NADH-dependent fumarate reductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-dependent fumarate reductase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7Y6_LEIDO

TriTrypDb:

LdBPK_350850.1 , LdCL_350013300 , LDHU3_35.1040

Length:

1194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005815	microtubule organizing center	2	1
GO:0020015	glycosome	7	1
GO:0036064	ciliary basal body	3	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A0A3S5H7Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y6

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	20
GO:0008152	metabolic process	1	20
GO:0017013	protein flavinylation	5	20
GO:0019538	protein metabolic process	3	20
GO:0036211	protein modification process	4	20
GO:0043170	macromolecule metabolic process	3	20
GO:0043412	macromolecule modification	4	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20
GO:1901564	organonitrogen compound metabolic process	3	20

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	20
GO:0005488	binding	1	20
GO:0010181	FMN binding	4	19
GO:0016156	fumarate reductase (NADH) activity	5	1
GO:0016491	oxidoreductase activity	2	20
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0016740	transferase activity	2	20
GO:0032553	ribonucleotide binding	3	19

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.240
CLV_C14_Caspase3-7	560	564	PF00656	0.297
CLV_C14_Caspase3-7	623	627	PF00656	0.448
CLV_NRD_NRD_1	10	12	PF00675	0.646
CLV_NRD_NRD_1	1053	1055	PF00675	0.446
CLV_NRD_NRD_1	1058	1060	PF00675	0.388
CLV_NRD_NRD_1	164	166	PF00675	0.441
CLV_NRD_NRD_1	199	201	PF00675	0.332
CLV_NRD_NRD_1	346	348	PF00675	0.358
CLV_NRD_NRD_1	553	555	PF00675	0.302

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P690	Leptomonas seymouri	60%	100%
A0A0N1I186	Leptomonas seymouri	77%	97%
A0A0S4IK89	Bodo saltans	52%	100%
A0A0S4IZL1	Bodo saltans	52%	100%
A0A1X0NJ99	Trypanosomatidae	64%	97%
A0A3Q8IJ78	Leishmania donovani	60%	97%
A0A422NIA0	Trypanosoma rangeli	62%	93%
A4HMB4	Leishmania braziliensis	89%	100%
A4HMD9	Leishmania braziliensis	59%	97%
A4IAY0	Leishmania infantum	100%	100%

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