Short chain dehydrogenase family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7Y1_LEIDO

TriTrypDb:

LdBPK_044270.1 , LdCL_340051200 , LdCL_340051500 , LDHU3_34.6510

Length:

229

Annotations

Annotations by Jardim et al.

Oxidoreductase, Quinonoid dihydropteridine reductase QDPR-7

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S5H7Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Y1

PDB structure(s): 8b5t_A , 8b5t_B , 8b5t_C , 8b5u_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	2
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006558	L-phenylalanine metabolic process	5	2
GO:0006559	L-phenylalanine catabolic process	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006729	tetrahydrobiopterin biosynthetic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	7
GO:0004155	6,7-dihydropteridine reductase activity	5	6
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	7
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	6
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	6
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.298
CLV_NRD_NRD_1	208	210	PF00675	0.654
CLV_PCSK_KEX2_1	208	210	PF00082	0.632
CLV_PCSK_SKI1_1	2	6	PF00082	0.334
CLV_PCSK_SKI1_1	217	221	PF00082	0.608
DEG_Nend_UBRbox_1	1	4	PF02207	0.381
DOC_CKS1_1	173	178	PF01111	0.315
DOC_MAPK_gen_1	23	31	PF00069	0.271
DOC_USP7_MATH_1	154	158	PF00917	0.259
DOC_USP7_MATH_1	185	189	PF00917	0.576

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI9	Leptomonas seymouri	73%	100%
A0A0S4IVE4	Bodo saltans	49%	86%
A0A422N4V6	Trypanosoma rangeli	53%	95%
A4HBF7	Leishmania braziliensis	83%	100%
A4IAL5	Leishmania infantum	100%	100%
E9B5M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P09417	Homo sapiens	41%	94%
P11348	Rattus norvegicus	41%	95%
Q3T0Z7	Bos taurus	42%	95%
Q4Q290	Leishmania major	96%	100%

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