LeishMANIAdb
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D-isomer specific 2-hydroxyacid dehydrogenase-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
D-isomer specific 2-hydroxyacid dehydrogenase-protein
Gene product:
D-isomer specific 2-hydroxyacid dehydrogenase (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S5H7W5_LEIDO
TriTrypDb:
LdBPK_044360.1 , LdCL_340021200 , LdCL_340021300 , LDHU3_34.2320
Length:
335

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7W5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7W5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0005488 binding 1 17
GO:0036094 small molecule binding 2 17
GO:0051287 NAD binding 4 17
GO:0097159 organic cyclic compound binding 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 284 288 PF00656 0.418
CLV_NRD_NRD_1 151 153 PF00675 0.288
CLV_NRD_NRD_1 182 184 PF00675 0.284
CLV_NRD_NRD_1 223 225 PF00675 0.235
CLV_NRD_NRD_1 75 77 PF00675 0.317
CLV_PCSK_KEX2_1 151 153 PF00082 0.374
CLV_PCSK_KEX2_1 182 184 PF00082 0.239
CLV_PCSK_KEX2_1 223 225 PF00082 0.307
CLV_PCSK_KEX2_1 75 77 PF00082 0.317
CLV_PCSK_SKI1_1 223 227 PF00082 0.242
CLV_PCSK_SKI1_1 228 232 PF00082 0.232
CLV_PCSK_SKI1_1 289 293 PF00082 0.237
CLV_PCSK_SKI1_1 306 310 PF00082 0.526
CLV_PCSK_SKI1_1 75 79 PF00082 0.395
DEG_APCC_DBOX_1 151 159 PF00400 0.401
DOC_MAPK_gen_1 151 158 PF00069 0.463
DOC_MAPK_gen_1 187 196 PF00069 0.492
DOC_MAPK_gen_1 233 241 PF00069 0.488
DOC_MAPK_MEF2A_6 235 243 PF00069 0.411
DOC_PP2B_PxIxI_1 2 8 PF00149 0.383
DOC_USP7_MATH_1 144 148 PF00917 0.475
DOC_USP7_UBL2_3 137 141 PF12436 0.498
DOC_USP7_UBL2_3 187 191 PF12436 0.475
DOC_WW_Pin1_4 277 282 PF00397 0.428
LIG_14-3-3_CanoR_1 245 250 PF00244 0.440
LIG_AP2alpha_1 311 315 PF02296 0.286
LIG_AP2alpha_2 143 145 PF02296 0.407
LIG_APCC_ABBA_1 308 313 PF00400 0.297
LIG_BIR_II_1 1 5 PF00653 0.388
LIG_BRCT_BRCA1_1 236 240 PF00533 0.484
LIG_deltaCOP1_diTrp_1 139 145 PF00928 0.453
LIG_FHA_1 2 8 PF00498 0.364
LIG_FHA_1 298 304 PF00498 0.435
LIG_FHA_1 305 311 PF00498 0.402
LIG_LIR_Apic_2 280 286 PF02991 0.521
LIG_LIR_Gen_1 117 126 PF02991 0.394
LIG_LIR_Gen_1 143 150 PF02991 0.431
LIG_LIR_Gen_1 237 247 PF02991 0.449
LIG_LIR_Gen_1 38 45 PF02991 0.530
LIG_LIR_Gen_1 48 59 PF02991 0.313
LIG_LIR_Nem_3 117 121 PF02991 0.405
LIG_LIR_Nem_3 139 145 PF02991 0.483
LIG_LIR_Nem_3 237 243 PF02991 0.432
LIG_LIR_Nem_3 312 318 PF02991 0.431
LIG_LIR_Nem_3 38 43 PF02991 0.417
LIG_LIR_Nem_3 48 54 PF02991 0.358
LIG_Pex14_2 226 230 PF04695 0.475
LIG_Pex14_2 311 315 PF04695 0.473
LIG_REV1ctd_RIR_1 223 232 PF16727 0.453
LIG_SH2_CRK 160 164 PF00017 0.497
LIG_SH2_GRB2like 125 128 PF00017 0.317
LIG_SH2_STAP1 81 85 PF00017 0.416
LIG_SH2_STAT5 118 121 PF00017 0.339
LIG_SH2_STAT5 125 128 PF00017 0.238
LIG_TYR_ITIM 158 163 PF00017 0.432
LIG_UBA3_1 254 260 PF00899 0.475
MOD_CK1_1 293 299 PF00069 0.518
MOD_CK1_1 325 331 PF00069 0.514
MOD_CK2_1 133 139 PF00069 0.430
MOD_CK2_1 143 149 PF00069 0.436
MOD_CK2_1 202 208 PF00069 0.498
MOD_CK2_1 245 251 PF00069 0.433
MOD_GlcNHglycan 183 186 PF01048 0.249
MOD_GlcNHglycan 236 239 PF01048 0.238
MOD_GlcNHglycan 28 31 PF01048 0.501
MOD_GlcNHglycan 292 295 PF01048 0.262
MOD_GlcNHglycan 324 327 PF01048 0.493
MOD_GlcNHglycan 54 57 PF01048 0.429
MOD_GlcNHglycan 83 86 PF01048 0.334
MOD_GlcNHglycan 99 102 PF01048 0.420
MOD_GSK3_1 293 300 PF00069 0.465
MOD_GSK3_1 316 323 PF00069 0.463
MOD_GSK3_1 35 42 PF00069 0.429
MOD_N-GLC_1 297 302 PF02516 0.505
MOD_NEK2_1 133 138 PF00069 0.487
MOD_NEK2_1 176 181 PF00069 0.434
MOD_NEK2_1 202 207 PF00069 0.537
MOD_NEK2_1 211 216 PF00069 0.491
MOD_NEK2_1 290 295 PF00069 0.493
MOD_NEK2_1 52 57 PF00069 0.402
MOD_NEK2_1 79 84 PF00069 0.446
MOD_NEK2_2 39 44 PF00069 0.466
MOD_OFUCOSY 33 39 PF10250 0.391
MOD_PK_1 245 251 PF00069 0.577
MOD_PKA_1 259 265 PF00069 0.424
MOD_PKA_2 181 187 PF00069 0.484
MOD_PKA_2 26 32 PF00069 0.394
MOD_Plk_1 202 208 PF00069 0.498
MOD_Plk_1 304 310 PF00069 0.474
MOD_Plk_1 35 41 PF00069 0.512
MOD_Plk_4 211 217 PF00069 0.533
MOD_ProDKin_1 277 283 PF00069 0.428
MOD_SUMO_rev_2 184 189 PF00179 0.498
MOD_SUMO_rev_2 284 291 PF00179 0.458
TRG_ENDOCYTIC_2 118 121 PF00928 0.387
TRG_ENDOCYTIC_2 160 163 PF00928 0.434
TRG_ER_diArg_1 150 152 PF00400 0.499
TRG_ER_diArg_1 181 183 PF00400 0.484
TRG_ER_diArg_1 223 225 PF00400 0.435
TRG_ER_diArg_1 75 77 PF00400 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBM0 Leptomonas seymouri 57% 99%
A0A0S4JA38 Bodo saltans 46% 100%
A0A1X0PAE4 Trypanosomatidae 48% 93%
A0A1X0PAT7 Trypanosomatidae 49% 97%
A0A2Z4HPZ6 Hormonema carpetanum 28% 84%
A0A381MVV1 Leishmania infantum 99% 100%
A0A3Q8IN76 Leishmania donovani 100% 100%
A0A3S7X7S4 Leishmania donovani 94% 100%
A0A422MS54 Trypanosoma rangeli 50% 100%
A1A9T1 Escherichia coli O1:K1 / APEC 28% 100%
A1JRR3 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 28% 100%
A1RYE4 Thermofilum pendens (strain DSM 2475 / Hrk 5) 28% 99%
A4H7T3 Leishmania braziliensis 76% 100%
A4TGN1 Yersinia pestis (strain Pestoides F) 33% 100%
A4W948 Enterobacter sp. (strain 638) 28% 100%
A5WHK7 Psychrobacter sp. (strain PRwf-1) 30% 90%
A6T7B8 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 27% 100%
A7FPA2 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 33% 100%
A7MFZ8 Cronobacter sakazakii (strain ATCC BAA-894) 27% 100%
A7ZYY6 Escherichia coli O9:H4 (strain HS) 28% 100%
A8AI49 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 28% 100%
A8GD46 Serratia proteamaculans (strain 568) 28% 100%
A8GH44 Serratia proteamaculans (strain 568) 28% 90%
A9MH27 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 30% 100%
A9N5T3 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 30% 100%
A9R4G6 Yersinia pestis bv. Antiqua (strain Angola) 33% 100%
B1IV68 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 28% 100%
B1JH01 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 32% 100%
B1L765 Korarchaeum cryptofilum (strain OPF8) 27% 100%
B1LIY1 Escherichia coli (strain SMS-3-5 / SECEC) 28% 100%
B1X9E7 Escherichia coli (strain K12 / DH10B) 28% 100%
B2K7F1 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 33% 100%
B2TTN6 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 28% 100%
B2VCD1 Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99) 31% 100%
B4T2W6 Salmonella newport (strain SL254) 30% 100%
B4TEQ6 Salmonella heidelberg (strain SL476) 30% 100%
B4TSP5 Salmonella schwarzengrund (strain CVM19633) 30% 100%
B5BBF3 Salmonella paratyphi A (strain AKU_12601) 30% 100%
B5F974 Salmonella agona (strain SL483) 30% 100%
B5FL30 Salmonella dublin (strain CT_02021853) 29% 100%
B5QY30 Salmonella enteritidis PT4 (strain P125109) 30% 100%
B5RBG3 Salmonella gallinarum (strain 287/91 / NCTC 13346) 30% 100%
B5XXL3 Klebsiella pneumoniae (strain 342) 27% 100%
B5YVQ3 Escherichia coli O157:H7 (strain EC4115 / EHEC) 28% 100%
B6I9A9 Escherichia coli (strain SE11) 28% 100%
B7LFE3 Escherichia coli (strain 55989 / EAEC) 28% 100%
B7LTA2 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 29% 100%
B7M907 Escherichia coli O8 (strain IAI1) 28% 100%
B7MIH3 Escherichia coli O45:K1 (strain S88 / ExPEC) 28% 100%
B7MTG4 Escherichia coli O81 (strain ED1a) 28% 100%
B7N3I0 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 28% 100%
B7NLA1 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 28% 100%
B7UP47 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 28% 100%
C0Q872 Salmonella paratyphi C (strain RKS4594) 30% 100%
C4ZRX4 Escherichia coli (strain K12 / MC4100 / BW2952) 28% 100%
C6DJ88 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 34% 100%
D2RJU7 Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) 23% 100%
E9B4W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B4W6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
G9EZR6 Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) 25% 100%
J7SHB8 Clostridium sporogenes (strain ATCC 15579) 25% 100%
O13437 Candida boidinii 23% 92%
O32264 Bacillus subtilis (strain 168) 29% 100%
O34815 Bacillus subtilis (strain 168) 25% 97%
O83080 Treponema pallidum (strain Nichols) 26% 100%
P0C1E8 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) 30% 100%
P0C1E9 Corynebacterium melassecola 29% 100%
P17584 Lacticaseibacillus paracasei 24% 100%
P26297 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) 24% 100%
P26298 Lactiplantibacillus pentosus 26% 100%
P30901 Lactobacillus helveticus 24% 99%
P36234 Hyphomicrobium methylovorum 25% 100%
P43169 Streptomyces coelicolor 29% 100%
P51011 Leuconostoc mesenteroides subsp. cremoris 27% 100%
P63940 Staphylococcus aureus (strain Mu50 / ATCC 700699) 26% 100%
P72357 Staphylococcus aureus 27% 100%
P75913 Escherichia coli (strain K12) 28% 100%
P99116 Staphylococcus aureus (strain N315) 26% 100%
Q03134 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 28% 92%
Q0TJ41 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 28% 100%
Q0W9V5 Yersinia pestis 33% 100%
Q1C3K4 Yersinia pestis bv. Antiqua (strain Antiqua) 33% 100%
Q1CD80 Yersinia pestis bv. Antiqua (strain Nepal516) 33% 100%
Q1QE21 Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5) 25% 87%
Q1QWN6 Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) 27% 100%
Q1RDC8 Escherichia coli (strain UTI89 / UPEC) 28% 100%
Q2FEI9 Staphylococcus aureus (strain USA300) 28% 100%
Q2FVW4 Staphylococcus aureus (strain NCTC 8325 / PS 47) 28% 100%
Q2VEQ7 Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) 32% 100%
Q2YYT9 Staphylococcus aureus (strain bovine RF122 / ET3-1) 28% 100%
Q31Z89 Shigella boydii serotype 4 (strain Sb227) 28% 100%
Q32HN5 Shigella dysenteriae serotype 1 (strain Sd197) 28% 100%
Q3IF36 Pseudoalteromonas translucida (strain TAC 125) 25% 90%
Q3Z393 Shigella sonnei (strain Ss046) 28% 100%
Q49ZM5 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 31% 100%
Q4FV16 Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) 27% 89%
Q4Q361 Leishmania major 92% 100%
Q4Q362 Leishmania major 84% 100%
Q54UH8 Dictyostelium discoideum 26% 82%
Q57QM2 Salmonella choleraesuis (strain SC-B67) 30% 100%
Q59516 Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) 30% 100%
Q59642 Pediococcus acidilactici 23% 100%
Q5FTU6 Gluconobacter oxydans (strain 621H) 25% 100%
Q5HD29 Staphylococcus aureus (strain COL) 27% 100%
Q5HDQ4 Staphylococcus aureus (strain COL) 28% 100%
Q5HLA0 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 26% 100%
Q5PGZ3 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 30% 100%
Q663W4 Yersinia pseudotuberculosis serotype I (strain IP32953) 33% 100%
Q6DB24 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 34% 100%
Q6F943 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 29% 94%
Q6G6F1 Staphylococcus aureus (strain MSSA476) 27% 100%
Q6G716 Staphylococcus aureus (strain MSSA476) 28% 100%
Q6GDS2 Staphylococcus aureus (strain MRSA252) 26% 100%
Q6GEC9 Staphylococcus aureus (strain MRSA252) 28% 100%
Q7N571 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 27% 100%
Q88VJ2 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 26% 100%
Q8CN22 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 26% 100%
Q8E0N5 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) 27% 100%
Q8E6A9 Streptococcus agalactiae serotype III (strain NEM316) 27% 100%
Q8FIT1 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 28% 100%
Q8NUT2 Staphylococcus aureus (strain MW2) 27% 100%
Q8NV80 Staphylococcus aureus (strain MW2) 28% 100%
Q8U3Y2 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 28% 100%
Q8X9K1 Escherichia coli O157:H7 28% 100%
Q8Z7M6 Salmonella typhi 30% 100%
Q8ZQ30 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 30% 100%
Q91Z53 Mus musculus 32% 100%
Q99ZM2 Streptococcus pyogenes serotype M1 25% 100%
Q9C4M5 Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) 27% 100%
Q9CA90 Arabidopsis thaliana 26% 100%
Q9LE33 Arabidopsis thaliana 25% 100%
Q9UBQ7 Homo sapiens 32% 100%
Q9W758 Xenopus laevis 25% 77%
Q9YAW4 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 29% 100%
Q9YHU0 Xenopus laevis 25% 76%
V5B3E2 Trypanosoma cruzi 50% 100%
V5BIV9 Trypanosoma cruzi 44% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS