Glucose-6-phosphate 1-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7X6_LEIDO

TriTrypDb:

LdBPK_343160.1 , LdCL_340040500 , LDHU3_34.5330

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016854	racemase and epimerase activity	3	12
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	12
GO:0030246	carbohydrate binding	2	12
GO:0047938	glucose-6-phosphate 1-epimerase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.527
CLV_PCSK_SKI1_1	270	274	PF00082	0.304
CLV_PCSK_SKI1_1	56	60	PF00082	0.325
DEG_APCC_DBOX_1	102	110	PF00400	0.497
DOC_MAPK_gen_1	39	47	PF00069	0.561
DOC_MAPK_gen_1	9	16	PF00069	0.516
DOC_MAPK_MEF2A_6	60	67	PF00069	0.459
DOC_MAPK_MEF2A_6	97	106	PF00069	0.470
DOC_PP2B_LxvP_1	102	105	PF13499	0.464
DOC_USP7_MATH_1	111	115	PF00917	0.534
DOC_USP7_MATH_1	244	248	PF00917	0.497
DOC_USP7_MATH_1	279	283	PF00917	0.531
DOC_USP7_MATH_1	296	300	PF00917	0.662
DOC_USP7_MATH_1	31	35	PF00917	0.555
DOC_USP7_UBL2_3	138	142	PF12436	0.534
DOC_USP7_UBL2_3	270	274	PF12436	0.504
DOC_WW_Pin1_4	116	121	PF00397	0.534
DOC_WW_Pin1_4	175	180	PF00397	0.506
DOC_WW_Pin1_4	192	197	PF00397	0.427
DOC_WW_Pin1_4	2	7	PF00397	0.530
DOC_WW_Pin1_4	230	235	PF00397	0.534
DOC_WW_Pin1_4	292	297	PF00397	0.592
DOC_WW_Pin1_4	45	50	PF00397	0.459
LIG_14-3-3_CanoR_1	84	89	PF00244	0.529
LIG_14-3-3_CanoR_1	97	103	PF00244	0.441
LIG_Actin_WH2_2	259	275	PF00022	0.509
LIG_APCC_ABBA_1	14	19	PF00400	0.525
LIG_BRCT_BRCA1_1	150	154	PF00533	0.561
LIG_BRCT_BRCA1_1	78	82	PF00533	0.496
LIG_FHA_1	226	232	PF00498	0.456
LIG_FHA_1	284	290	PF00498	0.514
LIG_FHA_2	144	150	PF00498	0.532
LIG_FHA_2	23	29	PF00498	0.516
LIG_HCF-1_HBM_1	43	46	PF13415	0.534
LIG_LIR_Apic_2	43	49	PF02991	0.459
LIG_LIR_Gen_1	79	90	PF02991	0.525
LIG_LIR_Nem_3	160	164	PF02991	0.459
LIG_LIR_Nem_3	258	263	PF02991	0.453
LIG_LIR_Nem_3	79	85	PF02991	0.483
LIG_PDZ_Class_1	296	301	PF00595	0.639
LIG_Pex14_2	154	158	PF04695	0.459
LIG_SH2_CRK	73	77	PF00017	0.525
LIG_SH2_STAP1	128	132	PF00017	0.459
LIG_SH2_STAT3	211	214	PF00017	0.459
LIG_SH2_STAT5	128	131	PF00017	0.455
LIG_SH2_STAT5	161	164	PF00017	0.448
LIG_SH2_STAT5	46	49	PF00017	0.459
LIG_SH2_STAT6	259	263	PF00017	0.473
LIG_SH3_3	191	197	PF00018	0.484
LIG_SH3_3	272	278	PF00018	0.458
LIG_SH3_3	72	78	PF00018	0.509
LIG_SUMO_SIM_anti_2	288	295	PF11976	0.550
LIG_TRAF2_1	146	149	PF00917	0.553
MOD_CDK_SPK_2	292	297	PF00069	0.405
MOD_CDK_SPxxK_3	2	9	PF00069	0.480
MOD_CK1_1	114	120	PF00069	0.502
MOD_CK1_1	165	171	PF00069	0.553
MOD_CK1_1	22	28	PF00069	0.472
MOD_CK1_1	281	287	PF00069	0.511
MOD_CK1_1	35	41	PF00069	0.438
MOD_CK2_1	130	136	PF00069	0.502
MOD_CK2_1	143	149	PF00069	0.442
MOD_CK2_1	192	198	PF00069	0.553
MOD_CK2_1	22	28	PF00069	0.514
MOD_CK2_1	292	298	PF00069	0.629
MOD_GlcNHglycan	121	124	PF01048	0.273
MOD_GlcNHglycan	148	153	PF01048	0.314
MOD_GlcNHglycan	172	175	PF01048	0.297
MOD_GlcNHglycan	94	97	PF01048	0.258
MOD_GSK3_1	112	119	PF00069	0.505
MOD_GSK3_1	126	133	PF00069	0.471
MOD_GSK3_1	144	151	PF00069	0.390
MOD_GSK3_1	15	22	PF00069	0.489
MOD_GSK3_1	225	232	PF00069	0.459
MOD_GSK3_1	279	286	PF00069	0.511
MOD_GSK3_1	292	299	PF00069	0.558
MOD_GSK3_1	31	38	PF00069	0.432
MOD_GSK3_1	92	99	PF00069	0.447
MOD_N-GLC_1	144	149	PF02516	0.319
MOD_N-GLC_1	175	180	PF02516	0.252
MOD_N-GLC_1	234	239	PF02516	0.297
MOD_NEK2_1	126	131	PF00069	0.459
MOD_NEK2_1	141	146	PF00069	0.459
MOD_NEK2_1	229	234	PF00069	0.546
MOD_NEK2_2	98	103	PF00069	0.497
MOD_PIKK_1	189	195	PF00454	0.400
MOD_PIKK_1	283	289	PF00454	0.462
MOD_PK_1	86	92	PF00069	0.345
MOD_PKA_2	96	102	PF00069	0.493
MOD_PKB_1	84	92	PF00069	0.345
MOD_Plk_1	111	117	PF00069	0.552
MOD_Plk_1	54	60	PF00069	0.542
MOD_Plk_2-3	112	118	PF00069	0.428
MOD_Plk_4	157	163	PF00069	0.448
MOD_Plk_4	167	173	PF00069	0.448
MOD_Plk_4	22	28	PF00069	0.418
MOD_ProDKin_1	116	122	PF00069	0.534
MOD_ProDKin_1	175	181	PF00069	0.506
MOD_ProDKin_1	192	198	PF00069	0.427
MOD_ProDKin_1	2	8	PF00069	0.536
MOD_ProDKin_1	230	236	PF00069	0.534
MOD_ProDKin_1	292	298	PF00069	0.602
MOD_ProDKin_1	45	51	PF00069	0.459
MOD_SUMO_rev_2	133	139	PF00179	0.517
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.534
TRG_ENDOCYTIC_2	161	164	PF00928	0.448
TRG_ENDOCYTIC_2	260	263	PF00928	0.448
TRG_ENDOCYTIC_2	73	76	PF00928	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S8	Leptomonas seymouri	69%	100%
A0A0S4IIG2	Bodo saltans	34%	100%
A0A1X0P9Y8	Trypanosomatidae	49%	100%
A0A422NEP9	Trypanosoma rangeli	47%	100%
A4HB57	Leishmania braziliensis	78%	100%
A4IAA4	Leishmania infantum	99%	100%
C9ZLY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B5C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P39173	Escherichia coli (strain K12)	32%	100%
P44160	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
Q03161	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q40784	Cenchrus ciliaris	31%	91%
Q4Q2K6	Leishmania major	95%	100%
Q8ZPV9	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
V5BV57	Trypanosoma cruzi	49%	100%