Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7X4_LEIDO

TriTrypDb:

LdBPK_342870.1 , LdCL_340036800 , LDHU3_34.4880

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.472
CLV_C14_Caspase3-7	57	61	PF00656	0.550
CLV_C14_Caspase3-7	82	86	PF00656	0.666
CLV_NRD_NRD_1	158	160	PF00675	0.456
CLV_NRD_NRD_1	247	249	PF00675	0.578
CLV_NRD_NRD_1	359	361	PF00675	0.559
CLV_NRD_NRD_1	531	533	PF00675	0.464
CLV_PCSK_KEX2_1	158	160	PF00082	0.456
CLV_PCSK_KEX2_1	531	533	PF00082	0.500
CLV_PCSK_SKI1_1	15	19	PF00082	0.641
CLV_PCSK_SKI1_1	226	230	PF00082	0.730
CLV_PCSK_SKI1_1	290	294	PF00082	0.517
CLV_PCSK_SKI1_1	323	327	PF00082	0.542
CLV_PCSK_SKI1_1	361	365	PF00082	0.457
CLV_PCSK_SKI1_1	441	445	PF00082	0.529
DOC_ANK_TNKS_1	531	538	PF00023	0.540
DOC_CKS1_1	491	496	PF01111	0.605
DOC_CYCLIN_RxL_1	358	365	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.709
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.560
DOC_MAPK_gen_1	158	166	PF00069	0.496
DOC_MAPK_RevD_3	236	250	PF00069	0.643
DOC_MAPK_RevD_3	517	532	PF00069	0.539
DOC_PP2B_LxvP_1	207	210	PF13499	0.750
DOC_PP2B_LxvP_1	73	76	PF13499	0.571
DOC_PP4_FxxP_1	278	281	PF00568	0.520
DOC_PP4_FxxP_1	294	297	PF00568	0.419
DOC_PP4_FxxP_1	341	344	PF00568	0.383
DOC_USP7_MATH_1	10	14	PF00917	0.782
DOC_USP7_MATH_1	218	222	PF00917	0.768
DOC_USP7_MATH_1	303	307	PF00917	0.533
DOC_USP7_MATH_1	351	355	PF00917	0.477
DOC_USP7_MATH_1	387	391	PF00917	0.750
DOC_USP7_MATH_1	48	52	PF00917	0.500
DOC_USP7_UBL2_3	225	229	PF12436	0.701
DOC_USP7_UBL2_3	231	235	PF12436	0.676
DOC_USP7_UBL2_3	488	492	PF12436	0.632
DOC_USP7_UBL2_3	5	9	PF12436	0.703
DOC_WW_Pin1_4	236	241	PF00397	0.684
DOC_WW_Pin1_4	378	383	PF00397	0.556
DOC_WW_Pin1_4	405	410	PF00397	0.738
DOC_WW_Pin1_4	490	495	PF00397	0.659
LIG_14-3-3_CanoR_1	158	166	PF00244	0.545
LIG_14-3-3_CanoR_1	259	265	PF00244	0.521
LIG_14-3-3_CanoR_1	290	295	PF00244	0.472
LIG_14-3-3_CanoR_1	302	308	PF00244	0.495
LIG_14-3-3_CanoR_1	531	535	PF00244	0.526
LIG_APCC_ABBA_1	148	153	PF00400	0.632
LIG_BIR_III_4	58	62	PF00653	0.625
LIG_BRCT_BRCA1_1	507	511	PF00533	0.492
LIG_deltaCOP1_diTrp_1	282	289	PF00928	0.374
LIG_eIF4E_1	160	166	PF01652	0.395
LIG_FHA_1	159	165	PF00498	0.542
LIG_FHA_1	26	32	PF00498	0.655
LIG_FHA_1	316	322	PF00498	0.444
LIG_FHA_1	479	485	PF00498	0.557
LIG_FHA_1	562	568	PF00498	0.548
LIG_FHA_1	68	74	PF00498	0.507
LIG_FHA_2	502	508	PF00498	0.479
LIG_FHA_2	55	61	PF00498	0.544
LIG_IBAR_NPY_1	149	151	PF08397	0.616
LIG_LIR_Apic_2	277	281	PF02991	0.610
LIG_LIR_Apic_2	293	297	PF02991	0.498
LIG_LIR_Apic_2	340	344	PF02991	0.381
LIG_LIR_Apic_2	587	593	PF02991	0.592
LIG_LIR_Gen_1	282	292	PF02991	0.449
LIG_LIR_Gen_1	37	45	PF02991	0.569
LIG_LIR_Gen_1	466	475	PF02991	0.413
LIG_LIR_Gen_1	508	519	PF02991	0.519
LIG_LIR_Gen_1	579	585	PF02991	0.601
LIG_LIR_Nem_3	282	287	PF02991	0.427
LIG_LIR_Nem_3	329	334	PF02991	0.492
LIG_LIR_Nem_3	37	42	PF02991	0.603
LIG_LIR_Nem_3	466	470	PF02991	0.410
LIG_LIR_Nem_3	479	483	PF02991	0.529
LIG_LIR_Nem_3	508	514	PF02991	0.516
LIG_LIR_Nem_3	579	583	PF02991	0.527
LIG_MYND_1	236	240	PF01753	0.662
LIG_Pex14_2	32	36	PF04695	0.693
LIG_PTB_Apo_2	306	313	PF02174	0.437
LIG_SH2_CRK	331	335	PF00017	0.493
LIG_SH2_CRK	350	354	PF00017	0.261
LIG_SH2_CRK	590	594	PF00017	0.624
LIG_SH2_NCK_1	151	155	PF00017	0.404
LIG_SH2_NCK_1	350	354	PF00017	0.484
LIG_SH2_NCK_1	39	43	PF00017	0.619
LIG_SH2_SRC	151	154	PF00017	0.655
LIG_SH2_SRC	534	537	PF00017	0.531
LIG_SH2_STAP1	151	155	PF00017	0.603
LIG_SH2_STAP1	160	164	PF00017	0.563
LIG_SH2_STAP1	480	484	PF00017	0.570
LIG_SH2_STAT3	257	260	PF00017	0.584
LIG_SH2_STAT5	160	163	PF00017	0.627
LIG_SH2_STAT5	274	277	PF00017	0.676
LIG_SH2_STAT5	331	334	PF00017	0.407
LIG_SH2_STAT5	475	478	PF00017	0.479
LIG_SH2_STAT5	480	483	PF00017	0.561
LIG_SH2_STAT5	534	537	PF00017	0.477
LIG_SH2_STAT5	558	561	PF00017	0.552
LIG_SH3_1	488	494	PF00018	0.694
LIG_SH3_2	194	199	PF14604	0.581
LIG_SH3_3	122	128	PF00018	0.740
LIG_SH3_3	188	194	PF00018	0.525
LIG_SH3_3	403	409	PF00018	0.701
LIG_SH3_3	488	494	PF00018	0.596
LIG_SH3_3	60	66	PF00018	0.565
LIG_SUMO_SIM_anti_2	70	78	PF11976	0.538
LIG_SUMO_SIM_par_1	322	329	PF11976	0.536
LIG_SUMO_SIM_par_1	70	78	PF11976	0.638
LIG_SUMO_SIM_par_1	93	99	PF11976	0.515
LIG_TRAF2_1	143	146	PF00917	0.674
LIG_TRAF2_1	268	271	PF00917	0.516
LIG_WRC_WIRS_1	275	280	PF05994	0.615
MOD_CK1_1	38	44	PF00069	0.565
MOD_CK1_1	46	52	PF00069	0.478
MOD_CK1_1	505	511	PF00069	0.454
MOD_CK2_1	10	16	PF00069	0.746
MOD_CK2_1	530	536	PF00069	0.537
MOD_DYRK1A_RPxSP_1	405	409	PF00069	0.660
MOD_GlcNHglycan	353	356	PF01048	0.534
MOD_GlcNHglycan	397	402	PF01048	0.745
MOD_GlcNHglycan	414	419	PF01048	0.489
MOD_GlcNHglycan	446	450	PF01048	0.478
MOD_GlcNHglycan	536	540	PF01048	0.532
MOD_GlcNHglycan	85	88	PF01048	0.653
MOD_GSK3_1	34	41	PF00069	0.619
MOD_GSK3_1	478	485	PF00069	0.532
MOD_GSK3_1	5	12	PF00069	0.752
MOD_GSK3_1	501	508	PF00069	0.485
MOD_GSK3_1	522	529	PF00069	0.532
MOD_N-GLC_1	10	15	PF02516	0.722
MOD_N-GLC_1	25	30	PF02516	0.455
MOD_NEK2_1	326	331	PF00069	0.451
MOD_NEK2_1	521	526	PF00069	0.520
MOD_NEK2_2	27	32	PF00069	0.694
MOD_NEK2_2	478	483	PF00069	0.557
MOD_NEK2_2	561	566	PF00069	0.556
MOD_NEK2_2	594	599	PF00069	0.583
MOD_PIKK_1	158	164	PF00454	0.636
MOD_PIKK_1	326	332	PF00454	0.417
MOD_PIKK_1	43	49	PF00454	0.467
MOD_PK_1	526	532	PF00069	0.507
MOD_PKA_1	158	164	PF00069	0.636
MOD_PKA_1	224	230	PF00069	0.668
MOD_PKA_1	231	237	PF00069	0.662
MOD_PKA_1	4	10	PF00069	0.701
MOD_PKA_2	158	164	PF00069	0.552
MOD_PKA_2	258	264	PF00069	0.513
MOD_PKA_2	522	528	PF00069	0.520
MOD_PKA_2	530	536	PF00069	0.436
MOD_Plk_1	502	508	PF00069	0.550
MOD_Plk_1	561	567	PF00069	0.553
MOD_Plk_1	586	592	PF00069	0.574
MOD_Plk_2-3	203	209	PF00069	0.667
MOD_Plk_4	27	33	PF00069	0.632
MOD_Plk_4	478	484	PF00069	0.532
MOD_Plk_4	548	554	PF00069	0.440
MOD_ProDKin_1	236	242	PF00069	0.678
MOD_ProDKin_1	378	384	PF00069	0.568
MOD_ProDKin_1	405	411	PF00069	0.739
MOD_ProDKin_1	490	496	PF00069	0.662
MOD_SUMO_for_1	143	146	PF00179	0.660
MOD_SUMO_for_1	268	271	PF00179	0.562
MOD_SUMO_rev_2	241	251	PF00179	0.539
MOD_SUMO_rev_2	414	423	PF00179	0.575
TRG_DiLeu_BaEn_1	271	276	PF01217	0.576
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.575
TRG_ENDOCYTIC_2	331	334	PF00928	0.407
TRG_ENDOCYTIC_2	39	42	PF00928	0.579
TRG_ER_diArg_1	158	160	PF00400	0.456
TRG_ER_diArg_1	530	532	PF00400	0.498
TRG_ER_diArg_1	565	568	PF00400	0.546
TRG_NLS_MonoCore_2	222	227	PF00514	0.717
TRG_NLS_MonoExtC_3	230	235	PF00514	0.750
TRG_NLS_MonoExtN_4	2	8	PF00514	0.703
TRG_NLS_MonoExtN_4	223	228	PF00514	0.753
TRG_NLS_MonoExtN_4	229	236	PF00514	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J9	Leptomonas seymouri	58%	100%
A0A1X0PAQ0	Trypanosomatidae	30%	100%
A4HB23	Leishmania braziliensis	75%	100%
A4IA80	Leishmania infantum	99%	100%
C9ZM29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B593	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2P0	Leishmania major	92%	100%