LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H7X2_LEIDO
TriTrypDb:
LdBPK_342600.1 , LdCL_340033600 , LDHU3_34.4220
Length:
343

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7X2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 197 201 PF00656 0.706
CLV_NRD_NRD_1 108 110 PF00675 0.604
CLV_NRD_NRD_1 223 225 PF00675 0.633
CLV_NRD_NRD_1 44 46 PF00675 0.628
CLV_NRD_NRD_1 57 59 PF00675 0.737
CLV_NRD_NRD_1 81 83 PF00675 0.726
CLV_NRD_NRD_1 93 95 PF00675 0.655
CLV_PCSK_FUR_1 57 61 PF00082 0.720
CLV_PCSK_KEX2_1 107 109 PF00082 0.791
CLV_PCSK_KEX2_1 223 225 PF00082 0.633
CLV_PCSK_KEX2_1 57 59 PF00082 0.828
CLV_PCSK_KEX2_1 69 71 PF00082 0.651
CLV_PCSK_KEX2_1 81 83 PF00082 0.699
CLV_PCSK_PC1ET2_1 107 109 PF00082 0.745
CLV_PCSK_PC1ET2_1 59 61 PF00082 0.776
CLV_PCSK_PC1ET2_1 69 71 PF00082 0.733
CLV_PCSK_SKI1_1 325 329 PF00082 0.608
DEG_SPOP_SBC_1 211 215 PF00917 0.771
DOC_ANK_TNKS_1 100 107 PF00023 0.715
DOC_CKS1_1 65 70 PF01111 0.831
DOC_CYCLIN_RxL_1 315 323 PF00134 0.647
DOC_MAPK_MEF2A_6 30 39 PF00069 0.734
DOC_MAPK_MEF2A_6 325 334 PF00069 0.690
DOC_PP2B_LxvP_1 11 14 PF13499 0.757
DOC_PP2B_LxvP_1 232 235 PF13499 0.792
DOC_USP7_MATH_1 120 124 PF00917 0.848
DOC_USP7_MATH_1 147 151 PF00917 0.762
DOC_USP7_MATH_1 169 173 PF00917 0.681
DOC_USP7_MATH_1 193 197 PF00917 0.649
DOC_USP7_MATH_1 225 229 PF00917 0.636
DOC_USP7_MATH_1 300 304 PF00917 0.704
DOC_WW_Pin1_4 100 105 PF00397 0.581
DOC_WW_Pin1_4 141 146 PF00397 0.838
DOC_WW_Pin1_4 320 325 PF00397 0.707
DOC_WW_Pin1_4 64 69 PF00397 0.826
DOC_WW_Pin1_4 85 90 PF00397 0.771
LIG_14-3-3_CanoR_1 128 136 PF00244 0.704
LIG_14-3-3_CanoR_1 140 145 PF00244 0.741
LIG_14-3-3_CanoR_1 290 295 PF00244 0.782
LIG_14-3-3_CanoR_1 331 335 PF00244 0.582
LIG_FHA_1 133 139 PF00498 0.834
LIG_FHA_1 234 240 PF00498 0.651
LIG_FHA_2 155 161 PF00498 0.694
LIG_FHA_2 189 195 PF00498 0.601
LIG_FHA_2 86 92 PF00498 0.841
LIG_Integrin_RGD_1 198 200 PF01839 0.748
LIG_SH2_STAT5 177 180 PF00017 0.642
LIG_SH3_1 59 65 PF00018 0.793
LIG_SH3_2 313 318 PF14604 0.673
LIG_SH3_2 65 70 PF14604 0.734
LIG_SH3_2 77 82 PF14604 0.680
LIG_SH3_3 133 139 PF00018 0.718
LIG_SH3_3 310 316 PF00018 0.721
LIG_SH3_3 59 65 PF00018 0.793
LIG_SH3_3 74 80 PF00018 0.577
LIG_SUMO_SIM_anti_2 157 165 PF11976 0.672
LIG_SUMO_SIM_anti_2 236 243 PF11976 0.613
LIG_SUMO_SIM_par_1 228 236 PF11976 0.782
LIG_SUMO_SIM_par_1 237 243 PF11976 0.659
LIG_UBA3_1 161 168 PF00899 0.595
MOD_CDK_SPK_2 320 325 PF00069 0.697
MOD_CDK_SPK_2 64 69 PF00069 0.826
MOD_CDK_SPxK_1 64 70 PF00069 0.732
MOD_CDK_SPxxK_3 100 107 PF00069 0.773
MOD_CK1_1 201 207 PF00069 0.655
MOD_CK1_1 213 219 PF00069 0.700
MOD_CK1_1 286 292 PF00069 0.677
MOD_CK1_1 293 299 PF00069 0.640
MOD_CK1_1 333 339 PF00069 0.588
MOD_CK1_1 85 91 PF00069 0.840
MOD_CK2_1 147 153 PF00069 0.753
MOD_CK2_1 188 194 PF00069 0.589
MOD_CK2_1 85 91 PF00069 0.846
MOD_Cter_Amidation 105 108 PF01082 0.643
MOD_GlcNHglycan 118 121 PF01048 0.777
MOD_GlcNHglycan 200 203 PF01048 0.643
MOD_GlcNHglycan 256 259 PF01048 0.821
MOD_GlcNHglycan 269 272 PF01048 0.751
MOD_GlcNHglycan 4 7 PF01048 0.681
MOD_GlcNHglycan 47 50 PF01048 0.823
MOD_GlcNHglycan 84 87 PF01048 0.680
MOD_GSK3_1 116 123 PF00069 0.799
MOD_GSK3_1 128 135 PF00069 0.686
MOD_GSK3_1 206 213 PF00069 0.687
MOD_GSK3_1 215 222 PF00069 0.819
MOD_GSK3_1 282 289 PF00069 0.684
MOD_GSK3_1 29 36 PF00069 0.698
MOD_GSK3_1 81 88 PF00069 0.780
MOD_N-GLC_1 19 24 PF02516 0.633
MOD_N-GLC_1 300 305 PF02516 0.684
MOD_NEK2_1 175 180 PF00069 0.601
MOD_NEK2_1 330 335 PF00069 0.566
MOD_NEK2_2 147 152 PF00069 0.622
MOD_NEK2_2 176 181 PF00069 0.673
MOD_PIKK_1 302 308 PF00454 0.606
MOD_PIKK_1 325 331 PF00454 0.650
MOD_PK_1 109 115 PF00069 0.851
MOD_PKA_1 45 51 PF00069 0.630
MOD_PKA_1 81 87 PF00069 0.730
MOD_PKA_2 289 295 PF00069 0.782
MOD_PKA_2 330 336 PF00069 0.654
MOD_PKA_2 81 87 PF00069 0.730
MOD_PKB_1 17 25 PF00069 0.673
MOD_Plk_1 300 306 PF00069 0.705
MOD_Plk_4 330 336 PF00069 0.654
MOD_ProDKin_1 100 106 PF00069 0.582
MOD_ProDKin_1 141 147 PF00069 0.838
MOD_ProDKin_1 320 326 PF00069 0.703
MOD_ProDKin_1 64 70 PF00069 0.829
MOD_ProDKin_1 85 91 PF00069 0.768
MOD_SUMO_rev_2 22 32 PF00179 0.695
TRG_ENDOCYTIC_2 177 180 PF00928 0.671
TRG_ER_diArg_1 266 269 PF00400 0.738
TRG_ER_diArg_1 56 58 PF00400 0.739
TRG_ER_diArg_1 80 82 PF00400 0.727
TRG_NLS_Bipartite_1 45 62 PF00514 0.616
TRG_NLS_Bipartite_1 94 111 PF00514 0.640
TRG_NLS_MonoExtC_3 57 62 PF00514 0.623
TRG_NLS_MonoExtN_4 104 111 PF00514 0.641
TRG_NLS_MonoExtN_4 316 322 PF00514 0.654
TRG_NLS_MonoExtN_4 55 62 PF00514 0.622

Homologs

Protein Taxonomy Sequence identity Coverage
A4HAZ3 Leishmania braziliensis 53% 99%
A4IA53 Leishmania infantum 100% 100%
E9B567 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q2R8 Leishmania major 87% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS