Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7Z3_LEIDO

TriTrypDb:

LdBPK_352100.1 , LdCL_350026200 , LDHU3_35.2710

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.489
CLV_C14_Caspase3-7	717	721	PF00656	0.557
CLV_NRD_NRD_1	164	166	PF00675	0.654
CLV_NRD_NRD_1	171	173	PF00675	0.520
CLV_NRD_NRD_1	284	286	PF00675	0.593
CLV_NRD_NRD_1	329	331	PF00675	0.505
CLV_NRD_NRD_1	351	353	PF00675	0.494
CLV_NRD_NRD_1	380	382	PF00675	0.512
CLV_NRD_NRD_1	451	453	PF00675	0.460
CLV_NRD_NRD_1	590	592	PF00675	0.645
CLV_PCSK_FUR_1	169	173	PF00082	0.680
CLV_PCSK_FUR_1	210	214	PF00082	0.670
CLV_PCSK_FUR_1	282	286	PF00082	0.548
CLV_PCSK_FUR_1	600	604	PF00082	0.497
CLV_PCSK_KEX2_1	169	171	PF00082	0.644
CLV_PCSK_KEX2_1	179	181	PF00082	0.653
CLV_PCSK_KEX2_1	212	214	PF00082	0.671
CLV_PCSK_KEX2_1	284	286	PF00082	0.557
CLV_PCSK_KEX2_1	329	331	PF00082	0.509
CLV_PCSK_KEX2_1	351	353	PF00082	0.494
CLV_PCSK_KEX2_1	380	382	PF00082	0.512
CLV_PCSK_KEX2_1	451	453	PF00082	0.439
CLV_PCSK_KEX2_1	590	592	PF00082	0.645
CLV_PCSK_KEX2_1	602	604	PF00082	0.535
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.699
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.671
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.495
CLV_PCSK_PC7_1	165	171	PF00082	0.677
CLV_PCSK_SKI1_1	179	183	PF00082	0.720
CLV_PCSK_SKI1_1	339	343	PF00082	0.497
CLV_PCSK_SKI1_1	381	385	PF00082	0.491
CLV_PCSK_SKI1_1	428	432	PF00082	0.484
CLV_PCSK_SKI1_1	435	439	PF00082	0.376
CLV_PCSK_SKI1_1	46	50	PF00082	0.525
CLV_PCSK_SKI1_1	94	98	PF00082	0.581
DEG_APCC_DBOX_1	12	20	PF00400	0.539
DEG_APCC_DBOX_1	265	273	PF00400	0.486
DEG_SCF_FBW7_1	132	139	PF00400	0.560
DEG_SPOP_SBC_1	181	185	PF00917	0.718
DEG_SPOP_SBC_1	630	634	PF00917	0.586
DEG_SPOP_SBC_1	700	704	PF00917	0.610
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.646
DOC_MAPK_gen_1	282	290	PF00069	0.551
DOC_MAPK_gen_1	292	299	PF00069	0.547
DOC_MAPK_gen_1	46	55	PF00069	0.571
DOC_MAPK_gen_1	474	483	PF00069	0.416
DOC_MAPK_gen_1	605	613	PF00069	0.578
DOC_MAPK_MEF2A_6	49	57	PF00069	0.575
DOC_PP1_RVXF_1	337	344	PF00149	0.494
DOC_PP1_RVXF_1	458	465	PF00149	0.391
DOC_PP2B_PxIxI_1	220	226	PF00149	0.549
DOC_PP4_FxxP_1	311	314	PF00568	0.552
DOC_PP4_FxxP_1	456	459	PF00568	0.440
DOC_USP7_MATH_1	181	185	PF00917	0.718
DOC_USP7_MATH_1	234	238	PF00917	0.715
DOC_USP7_MATH_1	403	407	PF00917	0.621
DOC_USP7_MATH_1	433	437	PF00917	0.465
DOC_USP7_MATH_1	548	552	PF00917	0.500
DOC_USP7_MATH_1	582	586	PF00917	0.588
DOC_USP7_MATH_1	630	634	PF00917	0.572
DOC_USP7_MATH_1	637	641	PF00917	0.607
DOC_USP7_MATH_1	699	703	PF00917	0.723
DOC_USP7_UBL2_3	59	63	PF12436	0.515
DOC_WW_Pin1_4	132	137	PF00397	0.708
DOC_WW_Pin1_4	416	421	PF00397	0.633
DOC_WW_Pin1_4	649	654	PF00397	0.675
DOC_WW_Pin1_4	680	685	PF00397	0.649
DOC_WW_Pin1_4	703	708	PF00397	0.633
DOC_WW_Pin1_4	711	716	PF00397	0.565
LIG_14-3-3_CanoR_1	13	22	PF00244	0.468
LIG_14-3-3_CanoR_1	180	190	PF00244	0.691
LIG_14-3-3_CanoR_1	224	230	PF00244	0.718
LIG_14-3-3_CanoR_1	266	270	PF00244	0.577
LIG_14-3-3_CanoR_1	415	419	PF00244	0.602
LIG_14-3-3_CanoR_1	428	433	PF00244	0.447
LIG_14-3-3_CanoR_1	435	441	PF00244	0.288
LIG_14-3-3_CanoR_1	605	611	PF00244	0.583
LIG_APCC_ABBA_1	288	293	PF00400	0.557
LIG_APCC_ABBA_1	53	58	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BIR_III_3	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	307	311	PF00533	0.513
LIG_BRCT_BRCA1_1	460	464	PF00533	0.448
LIG_BRCT_BRCA1_1	631	635	PF00533	0.634
LIG_BRCT_BRCA1_1	639	643	PF00533	0.611
LIG_Clathr_ClatBox_1	296	300	PF01394	0.537
LIG_FHA_1	247	253	PF00498	0.654
LIG_FHA_1	333	339	PF00498	0.499
LIG_FHA_1	491	497	PF00498	0.357
LIG_FHA_1	587	593	PF00498	0.796
LIG_FHA_1	594	600	PF00498	0.665
LIG_FHA_1	676	682	PF00498	0.782
LIG_FHA_2	31	37	PF00498	0.509
LIG_FHA_2	429	435	PF00498	0.494
LIG_FHA_2	437	443	PF00498	0.369
LIG_FHA_2	468	474	PF00498	0.419
LIG_Integrin_RGD_1	241	243	PF01839	0.662
LIG_LIR_Apic_2	308	314	PF02991	0.518
LIG_LIR_Gen_1	305	315	PF02991	0.520
LIG_LIR_Gen_1	84	93	PF02991	0.575
LIG_LIR_Nem_3	305	310	PF02991	0.559
LIG_LIR_Nem_3	575	579	PF02991	0.615
LIG_LIR_Nem_3	612	617	PF02991	0.564
LIG_LIR_Nem_3	80	86	PF02991	0.601
LIG_MLH1_MIPbox_1	307	311	PF16413	0.513
LIG_MYND_1	649	653	PF01753	0.710
LIG_NRBOX	491	497	PF00104	0.469
LIG_PCNA_PIPBox_1	312	321	PF02747	0.494
LIG_PCNA_PIPBox_1	488	497	PF02747	0.348
LIG_PDZ_Class_1	718	723	PF00595	0.646
LIG_Pex14_2	22	26	PF04695	0.466
LIG_Pex14_2	307	311	PF04695	0.513
LIG_Pex14_2	464	468	PF04695	0.378
LIG_Rb_pABgroove_1	608	616	PF01858	0.576
LIG_REV1ctd_RIR_1	308	313	PF16727	0.519
LIG_SH2_CRK	503	507	PF00017	0.422
LIG_SH2_NCK_1	324	328	PF00017	0.513
LIG_SH2_NCK_1	86	90	PF00017	0.588
LIG_SH2_PTP2	576	579	PF00017	0.615
LIG_SH2_SRC	576	579	PF00017	0.615
LIG_SH2_STAT5	147	150	PF00017	0.542
LIG_SH2_STAT5	318	321	PF00017	0.482
LIG_SH2_STAT5	324	327	PF00017	0.496
LIG_SH2_STAT5	576	579	PF00017	0.676
LIG_SH2_STAT5	64	67	PF00017	0.500
LIG_SH2_STAT5	7	10	PF00017	0.529
LIG_SH3_3	251	257	PF00018	0.564
LIG_SH3_3	576	582	PF00018	0.736
LIG_SH3_3	709	715	PF00018	0.654
LIG_SH3_CIN85_PxpxPR_1	645	650	PF14604	0.573
LIG_SUMO_SIM_anti_2	251	256	PF11976	0.564
LIG_SUMO_SIM_anti_2	357	362	PF11976	0.450
LIG_SUMO_SIM_par_1	436	443	PF11976	0.481
LIG_SUMO_SIM_par_1	485	493	PF11976	0.376
LIG_SUMO_SIM_par_1	609	615	PF11976	0.573
LIG_TYR_ITIM	501	506	PF00017	0.472
LIG_UBA3_1	610	618	PF00899	0.606
LIG_WRC_WIRS_1	19	24	PF05994	0.642
LIG_WW_3	91	95	PF00397	0.511
MOD_CDK_SPxxK_3	416	423	PF00069	0.564
MOD_CK1_1	142	148	PF00069	0.614
MOD_CK1_1	150	156	PF00069	0.562
MOD_CK1_1	161	167	PF00069	0.667
MOD_CK1_1	18	24	PF00069	0.485
MOD_CK1_1	219	225	PF00069	0.665
MOD_CK1_1	235	241	PF00069	0.672
MOD_CK1_1	3	9	PF00069	0.461
MOD_CK1_1	436	442	PF00069	0.362
MOD_CK1_1	585	591	PF00069	0.674
MOD_CK1_1	703	709	PF00069	0.648
MOD_CK1_1	714	720	PF00069	0.558
MOD_CK2_1	225	231	PF00069	0.746
MOD_CK2_1	299	305	PF00069	0.582
MOD_CK2_1	30	36	PF00069	0.495
MOD_CK2_1	391	397	PF00069	0.598
MOD_CK2_1	428	434	PF00069	0.449
MOD_CK2_1	436	442	PF00069	0.382
MOD_GlcNHglycan	2	5	PF01048	0.634
MOD_GlcNHglycan	325	328	PF01048	0.489
MOD_GlcNHglycan	517	520	PF01048	0.548
MOD_GlcNHglycan	584	587	PF01048	0.637
MOD_GlcNHglycan	620	624	PF01048	0.578
MOD_GlcNHglycan	658	661	PF01048	0.696
MOD_GlcNHglycan	697	700	PF01048	0.764
MOD_GlcNHglycan	703	706	PF01048	0.711
MOD_GSK3_1	132	139	PF00069	0.658
MOD_GSK3_1	14	21	PF00069	0.489
MOD_GSK3_1	142	149	PF00069	0.539
MOD_GSK3_1	150	157	PF00069	0.577
MOD_GSK3_1	219	226	PF00069	0.738
MOD_GSK3_1	318	325	PF00069	0.419
MOD_GSK3_1	367	374	PF00069	0.573
MOD_GSK3_1	581	588	PF00069	0.668
MOD_GSK3_1	649	656	PF00069	0.672
MOD_GSK3_1	675	682	PF00069	0.772
MOD_GSK3_1	695	702	PF00069	0.627
MOD_GSK3_1	714	721	PF00069	0.500
MOD_LATS_1	178	184	PF00433	0.695
MOD_N-GLC_1	656	661	PF02516	0.619
MOD_NEK2_1	371	376	PF00069	0.589
MOD_NEK2_1	391	396	PF00069	0.434
MOD_NEK2_1	490	495	PF00069	0.370
MOD_NEK2_1	572	577	PF00069	0.608
MOD_NEK2_1	695	700	PF00069	0.610
MOD_PIKK_1	173	179	PF00454	0.717
MOD_PIKK_1	182	188	PF00454	0.651
MOD_PIKK_1	332	338	PF00454	0.493
MOD_PIKK_1	651	657	PF00454	0.676
MOD_PIKK_1	714	720	PF00454	0.651
MOD_PKA_1	171	177	PF00069	0.653
MOD_PKA_2	171	177	PF00069	0.686
MOD_PKA_2	223	229	PF00069	0.650
MOD_PKA_2	235	241	PF00069	0.564
MOD_PKA_2	265	271	PF00069	0.574
MOD_PKA_2	414	420	PF00069	0.613
MOD_PKA_2	42	48	PF00069	0.484
MOD_PKB_1	169	177	PF00069	0.652
MOD_Plk_1	150	156	PF00069	0.655
MOD_Plk_1	413	419	PF00069	0.580
MOD_Plk_1	433	439	PF00069	0.389
MOD_Plk_2-3	84	90	PF00069	0.591
MOD_Plk_4	142	148	PF00069	0.600
MOD_Plk_4	15	21	PF00069	0.530
MOD_Plk_4	265	271	PF00069	0.574
MOD_Plk_4	3	9	PF00069	0.578
MOD_Plk_4	367	373	PF00069	0.524
MOD_Plk_4	458	464	PF00069	0.470
MOD_Plk_4	572	578	PF00069	0.607
MOD_Plk_4	84	90	PF00069	0.556
MOD_ProDKin_1	132	138	PF00069	0.709
MOD_ProDKin_1	416	422	PF00069	0.634
MOD_ProDKin_1	649	655	PF00069	0.675
MOD_ProDKin_1	680	686	PF00069	0.650
MOD_ProDKin_1	703	709	PF00069	0.633
MOD_ProDKin_1	711	717	PF00069	0.564
MOD_SUMO_for_1	343	346	PF00179	0.564
MOD_SUMO_for_1	617	620	PF00179	0.602
MOD_SUMO_rev_2	31	39	PF00179	0.485
MOD_SUMO_rev_2	58	65	PF00179	0.479
TRG_DiLeu_BaEn_1	357	362	PF01217	0.575
TRG_DiLeu_BaEn_2	76	82	PF01217	0.587
TRG_DiLeu_BaEn_3	486	492	PF01217	0.373
TRG_ENDOCYTIC_2	503	506	PF00928	0.416
TRG_ENDOCYTIC_2	576	579	PF00928	0.615
TRG_ENDOCYTIC_2	86	89	PF00928	0.589
TRG_ER_diArg_1	124	127	PF00400	0.577
TRG_ER_diArg_1	169	172	PF00400	0.679
TRG_ER_diArg_1	191	194	PF00400	0.687
TRG_ER_diArg_1	282	285	PF00400	0.546
TRG_ER_diArg_1	329	331	PF00400	0.509
TRG_ER_diArg_1	350	352	PF00400	0.486
TRG_ER_diArg_1	380	382	PF00400	0.512
TRG_ER_diArg_1	590	592	PF00400	0.642
TRG_NLS_Bipartite_1	165	183	PF00514	0.691
TRG_NLS_MonoExtC_3	164	169	PF00514	0.674
TRG_NLS_MonoExtN_4	163	170	PF00514	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W4	Leptomonas seymouri	57%	100%
A4HMN1	Leishmania braziliensis	75%	100%
A4IBA8	Leishmania infantum	100%	100%
E9AF33	Leishmania major	93%	100%
E9B688	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%