LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Tripartite attachment complex protein 65
Species:
Leishmania donovani
UniProt:
A0A3S5H7Y7_LEIDO
TriTrypDb:
LdBPK_351090.1 , LdCL_350015700 , LDHU3_35.1400
Length:
507

Annotations

LeishMANIAdb annotations

A conserved but unique Kinetoplastid protein with 2-8 TM segments

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Y7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 372 376 PF00656 0.672
CLV_C14_Caspase3-7 395 399 PF00656 0.738
CLV_C14_Caspase3-7 463 467 PF00656 0.657
CLV_NRD_NRD_1 124 126 PF00675 0.514
CLV_NRD_NRD_1 223 225 PF00675 0.531
CLV_NRD_NRD_1 295 297 PF00675 0.612
CLV_NRD_NRD_1 298 300 PF00675 0.462
CLV_NRD_NRD_1 301 303 PF00675 0.575
CLV_NRD_NRD_1 304 306 PF00675 0.548
CLV_NRD_NRD_1 307 309 PF00675 0.533
CLV_NRD_NRD_1 310 312 PF00675 0.504
CLV_NRD_NRD_1 418 420 PF00675 0.646
CLV_PCSK_FUR_1 118 122 PF00082 0.536
CLV_PCSK_FUR_1 296 300 PF00082 0.591
CLV_PCSK_FUR_1 302 306 PF00082 0.604
CLV_PCSK_FUR_1 308 312 PF00082 0.584
CLV_PCSK_KEX2_1 120 122 PF00082 0.517
CLV_PCSK_KEX2_1 123 125 PF00082 0.507
CLV_PCSK_KEX2_1 223 225 PF00082 0.531
CLV_PCSK_KEX2_1 288 290 PF00082 0.646
CLV_PCSK_KEX2_1 295 297 PF00082 0.657
CLV_PCSK_KEX2_1 298 300 PF00082 0.452
CLV_PCSK_KEX2_1 301 303 PF00082 0.563
CLV_PCSK_KEX2_1 304 306 PF00082 0.532
CLV_PCSK_KEX2_1 307 309 PF00082 0.514
CLV_PCSK_KEX2_1 310 312 PF00082 0.490
CLV_PCSK_KEX2_1 32 34 PF00082 0.647
CLV_PCSK_KEX2_1 418 420 PF00082 0.646
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.645
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.660
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.626
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.647
CLV_PCSK_PC7_1 302 308 PF00082 0.649
CLV_PCSK_SKI1_1 105 109 PF00082 0.489
CLV_PCSK_SKI1_1 124 128 PF00082 0.336
CLV_PCSK_SKI1_1 173 177 PF00082 0.670
CLV_PCSK_SKI1_1 208 212 PF00082 0.547
CLV_PCSK_SKI1_1 384 388 PF00082 0.624
CLV_PCSK_SKI1_1 4 8 PF00082 0.606
CLV_PCSK_SKI1_1 422 426 PF00082 0.650
CLV_PCSK_SKI1_1 93 97 PF00082 0.485
CLV_Separin_Metazoa 350 354 PF03568 0.595
DEG_Nend_UBRbox_1 1 4 PF02207 0.712
DEG_SPOP_SBC_1 430 434 PF00917 0.611
DOC_CDC14_PxL_1 35 43 PF14671 0.665
DOC_CYCLIN_RxL_1 170 177 PF00134 0.614
DOC_CYCLIN_yCln2_LP_2 363 369 PF00134 0.607
DOC_CYCLIN_yCln2_LP_2 81 87 PF00134 0.538
DOC_MAPK_DCC_7 33 43 PF00069 0.659
DOC_MAPK_gen_1 32 40 PF00069 0.658
DOC_MAPK_gen_1 353 360 PF00069 0.585
DOC_MAPK_MEF2A_6 315 323 PF00069 0.642
DOC_MAPK_RevD_3 209 224 PF00069 0.526
DOC_PP1_RVXF_1 103 109 PF00149 0.593
DOC_PP1_RVXF_1 123 130 PF00149 0.306
DOC_PP1_RVXF_1 171 177 PF00149 0.609
DOC_PP1_RVXF_1 490 497 PF00149 0.533
DOC_PP2B_LxvP_1 197 200 PF13499 0.533
DOC_PP2B_LxvP_1 81 84 PF13499 0.666
DOC_USP7_MATH_1 200 204 PF00917 0.496
DOC_USP7_MATH_1 464 468 PF00917 0.585
DOC_WW_Pin1_4 154 159 PF00397 0.614
DOC_WW_Pin1_4 162 167 PF00397 0.717
DOC_WW_Pin1_4 46 51 PF00397 0.704
DOC_WW_Pin1_4 476 481 PF00397 0.463
DOC_WW_Pin1_4 59 64 PF00397 0.468
LIG_14-3-3_CanoR_1 132 141 PF00244 0.509
LIG_14-3-3_CanoR_1 173 179 PF00244 0.669
LIG_14-3-3_CanoR_1 208 214 PF00244 0.576
LIG_14-3-3_CanoR_1 247 251 PF00244 0.790
LIG_14-3-3_CanoR_1 259 265 PF00244 0.681
LIG_14-3-3_CanoR_1 33 39 PF00244 0.651
LIG_14-3-3_CanoR_1 330 336 PF00244 0.536
LIG_14-3-3_CanoR_1 353 359 PF00244 0.587
LIG_14-3-3_CanoR_1 42 50 PF00244 0.549
LIG_14-3-3_CanoR_1 422 431 PF00244 0.599
LIG_14-3-3_CanoR_1 451 457 PF00244 0.586
LIG_14-3-3_CanoR_1 473 479 PF00244 0.570
LIG_Actin_WH2_2 119 134 PF00022 0.559
LIG_Actin_WH2_2 28 44 PF00022 0.594
LIG_AP2alpha_2 140 142 PF02296 0.593
LIG_BRCT_BRCA1_1 466 470 PF00533 0.606
LIG_CaM_IQ_9 290 306 PF13499 0.657
LIG_CSL_BTD_1 70 73 PF09270 0.674
LIG_eIF4E_1 85 91 PF01652 0.527
LIG_EVH1_1 167 171 PF00568 0.730
LIG_FHA_1 279 285 PF00498 0.733
LIG_FHA_1 35 41 PF00498 0.528
LIG_FHA_1 355 361 PF00498 0.485
LIG_FHA_1 391 397 PF00498 0.665
LIG_FHA_1 423 429 PF00498 0.654
LIG_FHA_1 440 446 PF00498 0.362
LIG_FHA_2 135 141 PF00498 0.454
LIG_FHA_2 210 216 PF00498 0.584
LIG_FHA_2 393 399 PF00498 0.747
LIG_FHA_2 486 492 PF00498 0.549
LIG_IRF3_LxIS_1 182 188 PF10401 0.608
LIG_LIR_Gen_1 212 222 PF02991 0.545
LIG_LIR_Gen_1 378 387 PF02991 0.586
LIG_LIR_Gen_1 495 504 PF02991 0.566
LIG_LIR_Gen_1 75 86 PF02991 0.667
LIG_LIR_LC3C_4 109 114 PF02991 0.563
LIG_LIR_Nem_3 137 142 PF02991 0.571
LIG_LIR_Nem_3 212 217 PF02991 0.538
LIG_LIR_Nem_3 378 382 PF02991 0.582
LIG_LIR_Nem_3 479 485 PF02991 0.496
LIG_LIR_Nem_3 495 500 PF02991 0.540
LIG_LIR_Nem_3 75 81 PF02991 0.678
LIG_NRBOX 347 353 PF00104 0.521
LIG_NRBOX 359 365 PF00104 0.622
LIG_PALB2_WD40_1 73 81 PF16756 0.690
LIG_SH2_CRK 329 333 PF00017 0.600
LIG_SH2_STAP1 385 389 PF00017 0.657
LIG_SH2_STAT3 385 388 PF00017 0.623
LIG_SH2_STAT3 483 486 PF00017 0.616
LIG_SH2_STAT5 102 105 PF00017 0.491
LIG_SH2_STAT5 11 14 PF00017 0.655
LIG_SH2_STAT5 219 222 PF00017 0.484
LIG_SH2_STAT5 27 30 PF00017 0.381
LIG_SH2_STAT5 85 88 PF00017 0.663
LIG_SH3_2 168 173 PF14604 0.705
LIG_SH3_3 135 141 PF00018 0.576
LIG_SH3_3 165 171 PF00018 0.708
LIG_SH3_CIN85_PxpxPR_1 168 173 PF14604 0.705
LIG_SUMO_SIM_anti_2 427 434 PF11976 0.584
LIG_SUMO_SIM_par_1 148 153 PF11976 0.632
LIG_SUMO_SIM_par_1 209 216 PF11976 0.580
LIG_SUMO_SIM_par_1 391 398 PF11976 0.653
LIG_SUMO_SIM_par_1 427 434 PF11976 0.615
LIG_TRAF2_1 405 408 PF00917 0.657
LIG_TYR_ITIM 327 332 PF00017 0.610
LIG_WRC_WIRS_1 493 498 PF05994 0.618
LIG_WW_3 170 174 PF00397 0.687
MOD_CDK_SPxxK_3 166 173 PF00069 0.721
MOD_CK1_1 249 255 PF00069 0.722
MOD_CK1_1 260 266 PF00069 0.626
MOD_CK1_1 267 273 PF00069 0.537
MOD_CK1_1 397 403 PF00069 0.699
MOD_CK1_1 434 440 PF00069 0.543
MOD_CK1_1 476 482 PF00069 0.564
MOD_CK1_1 49 55 PF00069 0.713
MOD_CK2_1 209 215 PF00069 0.586
MOD_GlcNHglycan 187 190 PF01048 0.531
MOD_GlcNHglycan 251 254 PF01048 0.783
MOD_GlcNHglycan 273 276 PF01048 0.700
MOD_GlcNHglycan 284 287 PF01048 0.455
MOD_GlcNHglycan 438 441 PF01048 0.584
MOD_GlcNHglycan 462 465 PF01048 0.584
MOD_GlcNHglycan 466 469 PF01048 0.638
MOD_GSK3_1 150 157 PF00069 0.643
MOD_GSK3_1 162 169 PF00069 0.654
MOD_GSK3_1 209 216 PF00069 0.459
MOD_GSK3_1 260 267 PF00069 0.711
MOD_GSK3_1 278 285 PF00069 0.697
MOD_GSK3_1 354 361 PF00069 0.526
MOD_GSK3_1 371 378 PF00069 0.460
MOD_GSK3_1 390 397 PF00069 0.660
MOD_GSK3_1 430 437 PF00069 0.524
MOD_GSK3_1 460 467 PF00069 0.571
MOD_GSK3_1 52 59 PF00069 0.755
MOD_N-GLC_1 264 269 PF02516 0.669
MOD_N-GLC_1 4 9 PF02516 0.671
MOD_NEK2_1 108 113 PF00069 0.543
MOD_NEK2_1 142 147 PF00069 0.565
MOD_NEK2_1 150 155 PF00069 0.531
MOD_NEK2_1 185 190 PF00069 0.599
MOD_NEK2_1 358 363 PF00069 0.490
MOD_NEK2_1 389 394 PF00069 0.514
MOD_NEK2_1 431 436 PF00069 0.490
MOD_NEK2_1 471 476 PF00069 0.547
MOD_NEK2_2 209 214 PF00069 0.583
MOD_NEK2_2 354 359 PF00069 0.572
MOD_PIKK_1 200 206 PF00454 0.507
MOD_PIKK_1 257 263 PF00454 0.755
MOD_PIKK_1 422 428 PF00454 0.574
MOD_PKA_2 246 252 PF00069 0.722
MOD_PKA_2 354 360 PF00069 0.594
MOD_PKA_2 41 47 PF00069 0.616
MOD_Plk_1 108 114 PF00069 0.631
MOD_Plk_1 264 270 PF00069 0.668
MOD_Plk_1 390 396 PF00069 0.575
MOD_Plk_4 108 114 PF00069 0.561
MOD_Plk_4 134 140 PF00069 0.548
MOD_Plk_4 142 148 PF00069 0.500
MOD_Plk_4 209 215 PF00069 0.577
MOD_Plk_4 331 337 PF00069 0.532
MOD_Plk_4 343 349 PF00069 0.419
MOD_Plk_4 412 418 PF00069 0.683
MOD_Plk_4 431 437 PF00069 0.538
MOD_Plk_4 492 498 PF00069 0.590
MOD_ProDKin_1 154 160 PF00069 0.625
MOD_ProDKin_1 162 168 PF00069 0.713
MOD_ProDKin_1 46 52 PF00069 0.707
MOD_ProDKin_1 476 482 PF00069 0.467
MOD_ProDKin_1 59 65 PF00069 0.461
TRG_DiLeu_BaLyEn_6 122 127 PF01217 0.630
TRG_DiLeu_BaLyEn_6 146 151 PF01217 0.626
TRG_DiLeu_BaLyEn_6 36 41 PF01217 0.611
TRG_ENDOCYTIC_2 219 222 PF00928 0.490
TRG_ENDOCYTIC_2 329 332 PF00928 0.608
TRG_ENDOCYTIC_2 367 370 PF00928 0.610
TRG_ENDOCYTIC_2 482 485 PF00928 0.581
TRG_ENDOCYTIC_2 497 500 PF00928 0.549
TRG_ER_diArg_1 121 124 PF00400 0.516
TRG_ER_diArg_1 222 224 PF00400 0.517
TRG_ER_diArg_1 295 298 PF00400 0.594
TRG_ER_diArg_1 304 307 PF00400 0.598
TRG_ER_diArg_1 352 355 PF00400 0.589
TRG_ER_diArg_1 417 419 PF00400 0.671
TRG_NLS_MonoExtC_3 119 124 PF00514 0.642
TRG_NLS_MonoExtN_4 118 124 PF00514 0.646
TRG_Pf-PMV_PEXEL_1 295 300 PF00026 0.592
TRG_Pf-PMV_PEXEL_1 422 426 PF00026 0.586

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JMW3 Bodo saltans 23% 100%
A0A422N586 Trypanosoma rangeli 34% 85%
A4IB04 Leishmania infantum 99% 100%
C9ZNK4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 85%
E9AET2 Leishmania major 94% 100%
E9B5Y7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5D9L8 Trypanosoma cruzi 32% 84%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS