Arrestin (Or S-antigen), N-terminal domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7Y4_LEIDO

TriTrypDb:

LdBPK_350430.1 , LdCL_350009400 , LDHU3_35.0590

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.651
CLV_NRD_NRD_1	306	308	PF00675	0.625
CLV_NRD_NRD_1	333	335	PF00675	0.574
CLV_NRD_NRD_1	377	379	PF00675	0.621
CLV_NRD_NRD_1	570	572	PF00675	0.564
CLV_PCSK_FUR_1	568	572	PF00082	0.552
CLV_PCSK_KEX2_1	277	279	PF00082	0.649
CLV_PCSK_KEX2_1	281	283	PF00082	0.630
CLV_PCSK_KEX2_1	306	308	PF00082	0.625
CLV_PCSK_KEX2_1	333	335	PF00082	0.574
CLV_PCSK_KEX2_1	376	378	PF00082	0.658
CLV_PCSK_KEX2_1	570	572	PF00082	0.564
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.696
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.676
CLV_PCSK_SKI1_1	306	310	PF00082	0.636
CLV_PCSK_SKI1_1	442	446	PF00082	0.563
CLV_PCSK_SKI1_1	46	50	PF00082	0.463
CLV_PCSK_SKI1_1	529	533	PF00082	0.583
CLV_PCSK_SKI1_1	80	84	PF00082	0.582
DEG_APCC_DBOX_1	517	525	PF00400	0.474
DEG_SIAH_1	112	120	PF03145	0.551
DOC_CKS1_1	490	495	PF01111	0.620
DOC_CKS1_1	531	536	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	469	475	PF00134	0.670
DOC_CYCLIN_yCln2_LP_2	579	582	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.553
DOC_MAPK_gen_1	303	313	PF00069	0.590
DOC_MAPK_MEF2A_6	25	34	PF00069	0.323
DOC_MAPK_MEF2A_6	5	13	PF00069	0.432
DOC_MAPK_MEF2A_6	518	527	PF00069	0.480
DOC_PP1_RVXF_1	29	35	PF00149	0.486
DOC_PP1_RVXF_1	44	50	PF00149	0.443
DOC_PP2B_LxvP_1	474	477	PF13499	0.597
DOC_PP2B_LxvP_1	579	582	PF13499	0.523
DOC_PP2B_LxvP_1	630	633	PF13499	0.553
DOC_PP4_FxxP_1	208	211	PF00568	0.304
DOC_USP7_MATH_1	362	366	PF00917	0.825
DOC_USP7_MATH_1	461	465	PF00917	0.625
DOC_USP7_UBL2_3	277	281	PF12436	0.646
DOC_WW_Pin1_4	109	114	PF00397	0.547
DOC_WW_Pin1_4	16	21	PF00397	0.438
DOC_WW_Pin1_4	479	484	PF00397	0.599
DOC_WW_Pin1_4	489	494	PF00397	0.523
DOC_WW_Pin1_4	530	535	PF00397	0.535
LIG_14-3-3_CanoR_1	186	196	PF00244	0.530
LIG_14-3-3_CanoR_1	306	312	PF00244	0.634
LIG_14-3-3_CanoR_1	459	469	PF00244	0.688
LIG_14-3-3_CanoR_1	80	85	PF00244	0.583
LIG_14-3-3_CterR_2	635	637	PF00244	0.548
LIG_BRCT_BRCA1_1	245	249	PF00533	0.626
LIG_BRCT_BRCA1_1	591	595	PF00533	0.456
LIG_CSL_BTD_1	212	215	PF09270	0.304
LIG_eIF4E_1	130	136	PF01652	0.485
LIG_eIF4E_1	314	320	PF01652	0.452
LIG_eIF4E_1	42	48	PF01652	0.451
LIG_FHA_1	343	349	PF00498	0.623
LIG_FHA_1	393	399	PF00498	0.643
LIG_FHA_1	441	447	PF00498	0.546
LIG_FHA_1	498	504	PF00498	0.509
LIG_FHA_1	509	515	PF00498	0.407
LIG_FHA_1	546	552	PF00498	0.426
LIG_FHA_1	620	626	PF00498	0.574
LIG_FHA_1	95	101	PF00498	0.611
LIG_FHA_2	129	135	PF00498	0.570
LIG_FHA_2	188	194	PF00498	0.590
LIG_FHA_2	256	262	PF00498	0.586
LIG_FHA_2	572	578	PF00498	0.552
LIG_FHA_2	603	609	PF00498	0.529
LIG_FHA_2	87	93	PF00498	0.581
LIG_IRF3_LxIS_1	7	12	PF10401	0.431
LIG_LIR_Apic_2	544	550	PF02991	0.436
LIG_LIR_Gen_1	112	122	PF02991	0.550
LIG_LIR_Gen_1	217	225	PF02991	0.307
LIG_LIR_Gen_1	409	420	PF02991	0.520
LIG_LIR_Gen_1	541	550	PF02991	0.438
LIG_LIR_Gen_1	592	603	PF02991	0.444
LIG_LIR_Gen_1	63	71	PF02991	0.532
LIG_LIR_LC3C_4	435	439	PF02991	0.537
LIG_LIR_Nem_3	112	117	PF02991	0.588
LIG_LIR_Nem_3	125	130	PF02991	0.537
LIG_LIR_Nem_3	191	197	PF02991	0.503
LIG_LIR_Nem_3	201	207	PF02991	0.313
LIG_LIR_Nem_3	217	223	PF02991	0.273
LIG_LIR_Nem_3	246	251	PF02991	0.743
LIG_LIR_Nem_3	339	343	PF02991	0.765
LIG_LIR_Nem_3	409	415	PF02991	0.517
LIG_LIR_Nem_3	448	453	PF02991	0.489
LIG_LIR_Nem_3	526	531	PF02991	0.499
LIG_LIR_Nem_3	536	540	PF02991	0.487
LIG_LIR_Nem_3	541	545	PF02991	0.442
LIG_LIR_Nem_3	592	598	PF02991	0.441
LIG_LIR_Nem_3	63	67	PF02991	0.521
LIG_MYND_1	195	199	PF01753	0.304
LIG_MYND_1	212	216	PF01753	0.304
LIG_Pex14_2	204	208	PF04695	0.344
LIG_Pex14_2	218	222	PF04695	0.322
LIG_Pex14_2	415	419	PF04695	0.505
LIG_SH2_CRK	114	118	PF00017	0.549
LIG_SH2_CRK	220	224	PF00017	0.384
LIG_SH2_CRK	547	551	PF00017	0.424
LIG_SH2_NCK_1	114	118	PF00017	0.549
LIG_SH2_STAP1	114	118	PF00017	0.549
LIG_SH2_STAP1	231	235	PF00017	0.304
LIG_SH2_STAT5	130	133	PF00017	0.526
LIG_SH2_STAT5	508	511	PF00017	0.479
LIG_SH2_STAT5	547	550	PF00017	0.433
LIG_SH2_STAT5	604	607	PF00017	0.530
LIG_SH2_STAT5	71	74	PF00017	0.595
LIG_SH2_STAT5	77	80	PF00017	0.639
LIG_SH3_1	209	215	PF00018	0.304
LIG_SH3_1	547	553	PF00018	0.425
LIG_SH3_2	119	124	PF14604	0.579
LIG_SH3_3	116	122	PF00018	0.657
LIG_SH3_3	189	195	PF00018	0.591
LIG_SH3_3	209	215	PF00018	0.197
LIG_SH3_3	310	316	PF00018	0.601
LIG_SH3_3	455	461	PF00018	0.568
LIG_SH3_3	477	483	PF00018	0.593
LIG_SH3_3	484	490	PF00018	0.590
LIG_SH3_3	547	553	PF00018	0.425
LIG_SH3_3	595	601	PF00018	0.427
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.510
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.486
LIG_SUMO_SIM_anti_2	435	440	PF11976	0.478
LIG_SUMO_SIM_par_1	290	299	PF11976	0.644
LIG_SUMO_SIM_par_1	442	449	PF11976	0.583
LIG_SUMO_SIM_par_1	621	628	PF11976	0.516
LIG_TRAF2_1	131	134	PF00917	0.499
LIG_TRFH_1	208	212	PF08558	0.304
LIG_TYR_ITIM	40	45	PF00017	0.426
LIG_TYR_ITSM	110	117	PF00017	0.550
LIG_UBA3_1	527	532	PF00899	0.570
LIG_WRC_WIRS_1	219	224	PF05994	0.304
LIG_WRC_WIRS_1	412	417	PF05994	0.510
LIG_WRC_WIRS_1	542	547	PF05994	0.431
MOD_CK1_1	168	174	PF00069	0.615
MOD_CK1_1	256	262	PF00069	0.608
MOD_CK1_1	391	397	PF00069	0.711
MOD_CK1_1	530	536	PF00069	0.531
MOD_CK1_1	541	547	PF00069	0.436
MOD_CK2_1	128	134	PF00069	0.518
MOD_CK2_1	187	193	PF00069	0.595
MOD_CK2_1	571	577	PF00069	0.549
MOD_CK2_1	602	608	PF00069	0.520
MOD_CK2_1	86	92	PF00069	0.584
MOD_CK2_1	9	15	PF00069	0.445
MOD_GlcNHglycan	179	182	PF01048	0.795
MOD_GlcNHglycan	231	234	PF01048	0.304
MOD_GlcNHglycan	254	258	PF01048	0.630
MOD_GlcNHglycan	274	277	PF01048	0.679
MOD_GlcNHglycan	287	290	PF01048	0.542
MOD_GlcNHglycan	390	393	PF01048	0.720
MOD_GlcNHglycan	408	411	PF01048	0.562
MOD_GSK3_1	142	149	PF00069	0.570
MOD_GSK3_1	16	23	PF00069	0.552
MOD_GSK3_1	214	221	PF00069	0.422
MOD_GSK3_1	229	236	PF00069	0.315
MOD_GSK3_1	252	259	PF00069	0.539
MOD_GSK3_1	314	321	PF00069	0.582
MOD_GSK3_1	388	395	PF00069	0.626
MOD_GSK3_1	541	548	PF00069	0.437
MOD_GSK3_1	571	578	PF00069	0.556
MOD_GSK3_1	584	591	PF00069	0.529
MOD_GSK3_1	82	89	PF00069	0.611
MOD_N-GLC_1	363	368	PF02516	0.614
MOD_N-GLC_1	588	593	PF02516	0.472
MOD_N-GLC_2	163	165	PF02516	0.632
MOD_N-GLC_2	422	424	PF02516	0.535
MOD_N-GLC_2	507	509	PF02516	0.422
MOD_NEK2_1	142	147	PF00069	0.668
MOD_NEK2_1	218	223	PF00069	0.342
MOD_NEK2_1	229	234	PF00069	0.328
MOD_NEK2_1	406	411	PF00069	0.542
MOD_NEK2_1	545	550	PF00069	0.433
MOD_NEK2_1	596	601	PF00069	0.490
MOD_NEK2_1	9	14	PF00069	0.445
MOD_NEK2_2	20	25	PF00069	0.422
MOD_NEK2_2	497	502	PF00069	0.521
MOD_PIKK_1	165	171	PF00454	0.741
MOD_PIKK_1	86	92	PF00454	0.719
MOD_PKA_1	306	312	PF00069	0.634
MOD_PKA_2	259	265	PF00069	0.584
MOD_PKA_2	306	312	PF00069	0.634
MOD_PKA_2	350	356	PF00069	0.702
MOD_Plk_1	262	268	PF00069	0.674
MOD_Plk_1	401	407	PF00069	0.641
MOD_Plk_1	52	58	PF00069	0.489
MOD_Plk_1	545	551	PF00069	0.492
MOD_Plk_4	214	220	PF00069	0.350
MOD_Plk_4	233	239	PF00069	0.304
MOD_Plk_4	243	249	PF00069	0.572
MOD_Plk_4	326	332	PF00069	0.499
MOD_Plk_4	575	581	PF00069	0.533
MOD_Plk_4	591	597	PF00069	0.503
MOD_Plk_4	602	608	PF00069	0.520
MOD_ProDKin_1	109	115	PF00069	0.546
MOD_ProDKin_1	16	22	PF00069	0.434
MOD_ProDKin_1	479	485	PF00069	0.599
MOD_ProDKin_1	489	495	PF00069	0.515
MOD_ProDKin_1	530	536	PF00069	0.531
MOD_SUMO_for_1	276	279	PF00179	0.578
MOD_SUMO_rev_2	27	32	PF00179	0.373
MOD_SUMO_rev_2	275	283	PF00179	0.603
MOD_SUMO_rev_2	384	391	PF00179	0.704
MOD_SUMO_rev_2	515	524	PF00179	0.432
MOD_SUMO_rev_2	608	616	PF00179	0.557
TRG_DiLeu_BaEn_1	193	198	PF01217	0.545
TRG_DiLeu_BaEn_1	43	48	PF01217	0.458
TRG_DiLeu_BaEn_1	433	438	PF01217	0.463
TRG_DiLeu_BaEn_1	63	68	PF01217	0.401
TRG_DiLeu_BaEn_2	101	107	PF01217	0.620
TRG_DiLeu_BaEn_4	102	108	PF01217	0.618
TRG_ENDOCYTIC_2	114	117	PF00928	0.547
TRG_ENDOCYTIC_2	219	222	PF00928	0.326
TRG_ENDOCYTIC_2	340	343	PF00928	0.592
TRG_ENDOCYTIC_2	412	415	PF00928	0.512
TRG_ENDOCYTIC_2	42	45	PF00928	0.488
TRG_ENDOCYTIC_2	542	545	PF00928	0.438
TRG_ENDOCYTIC_2	604	607	PF00928	0.530
TRG_ER_diArg_1	280	283	PF00400	0.635
TRG_ER_diArg_1	306	308	PF00400	0.625
TRG_ER_diArg_1	332	334	PF00400	0.565
TRG_ER_diArg_1	375	378	PF00400	0.635
TRG_ER_diArg_1	501	504	PF00400	0.446
TRG_ER_diArg_1	569	571	PF00400	0.544
TRG_NLS_MonoExtC_3	372	377	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	334	339	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	62%	96%
A4HM80	Leishmania braziliensis	79%	99%
A4IAU3	Leishmania infantum	100%	100%
E9AEM1	Leishmania major	94%	100%
E9B5T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%