256	262	PF00018	0.395
LIG_TRAF2_1	383	386	PF00917	0.549
LIG_TYR_ITIM	279	284	PF00017	0.257
LIG_UBA3_1	121	128	PF00899	0.491
MOD_CK1_1	360	366	PF00069	0.390
MOD_CK1_1	76	82	PF00069	0.691
MOD_CK2_1	150	156	PF00069	0.554
MOD_CK2_1	380	386	PF00069	0.376
MOD_CK2_1	77	83	PF00069	0.670
MOD_Cter_Amidation	147	150	PF01082	0.618
MOD_DYRK1A_RPxSP_1	199	203	PF00069	0.570
MOD_DYRK1A_RPxSP_1	226	230	PF00069	0.491
MOD_GlcNHglycan	152	155	PF01048	0.600
MOD_GlcNHglycan	191	194	PF01048	0.788
MOD_GlcNHglycan	362	365	PF01048	0.572
MOD_GlcNHglycan	373	376	PF01048	0.382
MOD_GlcNHglycan	48	51	PF01048	0.612
MOD_GlcNHglycan	54	57	PF01048	0.566
MOD_GlcNHglycan	79	82	PF01048	0.725
MOD_GlcNHglycan	94	97	PF01048	0.479
MOD_GSK3_1	17	24	PF00069	0.740
MOD_GSK3_1	187	194	PF00069	0.615
MOD_GSK3_1	293	300	PF00069	0.495
MOD_GSK3_1	330	337	PF00069	0.517
MOD_GSK3_1	41	48	PF00069	0.573
MOD_GSK3_1	58	65	PF00069	0.718
MOD_GSK3_1	69	76	PF00069	0.584
MOD_GSK3_1	77	84	PF00069	0.574
MOD_N-GLC_1	340	345	PF02516	0.366
MOD_NEK2_1	3	8	PF00069	0.615
MOD_NEK2_1	330	335	PF00069	0.462
MOD_NEK2_1	371	376	PF00069	0.394
MOD_PIKK_1	135	141	PF00454	0.434
MOD_PIKK_1	293	299	PF00454	0.490
MOD_PKA_1	104	110	PF00069	0.477
MOD_PKA_1	397	403	PF00069	0.447
MOD_PKA_1	45	51	PF00069	0.715
MOD_PKA_2	297	303	PF00069	0.364
MOD_PKA_2	380	386	PF00069	0.490
MOD_PKA_2	397	403	PF00069	0.253
MOD_PKA_2	45	51	PF00069	0.738
MOD_PKB_1	395	403	PF00069	0.487
MOD_Plk_1	38	44	PF00069	0.650
MOD_Plk_4	335	341	PF00069	0.392
MOD_ProDKin_1	17	23	PF00069	0.744
MOD_ProDKin_1	199	205	PF00069	0.566
MOD_ProDKin_1	226	232	PF00069	0.500
MOD_ProDKin_1	64	70	PF00069	0.686
TRG_DiLeu_BaEn_1	306	311	PF01217	0.462
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.527
TRG_DiLeu_LyEn_5	306	311	PF01217	0.462
TRG_ENDOCYTIC_2	215	218	PF00928	0.637
TRG_ENDOCYTIC_2	281	284	PF00928	0.263
TRG_ENDOCYTIC_2	308	311	PF00928	0.314
TRG_ENDOCYTIC_2	322	325	PF00928	0.323
TRG_ENDOCYTIC_2	366	369	PF00928	0.371
TRG_ER_diArg_1	101	104	PF00400	0.496
TRG_ER_diArg_1	320	322	PF00400	0.325
TRG_ER_diArg_1	323	326	PF00400	0.342
TRG_ER_diArg_1	395	398	PF00400	0.428
TRG_ER_diArg_1	97	100	PF00400	0.521
TRG_NLS_MonoExtC_3	103	109	PF00514	0.492
TRG_NLS_MonoExtN_4	101	108	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN6	Leptomonas seymouri	60%	92%
A0A0S4JDE7	Bodo saltans	42%	100%
A0A1X0P5P1	Trypanosomatidae	48%	100%
A0A422NM18	Trypanosoma rangeli	48%	100%
A4HMQ4	Leishmania braziliensis	83%	100%
A4IBC2	Leishmania infantum	100%	100%
C9ZZC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AF54	Leishmania major	94%	100%
E9B6B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BJA6	Trypanosoma cruzi	48%	100%