Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7Z2_LEIDO

TriTrypDb:

LdBPK_351920.1 , LdCL_350024400 , LDHU3_35.2520

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.839
CLV_NRD_NRD_1	437	439	PF00675	0.718
CLV_PCSK_FUR_1	108	112	PF00082	0.754
CLV_PCSK_KEX2_1	110	112	PF00082	0.839
CLV_Separin_Metazoa	187	191	PF03568	0.570
CLV_Separin_Metazoa	316	320	PF03568	0.640
DEG_APCC_KENBOX_2	408	412	PF00400	0.762
DOC_MAPK_gen_1	438	448	PF00069	0.709
DOC_PP2B_LxvP_1	135	138	PF13499	0.766
DOC_PP2B_LxvP_1	97	100	PF13499	0.733
DOC_PP4_FxxP_1	340	343	PF00568	0.593
DOC_PP4_FxxP_1	345	348	PF00568	0.539
DOC_USP7_MATH_1	136	140	PF00917	0.771
DOC_USP7_MATH_1	162	166	PF00917	0.489
DOC_USP7_MATH_1	243	247	PF00917	0.789
DOC_USP7_MATH_1	263	267	PF00917	0.503
DOC_USP7_MATH_1	268	272	PF00917	0.591
DOC_USP7_MATH_1	282	286	PF00917	0.587
DOC_USP7_MATH_1	296	300	PF00917	0.656
DOC_USP7_MATH_1	384	388	PF00917	0.461
DOC_USP7_MATH_1	59	63	PF00917	0.637
DOC_USP7_MATH_1	83	87	PF00917	0.762
DOC_USP7_MATH_1	88	92	PF00917	0.684
DOC_WW_Pin1_4	125	130	PF00397	0.729
DOC_WW_Pin1_4	141	146	PF00397	0.808
DOC_WW_Pin1_4	156	161	PF00397	0.636
DOC_WW_Pin1_4	245	250	PF00397	0.794
DOC_WW_Pin1_4	272	277	PF00397	0.818
DOC_WW_Pin1_4	280	285	PF00397	0.695
DOC_WW_Pin1_4	364	369	PF00397	0.534
DOC_WW_Pin1_4	6	11	PF00397	0.744
LIG_14-3-3_CanoR_1	380	384	PF00244	0.678
LIG_14-3-3_CanoR_1	63	73	PF00244	0.560
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_4	58	62	PF00653	0.641
LIG_BRCT_BRCA1_1	412	416	PF00533	0.589
LIG_deltaCOP1_diTrp_1	327	333	PF00928	0.509
LIG_FHA_1	10	16	PF00498	0.641
LIG_FHA_1	152	158	PF00498	0.606
LIG_FHA_1	380	386	PF00498	0.512
LIG_FHA_1	431	437	PF00498	0.607
LIG_FHA_1	94	100	PF00498	0.789
LIG_FHA_2	113	119	PF00498	0.670
LIG_LIR_Apic_2	397	402	PF02991	0.700
LIG_LIR_Gen_1	76	85	PF02991	0.587
LIG_LIR_Nem_3	171	177	PF02991	0.560
LIG_LIR_Nem_3	246	250	PF02991	0.732
LIG_LIR_Nem_3	327	332	PF02991	0.554
LIG_LIR_Nem_3	76	82	PF02991	0.577
LIG_MAD2	423	431	PF02301	0.587
LIG_PDZ_Class_2	443	448	PF00595	0.760
LIG_Pex14_1	329	333	PF04695	0.504
LIG_Pex14_2	206	210	PF04695	0.539
LIG_PTB_Apo_2	188	195	PF02174	0.576
LIG_SH2_CRK	247	251	PF00017	0.737
LIG_SH2_CRK	321	325	PF00017	0.505
LIG_SH2_GRB2like	73	76	PF00017	0.686
LIG_SH2_NCK_1	79	83	PF00017	0.753
LIG_SH2_SRC	79	82	PF00017	0.659
LIG_SH2_STAP1	73	77	PF00017	0.586
LIG_SH2_STAP1	79	83	PF00017	0.651
LIG_SH2_STAT3	332	335	PF00017	0.459
LIG_SH2_STAT5	114	117	PF00017	0.802
LIG_SH2_STAT5	177	180	PF00017	0.500
LIG_SH2_STAT5	332	335	PF00017	0.455
LIG_SH2_STAT5	376	379	PF00017	0.568
LIG_SH2_STAT5	39	42	PF00017	0.528
LIG_SH3_3	140	146	PF00018	0.806
LIG_SH3_3	247	253	PF00018	0.595
LIG_SH3_3	271	277	PF00018	0.776
LIG_SH3_3	281	287	PF00018	0.704
LIG_SH3_3	386	392	PF00018	0.503
LIG_TRAF2_1	237	240	PF00917	0.719
LIG_TRAF2_1	262	265	PF00917	0.561
LIG_WRC_WIRS_1	5	10	PF05994	0.653
MOD_CDC14_SPxK_1	248	251	PF00782	0.808
MOD_CDK_SPxK_1	245	251	PF00069	0.810
MOD_CK1_1	139	145	PF00069	0.803
MOD_CK1_1	148	154	PF00069	0.652
MOD_CK2_1	112	118	PF00069	0.671
MOD_CK2_1	282	288	PF00069	0.756
MOD_GlcNHglycan	103	106	PF01048	0.765
MOD_GlcNHglycan	138	141	PF01048	0.803
MOD_GlcNHglycan	164	167	PF01048	0.637
MOD_GlcNHglycan	253	256	PF01048	0.667
MOD_GlcNHglycan	31	34	PF01048	0.639
MOD_GlcNHglycan	386	389	PF01048	0.492
MOD_GlcNHglycan	90	93	PF01048	0.643
MOD_GSK3_1	141	148	PF00069	0.773
MOD_GSK3_1	194	201	PF00069	0.628
MOD_GSK3_1	245	252	PF00069	0.649
MOD_GSK3_1	263	270	PF00069	0.606
MOD_GSK3_1	272	279	PF00069	0.646
MOD_GSK3_1	4	11	PF00069	0.587
MOD_GSK3_1	83	90	PF00069	0.773
MOD_N-GLC_1	194	199	PF02516	0.615
MOD_N-GLC_1	410	415	PF02516	0.623
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	194	199	PF00069	0.570
MOD_NEK2_1	378	383	PF00069	0.682
MOD_PIKK_1	109	115	PF00454	0.723
MOD_PKA_1	438	444	PF00069	0.733
MOD_PKA_2	109	115	PF00069	0.723
MOD_PKA_2	148	154	PF00069	0.762
MOD_PKA_2	213	219	PF00069	0.538
MOD_PKA_2	379	385	PF00069	0.669
MOD_Plk_1	194	200	PF00069	0.594
MOD_Plk_4	1	7	PF00069	0.698
MOD_Plk_4	213	219	PF00069	0.616
MOD_Plk_4	430	436	PF00069	0.710
MOD_ProDKin_1	125	131	PF00069	0.730
MOD_ProDKin_1	141	147	PF00069	0.810
MOD_ProDKin_1	156	162	PF00069	0.630
MOD_ProDKin_1	245	251	PF00069	0.795
MOD_ProDKin_1	272	278	PF00069	0.817
MOD_ProDKin_1	280	286	PF00069	0.694
MOD_ProDKin_1	364	370	PF00069	0.529
MOD_ProDKin_1	6	12	PF00069	0.745
MOD_SUMO_for_1	258	261	PF00179	0.746
TRG_DiLeu_BaEn_1	443	448	PF01217	0.721
TRG_DiLeu_BaEn_4	239	245	PF01217	0.729
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.758
TRG_ENDOCYTIC_2	247	250	PF00928	0.735
TRG_ENDOCYTIC_2	321	324	PF00928	0.511
TRG_ENDOCYTIC_2	79	82	PF00928	0.671
TRG_ER_diArg_1	108	111	PF00400	0.819

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ4	Leptomonas seymouri	48%	97%
A4HML4	Leishmania braziliensis	79%	100%
A4IB91	Leishmania infantum	98%	100%
E9AF15	Leishmania major	93%	100%
E9B671	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%