SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7Y5_LEIDO

TriTrypDb:

LdBPK_350740.1 , LdCL_350012100 , LDHU3_35.0880

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	4

Expansion

Sequence features

A0A3S5H7Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	557	561	PF00656	0.648
CLV_NRD_NRD_1	139	141	PF00675	0.461
CLV_NRD_NRD_1	2	4	PF00675	0.456
CLV_NRD_NRD_1	202	204	PF00675	0.438
CLV_NRD_NRD_1	223	225	PF00675	0.478
CLV_NRD_NRD_1	240	242	PF00675	0.466
CLV_NRD_NRD_1	322	324	PF00675	0.321
CLV_NRD_NRD_1	435	437	PF00675	0.283
CLV_NRD_NRD_1	686	688	PF00675	0.611
CLV_NRD_NRD_1	690	692	PF00675	0.599
CLV_NRD_NRD_1	93	95	PF00675	0.547
CLV_PCSK_FUR_1	203	207	PF00082	0.437
CLV_PCSK_KEX2_1	139	141	PF00082	0.461
CLV_PCSK_KEX2_1	2	4	PF00082	0.456
CLV_PCSK_KEX2_1	202	204	PF00082	0.438
CLV_PCSK_KEX2_1	205	207	PF00082	0.463
CLV_PCSK_KEX2_1	322	324	PF00082	0.321
CLV_PCSK_KEX2_1	686	688	PF00082	0.610
CLV_PCSK_KEX2_1	690	692	PF00082	0.601
CLV_PCSK_KEX2_1	92	94	PF00082	0.526
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.443
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.526
CLV_PCSK_PC7_1	686	692	PF00082	0.660
CLV_PCSK_PC7_1	89	95	PF00082	0.491
CLV_PCSK_SKI1_1	202	206	PF00082	0.448
CLV_PCSK_SKI1_1	316	320	PF00082	0.254
CLV_PCSK_SKI1_1	323	327	PF00082	0.254
CLV_PCSK_SKI1_1	35	39	PF00082	0.449
CLV_PCSK_SKI1_1	644	648	PF00082	0.610
DEG_APCC_DBOX_1	690	698	PF00400	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.678
DEG_SPOP_SBC_1	389	393	PF00917	0.463
DEG_SPOP_SBC_1	49	53	PF00917	0.826
DEG_SPOP_SBC_1	500	504	PF00917	0.733
DOC_CDC14_PxL_1	550	558	PF14671	0.668
DOC_CYCLIN_RxL_1	2	12	PF00134	0.624
DOC_CYCLIN_RxL_1	313	321	PF00134	0.414
DOC_CYCLIN_yClb3_PxF_3	217	225	PF00134	0.691
DOC_MAPK_DCC_7	406	415	PF00069	0.474
DOC_MAPK_gen_1	181	190	PF00069	0.707
DOC_MAPK_gen_1	2	10	PF00069	0.659
DOC_MAPK_gen_1	202	212	PF00069	0.658
DOC_MAPK_gen_1	224	231	PF00069	0.704
DOC_MAPK_gen_1	322	333	PF00069	0.479
DOC_MAPK_gen_1	617	627	PF00069	0.481
DOC_MAPK_gen_1	686	694	PF00069	0.436
DOC_MAPK_gen_1	89	99	PF00069	0.726
DOC_MAPK_MEF2A_6	205	214	PF00069	0.691
DOC_MAPK_MEF2A_6	621	629	PF00069	0.499
DOC_MAPK_MEF2A_6	74	82	PF00069	0.733
DOC_MAPK_RevD_3	674	688	PF00069	0.433
DOC_PIKK_1	662	669	PF02985	0.419
DOC_PP1_RVXF_1	537	544	PF00149	0.629
DOC_PP2B_LxvP_1	231	234	PF13499	0.664
DOC_USP7_MATH_1	143	147	PF00917	0.832
DOC_USP7_MATH_1	388	392	PF00917	0.513
DOC_USP7_MATH_1	40	44	PF00917	0.768
DOC_USP7_MATH_1	481	485	PF00917	0.690
DOC_USP7_MATH_1	50	54	PF00917	0.836
DOC_USP7_MATH_1	500	504	PF00917	0.733
DOC_USP7_MATH_1	56	60	PF00917	0.791
DOC_USP7_MATH_1	658	662	PF00917	0.428
DOC_USP7_MATH_1	72	76	PF00917	0.635
DOC_USP7_MATH_2	29	35	PF00917	0.705
DOC_USP7_UBL2_3	205	209	PF12436	0.689
DOC_WW_Pin1_4	195	200	PF00397	0.718
DOC_WW_Pin1_4	21	26	PF00397	0.816
DOC_WW_Pin1_4	241	246	PF00397	0.697
DOC_WW_Pin1_4	29	34	PF00397	0.756
DOC_WW_Pin1_4	609	614	PF00397	0.647
LIG_14-3-3_CanoR_1	139	147	PF00244	0.768
LIG_14-3-3_CanoR_1	19	25	PF00244	0.717
LIG_14-3-3_CanoR_1	287	291	PF00244	0.675
LIG_14-3-3_CanoR_1	3	9	PF00244	0.669
LIG_14-3-3_CanoR_1	642	647	PF00244	0.345
LIG_14-3-3_CanoR_1	83	91	PF00244	0.689
LIG_Actin_WH2_2	631	649	PF00022	0.367
LIG_APCC_ABBA_1	249	254	PF00400	0.673
LIG_BIR_III_4	397	401	PF00653	0.509
LIG_BRCT_BRCA1_1	197	201	PF00533	0.708
LIG_CaM_IQ_9	330	345	PF13499	0.521
LIG_DLG_GKlike_1	642	650	PF00625	0.346
LIG_FHA_1	261	267	PF00498	0.720
LIG_FHA_1	319	325	PF00498	0.454
LIG_FHA_1	327	333	PF00498	0.454
LIG_FHA_1	352	358	PF00498	0.524
LIG_FHA_1	390	396	PF00498	0.472
LIG_FHA_1	455	461	PF00498	0.468
LIG_FHA_1	5	11	PF00498	0.639
LIG_FHA_2	102	108	PF00498	0.613
LIG_FHA_2	123	129	PF00498	0.738
LIG_FHA_2	478	484	PF00498	0.747
LIG_FHA_2	555	561	PF00498	0.652
LIG_FHA_2	83	89	PF00498	0.721
LIG_Integrin_isoDGR_2	298	300	PF01839	0.418
LIG_KLC1_Yacidic_2	470	474	PF13176	0.590
LIG_LIR_Apic_2	583	587	PF02991	0.524
LIG_LIR_Gen_1	457	466	PF02991	0.523
LIG_LIR_Gen_1	616	627	PF02991	0.586
LIG_LIR_Gen_1	651	660	PF02991	0.407
LIG_LIR_Nem_3	198	204	PF02991	0.672
LIG_LIR_Nem_3	216	222	PF02991	0.620
LIG_LIR_Nem_3	280	284	PF02991	0.701
LIG_LIR_Nem_3	616	622	PF02991	0.664
LIG_LIR_Nem_3	651	657	PF02991	0.421
LIG_LIR_Nem_3	70	76	PF02991	0.668
LIG_LYPXL_S_1	76	80	PF13949	0.512
LIG_LYPXL_yS_3	553	556	PF13949	0.664
LIG_LYPXL_yS_3	77	80	PF13949	0.671
LIG_NRP_CendR_1	726	729	PF00754	0.704
LIG_PTB_Apo_2	590	597	PF02174	0.537
LIG_PTB_Phospho_1	590	596	PF10480	0.538
LIG_SH2_CRK	281	285	PF00017	0.674
LIG_SH2_CRK	619	623	PF00017	0.631
LIG_SH2_CRK	73	77	PF00017	0.705
LIG_SH2_NCK_1	619	623	PF00017	0.631
LIG_SH2_PTP2	584	587	PF00017	0.526
LIG_SH2_SRC	584	587	PF00017	0.526
LIG_SH2_STAP1	654	658	PF00017	0.376
LIG_SH2_STAT5	370	373	PF00017	0.509
LIG_SH2_STAT5	441	444	PF00017	0.479
LIG_SH2_STAT5	472	475	PF00017	0.579
LIG_SH2_STAT5	522	525	PF00017	0.598
LIG_SH2_STAT5	564	567	PF00017	0.478
LIG_SH2_STAT5	584	587	PF00017	0.501
LIG_SH2_STAT5	596	599	PF00017	0.542
LIG_SH3_1	242	248	PF00018	0.691
LIG_SH3_3	188	194	PF00018	0.686
LIG_SH3_3	211	217	PF00018	0.668
LIG_SH3_3	242	248	PF00018	0.759
LIG_SH3_5	215	219	PF00018	0.686
LIG_SUMO_SIM_anti_2	328	336	PF11976	0.454
LIG_SUMO_SIM_par_1	420	426	PF11976	0.545
LIG_SUMO_SIM_par_1	6	12	PF11976	0.619
LIG_SUMO_SIM_par_1	628	633	PF11976	0.385
LIG_TRAF2_1	148	151	PF00917	0.686
LIG_TRAF2_1	484	487	PF00917	0.739
LIG_TRAF2_1	576	579	PF00917	0.569
LIG_TRAF2_1	661	664	PF00917	0.394
LIG_TRAF2_1	85	88	PF00917	0.783
LIG_TRAF2_1	98	101	PF00917	0.675
LIG_WRC_WIRS_1	219	224	PF05994	0.735
LIG_WRC_WIRS_1	424	429	PF05994	0.454
MOD_CDC14_SPxK_1	32	35	PF00782	0.767
MOD_CDK_SPxK_1	29	35	PF00069	0.770
MOD_CDK_SPxxK_3	195	202	PF00069	0.705
MOD_CK1_1	146	152	PF00069	0.755
MOD_CK1_1	43	49	PF00069	0.674
MOD_CK1_1	431	437	PF00069	0.516
MOD_CK2_1	101	107	PF00069	0.602
MOD_CK2_1	122	128	PF00069	0.753
MOD_CK2_1	269	275	PF00069	0.719
MOD_CK2_1	379	385	PF00069	0.479
MOD_CK2_1	429	435	PF00069	0.479
MOD_CK2_1	477	483	PF00069	0.682
MOD_CK2_1	658	664	PF00069	0.440
MOD_CK2_1	82	88	PF00069	0.729
MOD_GlcNHglycan	113	118	PF01048	0.529
MOD_GlcNHglycan	483	486	PF01048	0.479
MOD_GlcNHglycan	54	57	PF01048	0.549
MOD_GlcNHglycan	58	61	PF01048	0.556
MOD_GSK3_1	122	129	PF00069	0.717
MOD_GSK3_1	138	145	PF00069	0.805
MOD_GSK3_1	29	36	PF00069	0.719
MOD_GSK3_1	307	314	PF00069	0.590
MOD_GSK3_1	374	381	PF00069	0.467
MOD_GSK3_1	477	484	PF00069	0.738
MOD_GSK3_1	48	55	PF00069	0.798
MOD_GSK3_1	56	63	PF00069	0.761
MOD_N-GLC_1	448	453	PF02516	0.254
MOD_N-GLC_1	454	459	PF02516	0.254
MOD_NEK2_1	268	273	PF00069	0.762
MOD_NEK2_1	311	316	PF00069	0.603
MOD_NEK2_1	318	323	PF00069	0.501
MOD_NEK2_1	428	433	PF00069	0.479
MOD_NEK2_1	448	453	PF00069	0.362
MOD_NEK2_1	82	87	PF00069	0.720
MOD_NEK2_2	72	77	PF00069	0.711
MOD_PIKK_1	146	152	PF00454	0.733
MOD_PIKK_1	523	529	PF00454	0.677
MOD_PIKK_1	83	89	PF00454	0.737
MOD_PKA_2	138	144	PF00069	0.746
MOD_PKA_2	286	292	PF00069	0.694
MOD_PKA_2	466	472	PF00069	0.627
MOD_PKA_2	477	483	PF00069	0.728
MOD_PKA_2	82	88	PF00069	0.724
MOD_Plk_1	268	274	PF00069	0.722
MOD_Plk_1	40	46	PF00069	0.666
MOD_Plk_1	429	435	PF00069	0.454
MOD_Plk_1	454	460	PF00069	0.459
MOD_Plk_2-3	269	275	PF00069	0.719
MOD_Plk_4	326	332	PF00069	0.523
MOD_Plk_4	379	385	PF00069	0.454
MOD_Plk_4	423	429	PF00069	0.454
MOD_Plk_4	490	496	PF00069	0.648
MOD_Plk_4	630	636	PF00069	0.363
MOD_ProDKin_1	195	201	PF00069	0.716
MOD_ProDKin_1	21	27	PF00069	0.816
MOD_ProDKin_1	241	247	PF00069	0.694
MOD_ProDKin_1	29	35	PF00069	0.757
MOD_ProDKin_1	609	615	PF00069	0.655
MOD_SUMO_for_1	210	213	PF00179	0.721
MOD_SUMO_for_1	325	328	PF00179	0.576
MOD_SUMO_for_1	342	345	PF00179	0.391
MOD_SUMO_rev_2	430	439	PF00179	0.505
MOD_SUMO_rev_2	483	493	PF00179	0.576
MOD_SUMO_rev_2	612	620	PF00179	0.706
TRG_DiLeu_BaEn_2	164	170	PF01217	0.640
TRG_ENDOCYTIC_2	219	222	PF00928	0.690
TRG_ENDOCYTIC_2	281	284	PF00928	0.667
TRG_ENDOCYTIC_2	458	461	PF00928	0.467
TRG_ENDOCYTIC_2	553	556	PF00928	0.660
TRG_ENDOCYTIC_2	619	622	PF00928	0.598
TRG_ENDOCYTIC_2	654	657	PF00928	0.408
TRG_ENDOCYTIC_2	73	76	PF00928	0.700
TRG_ENDOCYTIC_2	77	80	PF00928	0.708
TRG_ER_diArg_1	1	3	PF00400	0.661
TRG_ER_diArg_1	109	112	PF00400	0.733
TRG_ER_diArg_1	201	203	PF00400	0.627
TRG_ER_diArg_1	322	324	PF00400	0.521
TRG_ER_diArg_1	641	644	PF00400	0.414
TRG_ER_diArg_1	669	672	PF00400	0.407
TRG_ER_diArg_1	690	692	PF00400	0.416
TRG_NLS_MonoExtC_3	686	691	PF00514	0.418
TRG_NLS_MonoExtN_4	686	691	PF00514	0.416
TRG_NLS_MonoExtN_4	89	96	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D5	Leptomonas seymouri	61%	99%
A0A0S4JG56	Bodo saltans	46%	100%
A4HMA5	Leishmania braziliensis	80%	98%
A4IAX0	Leishmania infantum	99%	100%
D0A284	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AEP8	Leishmania major	93%	100%
E9B5V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%