Amastin surface glycoprotein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7W6_LEIDO

TriTrypDb:

LdBPK_341050.1 , LdCL_340023300 , LdCL_340023400 , LDHU3_34.2560

Length:

199

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 191
NetGPI	no	yes: 0, no: 202

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	181
GO:0110165	cellular anatomical entity	1	181

Expansion

Sequence features

A0A3S5H7W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7W6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_MDM2_SWIB_1	170	178	PF02201	0.477
DEG_SPOP_SBC_1	5	9	PF00917	0.534
DOC_CKS1_1	186	191	PF01111	0.525
DOC_CKS1_1	38	43	PF01111	0.370
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.411
DOC_MAPK_gen_1	14	24	PF00069	0.548
DOC_MAPK_gen_1	48	57	PF00069	0.220
DOC_MAPK_MEF2A_6	121	129	PF00069	0.562
DOC_MAPK_MEF2A_6	16	24	PF00069	0.541
DOC_MAPK_MEF2A_6	50	59	PF00069	0.354
DOC_PP2B_LxvP_1	183	186	PF13499	0.575
DOC_WW_Pin1_4	185	190	PF00397	0.513
DOC_WW_Pin1_4	37	42	PF00397	0.359
LIG_14-3-3_CanoR_1	63	73	PF00244	0.298
LIG_Actin_WH2_2	107	123	PF00022	0.411
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_BIR_III_2	191	195	PF00653	0.546
LIG_BRCT_BRCA1_1	41	45	PF00533	0.210
LIG_Clathr_ClatBox_1	72	76	PF01394	0.197
LIG_CORNRBOX	175	183	PF00104	0.197
LIG_FHA_1	132	138	PF00498	0.384
LIG_FHA_2	186	192	PF00498	0.538
LIG_FHA_2	38	44	PF00498	0.403
LIG_LIR_Gen_1	165	175	PF02991	0.357
LIG_LIR_Gen_1	68	78	PF02991	0.344
LIG_LIR_Gen_1	7	18	PF02991	0.537
LIG_LIR_LC3C_4	21	24	PF02991	0.220
LIG_LIR_Nem_3	165	170	PF02991	0.370
LIG_LIR_Nem_3	68	74	PF02991	0.302
LIG_LIR_Nem_3	7	13	PF02991	0.538
LIG_Pex14_2	170	174	PF04695	0.390
LIG_Pex14_2	31	35	PF04695	0.252
LIG_Pex14_2	45	49	PF04695	0.204
LIG_SH2_PTP2	25	28	PF00017	0.353
LIG_SH2_STAT3	12	15	PF00017	0.540
LIG_SH2_STAT5	10	13	PF00017	0.626
LIG_SH2_STAT5	187	190	PF00017	0.592
LIG_SH2_STAT5	25	28	PF00017	0.475
LIG_SH2_STAT5	71	74	PF00017	0.394
LIG_SH3_3	183	189	PF00018	0.320
LIG_SH3_3	35	41	PF00018	0.372
LIG_TYR_ITIM	23	28	PF00017	0.468
MOD_GlcNHglycan	164	167	PF01048	0.410
MOD_GSK3_1	158	165	PF00069	0.195
MOD_GSK3_1	62	69	PF00069	0.300
MOD_N-GLC_1	18	23	PF02516	0.202
MOD_NEK2_1	115	120	PF00069	0.337
MOD_NEK2_1	142	147	PF00069	0.486
MOD_NEK2_1	55	60	PF00069	0.316
MOD_NEK2_1	6	11	PF00069	0.551
MOD_NEK2_1	62	67	PF00069	0.327
MOD_NEK2_2	116	121	PF00069	0.406
MOD_NEK2_2	131	136	PF00069	0.391
MOD_NEK2_2	96	101	PF00069	0.478
MOD_PK_1	158	164	PF00069	0.196
MOD_PKA_2	62	68	PF00069	0.312
MOD_Plk_1	18	24	PF00069	0.409
MOD_Plk_4	109	115	PF00069	0.368
MOD_Plk_4	131	137	PF00069	0.303
MOD_Plk_4	158	164	PF00069	0.206
MOD_Plk_4	18	24	PF00069	0.467
MOD_ProDKin_1	185	191	PF00069	0.517
MOD_ProDKin_1	37	43	PF00069	0.359
TRG_ENDOCYTIC_2	10	13	PF00928	0.651
TRG_ENDOCYTIC_2	187	190	PF00928	0.535
TRG_ENDOCYTIC_2	25	28	PF00928	0.454
TRG_ENDOCYTIC_2	71	74	PF00928	0.288
TRG_ER_diArg_1	83	86	PF00400	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	27%	100%
A0A0N0P547	Leptomonas seymouri	36%	100%
A0A0N0P6P9	Leptomonas seymouri	26%	87%
A0A0N0P993	Leptomonas seymouri	26%	89%
A0A0N1HWY5	Leptomonas seymouri	30%	100%
A0A0N1PDH0	Leptomonas seymouri	35%	99%
A0A0N1PFN2	Leptomonas seymouri	26%	100%
A0A1X0NQ58	Trypanosomatidae	33%	100%
A0A1X0NUH1	Trypanosomatidae	28%	88%
A0A1X0P2R3	Trypanosomatidae	32%	94%
A0A1X0P988	Trypanosomatidae	37%	100%
A0A381MTA7	Leishmania infantum	59%	100%
A0A381MTB8	Leishmania infantum	48%	100%
A0A381MTC7	Leishmania infantum	57%	100%
A0A381MTN2	Leishmania infantum	42%	100%
A0A381MVY0	Leishmania infantum	52%	100%
A0A3Q8ID16	Leishmania donovani	27%	100%
A0A3Q8IE85	Leishmania donovani	52%	100%
A0A3Q8IEC2	Leishmania donovani	51%	100%
A0A3Q8IEI1	Leishmania donovani	47%	100%
A0A3Q8IF65	Leishmania donovani	43%	100%
A0A3Q8IFB9	Leishmania donovani	29%	100%
A0A3Q8IFH7	Leishmania donovani	57%	100%
A0A3Q8IH65	Leishmania donovani	49%	100%
A0A3Q8IHN2	Leishmania donovani	47%	100%
A0A3Q8IHW7	Leishmania donovani	43%	100%
A0A3Q8IHZ6	Leishmania donovani	51%	100%
A0A3Q8IIH1	Leishmania donovani	49%	100%
A0A3Q8IL03	Leishmania donovani	47%	100%
A0A3Q8IUK8	Leishmania donovani	56%	100%
A0A3Q8IUR5	Leishmania donovani	42%	100%
A0A3S5H662	Leishmania donovani	41%	100%
A0A3S5H663	Leishmania donovani	41%	100%
A0A3S5H665	Leishmania donovani	41%	100%
A0A3S5H666	Leishmania donovani	43%	100%
A0A3S5H667	Leishmania donovani	41%	100%
A0A3S5H7D2	Leishmania donovani	29%	100%
A0A3S5H7L2	Leishmania donovani	46%	100%
A0A3S5H7V9	Leishmania donovani	40%	100%
A0A3S5H7W2	Leishmania donovani	32%	100%
A0A3S7WQA0	Leishmania donovani	40%	98%
A0A3S7WQA8	Leishmania donovani	44%	100%
A0A3S7WQC1	Leishmania donovani	41%	100%
A0A3S7X2E6	Leishmania donovani	44%	100%
A0A3S7X357	Leishmania donovani	27%	90%
A0A3S7X453	Leishmania donovani	41%	100%
A0A3S7X472	Leishmania donovani	41%	100%
A0A3S7X7E5	Leishmania donovani	48%	80%
A0A3S7X7M4	Leishmania donovani	53%	94%
A0A3S7X7U1	Leishmania donovani	54%	95%
A0A3S7X7U4	Leishmania donovani	46%	77%
A0A3S7X7W2	Leishmania donovani	48%	95%
A0A3S7X7Y0	Leishmania donovani	49%	100%
A4H595	Leishmania braziliensis	44%	100%
A4H596	Leishmania braziliensis	44%	100%
A4H597	Leishmania braziliensis	44%	100%
A4H5D1	Leishmania braziliensis	48%	100%
A4H5D2	Leishmania braziliensis	35%	100%
A4H5G0	Leishmania braziliensis	45%	100%
A4H5G4	Leishmania braziliensis	43%	100%
A4H5G6	Leishmania braziliensis	40%	100%
A4H5G7	Leishmania braziliensis	45%	100%
A4H5G9	Leishmania braziliensis	50%	100%
A4H5H0	Leishmania braziliensis	50%	100%
A4H5H1	Leishmania braziliensis	49%	100%
A4H5H2	Leishmania braziliensis	45%	100%
A4H5H3	Leishmania braziliensis	40%	100%
A4H6C8	Leishmania braziliensis	46%	100%
A4H7D7	Leishmania braziliensis	50%	100%
A4H9E8	Leishmania braziliensis	52%	100%
A4H9E9	Leishmania braziliensis	51%	100%
A4HAJ4	Leishmania braziliensis	46%	100%
A4HAJ5	Leishmania braziliensis	43%	100%
A4HAJ6	Leishmania braziliensis	45%	100%
A4HAL1	Leishmania braziliensis	46%	100%
A4HAL2	Leishmania braziliensis	35%	100%
A4HAM2	Leishmania braziliensis	46%	100%
A4HAM4	Leishmania braziliensis	46%	100%
A4HAR1	Leishmania braziliensis	46%	100%
A4HAZ8	Leishmania braziliensis	45%	100%
A4HB00	Leishmania braziliensis	47%	100%
A4HB02	Leishmania braziliensis	51%	100%
A4HB47	Leishmania braziliensis	33%	100%
A4HBJ0	Leishmania braziliensis	45%	100%
A4HBJ1	Leishmania braziliensis	46%	100%
A4HBJ2	Leishmania braziliensis	47%	100%
A4HDI3	Leishmania braziliensis	33%	100%
A4HDI4	Leishmania braziliensis	28%	100%
A4HDL3	Leishmania braziliensis	29%	100%
A4HDL4	Leishmania braziliensis	28%	100%
A4HTM3	Leishmania infantum	43%	100%
A4HTM4	Leishmania infantum	44%	100%
A4HTM5	Leishmania infantum	44%	100%
A4I0W5	Leishmania infantum	27%	100%
A4I0W6	Leishmania infantum	23%	67%
A4I4J2	Leishmania infantum	44%	100%
A4I4J3	Leishmania infantum	48%	77%
A4I5B9	Leishmania infantum	27%	90%
A4I6E5	Leishmania infantum	39%	100%
A4I9Q4	Leishmania infantum	44%	100%
A4I9R4	Leishmania infantum	32%	100%
A4I9R5	Leishmania infantum	29%	100%
A4I9R7	Leishmania infantum	49%	100%
A4I9W8	Leishmania infantum	47%	100%
A4I9X0	Leishmania infantum	46%	100%
A4IA59	Leishmania infantum	42%	100%
A4IAL7	Leishmania infantum	42%	100%
A4IAM1	Leishmania infantum	45%	100%
A4IAM2	Leishmania infantum	47%	100%
C6K3X9	Leptomonas seymouri	25%	100%
E8NHC3	Leishmania infantum	42%	100%
E8NHD3	Leishmania infantum	45%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AG81	Leishmania infantum	40%	100%
E9AG82	Leishmania infantum	40%	100%
E9AG83	Leishmania infantum	45%	100%
E9AG85	Leishmania infantum	40%	100%
E9AHI9	Leishmania infantum	45%	100%
E9AHT2	Leishmania infantum	51%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4Q1U9	Leishmania major	56%	100%
Q4Q305	Leishmania major	50%	100%
Q4Q309	Leishmania major	57%	100%
Q4Q313	Leishmania major	50%	100%
Q4Q317	Leishmania major	48%	100%
Q4Q325	Leishmania major	48%	100%
Q4Q327	Leishmania major	56%	100%
Q4Q329	Leishmania major	48%	100%
Q4Q333	Leishmania major	52%	100%
Q4Q335	Leishmania major	51%	100%
Q4Q337	Leishmania major	56%	100%
Q4Q339	Leishmania major	50%	100%
Q4Q341	Leishmania major	52%	100%
Q4Q397	Leishmania major	54%	76%
Q4Q3A7	Leishmania major	34%	100%
Q4Q3A8	Leishmania major	30%	100%
Q4Q3A9	Leishmania major	53%	100%
Q4Q3F7	Leishmania major	54%	100%
Q4Q6L8	Leishmania major	39%	100%
Q4Q7L6	Leishmania major	27%	90%
Q4QAK4	Leishmania major	24%	100%
Q4QAK5	Leishmania major	27%	100%
Q4QAK6	Leishmania major	28%	100%
Q4QAK7	Leishmania major	26%	100%
Q4QI84	Leishmania major	46%	100%
Q4QI85	Leishmania major	46%	100%
Q4QI86	Leishmania major	46%	100%
Q4QI87	Leishmania major	44%	100%
Q4QI88	Leishmania major	44%	100%
Q4QI92	Leishmania major	41%	100%
Q4QI93	Leishmania major	41%	100%
Q4QI95	Leishmania major	41%	100%
Q4QI97	Leishmania major	41%	100%
Q4QIA0	Leishmania major	40%	100%
Q4QIA1	Leishmania major	40%	100%