Coiled-coil domain-containing protein 40

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7Y8_LEIDO

TriTrypDb:

LdBPK_351250.1 , LdCL_350017400 , LDHU3_35.1660

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.696
CLV_C14_Caspase3-7	222	226	PF00656	0.545
CLV_NRD_NRD_1	133	135	PF00675	0.629
CLV_NRD_NRD_1	177	179	PF00675	0.536
CLV_NRD_NRD_1	244	246	PF00675	0.554
CLV_NRD_NRD_1	302	304	PF00675	0.638
CLV_NRD_NRD_1	316	318	PF00675	0.520
CLV_NRD_NRD_1	339	341	PF00675	0.662
CLV_NRD_NRD_1	401	403	PF00675	0.560
CLV_NRD_NRD_1	505	507	PF00675	0.669
CLV_NRD_NRD_1	622	624	PF00675	0.497
CLV_NRD_NRD_1	679	681	PF00675	0.582
CLV_NRD_NRD_1	719	721	PF00675	0.679
CLV_NRD_NRD_1	834	836	PF00675	0.590
CLV_NRD_NRD_1	89	91	PF00675	0.544
CLV_PCSK_FUR_1	620	624	PF00082	0.407
CLV_PCSK_FUR_1	818	822	PF00082	0.657
CLV_PCSK_KEX2_1	15	17	PF00082	0.569
CLV_PCSK_KEX2_1	177	179	PF00082	0.589
CLV_PCSK_KEX2_1	273	275	PF00082	0.586
CLV_PCSK_KEX2_1	302	304	PF00082	0.622
CLV_PCSK_KEX2_1	31	33	PF00082	0.429
CLV_PCSK_KEX2_1	316	318	PF00082	0.459
CLV_PCSK_KEX2_1	329	331	PF00082	0.319
CLV_PCSK_KEX2_1	339	341	PF00082	0.496
CLV_PCSK_KEX2_1	401	403	PF00082	0.638
CLV_PCSK_KEX2_1	622	624	PF00082	0.422
CLV_PCSK_KEX2_1	679	681	PF00082	0.582
CLV_PCSK_KEX2_1	719	721	PF00082	0.623
CLV_PCSK_KEX2_1	820	822	PF00082	0.612
CLV_PCSK_KEX2_1	89	91	PF00082	0.542
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.644
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.652
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.422
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.648
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.617
CLV_PCSK_PC7_1	173	179	PF00082	0.583
CLV_PCSK_SKI1_1	15	19	PF00082	0.608
CLV_PCSK_SKI1_1	173	177	PF00082	0.569
CLV_PCSK_SKI1_1	265	269	PF00082	0.659
CLV_PCSK_SKI1_1	330	334	PF00082	0.644
CLV_PCSK_SKI1_1	340	344	PF00082	0.610
CLV_PCSK_SKI1_1	365	369	PF00082	0.576
CLV_PCSK_SKI1_1	448	452	PF00082	0.550
CLV_PCSK_SKI1_1	709	713	PF00082	0.552
CLV_PCSK_SKI1_1	719	723	PF00082	0.571
CLV_PCSK_SKI1_1	765	769	PF00082	0.598
DEG_APCC_DBOX_1	315	323	PF00400	0.642
DEG_APCC_DBOX_1	477	485	PF00400	0.537
DEG_APCC_DBOX_1	621	629	PF00400	0.616
DEG_APCC_DBOX_1	708	716	PF00400	0.508
DEG_APCC_DBOX_1	778	786	PF00400	0.528
DEG_APCC_DBOX_1	799	807	PF00400	0.612
DOC_CYCLIN_RxL_1	75	85	PF00134	0.563
DOC_CYCLIN_RxL_1	762	772	PF00134	0.595
DOC_MAPK_gen_1	316	324	PF00069	0.641
DOC_MAPK_gen_1	413	420	PF00069	0.615
DOC_MAPK_gen_1	620	630	PF00069	0.575
DOC_MAPK_gen_1	833	843	PF00069	0.602
DOC_MAPK_HePTP_8	647	659	PF00069	0.503
DOC_MAPK_MEF2A_6	20	28	PF00069	0.656
DOC_MAPK_MEF2A_6	532	541	PF00069	0.429
DOC_MAPK_MEF2A_6	650	659	PF00069	0.509
DOC_MAPK_MEF2A_6	690	698	PF00069	0.576
DOC_MAPK_RevD_3	163	178	PF00069	0.436
DOC_USP7_MATH_1	107	111	PF00917	0.439
DOC_USP7_MATH_1	528	532	PF00917	0.588
DOC_USP7_MATH_1	635	639	PF00917	0.549
DOC_USP7_MATH_1	739	743	PF00917	0.765
DOC_USP7_MATH_1	771	775	PF00917	0.635
DOC_USP7_MATH_1	790	794	PF00917	0.328
DOC_USP7_MATH_1	91	95	PF00917	0.609
DOC_USP7_UBL2_3	413	417	PF12436	0.587
DOC_WW_Pin1_4	357	362	PF00397	0.682
DOC_WW_Pin1_4	665	670	PF00397	0.630
LIG_14-3-3_CanoR_1	16	24	PF00244	0.606
LIG_14-3-3_CanoR_1	32	36	PF00244	0.526
LIG_14-3-3_CanoR_1	4	10	PF00244	0.675
LIG_14-3-3_CanoR_1	466	471	PF00244	0.599
LIG_14-3-3_CanoR_1	499	503	PF00244	0.649
LIG_14-3-3_CanoR_1	506	510	PF00244	0.612
LIG_14-3-3_CanoR_1	679	683	PF00244	0.551
LIG_14-3-3_CanoR_1	719	729	PF00244	0.687
LIG_14-3-3_CanoR_1	807	811	PF00244	0.500
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_CaM_IQ_9	810	825	PF13499	0.613
LIG_Clathr_ClatBox_1	698	702	PF01394	0.608
LIG_eIF4E_1	682	688	PF01652	0.611
LIG_eIF4E_1	693	699	PF01652	0.525
LIG_FHA_1	16	22	PF00498	0.585
LIG_FHA_1	174	180	PF00498	0.624
LIG_FHA_1	219	225	PF00498	0.599
LIG_FHA_1	23	29	PF00498	0.591
LIG_FHA_1	388	394	PF00498	0.620
LIG_FHA_1	493	499	PF00498	0.672
LIG_FHA_1	536	542	PF00498	0.627
LIG_FHA_1	703	709	PF00498	0.501
LIG_FHA_1	758	764	PF00498	0.564
LIG_FHA_2	393	399	PF00498	0.664
LIG_FHA_2	506	512	PF00498	0.681
LIG_FHA_2	538	544	PF00498	0.549
LIG_FHA_2	56	62	PF00498	0.494
LIG_FHA_2	807	813	PF00498	0.596
LIG_Integrin_RGD_1	260	262	PF01839	0.541
LIG_LIR_Gen_1	159	168	PF02991	0.627
LIG_LIR_Gen_1	366	375	PF02991	0.441
LIG_LIR_Nem_3	159	165	PF02991	0.634
LIG_LIR_Nem_3	366	371	PF02991	0.565
LIG_NRP_CendR_1	844	847	PF00754	0.634
LIG_PCNA_yPIPBox_3	31	45	PF02747	0.575
LIG_PTAP_UEV_1	752	757	PF05743	0.640
LIG_SH2_SRC	632	635	PF00017	0.500
LIG_SH2_STAP1	277	281	PF00017	0.607
LIG_SH2_STAP1	632	636	PF00017	0.603
LIG_SH2_STAT3	277	280	PF00017	0.609
LIG_SH2_STAT5	218	221	PF00017	0.605
LIG_SH2_STAT5	581	584	PF00017	0.586
LIG_SH2_STAT5	693	696	PF00017	0.581
LIG_SH3_3	750	756	PF00018	0.686
LIG_SUMO_SIM_anti_2	320	328	PF11976	0.611
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.510
LIG_SUMO_SIM_par_1	24	30	PF11976	0.612
LIG_SUMO_SIM_par_1	320	328	PF11976	0.594
LIG_SUMO_SIM_par_1	536	543	PF11976	0.432
LIG_SUMO_SIM_par_1	697	702	PF11976	0.608
LIG_TRAF2_1	189	192	PF00917	0.413
LIG_TRAF2_1	422	425	PF00917	0.654
LIG_TRAF2_1	508	511	PF00917	0.728
LIG_TRAF2_1	540	543	PF00917	0.579
LIG_WRC_WIRS_1	393	398	PF05994	0.663
MOD_CK1_1	298	304	PF00069	0.658
MOD_CK1_1	419	425	PF00069	0.662
MOD_CK1_1	754	760	PF00069	0.694
MOD_CK2_1	103	109	PF00069	0.628
MOD_CK2_1	31	37	PF00069	0.582
MOD_CK2_1	373	379	PF00069	0.646
MOD_CK2_1	419	425	PF00069	0.646
MOD_CK2_1	436	442	PF00069	0.402
MOD_CK2_1	505	511	PF00069	0.631
MOD_CK2_1	537	543	PF00069	0.585
MOD_CK2_1	55	61	PF00069	0.498
MOD_CK2_1	766	772	PF00069	0.601
MOD_CK2_1	806	812	PF00069	0.596
MOD_Cter_Amidation	399	402	PF01082	0.627
MOD_GlcNHglycan	105	108	PF01048	0.656
MOD_GlcNHglycan	119	122	PF01048	0.524
MOD_GlcNHglycan	137	140	PF01048	0.538
MOD_GlcNHglycan	733	736	PF01048	0.614
MOD_GlcNHglycan	753	756	PF01048	0.725
MOD_GlcNHglycan	769	772	PF01048	0.647
MOD_GSK3_1	135	142	PF00069	0.687
MOD_GSK3_1	157	164	PF00069	0.687
MOD_GSK3_1	27	34	PF00069	0.577
MOD_GSK3_1	353	360	PF00069	0.687
MOD_GSK3_1	494	501	PF00069	0.619
MOD_GSK3_1	659	666	PF00069	0.634
MOD_GSK3_1	715	722	PF00069	0.608
MOD_GSK3_1	767	774	PF00069	0.615
MOD_GSK3_1	827	834	PF00069	0.591
MOD_GSK3_1	839	846	PF00069	0.648
MOD_GSK3_1	99	106	PF00069	0.588
MOD_N-GLC_1	10	15	PF02516	0.672
MOD_N-GLC_1	745	750	PF02516	0.711
MOD_NEK2_1	10	15	PF00069	0.632
MOD_NEK2_1	157	162	PF00069	0.614
MOD_NEK2_1	451	456	PF00069	0.492
MOD_NEK2_1	477	482	PF00069	0.543
MOD_NEK2_1	492	497	PF00069	0.581
MOD_NEK2_1	498	503	PF00069	0.550
MOD_NEK2_1	715	720	PF00069	0.604
MOD_NEK2_1	785	790	PF00069	0.467
MOD_NEK2_1	806	811	PF00069	0.595
MOD_NEK2_1	827	832	PF00069	0.572
MOD_NEK2_2	740	745	PF00069	0.690
MOD_PIKK_1	512	518	PF00454	0.672
MOD_PIKK_1	746	752	PF00454	0.776
MOD_PIKK_1	790	796	PF00454	0.575
MOD_PIKK_1	96	102	PF00454	0.665
MOD_PK_1	31	37	PF00069	0.624
MOD_PKA_1	15	21	PF00069	0.609
MOD_PKA_1	31	37	PF00069	0.582
MOD_PKA_1	719	725	PF00069	0.629
MOD_PKA_2	15	21	PF00069	0.580
MOD_PKA_2	31	37	PF00069	0.489
MOD_PKA_2	436	442	PF00069	0.418
MOD_PKA_2	477	483	PF00069	0.514
MOD_PKA_2	498	504	PF00069	0.653
MOD_PKA_2	505	511	PF00069	0.682
MOD_PKA_2	678	684	PF00069	0.582
MOD_PKA_2	715	721	PF00069	0.639
MOD_PKA_2	806	812	PF00069	0.519
MOD_PKA_2	827	833	PF00069	0.549
MOD_PKA_2	91	97	PF00069	0.583
MOD_PKB_1	115	123	PF00069	0.572
MOD_Plk_1	108	114	PF00069	0.556
MOD_Plk_1	295	301	PF00069	0.602
MOD_Plk_1	528	534	PF00069	0.551
MOD_Plk_1	535	541	PF00069	0.534
MOD_Plk_1	785	791	PF00069	0.617
MOD_Plk_1	796	802	PF00069	0.579
MOD_Plk_2-3	22	28	PF00069	0.596
MOD_Plk_4	157	163	PF00069	0.593
MOD_Plk_4	295	301	PF00069	0.602
MOD_Plk_4	373	379	PF00069	0.443
MOD_Plk_4	392	398	PF00069	0.652
MOD_Plk_4	466	472	PF00069	0.534
MOD_Plk_4	477	483	PF00069	0.536
MOD_Plk_4	5	11	PF00069	0.596
MOD_Plk_4	557	563	PF00069	0.558
MOD_ProDKin_1	357	363	PF00069	0.677
MOD_ProDKin_1	665	671	PF00069	0.625
MOD_SUMO_for_1	272	275	PF00179	0.657
MOD_SUMO_rev_2	73	77	PF00179	0.563
TRG_DiLeu_BaEn_1	132	137	PF01217	0.631
TRG_DiLeu_BaEn_1	320	325	PF01217	0.613
TRG_DiLeu_BaEn_1	328	333	PF01217	0.555
TRG_DiLeu_BaEn_1	40	45	PF01217	0.519
TRG_DiLeu_BaEn_1	447	452	PF01217	0.589
TRG_DiLeu_BaEn_1	683	688	PF01217	0.554
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.651
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.645
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.700
TRG_ENDOCYTIC_2	693	696	PF00928	0.581
TRG_ER_diArg_1	143	146	PF00400	0.703
TRG_ER_diArg_1	177	179	PF00400	0.536
TRG_ER_diArg_1	620	623	PF00400	0.453
TRG_ER_diArg_1	628	631	PF00400	0.490
TRG_ER_diArg_1	678	680	PF00400	0.584
TRG_ER_diArg_1	719	721	PF00400	0.623
TRG_ER_diArg_1	800	803	PF00400	0.537
TRG_ER_diArg_1	89	92	PF00400	0.566
TRG_NES_CRM1_1	209	220	PF08389	0.606
TRG_NES_CRM1_1	449	461	PF08389	0.629
TRG_NES_CRM1_1	596	610	PF08389	0.537
TRG_NLS_MonoExtC_3	245	251	PF00514	0.507
TRG_NLS_MonoExtN_4	243	250	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX59	Leptomonas seymouri	52%	99%
A0A1X0NHD9	Trypanosomatidae	25%	100%
A0A3R7K5V9	Trypanosoma rangeli	27%	100%
A4HME6	Leishmania braziliensis	78%	100%
A4IB18	Leishmania infantum	100%	100%
C9ZNP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
E9AEU7	Leishmania major	92%	100%
E9B603	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%