LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H7X0_LEIDO
TriTrypDb:
LdBPK_342270.1 , LdCL_340030400 , LDHU3_34.3790
Length:
405

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7X0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7X0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 139 143 PF00656 0.699
CLV_C14_Caspase3-7 320 324 PF00656 0.746
CLV_NRD_NRD_1 302 304 PF00675 0.664
CLV_NRD_NRD_1 350 352 PF00675 0.742
CLV_PCSK_KEX2_1 350 352 PF00082 0.719
DEG_Nend_UBRbox_1 1 4 PF02207 0.577
DOC_CDC14_PxL_1 257 265 PF14671 0.665
DOC_CYCLIN_yCln2_LP_2 381 387 PF00134 0.524
DOC_PP4_FxxP_1 266 269 PF00568 0.602
DOC_SPAK_OSR1_1 18 22 PF12202 0.762
DOC_USP7_MATH_1 118 122 PF00917 0.665
DOC_USP7_MATH_1 150 154 PF00917 0.782
DOC_USP7_MATH_1 184 188 PF00917 0.580
DOC_USP7_MATH_1 204 208 PF00917 0.600
DOC_USP7_MATH_1 239 243 PF00917 0.797
DOC_USP7_MATH_1 244 248 PF00917 0.728
DOC_USP7_MATH_1 289 293 PF00917 0.688
DOC_USP7_MATH_1 307 311 PF00917 0.663
DOC_USP7_MATH_1 358 362 PF00917 0.668
DOC_USP7_MATH_1 36 40 PF00917 0.594
DOC_USP7_MATH_1 58 62 PF00917 0.698
DOC_WW_Pin1_4 228 233 PF00397 0.713
DOC_WW_Pin1_4 265 270 PF00397 0.641
DOC_WW_Pin1_4 67 72 PF00397 0.727
LIG_14-3-3_CanoR_1 149 159 PF00244 0.758
LIG_14-3-3_CanoR_1 251 257 PF00244 0.669
LIG_14-3-3_CanoR_1 339 344 PF00244 0.727
LIG_14-3-3_CanoR_1 391 396 PF00244 0.609
LIG_BIR_III_2 217 221 PF00653 0.713
LIG_BRCT_BRCA1_1 176 180 PF00533 0.740
LIG_BRCT_BRCA1_1 371 375 PF00533 0.716
LIG_DLG_GKlike_1 391 399 PF00625 0.557
LIG_eIF4E_1 95 101 PF01652 0.643
LIG_FHA_1 121 127 PF00498 0.696
LIG_FHA_1 183 189 PF00498 0.759
LIG_FHA_1 195 201 PF00498 0.597
LIG_FHA_1 229 235 PF00498 0.805
LIG_FHA_1 71 77 PF00498 0.664
LIG_FHA_1 95 101 PF00498 0.601
LIG_LIR_Apic_2 265 269 PF02991 0.600
LIG_LIR_Gen_1 177 188 PF02991 0.754
LIG_LIR_Nem_3 177 183 PF02991 0.705
LIG_LIR_Nem_3 341 346 PF02991 0.646
LIG_LIR_Nem_3 5 10 PF02991 0.578
LIG_Pex14_1 172 176 PF04695 0.641
LIG_PTAP_UEV_1 273 278 PF05743 0.600
LIG_SH2_NCK_1 308 312 PF00017 0.728
LIG_SH2_STAP1 122 126 PF00017 0.651
LIG_SH2_STAP1 176 180 PF00017 0.639
LIG_SH2_STAP1 308 312 PF00017 0.728
LIG_SH2_STAT5 122 125 PF00017 0.636
LIG_SH2_STAT5 208 211 PF00017 0.637
LIG_SH2_STAT5 308 311 PF00017 0.726
LIG_SH3_3 183 189 PF00018 0.586
LIG_SH3_3 255 261 PF00018 0.673
LIG_SH3_3 271 277 PF00018 0.687
LIG_SH3_3 352 358 PF00018 0.640
LIG_SH3_3 364 370 PF00018 0.542
LIG_SUMO_SIM_anti_2 252 259 PF11976 0.664
LIG_SUMO_SIM_par_1 97 104 PF11976 0.649
LIG_TRAF2_1 152 155 PF00917 0.790
MOD_CK1_1 191 197 PF00069 0.698
MOD_CK1_1 268 274 PF00069 0.644
MOD_CK1_1 292 298 PF00069 0.757
MOD_CK1_1 3 9 PF00069 0.571
MOD_CK1_1 306 312 PF00069 0.537
MOD_CK1_1 39 45 PF00069 0.727
MOD_CK1_1 394 400 PF00069 0.577
MOD_CK1_1 70 76 PF00069 0.629
MOD_CK1_1 94 100 PF00069 0.585
MOD_CK2_1 148 154 PF00069 0.811
MOD_CK2_1 161 167 PF00069 0.531
MOD_CK2_1 314 320 PF00069 0.790
MOD_CK2_1 390 396 PF00069 0.721
MOD_GlcNHglycan 131 134 PF01048 0.722
MOD_GlcNHglycan 150 153 PF01048 0.489
MOD_GlcNHglycan 246 249 PF01048 0.625
MOD_GlcNHglycan 291 294 PF01048 0.658
MOD_GlcNHglycan 305 308 PF01048 0.663
MOD_GlcNHglycan 309 312 PF01048 0.737
MOD_GlcNHglycan 34 37 PF01048 0.709
MOD_GlcNHglycan 396 399 PF01048 0.674
MOD_GlcNHglycan 40 44 PF01048 0.712
MOD_GlcNHglycan 60 63 PF01048 0.466
MOD_GSK3_1 113 120 PF00069 0.644
MOD_GSK3_1 174 181 PF00069 0.747
MOD_GSK3_1 184 191 PF00069 0.601
MOD_GSK3_1 252 259 PF00069 0.643
MOD_GSK3_1 268 275 PF00069 0.689
MOD_GSK3_1 288 295 PF00069 0.603
MOD_GSK3_1 303 310 PF00069 0.574
MOD_GSK3_1 314 321 PF00069 0.622
MOD_GSK3_1 32 39 PF00069 0.738
MOD_GSK3_1 390 397 PF00069 0.599
MOD_GSK3_1 70 77 PF00069 0.685
MOD_N-GLC_1 191 196 PF02516 0.701
MOD_PIKK_1 268 274 PF00454 0.644
MOD_PKA_1 303 309 PF00069 0.697
MOD_PKA_2 148 154 PF00069 0.776
MOD_PKA_2 178 184 PF00069 0.753
MOD_PKA_2 220 226 PF00069 0.747
MOD_PKA_2 338 344 PF00069 0.731
MOD_PKA_2 390 396 PF00069 0.721
MOD_Plk_1 106 112 PF00069 0.663
MOD_Plk_1 39 45 PF00069 0.753
MOD_Plk_1 48 54 PF00069 0.608
MOD_Plk_1 81 87 PF00069 0.682
MOD_Plk_2-3 48 54 PF00069 0.679
MOD_Plk_4 204 210 PF00069 0.662
MOD_Plk_4 252 258 PF00069 0.664
MOD_ProDKin_1 228 234 PF00069 0.710
MOD_ProDKin_1 265 271 PF00069 0.643
MOD_ProDKin_1 67 73 PF00069 0.726
TRG_DiLeu_BaEn_1 40 45 PF01217 0.679
TRG_DiLeu_BaEn_4 154 160 PF01217 0.779
TRG_ER_diArg_1 158 161 PF00400 0.692
TRG_ER_diArg_1 16 19 PF00400 0.542
TRG_ER_diArg_1 85 88 PF00400 0.698
TRG_NLS_MonoExtN_4 300 307 PF00514 0.585

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMR5 Leptomonas seymouri 34% 100%
A4HAW1 Leishmania braziliensis 68% 100%
A4IA21 Leishmania infantum 99% 100%
E9B536 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q2V0 Leishmania major 80% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS