Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7W9_LEIDO

TriTrypDb:

LdBPK_342090.1 , LdCL_340028600 , LDHU3_34.3510

Length:

132

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S5H7W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7W9

Function

Biological processes
Term	Name	Level	Count
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	115	117	PF00082	0.513
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.494
DOC_USP7_UBL2_3	120	124	PF12436	0.733
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_eIF4E_1	9	15	PF01652	0.427
LIG_FHA_1	57	63	PF00498	0.364
LIG_FHA_1	86	92	PF00498	0.692
LIG_LIR_Nem_3	5	9	PF02991	0.397
LIG_LIR_Nem_3	88	93	PF02991	0.623
LIG_SH2_CRK	9	13	PF00017	0.446
LIG_SH2_GRB2like	93	96	PF00017	0.689
LIG_SH2_STAP1	93	97	PF00017	0.599
LIG_SH2_STAT3	93	96	PF00017	0.689
LIG_SH2_STAT5	6	9	PF00017	0.407
LIG_SH2_STAT5	90	93	PF00017	0.681
LIG_SH3_4	124	131	PF00018	0.722
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.420
LIG_SUMO_SIM_par_1	56	61	PF11976	0.427
LIG_TYR_ITIM	7	12	PF00017	0.381
MOD_CK1_1	32	38	PF00069	0.441
MOD_CK2_1	21	27	PF00069	0.533
MOD_GlcNHglycan	98	101	PF01048	0.514
MOD_N-GLC_1	47	52	PF02516	0.663
MOD_NEK2_1	21	26	PF00069	0.468
MOD_NEK2_1	29	34	PF00069	0.524
MOD_NEK2_1	63	68	PF00069	0.411
MOD_PKA_2	108	114	PF00069	0.675
MOD_Plk_1	47	53	PF00069	0.450
MOD_Plk_4	63	69	PF00069	0.426
MOD_SUMO_for_1	119	122	PF00179	0.676
MOD_SUMO_rev_2	117	126	PF00179	0.729
TRG_ENDOCYTIC_2	9	12	PF00928	0.354
TRG_ER_diLys_1	129	132	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ3	Leptomonas seymouri	60%	100%
A0A0S4JQP5	Bodo saltans	37%	100%
A0A1X0PAH4	Trypanosomatidae	38%	92%
A0A3S5ISH1	Trypanosoma rangeli	38%	92%
A4HAU4	Leishmania braziliensis	77%	100%
A4IA11	Leishmania infantum	100%	100%
C9ZMM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	92%
E9B518	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q2W8	Leishmania major	98%	100%