RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA helicase

Gene product:

ATP-dependent RNA and DNA helicase, mitochondrial, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7X1_LEIDO

TriTrypDb:

LdBPK_342450.1 , LdCL_340032100 , LDHU3_34.4030

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0000178	exosome (RNase complex)	4	1
GO:0032991	protein-containing complex	1	1
GO:0045025	mitochondrial degradosome	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A0A3S5H7X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X1

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0000963	mitochondrial RNA processing	6	1
GO:0000965	mitochondrial RNA 3'-end processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010467	gene expression	4	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140053	mitochondrial gene expression	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003724	RNA helicase activity	3	13
GO:0003824	catalytic activity	1	13
GO:0004386	helicase activity	2	13
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008186	ATP-dependent activity, acting on RNA	2	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016462	pyrophosphatase activity	5	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.439
CLV_MEL_PAP_1	655	661	PF00089	0.262
CLV_NRD_NRD_1	117	119	PF00675	0.492
CLV_NRD_NRD_1	141	143	PF00675	0.339
CLV_NRD_NRD_1	274	276	PF00675	0.484
CLV_NRD_NRD_1	424	426	PF00675	0.445
CLV_NRD_NRD_1	5	7	PF00675	0.543
CLV_NRD_NRD_1	506	508	PF00675	0.545
CLV_PCSK_KEX2_1	140	142	PF00082	0.374
CLV_PCSK_KEX2_1	284	286	PF00082	0.454
CLV_PCSK_KEX2_1	4	6	PF00082	0.557
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.464
CLV_PCSK_PC7_1	137	143	PF00082	0.416
CLV_PCSK_SKI1_1	142	146	PF00082	0.368
CLV_PCSK_SKI1_1	243	247	PF00082	0.325
CLV_PCSK_SKI1_1	316	320	PF00082	0.375
CLV_PCSK_SKI1_1	354	358	PF00082	0.497
CLV_PCSK_SKI1_1	399	403	PF00082	0.363
CLV_PCSK_SKI1_1	418	422	PF00082	0.330
CLV_PCSK_SKI1_1	545	549	PF00082	0.402
CLV_PCSK_SKI1_1	55	59	PF00082	0.542
CLV_PCSK_SKI1_1	565	569	PF00082	0.236
DEG_APCC_DBOX_1	274	282	PF00400	0.517
DEG_APCC_DBOX_1	321	329	PF00400	0.493
DOC_CYCLIN_RxL_1	542	552	PF00134	0.478
DOC_CYCLIN_RxL_1	665	675	PF00134	0.548
DOC_MAPK_gen_1	186	195	PF00069	0.504
DOC_MAPK_gen_1	284	291	PF00069	0.424
DOC_MAPK_gen_1	315	321	PF00069	0.507
DOC_MAPK_gen_1	507	516	PF00069	0.441
DOC_MAPK_MEF2A_6	284	291	PF00069	0.429
DOC_MAPK_MEF2A_6	507	516	PF00069	0.537
DOC_PP1_RVXF_1	563	569	PF00149	0.433
DOC_PP2B_LxvP_1	246	249	PF13499	0.323
DOC_SPAK_OSR1_1	600	604	PF12202	0.490
DOC_USP7_MATH_1	149	153	PF00917	0.376
DOC_USP7_MATH_1	176	180	PF00917	0.427
DOC_USP7_MATH_1	32	36	PF00917	0.642
DOC_USP7_MATH_1	362	366	PF00917	0.583
DOC_USP7_MATH_1	375	379	PF00917	0.661
DOC_USP7_MATH_1	387	391	PF00917	0.756
DOC_USP7_MATH_1	444	448	PF00917	0.490
DOC_USP7_MATH_1	474	478	PF00917	0.444
DOC_USP7_UBL2_3	119	123	PF12436	0.552
DOC_USP7_UBL2_3	426	430	PF12436	0.441
DOC_WW_Pin1_4	15	20	PF00397	0.659
DOC_WW_Pin1_4	212	217	PF00397	0.328
DOC_WW_Pin1_4	28	33	PF00397	0.477
DOC_WW_Pin1_4	289	294	PF00397	0.401
DOC_WW_Pin1_4	379	384	PF00397	0.730
DOC_WW_Pin1_4	388	393	PF00397	0.593
DOC_WW_Pin1_4	621	626	PF00397	0.617
LIG_14-3-3_CanoR_1	110	117	PF00244	0.443
LIG_14-3-3_CanoR_1	23	32	PF00244	0.520
LIG_14-3-3_CanoR_1	418	427	PF00244	0.372
LIG_14-3-3_CanoR_1	460	464	PF00244	0.372
LIG_14-3-3_CanoR_1	473	483	PF00244	0.423
LIG_14-3-3_CanoR_1	658	664	PF00244	0.442
LIG_Actin_WH2_2	536	551	PF00022	0.456
LIG_APCC_ABBA_1	495	500	PF00400	0.511
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_BRCT_BRCA1_1	20	24	PF00533	0.692
LIG_BRCT_BRCA1_1	446	450	PF00533	0.499
LIG_BRCT_BRCA1_1	534	538	PF00533	0.416
LIG_BRCT_BRCA1_1	655	659	PF00533	0.491
LIG_BRCT_BRCA1_2	655	661	PF00533	0.533
LIG_deltaCOP1_diTrp_1	236	241	PF00928	0.351
LIG_deltaCOP1_diTrp_1	86	93	PF00928	0.518
LIG_eIF4E_1	133	139	PF01652	0.530
LIG_FHA_1	240	246	PF00498	0.325
LIG_FHA_1	355	361	PF00498	0.458
LIG_FHA_1	396	402	PF00498	0.449
LIG_FHA_1	403	409	PF00498	0.317
LIG_FHA_1	489	495	PF00498	0.379
LIG_FHA_1	511	517	PF00498	0.573
LIG_FHA_1	561	567	PF00498	0.508
LIG_FHA_1	615	621	PF00498	0.649
LIG_FHA_1	675	681	PF00498	0.540
LIG_FHA_1	89	95	PF00498	0.502
LIG_FHA_2	213	219	PF00498	0.360
LIG_FHA_2	231	237	PF00498	0.364
LIG_FHA_2	51	57	PF00498	0.487
LIG_FHA_2	638	644	PF00498	0.388
LIG_FHA_2	660	666	PF00498	0.519
LIG_LIR_Apic_2	167	173	PF02991	0.343
LIG_LIR_Gen_1	112	121	PF02991	0.554
LIG_LIR_Gen_1	179	190	PF02991	0.302
LIG_LIR_Gen_1	308	318	PF02991	0.447
LIG_LIR_Gen_1	520	530	PF02991	0.462
LIG_LIR_Gen_1	650	659	PF02991	0.436
LIG_LIR_Nem_3	112	117	PF02991	0.477
LIG_LIR_Nem_3	179	185	PF02991	0.414
LIG_LIR_Nem_3	308	313	PF02991	0.429
LIG_LIR_Nem_3	520	524	PF02991	0.435
LIG_LIR_Nem_3	650	655	PF02991	0.436
LIG_PCNA_yPIPBox_3	351	360	PF02747	0.501
LIG_PCNA_yPIPBox_3	413	426	PF02747	0.397
LIG_PCNA_yPIPBox_3	644	655	PF02747	0.501
LIG_Pex14_1	89	93	PF04695	0.504
LIG_Pex14_2	659	663	PF04695	0.436
LIG_PTB_Apo_2	264	271	PF02174	0.465
LIG_PTB_Phospho_1	264	270	PF10480	0.461
LIG_SH2_CRK	170	174	PF00017	0.322
LIG_SH2_GRB2like	359	362	PF00017	0.462
LIG_SH2_SRC	359	362	PF00017	0.462
LIG_SH2_STAT5	170	173	PF00017	0.312
LIG_SH2_STAT5	359	362	PF00017	0.518
LIG_SH2_STAT5	570	573	PF00017	0.462
LIG_SH2_STAT5	652	655	PF00017	0.446
LIG_SH3_3	214	220	PF00018	0.446
LIG_SH3_3	26	32	PF00018	0.543
LIG_SUMO_SIM_par_1	287	292	PF11976	0.452
LIG_SUMO_SIM_par_1	317	323	PF11976	0.500
LIG_SUMO_SIM_par_1	512	517	PF11976	0.529
LIG_UBA3_1	497	505	PF00899	0.547
LIG_WRC_WIRS_1	525	530	PF05994	0.467
MOD_CDK_SPxK_1	393	399	PF00069	0.579
MOD_CDK_SPxxK_3	289	296	PF00069	0.508
MOD_CDK_SPxxK_3	379	386	PF00069	0.549
MOD_CDK_SPxxK_3	621	628	PF00069	0.626
MOD_CK1_1	152	158	PF00069	0.376
MOD_CK1_1	18	24	PF00069	0.647
MOD_CK1_1	294	300	PF00069	0.493
MOD_CK1_1	31	37	PF00069	0.635
MOD_CK1_1	329	335	PF00069	0.504
MOD_CK1_1	378	384	PF00069	0.758
MOD_CK1_1	391	397	PF00069	0.635
MOD_CK1_1	503	509	PF00069	0.584
MOD_CK1_1	517	523	PF00069	0.463
MOD_CK1_1	574	580	PF00069	0.343
MOD_CK1_1	66	72	PF00069	0.530
MOD_CK1_1	98	104	PF00069	0.534
MOD_CK2_1	276	282	PF00069	0.511
MOD_CK2_1	387	393	PF00069	0.771
MOD_CK2_1	50	56	PF00069	0.423
MOD_CK2_1	517	523	PF00069	0.579
MOD_CK2_1	528	534	PF00069	0.510
MOD_CK2_1	637	643	PF00069	0.419
MOD_CK2_1	659	665	PF00069	0.438
MOD_CMANNOS	654	657	PF00535	0.294
MOD_GlcNHglycan	151	154	PF01048	0.366
MOD_GlcNHglycan	166	169	PF01048	0.335
MOD_GlcNHglycan	25	28	PF01048	0.644
MOD_GlcNHglycan	328	331	PF01048	0.459
MOD_GlcNHglycan	333	336	PF01048	0.412
MOD_GlcNHglycan	34	37	PF01048	0.607
MOD_GlcNHglycan	362	365	PF01048	0.537
MOD_GlcNHglycan	366	369	PF01048	0.581
MOD_GlcNHglycan	446	449	PF01048	0.506
MOD_GlcNHglycan	476	479	PF01048	0.523
MOD_GlcNHglycan	50	53	PF01048	0.308
MOD_GlcNHglycan	502	505	PF01048	0.503
MOD_GlcNHglycan	515	519	PF01048	0.530
MOD_GlcNHglycan	575	579	PF01048	0.426
MOD_GlcNHglycan	68	71	PF01048	0.380
MOD_GSK3_1	109	116	PF00069	0.482
MOD_GSK3_1	208	215	PF00069	0.334
MOD_GSK3_1	28	35	PF00069	0.685
MOD_GSK3_1	287	294	PF00069	0.418
MOD_GSK3_1	326	333	PF00069	0.458
MOD_GSK3_1	360	367	PF00069	0.535
MOD_GSK3_1	375	382	PF00069	0.505
MOD_GSK3_1	387	394	PF00069	0.547
MOD_GSK3_1	510	517	PF00069	0.593
MOD_GSK3_1	524	531	PF00069	0.391
MOD_GSK3_1	573	580	PF00069	0.345
MOD_GSK3_1	653	660	PF00069	0.449
MOD_GSK3_1	674	681	PF00069	0.362
MOD_GSK3_1	88	95	PF00069	0.505
MOD_N-GLC_1	276	281	PF02516	0.549
MOD_N-GLC_1	360	365	PF02516	0.542
MOD_N-GLC_1	558	563	PF02516	0.418
MOD_N-GLC_2	43	45	PF02516	0.451
MOD_NEK2_1	419	424	PF00069	0.447
MOD_NEK2_1	450	455	PF00069	0.485
MOD_NEK2_1	524	529	PF00069	0.388
MOD_NEK2_1	573	578	PF00069	0.435
MOD_NEK2_1	659	664	PF00069	0.285
MOD_NEK2_1	672	677	PF00069	0.292
MOD_NEK2_1	94	99	PF00069	0.527
MOD_PIKK_1	176	182	PF00454	0.402
MOD_PIKK_1	99	105	PF00454	0.533
MOD_PKA_2	109	115	PF00069	0.451
MOD_PKA_2	326	332	PF00069	0.514
MOD_PKA_2	387	393	PF00069	0.742
MOD_PKA_2	459	465	PF00069	0.374
MOD_PKA_2	657	663	PF00069	0.321
MOD_PKB_1	298	306	PF00069	0.471
MOD_Plk_1	276	282	PF00069	0.553
MOD_Plk_1	558	564	PF00069	0.384
MOD_Plk_2-3	637	643	PF00069	0.487
MOD_Plk_4	459	465	PF00069	0.472
MOD_Plk_4	517	523	PF00069	0.442
MOD_Plk_4	659	665	PF00069	0.311
MOD_ProDKin_1	15	21	PF00069	0.660
MOD_ProDKin_1	212	218	PF00069	0.340
MOD_ProDKin_1	28	34	PF00069	0.469
MOD_ProDKin_1	289	295	PF00069	0.399
MOD_ProDKin_1	379	385	PF00069	0.730
MOD_ProDKin_1	388	394	PF00069	0.588
MOD_ProDKin_1	621	627	PF00069	0.614
MOD_SUMO_rev_2	279	286	PF00179	0.495
MOD_SUMO_rev_2	665	675	PF00179	0.457
TRG_DiLeu_BaEn_1	282	287	PF01217	0.442
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.334
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.532
TRG_ENDOCYTIC_2	337	340	PF00928	0.402
TRG_ENDOCYTIC_2	570	573	PF00928	0.322
TRG_ENDOCYTIC_2	652	655	PF00928	0.294
TRG_ER_diArg_1	139	142	PF00400	0.381
TRG_ER_diArg_1	163	166	PF00400	0.476
TRG_ER_diArg_1	295	298	PF00400	0.577
TRG_ER_diArg_1	3	6	PF00400	0.551
TRG_NES_CRM1_1	552	564	PF08389	0.296
TRG_Pf-PMV_PEXEL_1	636	641	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL37	Leptomonas seymouri	67%	98%
A0A0S4JQD9	Bodo saltans	44%	100%
A0A0S4JTX4	Bodo saltans	44%	100%
A0A1X0PB30	Trypanosomatidae	54%	100%
A0A3R7MLZ5	Trypanosoma rangeli	52%	100%
A4HAX9	Leishmania braziliensis	83%	100%
A4IA38	Leishmania infantum	99%	100%
A4IG62	Danio rerio	32%	90%
C9ZM61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B553	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4KFV7	Arabidopsis thaliana	32%	89%
O74727	Saccharomyces paradoxus	29%	93%
P32580	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	93%
Q01IJ3	Oryza sativa subsp. indica	31%	94%
Q10D00	Oryza sativa subsp. japonica	32%	100%
Q17828	Caenorhabditis elegans	32%	96%
Q295E6	Drosophila pseudoobscura pseudoobscura	35%	90%
Q4Q2T3	Leishmania major	94%	100%
Q59TB2	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	95%
Q5EBA1	Rattus norvegicus	34%	89%
Q5ZJT0	Gallus gallus	32%	87%
Q61SU7	Caenorhabditis briggsae	32%	95%
Q7X745	Oryza sativa subsp. japonica	31%	94%
Q80YD1	Mus musculus	33%	88%
Q8IYB8	Homo sapiens	34%	87%
Q9SMX1	Arabidopsis thaliana	32%	100%
Q9VN03	Drosophila melanogaster	33%	90%
V5DLS8	Trypanosoma cruzi	52%	100%