Expression site-associated protein 5 (ESAG5), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression site-associated protein 5 (ESAG5), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7X9_LEIDO

TriTrypDb:

LdBPK_343740.1 , LdCL_340046800 , LDHU3_34.6010

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H7X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008289	lipid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.411
CLV_NRD_NRD_1	244	246	PF00675	0.546
CLV_NRD_NRD_1	423	425	PF00675	0.641
CLV_NRD_NRD_1	433	435	PF00675	0.651
CLV_PCSK_FUR_1	424	428	PF00082	0.625
CLV_PCSK_KEX2_1	13	15	PF00082	0.748
CLV_PCSK_KEX2_1	23	25	PF00082	0.525
CLV_PCSK_KEX2_1	236	238	PF00082	0.478
CLV_PCSK_KEX2_1	426	428	PF00082	0.652
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.748
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.525
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.478
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.626
CLV_PCSK_SKI1_1	113	117	PF00082	0.454
CLV_PCSK_SKI1_1	151	155	PF00082	0.574
CLV_PCSK_SKI1_1	194	198	PF00082	0.447
CLV_PCSK_SKI1_1	236	240	PF00082	0.582
CLV_PCSK_SKI1_1	261	265	PF00082	0.555
CLV_PCSK_SKI1_1	434	438	PF00082	0.483
CLV_PCSK_SKI1_1	490	494	PF00082	0.540
CLV_Separin_Metazoa	242	246	PF03568	0.513
DEG_COP1_1	125	133	PF00400	0.469
DEG_COP1_1	288	298	PF00400	0.527
DEG_SPOP_SBC_1	74	78	PF00917	0.549
DOC_CYCLIN_yClb1_LxF_4	509	514	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.535
DOC_MAPK_gen_1	23	31	PF00069	0.679
DOC_MAPK_gen_1	434	442	PF00069	0.531
DOC_MAPK_MEF2A_6	139	147	PF00069	0.577
DOC_MAPK_MEF2A_6	24	33	PF00069	0.673
DOC_MAPK_MEF2A_6	372	380	PF00069	0.523
DOC_MAPK_MEF2A_6	434	442	PF00069	0.538
DOC_MAPK_MEF2A_6	67	75	PF00069	0.447
DOC_PP2B_LxvP_1	510	513	PF13499	0.604
DOC_PP2B_LxvP_1	99	102	PF13499	0.568
DOC_PP2B_PxIxI_1	365	371	PF00149	0.430
DOC_PP4_FxxP_1	499	502	PF00568	0.561
DOC_SPAK_OSR1_1	257	261	PF12202	0.508
DOC_USP7_MATH_1	290	294	PF00917	0.615
DOC_USP7_MATH_1	391	395	PF00917	0.436
DOC_USP7_MATH_1	399	403	PF00917	0.456
DOC_USP7_MATH_1	418	422	PF00917	0.422
DOC_USP7_MATH_1	69	73	PF00917	0.447
DOC_USP7_MATH_1	7	11	PF00917	0.637
DOC_USP7_MATH_1	74	78	PF00917	0.458
DOC_USP7_UBL2_3	486	490	PF12436	0.580
DOC_USP7_UBL2_3	9	13	PF12436	0.673
DOC_WW_Pin1_4	261	266	PF00397	0.424
DOC_WW_Pin1_4	286	291	PF00397	0.524
DOC_WW_Pin1_4	505	510	PF00397	0.505
LIG_14-3-3_CanoR_1	179	183	PF00244	0.525
LIG_14-3-3_CanoR_1	187	193	PF00244	0.360
LIG_14-3-3_CanoR_1	306	316	PF00244	0.574
LIG_14-3-3_CanoR_1	355	360	PF00244	0.523
LIG_14-3-3_CanoR_1	412	422	PF00244	0.581
LIG_14-3-3_CanoR_1	42	52	PF00244	0.661
LIG_14-3-3_CanoR_1	56	64	PF00244	0.678
LIG_APCC_ABBA_1	202	207	PF00400	0.464
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	1	5	PF00533	0.689
LIG_BRCT_BRCA1_1	161	165	PF00533	0.462
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.557
LIG_FHA_1	210	216	PF00498	0.523
LIG_FHA_1	222	228	PF00498	0.428
LIG_FHA_1	262	268	PF00498	0.436
LIG_FHA_1	274	280	PF00498	0.449
LIG_FHA_1	335	341	PF00498	0.510
LIG_FHA_1	483	489	PF00498	0.562
LIG_FHA_1	96	102	PF00498	0.612
LIG_FHA_2	170	176	PF00498	0.497
LIG_FHA_2	292	298	PF00498	0.588
LIG_LIR_Apic_2	498	502	PF02991	0.581
LIG_LIR_Gen_1	164	174	PF02991	0.547
LIG_LIR_Gen_1	2	11	PF02991	0.629
LIG_LIR_Gen_1	253	263	PF02991	0.507
LIG_LIR_Gen_1	460	471	PF02991	0.573
LIG_LIR_Gen_1	493	504	PF02991	0.521
LIG_LIR_Nem_3	164	169	PF02991	0.484
LIG_LIR_Nem_3	191	195	PF02991	0.512
LIG_LIR_Nem_3	198	202	PF02991	0.461
LIG_LIR_Nem_3	253	258	PF02991	0.526
LIG_LIR_Nem_3	342	347	PF02991	0.521
LIG_LIR_Nem_3	35	41	PF02991	0.603
LIG_LIR_Nem_3	416	422	PF02991	0.612
LIG_LIR_Nem_3	460	466	PF02991	0.517
LIG_LIR_Nem_3	493	499	PF02991	0.525
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.376
LIG_PDZ_Class_1	543	548	PF00595	0.640
LIG_Pex14_1	188	192	PF04695	0.538
LIG_Pex14_2	79	83	PF04695	0.439
LIG_PTB_Apo_2	311	318	PF02174	0.484
LIG_PTB_Phospho_1	311	317	PF10480	0.518
LIG_SH2_CRK	156	160	PF00017	0.566
LIG_SH2_CRK	317	321	PF00017	0.497
LIG_SH2_NCK_1	317	321	PF00017	0.575
LIG_SH2_NCK_1	357	361	PF00017	0.573
LIG_SH2_PTP2	388	391	PF00017	0.499
LIG_SH2_STAT5	357	360	PF00017	0.488
LIG_SH2_STAT5	388	391	PF00017	0.499
LIG_SH3_3	187	193	PF00018	0.493
LIG_SUMO_SIM_par_1	218	224	PF11976	0.498
LIG_TRAF2_1	102	105	PF00917	0.612
LIG_TRFH_1	463	467	PF08558	0.568
LIG_TYR_ITIM	315	320	PF00017	0.452
LIG_TYR_ITIM	461	466	PF00017	0.516
LIG_WRC_WIRS_1	419	424	PF05994	0.391
LIG_WRC_WIRS_1	80	85	PF05994	0.450
MOD_CDC14_SPxK_1	508	511	PF00782	0.554
MOD_CDK_SPxK_1	505	511	PF00069	0.550
MOD_CK1_1	288	294	PF00069	0.547
MOD_CK1_1	394	400	PF00069	0.573
MOD_CK1_1	402	408	PF00069	0.538
MOD_CK1_1	445	451	PF00069	0.495
MOD_CK1_1	454	460	PF00069	0.512
MOD_CK2_1	165	171	PF00069	0.514
MOD_CK2_1	291	297	PF00069	0.530
MOD_CK2_1	532	538	PF00069	0.541
MOD_Cter_Amidation	11	14	PF01082	0.750
MOD_DYRK1A_RPxSP_1	261	265	PF00069	0.562
MOD_GlcNHglycan	1	4	PF01048	0.681
MOD_GlcNHglycan	161	164	PF01048	0.517
MOD_GlcNHglycan	331	334	PF01048	0.588
MOD_GlcNHglycan	34	37	PF01048	0.563
MOD_GlcNHglycan	397	400	PF01048	0.594
MOD_GlcNHglycan	415	418	PF01048	0.541
MOD_GlcNHglycan	444	447	PF01048	0.463
MOD_GlcNHglycan	453	456	PF01048	0.450
MOD_GlcNHglycan	505	508	PF01048	0.515
MOD_GlcNHglycan	67	70	PF01048	0.470
MOD_GSK3_1	120	127	PF00069	0.519
MOD_GSK3_1	161	168	PF00069	0.427
MOD_GSK3_1	207	214	PF00069	0.455
MOD_GSK3_1	286	293	PF00069	0.505
MOD_GSK3_1	304	311	PF00069	0.473
MOD_GSK3_1	390	397	PF00069	0.570
MOD_GSK3_1	398	405	PF00069	0.549
MOD_GSK3_1	453	460	PF00069	0.484
MOD_GSK3_1	65	72	PF00069	0.448
MOD_GSK3_1	75	82	PF00069	0.421
MOD_LATS_1	118	124	PF00433	0.574
MOD_N-GLC_1	147	152	PF02516	0.437
MOD_N-GLC_1	188	193	PF02516	0.475
MOD_N-GLC_1	335	340	PF02516	0.504
MOD_N-GLC_1	391	396	PF02516	0.565
MOD_N-GLC_1	451	456	PF02516	0.494
MOD_N-GLC_1	532	537	PF02516	0.561
MOD_N-GLC_1	69	74	PF02516	0.449
MOD_N-GLC_1	93	98	PF02516	0.647
MOD_NEK2_1	124	129	PF00069	0.485
MOD_NEK2_1	165	170	PF00069	0.454
MOD_NEK2_1	230	235	PF00069	0.555
MOD_NEK2_1	32	37	PF00069	0.543
MOD_NEK2_1	334	339	PF00069	0.512
MOD_NEK2_1	41	46	PF00069	0.560
MOD_NEK2_1	503	508	PF00069	0.609
MOD_NEK2_1	79	84	PF00069	0.458
MOD_PIKK_1	41	47	PF00454	0.579
MOD_PIKK_1	427	433	PF00454	0.615
MOD_PKA_1	426	432	PF00069	0.691
MOD_PKA_2	138	144	PF00069	0.535
MOD_PKA_2	159	165	PF00069	0.397
MOD_PKA_2	178	184	PF00069	0.442
MOD_PKA_2	305	311	PF00069	0.578
MOD_PKA_2	41	47	PF00069	0.520
MOD_PKA_2	426	432	PF00069	0.617
MOD_PKA_2	55	61	PF00069	0.615
MOD_Plk_1	147	153	PF00069	0.409
MOD_Plk_1	188	194	PF00069	0.486
MOD_Plk_1	335	341	PF00069	0.503
MOD_Plk_1	374	380	PF00069	0.480
MOD_Plk_1	532	538	PF00069	0.557
MOD_Plk_1	69	75	PF00069	0.451
MOD_Plk_4	132	138	PF00069	0.514
MOD_Plk_4	161	167	PF00069	0.466
MOD_Plk_4	178	184	PF00069	0.343
MOD_Plk_4	335	341	PF00069	0.469
MOD_Plk_4	34	40	PF00069	0.590
MOD_Plk_4	399	405	PF00069	0.535
MOD_Plk_4	75	81	PF00069	0.426
MOD_Plk_4	95	101	PF00069	0.298
MOD_ProDKin_1	261	267	PF00069	0.430
MOD_ProDKin_1	286	292	PF00069	0.521
MOD_ProDKin_1	505	511	PF00069	0.513
MOD_SUMO_for_1	536	539	PF00179	0.427
TRG_DiLeu_BaEn_2	225	231	PF01217	0.502
TRG_ENDOCYTIC_2	156	159	PF00928	0.573
TRG_ENDOCYTIC_2	317	320	PF00928	0.489
TRG_ENDOCYTIC_2	419	422	PF00928	0.555
TRG_ENDOCYTIC_2	463	466	PF00928	0.462
TRG_ER_diArg_1	409	412	PF00400	0.653
TRG_NLS_MonoExtN_4	424	429	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I082	Leptomonas seymouri	40%	98%
A4HBB4	Leishmania braziliensis	59%	100%
A4IAG2	Leishmania infantum	99%	100%
C9ZLT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	100%
E9B5I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2E9	Leishmania major	87%	100%
V5DMU0	Trypanosoma cruzi	21%	100%