Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7Z0_LEIDO

TriTrypDb:

LdBPK_351610.1 , LdCL_350021000 , LDHU3_35.2150

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S5H7Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	907	911	PF00656	0.743
CLV_C14_Caspase3-7	937	941	PF00656	0.677
CLV_NRD_NRD_1	269	271	PF00675	0.743
CLV_NRD_NRD_1	339	341	PF00675	0.701
CLV_NRD_NRD_1	489	491	PF00675	0.517
CLV_NRD_NRD_1	504	506	PF00675	0.304
CLV_NRD_NRD_1	825	827	PF00675	0.363
CLV_PCSK_KEX2_1	269	271	PF00082	0.743
CLV_PCSK_KEX2_1	339	341	PF00082	0.701
CLV_PCSK_KEX2_1	489	491	PF00082	0.517
CLV_PCSK_KEX2_1	504	506	PF00082	0.304
CLV_PCSK_KEX2_1	645	647	PF00082	0.511
CLV_PCSK_KEX2_1	825	827	PF00082	0.336
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.511
CLV_PCSK_SKI1_1	27	31	PF00082	0.473
CLV_PCSK_SKI1_1	490	494	PF00082	0.468
CLV_PCSK_SKI1_1	505	509	PF00082	0.513
CLV_PCSK_SKI1_1	528	532	PF00082	0.434
CLV_PCSK_SKI1_1	628	632	PF00082	0.433
CLV_PCSK_SKI1_1	732	736	PF00082	0.516
CLV_PCSK_SKI1_1	772	776	PF00082	0.447
CLV_PCSK_SKI1_1	802	806	PF00082	0.444
CLV_PCSK_SKI1_1	851	855	PF00082	0.665
DEG_APCC_DBOX_1	26	34	PF00400	0.655
DEG_APCC_DBOX_1	504	512	PF00400	0.677
DEG_APCC_DBOX_1	570	578	PF00400	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.726
DEG_SPOP_SBC_1	325	329	PF00917	0.447
DEG_SPOP_SBC_1	341	345	PF00917	0.462
DEG_SPOP_SBC_1	378	382	PF00917	0.471
DOC_CDC14_PxL_1	155	163	PF14671	0.521
DOC_CKS1_1	511	516	PF01111	0.696
DOC_CKS1_1	892	897	PF01111	0.724
DOC_CYCLIN_RxL_1	301	310	PF00134	0.414
DOC_CYCLIN_RxL_1	729	736	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.420
DOC_MAPK_gen_1	304	314	PF00069	0.474
DOC_MAPK_gen_1	825	831	PF00069	0.540
DOC_MAPK_gen_1	851	860	PF00069	0.336
DOC_MAPK_MEF2A_6	402	409	PF00069	0.478
DOC_MAPK_MEF2A_6	419	427	PF00069	0.361
DOC_MAPK_MEF2A_6	567	576	PF00069	0.488
DOC_MAPK_MEF2A_6	851	860	PF00069	0.339
DOC_PP2B_LxvP_1	142	145	PF13499	0.590
DOC_PP2B_LxvP_1	189	192	PF13499	0.500
DOC_PP2B_LxvP_1	193	196	PF13499	0.493
DOC_PP4_FxxP_1	816	819	PF00568	0.540
DOC_USP7_MATH_1	323	327	PF00917	0.503
DOC_USP7_MATH_1	341	345	PF00917	0.472
DOC_USP7_MATH_1	378	382	PF00917	0.490
DOC_USP7_MATH_1	512	516	PF00917	0.715
DOC_USP7_MATH_1	526	530	PF00917	0.625
DOC_USP7_MATH_1	791	795	PF00917	0.598
DOC_USP7_MATH_1	898	902	PF00917	0.698
DOC_USP7_MATH_1	906	910	PF00917	0.683
DOC_WW_Pin1_4	148	153	PF00397	0.553
DOC_WW_Pin1_4	174	179	PF00397	0.547
DOC_WW_Pin1_4	326	331	PF00397	0.480
DOC_WW_Pin1_4	510	515	PF00397	0.699
DOC_WW_Pin1_4	815	820	PF00397	0.488
DOC_WW_Pin1_4	891	896	PF00397	0.696
LIG_14-3-3_CanoR_1	204	213	PF00244	0.548
LIG_14-3-3_CanoR_1	221	229	PF00244	0.476
LIG_14-3-3_CanoR_1	274	282	PF00244	0.501
LIG_14-3-3_CanoR_1	291	301	PF00244	0.374
LIG_14-3-3_CanoR_1	444	448	PF00244	0.668
LIG_14-3-3_CanoR_1	538	542	PF00244	0.542
LIG_14-3-3_CanoR_1	571	575	PF00244	0.391
LIG_14-3-3_CanoR_1	622	630	PF00244	0.729
LIG_14-3-3_CanoR_1	635	640	PF00244	0.678
LIG_14-3-3_CanoR_1	876	880	PF00244	0.697
LIG_14-3-3_CanoR_1	899	903	PF00244	0.763
LIG_BRCT_BRCA1_1	100	104	PF00533	0.432
LIG_CSL_BTD_1	745	748	PF09270	0.725
LIG_EH1_1	417	425	PF00400	0.450
LIG_EH1_1	776	784	PF00400	0.444
LIG_eIF4E_1	10	16	PF01652	0.427
LIG_eIF4E_1	31	37	PF01652	0.533
LIG_EVH1_2	330	334	PF00568	0.407
LIG_EVH1_2	748	752	PF00568	0.651
LIG_FHA_1	179	185	PF00498	0.569
LIG_FHA_1	198	204	PF00498	0.565
LIG_FHA_1	230	236	PF00498	0.459
LIG_FHA_1	246	252	PF00498	0.521
LIG_FHA_1	378	384	PF00498	0.417
LIG_FHA_1	537	543	PF00498	0.527
LIG_FHA_1	571	577	PF00498	0.329
LIG_FHA_1	59	65	PF00498	0.419
LIG_FHA_1	705	711	PF00498	0.387
LIG_FHA_1	861	867	PF00498	0.429
LIG_FHA_2	122	128	PF00498	0.510
LIG_FHA_2	145	151	PF00498	0.536
LIG_FHA_2	331	337	PF00498	0.560
LIG_FHA_2	842	848	PF00498	0.411
LIG_GBD_Chelix_1	858	866	PF00786	0.429
LIG_GBD_Chelix_1	883	891	PF00786	0.476
LIG_Integrin_RGD_1	218	220	PF01839	0.719
LIG_LIR_Apic_2	745	749	PF02991	0.724
LIG_LIR_Apic_2	800	806	PF02991	0.429
LIG_LIR_Gen_1	276	287	PF02991	0.489
LIG_LIR_Gen_1	651	660	PF02991	0.504
LIG_LIR_Gen_1	74	82	PF02991	0.500
LIG_LIR_LC3C_4	436	440	PF02991	0.369
LIG_LIR_Nem_3	100	105	PF02991	0.355
LIG_LIR_Nem_3	276	282	PF02991	0.470
LIG_LIR_Nem_3	318	324	PF02991	0.392
LIG_LIR_Nem_3	43	49	PF02991	0.422
LIG_LIR_Nem_3	651	655	PF02991	0.649
LIG_LIR_Nem_3	74	78	PF02991	0.446
LIG_LIR_Nem_3	8	13	PF02991	0.533
LIG_LIR_Nem_3	847	853	PF02991	0.400
LIG_LIR_Nem_3	93	99	PF02991	0.597
LIG_MAD2	136	144	PF02301	0.533
LIG_MYND_1	140	144	PF01753	0.538
LIG_NRBOX	852	858	PF00104	0.369
LIG_NRBOX	865	871	PF00104	0.426
LIG_PCNA_PIPBox_1	626	635	PF02747	0.698
LIG_PCNA_yPIPBox_3	622	633	PF02747	0.722
LIG_PCNA_yPIPBox_3	842	854	PF02747	0.441
LIG_PDZ_Class_3	937	942	PF00595	0.679
LIG_Pex14_2	813	817	PF04695	0.401
LIG_SH2_CRK	10	14	PF00017	0.419
LIG_SH2_CRK	167	171	PF00017	0.525
LIG_SH2_CRK	279	283	PF00017	0.475
LIG_SH2_CRK	850	854	PF00017	0.443
LIG_SH2_STAP1	105	109	PF00017	0.485
LIG_SH2_STAP1	349	353	PF00017	0.400
LIG_SH2_STAP1	562	566	PF00017	0.492
LIG_SH2_STAP1	650	654	PF00017	0.676
LIG_SH2_STAP1	797	801	PF00017	0.391
LIG_SH2_STAT5	247	250	PF00017	0.578
LIG_SH2_STAT5	279	282	PF00017	0.501
LIG_SH2_STAT5	302	305	PF00017	0.447
LIG_SH2_STAT5	416	419	PF00017	0.448
LIG_SH2_STAT5	467	470	PF00017	0.692
LIG_SH2_STAT5	632	635	PF00017	0.644
LIG_SH2_STAT5	773	776	PF00017	0.337
LIG_SH2_STAT5	803	806	PF00017	0.338
LIG_SH2_STAT5	812	815	PF00017	0.365
LIG_SH2_STAT5	830	833	PF00017	0.471
LIG_SH3_3	109	115	PF00018	0.405
LIG_SH3_3	134	140	PF00018	0.545
LIG_SH3_3	286	292	PF00018	0.544
LIG_SH3_3	428	434	PF00018	0.444
LIG_SH3_3	588	594	PF00018	0.288
LIG_SH3_3	816	822	PF00018	0.604
LIG_Sin3_3	596	603	PF02671	0.597
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.485
LIG_SUMO_SIM_anti_2	436	442	PF11976	0.303
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.390
LIG_SUMO_SIM_par_1	74	81	PF11976	0.448
LIG_TYR_ITIM	771	776	PF00017	0.531
LIG_TYR_ITSM	6	13	PF00017	0.554
LIG_WRC_WIRS_1	91	96	PF05994	0.699
LIG_WRC_WIRS_1	99	104	PF05994	0.393
LIG_WW_3	143	147	PF00397	0.539
MOD_CK1_1	151	157	PF00069	0.533
MOD_CK1_1	182	188	PF00069	0.494
MOD_CK1_1	245	251	PF00069	0.532
MOD_CK1_1	293	299	PF00069	0.489
MOD_CK1_1	326	332	PF00069	0.557
MOD_CK1_1	343	349	PF00069	0.510
MOD_CK1_1	540	546	PF00069	0.378
MOD_CK1_1	742	748	PF00069	0.728
MOD_CK1_1	890	896	PF00069	0.681
MOD_CK1_1	90	96	PF00069	0.692
MOD_CK2_1	121	127	PF00069	0.566
MOD_CK2_1	144	150	PF00069	0.537
MOD_CK2_1	330	336	PF00069	0.505
MOD_CK2_1	379	385	PF00069	0.462
MOD_CMANNOS	408	411	PF00535	0.714
MOD_Cter_Amidation	267	270	PF01082	0.762
MOD_GlcNHglycan	127	131	PF01048	0.768
MOD_GlcNHglycan	173	177	PF01048	0.715
MOD_GlcNHglycan	184	187	PF01048	0.713
MOD_GlcNHglycan	237	240	PF01048	0.707
MOD_GlcNHglycan	255	258	PF01048	0.588
MOD_GlcNHglycan	292	295	PF01048	0.695
MOD_GlcNHglycan	345	348	PF01048	0.743
MOD_GlcNHglycan	435	438	PF01048	0.449
MOD_GlcNHglycan	450	453	PF01048	0.349
MOD_GlcNHglycan	486	489	PF01048	0.449
MOD_GlcNHglycan	515	518	PF01048	0.484
MOD_GlcNHglycan	528	531	PF01048	0.492
MOD_GlcNHglycan	542	545	PF01048	0.374
MOD_GlcNHglycan	69	72	PF01048	0.426
MOD_GlcNHglycan	83	86	PF01048	0.361
MOD_GSK3_1	144	151	PF00069	0.508
MOD_GSK3_1	174	181	PF00069	0.572
MOD_GSK3_1	235	242	PF00069	0.470
MOD_GSK3_1	292	299	PF00069	0.518
MOD_GSK3_1	326	333	PF00069	0.512
MOD_GSK3_1	536	543	PF00069	0.570
MOD_GSK3_1	67	74	PF00069	0.397
MOD_GSK3_1	700	707	PF00069	0.434
MOD_GSK3_1	738	745	PF00069	0.722
MOD_GSK3_1	887	894	PF00069	0.655
MOD_N-GLC_1	121	126	PF02516	0.711
MOD_N-GLC_1	209	214	PF02516	0.799
MOD_N-GLC_1	315	320	PF02516	0.584
MOD_N-GLC_1	67	72	PF02516	0.408
MOD_N-GLC_1	691	696	PF02516	0.584
MOD_NEK2_1	126	131	PF00069	0.560
MOD_NEK2_1	179	184	PF00069	0.533
MOD_NEK2_1	23	28	PF00069	0.406
MOD_NEK2_1	377	382	PF00069	0.412
MOD_NEK2_1	425	430	PF00069	0.465
MOD_NEK2_1	483	488	PF00069	0.694
MOD_NEK2_1	50	55	PF00069	0.458
MOD_NEK2_1	537	542	PF00069	0.568
MOD_NEK2_1	704	709	PF00069	0.379
MOD_NEK2_1	78	83	PF00069	0.622
MOD_NEK2_1	841	846	PF00069	0.513
MOD_NEK2_1	87	92	PF00069	0.666
MOD_NEK2_1	97	102	PF00069	0.287
MOD_NEK2_2	209	214	PF00069	0.509
MOD_NEK2_2	260	265	PF00069	0.546
MOD_NEK2_2	557	562	PF00069	0.525
MOD_NEK2_2	797	802	PF00069	0.308
MOD_PIKK_1	220	226	PF00454	0.598
MOD_PIKK_1	239	245	PF00454	0.336
MOD_PIKK_1	622	628	PF00454	0.723
MOD_PK_1	928	934	PF00069	0.756
MOD_PKA_1	214	220	PF00069	0.604
MOD_PKA_2	220	226	PF00069	0.573
MOD_PKA_2	273	279	PF00069	0.464
MOD_PKA_2	290	296	PF00069	0.382
MOD_PKA_2	443	449	PF00069	0.666
MOD_PKA_2	537	543	PF00069	0.561
MOD_PKA_2	570	576	PF00069	0.391
MOD_PKA_2	875	881	PF00069	0.696
MOD_PKA_2	898	904	PF00069	0.773
MOD_PKB_1	926	934	PF00069	0.756
MOD_Plk_1	121	127	PF00069	0.541
MOD_Plk_1	239	245	PF00069	0.500
MOD_Plk_1	315	321	PF00069	0.399
MOD_Plk_1	5	11	PF00069	0.706
MOD_Plk_1	50	56	PF00069	0.377
MOD_Plk_1	67	73	PF00069	0.485
MOD_Plk_1	691	697	PF00069	0.336
MOD_Plk_1	928	934	PF00069	0.770
MOD_Plk_4	296	302	PF00069	0.550
MOD_Plk_4	315	321	PF00069	0.255
MOD_Plk_4	379	385	PF00069	0.411
MOD_Plk_4	395	401	PF00069	0.441
MOD_Plk_4	5	11	PF00069	0.684
MOD_Plk_4	537	543	PF00069	0.560
MOD_Plk_4	570	576	PF00069	0.305
MOD_Plk_4	628	634	PF00069	0.685
MOD_Plk_4	635	641	PF00069	0.672
MOD_Plk_4	674	680	PF00069	0.409
MOD_Plk_4	683	689	PF00069	0.441
MOD_Plk_4	700	706	PF00069	0.228
MOD_Plk_4	71	77	PF00069	0.436
MOD_Plk_4	742	748	PF00069	0.726
MOD_Plk_4	785	791	PF00069	0.385
MOD_Plk_4	98	104	PF00069	0.349
MOD_ProDKin_1	148	154	PF00069	0.552
MOD_ProDKin_1	174	180	PF00069	0.548
MOD_ProDKin_1	326	332	PF00069	0.484
MOD_ProDKin_1	510	516	PF00069	0.697
MOD_ProDKin_1	815	821	PF00069	0.493
MOD_ProDKin_1	891	897	PF00069	0.699
MOD_SUMO_for_1	170	173	PF00179	0.508
TRG_DiLeu_BaEn_1	127	132	PF01217	0.536
TRG_DiLeu_BaEn_2	716	722	PF01217	0.678
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.463
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.440
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.654
TRG_ENDOCYTIC_2	10	13	PF00928	0.441
TRG_ENDOCYTIC_2	167	170	PF00928	0.480
TRG_ENDOCYTIC_2	279	282	PF00928	0.474
TRG_ENDOCYTIC_2	650	653	PF00928	0.552
TRG_ENDOCYTIC_2	773	776	PF00928	0.397
TRG_ENDOCYTIC_2	850	853	PF00928	0.443
TRG_ER_diArg_1	306	309	PF00400	0.414
TRG_ER_diArg_1	824	826	PF00400	0.695
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	851	855	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N6	Leptomonas seymouri	39%	98%
A0A1X0P5S8	Trypanosomatidae	22%	100%
A0A3R7L4T2	Trypanosoma rangeli	23%	100%
A4HMI2	Leishmania braziliensis	70%	99%
A4IB62	Leishmania infantum	99%	100%
C9ZZH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AEY3	Leishmania major	90%	100%
E9B639	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%