Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7X8_LEIDO

TriTrypDb:

LdBPK_343540.1 , LdCL_340044800 , LDHU3_34.5780

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.697
CLV_MEL_PAP_1	151	157	PF00089	0.570
CLV_NRD_NRD_1	215	217	PF00675	0.799
CLV_NRD_NRD_1	66	68	PF00675	0.558
CLV_PCSK_KEX2_1	215	217	PF00082	0.799
CLV_PCSK_KEX2_1	240	242	PF00082	0.729
CLV_PCSK_KEX2_1	66	68	PF00082	0.591
CLV_PCSK_KEX2_1	84	86	PF00082	0.630
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.620
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.622
CLV_PCSK_PC7_1	236	242	PF00082	0.654
CLV_PCSK_PC7_1	62	68	PF00082	0.513
CLV_PCSK_SKI1_1	422	426	PF00082	0.742
CLV_PCSK_SKI1_1	67	71	PF00082	0.566
CLV_PCSK_SKI1_1	99	103	PF00082	0.677
DEG_APCC_DBOX_1	215	223	PF00400	0.738
DEG_SPOP_SBC_1	436	440	PF00917	0.520
DOC_CKS1_1	182	187	PF01111	0.601
DOC_CKS1_1	431	436	PF01111	0.630
DOC_PP2B_LxvP_1	376	379	PF13499	0.559
DOC_USP7_MATH_1	250	254	PF00917	0.670
DOC_USP7_MATH_1	351	355	PF00917	0.659
DOC_USP7_MATH_1	360	364	PF00917	0.762
DOC_USP7_MATH_1	404	408	PF00917	0.632
DOC_WW_Pin1_4	108	113	PF00397	0.698
DOC_WW_Pin1_4	181	186	PF00397	0.646
DOC_WW_Pin1_4	271	276	PF00397	0.758
DOC_WW_Pin1_4	317	322	PF00397	0.754
DOC_WW_Pin1_4	331	336	PF00397	0.601
DOC_WW_Pin1_4	379	384	PF00397	0.755
DOC_WW_Pin1_4	430	435	PF00397	0.640
DOC_WW_Pin1_4	73	78	PF00397	0.581
LIG_14-3-3_CanoR_1	131	135	PF00244	0.564
LIG_14-3-3_CanoR_1	154	164	PF00244	0.559
LIG_14-3-3_CanoR_1	249	255	PF00244	0.577
LIG_14-3-3_CanoR_1	281	290	PF00244	0.607
LIG_14-3-3_CanoR_1	308	316	PF00244	0.673
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BIR_III_1	1	5	PF00653	0.670
LIG_BIR_III_3	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	112	116	PF00533	0.654
LIG_BRCT_BRCA1_1	157	161	PF00533	0.546
LIG_BRCT_BRCA1_1	365	369	PF00533	0.567
LIG_BRCT_BRCA1_1	409	413	PF00533	0.772
LIG_BRCT_BRCA1_1	75	79	PF00533	0.678
LIG_Clathr_ClatBox_1	78	82	PF01394	0.721
LIG_FHA_1	232	238	PF00498	0.593
LIG_FHA_1	339	345	PF00498	0.668
LIG_FHA_1	382	388	PF00498	0.650
LIG_FHA_1	395	401	PF00498	0.694
LIG_FHA_1	423	429	PF00498	0.677
LIG_FHA_1	46	52	PF00498	0.498
LIG_FHA_1	96	102	PF00498	0.547
LIG_FHA_2	158	164	PF00498	0.550
LIG_FHA_2	222	228	PF00498	0.765
LIG_FXI_DFP_1	347	351	PF00024	0.555
LIG_LIR_Gen_1	38	46	PF02991	0.480
LIG_LIR_Nem_3	158	164	PF02991	0.522
LIG_LIR_Nem_3	38	43	PF02991	0.496
LIG_MYND_1	207	211	PF01753	0.711
LIG_MYND_1	217	221	PF01753	0.718
LIG_SH2_CRK	164	168	PF00017	0.560
LIG_SH2_CRK	75	79	PF00017	0.578
LIG_SH2_NCK_1	316	320	PF00017	0.541
LIG_SH2_STAT5	152	155	PF00017	0.541
LIG_SH3_2	211	216	PF14604	0.731
LIG_SH3_3	208	214	PF00018	0.779
LIG_SH3_3	318	324	PF00018	0.712
LIG_SH3_3	428	434	PF00018	0.643
LIG_TRAF2_1	262	265	PF00917	0.585
MOD_CDK_SPK_2	317	322	PF00069	0.632
MOD_CDK_SPxxK_3	108	115	PF00069	0.653
MOD_CK1_1	127	133	PF00069	0.689
MOD_CK1_1	253	259	PF00069	0.702
MOD_CK1_1	274	280	PF00069	0.800
MOD_CK1_1	317	323	PF00069	0.761
MOD_CK1_1	35	41	PF00069	0.692
MOD_CK1_1	363	369	PF00069	0.651
MOD_CK1_1	392	398	PF00069	0.734
MOD_CK1_1	407	413	PF00069	0.620
MOD_CK2_1	157	163	PF00069	0.565
MOD_GlcNHglycan	136	139	PF01048	0.718
MOD_GlcNHglycan	185	188	PF01048	0.628
MOD_GlcNHglycan	21	24	PF01048	0.596
MOD_GlcNHglycan	245	248	PF01048	0.684
MOD_GlcNHglycan	250	253	PF01048	0.726
MOD_GlcNHglycan	357	360	PF01048	0.725
MOD_GlcNHglycan	366	369	PF01048	0.609
MOD_GlcNHglycan	391	394	PF01048	0.669
MOD_GlcNHglycan	402	405	PF01048	0.655
MOD_GlcNHglycan	406	409	PF01048	0.545
MOD_GlcNHglycan	428	431	PF01048	0.671
MOD_GSK3_1	126	133	PF00069	0.702
MOD_GSK3_1	134	141	PF00069	0.745
MOD_GSK3_1	177	184	PF00069	0.600
MOD_GSK3_1	271	278	PF00069	0.746
MOD_GSK3_1	279	286	PF00069	0.700
MOD_GSK3_1	351	358	PF00069	0.681
MOD_GSK3_1	360	367	PF00069	0.639
MOD_GSK3_1	377	384	PF00069	0.549
MOD_GSK3_1	385	392	PF00069	0.808
MOD_GSK3_1	400	407	PF00069	0.656
MOD_GSK3_1	418	425	PF00069	0.478
MOD_GSK3_1	426	433	PF00069	0.518
MOD_GSK3_1	95	102	PF00069	0.511
MOD_LATS_1	420	426	PF00433	0.658
MOD_N-GLC_1	156	161	PF02516	0.591
MOD_N-GLC_1	32	37	PF02516	0.646
MOD_NEK2_1	140	145	PF00069	0.695
MOD_NEK2_1	231	236	PF00069	0.824
MOD_NEK2_1	369	374	PF00069	0.658
MOD_NEK2_1	400	405	PF00069	0.708
MOD_PIKK_1	253	259	PF00454	0.725
MOD_PIKK_1	314	320	PF00454	0.610
MOD_PIKK_1	377	383	PF00454	0.662
MOD_PKA_1	215	221	PF00069	0.735
MOD_PKA_1	67	73	PF00069	0.474
MOD_PKA_2	130	136	PF00069	0.714
MOD_PKA_2	215	221	PF00069	0.711
MOD_PKA_2	231	237	PF00069	0.815
MOD_PKA_2	248	254	PF00069	0.496
MOD_PKA_2	404	410	PF00069	0.647
MOD_PKA_2	418	424	PF00069	0.529
MOD_PKA_2	61	67	PF00069	0.619
MOD_Plk_1	156	162	PF00069	0.591
MOD_Plk_1	196	202	PF00069	0.632
MOD_Plk_1	32	38	PF00069	0.599
MOD_Plk_1	422	428	PF00069	0.745
MOD_Plk_1	51	57	PF00069	0.444
MOD_Plk_4	32	38	PF00069	0.723
MOD_Plk_4	67	73	PF00069	0.659
MOD_ProDKin_1	108	114	PF00069	0.703
MOD_ProDKin_1	181	187	PF00069	0.646
MOD_ProDKin_1	271	277	PF00069	0.759
MOD_ProDKin_1	317	323	PF00069	0.752
MOD_ProDKin_1	331	337	PF00069	0.599
MOD_ProDKin_1	379	385	PF00069	0.760
MOD_ProDKin_1	430	436	PF00069	0.637
MOD_ProDKin_1	73	79	PF00069	0.591
MOD_SUMO_for_1	122	125	PF00179	0.612
MOD_SUMO_rev_2	264	270	PF00179	0.759
MOD_SUMO_rev_2	76	86	PF00179	0.605
TRG_DiLeu_BaEn_1	423	428	PF01217	0.663
TRG_DiLeu_BaEn_4	265	271	PF01217	0.591
TRG_ENDOCYTIC_2	152	155	PF00928	0.541
TRG_ENDOCYTIC_2	164	167	PF00928	0.550
TRG_ENDOCYTIC_2	75	78	PF00928	0.567
TRG_ER_diArg_1	214	216	PF00400	0.805
TRG_ER_diArg_1	85	88	PF00400	0.656
TRG_NLS_Bipartite_1	66	88	PF00514	0.499
TRG_NLS_MonoExtC_3	83	89	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF19	Leptomonas seymouri	33%	98%
A4HB94	Leishmania braziliensis	57%	100%
A4IAE2	Leishmania infantum	100%	100%
E9B5G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q2G9	Leishmania major	81%	100%