Pyroglutamyl-peptidase I (C15 family)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyroglutamyl-peptidase I, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7W7_LEIDO

TriTrypDb:

LdBPK_341750.1 , LdCL_340025100 , LDHU3_34.3020

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7W7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008242	omega peptidase activity	4	1
GO:0016920	pyroglutamyl-peptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.767
CLV_PCSK_KEX2_1	38	40	PF00082	0.579
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.579
CLV_PCSK_SKI1_1	82	86	PF00082	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_MAPK_MEF2A_6	47	55	PF00069	0.511
DOC_MAPK_MEF2A_6	5	12	PF00069	0.357
DOC_PP4_FxxP_1	194	197	PF00568	0.507
DOC_WW_Pin1_4	142	147	PF00397	0.519
DOC_WW_Pin1_4	177	182	PF00397	0.507
LIG_14-3-3_CanoR_1	240	249	PF00244	0.602
LIG_14-3-3_CanoR_1	47	55	PF00244	0.521
LIG_APCC_ABBA_1	132	137	PF00400	0.493
LIG_APCC_ABBA_1	88	93	PF00400	0.485
LIG_Clathr_ClatBox_1	97	101	PF01394	0.372
LIG_FHA_1	129	135	PF00498	0.542
LIG_FHA_1	169	175	PF00498	0.626
LIG_FHA_1	18	24	PF00498	0.573
LIG_FHA_1	254	260	PF00498	0.407
LIG_FHA_1	92	98	PF00498	0.501
LIG_FHA_2	159	165	PF00498	0.571
LIG_FHA_2	173	179	PF00498	0.475
LIG_FHA_2	241	247	PF00498	0.521
LIG_FHA_2	47	53	PF00498	0.508
LIG_LIR_Gen_1	107	115	PF02991	0.510
LIG_LIR_Gen_1	45	55	PF02991	0.444
LIG_LIR_Nem_3	107	112	PF02991	0.505
LIG_LIR_Nem_3	13	18	PF02991	0.342
LIG_LIR_Nem_3	45	51	PF02991	0.442
LIG_Pex14_2	135	139	PF04695	0.505
LIG_SH2_CRK	215	219	PF00017	0.329
LIG_SH2_STAT5	208	211	PF00017	0.315
LIG_SH2_STAT5	48	51	PF00017	0.485
LIG_SH2_STAT5	61	64	PF00017	0.277
LIG_SH3_3	121	127	PF00018	0.469
LIG_SH3_3	232	238	PF00018	0.355
LIG_SUMO_SIM_par_1	270	277	PF11976	0.506
MOD_CK1_1	54	60	PF00069	0.482
MOD_CK2_1	158	164	PF00069	0.562
MOD_CK2_1	172	178	PF00069	0.648
MOD_CK2_1	240	246	PF00069	0.544
MOD_GSK3_1	158	165	PF00069	0.461
MOD_GSK3_1	168	175	PF00069	0.577
MOD_GSK3_1	195	202	PF00069	0.484
MOD_GSK3_1	254	261	PF00069	0.496
MOD_GSK3_1	270	277	PF00069	0.410
MOD_N-GLC_1	158	163	PF02516	0.507
MOD_N-GLC_1	91	96	PF02516	0.407
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	108	113	PF00069	0.500
MOD_NEK2_1	135	140	PF00069	0.466
MOD_NEK2_1	258	263	PF00069	0.390
MOD_NEK2_1	51	56	PF00069	0.488
MOD_NEK2_2	17	22	PF00069	0.574
MOD_PKA_2	46	52	PF00069	0.519
MOD_Plk_1	158	164	PF00069	0.415
MOD_Plk_1	51	57	PF00069	0.432
MOD_Plk_2-3	128	134	PF00069	0.323
MOD_Plk_4	135	141	PF00069	0.379
MOD_Plk_4	254	260	PF00069	0.442
MOD_Plk_4	270	276	PF00069	0.363
MOD_ProDKin_1	142	148	PF00069	0.513
MOD_ProDKin_1	177	183	PF00069	0.504
MOD_SUMO_rev_2	111	120	PF00179	0.430
MOD_SUMO_rev_2	182	189	PF00179	0.697
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.430
TRG_ENDOCYTIC_2	105	108	PF00928	0.322
TRG_ENDOCYTIC_2	15	18	PF00928	0.479
TRG_ENDOCYTIC_2	215	218	PF00928	0.322
TRG_ENDOCYTIC_2	229	232	PF00928	0.334
TRG_ENDOCYTIC_2	48	51	PF00928	0.418
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X3	Leptomonas seymouri	58%	99%
A0A0S4JYF2	Bodo saltans	28%	95%
A0A1X0P9S4	Trypanosomatidae	32%	100%
A0A3R7R5B2	Trypanosoma rangeli	31%	100%
A4HAR3	Leishmania braziliensis	73%	100%
A4I9X7	Leishmania infantum	99%	100%
C9ZMR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B4Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q301	Leishmania major	89%	100%
V5BNH8	Trypanosoma cruzi	29%	100%