LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H7Y9_LEIDO
TriTrypDb:
LdBPK_351470.1 , LdCL_350019600 , LDHU3_35.1920
Length:
329

Annotations

LeishMANIAdb annotations

A conserved mitochondrial transporter protein involed in organellar amino acid uptake. Localization: Mitochondrial (by homology)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 1
GO:0016020 membrane 2 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

A0A3S5H7Y9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y9

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 278 282 PF00656 0.365
CLV_NRD_NRD_1 21 23 PF00675 0.385
CLV_PCSK_KEX2_1 218 220 PF00082 0.617
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.555
CLV_PCSK_SKI1_1 185 189 PF00082 0.266
CLV_PCSK_SKI1_1 22 26 PF00082 0.366
CLV_PCSK_SKI1_1 83 87 PF00082 0.491
CLV_PCSK_SKI1_1 94 98 PF00082 0.459
DEG_APCC_DBOX_1 190 198 PF00400 0.464
DOC_CKS1_1 247 252 PF01111 0.265
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HT03 Leptomonas seymouri 77% 100%
A0A0S4IXN4 Bodo saltans 38% 100%
A0A1X0NHY2 Trypanosomatidae 60% 100%
A0A3R7NG75 Trypanosoma rangeli 59% 100%
A4HMG8 Leishmania braziliensis 90% 100%
A4IB40 Leishmania infantum 100% 100%
C9ZNP1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AEW9 Leishmania major 99% 100%
E9B625 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q9Y7X4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS