LeishMANIAdb
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Elongation_factor_1-beta/GeneDB:LmjF.34.0820

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation_factor_1-beta/GeneDB:LmjF.34.0820
Gene product:
elongation factor 1-beta
Species:
Leishmania donovani
UniProt:
A0A3S5H7W1_LEIDO
TriTrypDb:
LdBPK_340870.1 , LdCL_340014200 , LdCL_340014400 , LDHU3_34.1380 , LDHU3_34.1410
Length:
239

Annotations

Annotations by Jardim et al.

Translation, Elongation factor 1-beta eEF1B beta 2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 22
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005853 eukaryotic translation elongation factor 1 complex 2 24
GO:0032991 protein-containing complex 1 24
GO:0005829 cytosol 2 2
GO:0110165 cellular anatomical entity 1 2
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3S5H7W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7W1

Function

Biological processes
Term Name Level Count
GO:0006414 translational elongation 5 2
GO:0008152 metabolic process 1 2
GO:0009058 biosynthetic process 2 2
GO:0009059 macromolecule biosynthetic process 4 2
GO:0009987 cellular process 1 2
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0044237 cellular metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:1901576 organic substance biosynthetic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 24
GO:0003746 translation elongation factor activity 4 24
GO:0005488 binding 1 24
GO:0008135 translation factor activity, RNA binding 3 24
GO:0045182 translation regulator activity 1 24
GO:0090079 translation regulator activity, nucleic acid binding 2 24
GO:0097159 organic cyclic compound binding 2 24
GO:1901363 heterocyclic compound binding 2 24
GO:0005085 guanyl-nucleotide exchange factor activity 3 2
GO:0030234 enzyme regulator activity 2 2
GO:0030695 GTPase regulator activity 4 2
GO:0060589 nucleoside-triphosphatase regulator activity 3 2
GO:0098772 molecular function regulator activity 1 2
GO:0140677 molecular function activator activity 2 2
GO:0140678 molecular function inhibitor activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 61 63 PF00675 0.597
CLV_PCSK_KEX2_1 95 97 PF00082 0.632
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.632
CLV_PCSK_SKI1_1 130 134 PF00082 0.674
CLV_PCSK_SKI1_1 136 140 PF00082 0.661
CLV_PCSK_SKI1_1 144 148 PF00082 0.595
CLV_PCSK_SKI1_1 20 24 PF00082 0.549
CLV_PCSK_SKI1_1 49 53 PF00082 0.548
DOC_CYCLIN_yCln2_LP_2 76 82 PF00134 0.701
DOC_MAPK_gen_1 199 207 PF00069 0.389
DOC_MAPK_MEF2A_6 70 78 PF00069 0.687
DOC_PP2B_LxvP_1 76 79 PF13499 0.701
DOC_USP7_MATH_1 152 156 PF00917 0.468
DOC_USP7_MATH_1 86 90 PF00917 0.682
DOC_USP7_UBL2_3 139 143 PF12436 0.639
DOC_USP7_UBL2_3 144 148 PF12436 0.602
DOC_USP7_UBL2_3 16 20 PF12436 0.491
DOC_USP7_UBL2_3 4 8 PF12436 0.561
LIG_APCC_ABBA_1 119 124 PF00400 0.643
LIG_APCC_ABBA_1 33 38 PF00400 0.529
LIG_BIR_II_1 1 5 PF00653 0.595
LIG_BRCT_BRCA1_1 154 158 PF00533 0.408
LIG_Clathr_ClatBox_1 204 208 PF01394 0.389
LIG_FHA_1 164 170 PF00498 0.383
LIG_FHA_2 123 129 PF00498 0.637
LIG_FHA_2 27 33 PF00498 0.597
LIG_FHA_2 54 60 PF00498 0.567
LIG_SH2_STAT5 57 60 PF00017 0.618
LIG_SH3_3 101 107 PF00018 0.756
LIG_SH3_3 68 74 PF00018 0.634
LIG_SUMO_SIM_par_1 164 170 PF11976 0.410
LIG_SUMO_SIM_par_1 203 210 PF11976 0.389
LIG_TRAF2_1 111 114 PF00917 0.789
LIG_TRAF2_1 125 128 PF00917 0.582
LIG_UBA3_1 156 161 PF00899 0.455
LIG_UBA3_1 204 211 PF00899 0.393
MOD_CK2_1 122 128 PF00069 0.661
MOD_CK2_1 53 59 PF00069 0.557
MOD_GlcNHglycan 107 110 PF01048 0.595
MOD_GlcNHglycan 212 215 PF01048 0.408
MOD_Plk_1 163 169 PF00069 0.403
MOD_Plk_2-3 227 233 PF00069 0.420
MOD_Plk_4 152 158 PF00069 0.389
MOD_SUMO_rev_2 12 17 PF00179 0.502
MOD_SUMO_rev_2 124 132 PF00179 0.688
MOD_SUMO_rev_2 140 146 PF00179 0.556
MOD_SUMO_rev_2 154 162 PF00179 0.357
MOD_SUMO_rev_2 182 192 PF00179 0.389
MOD_SUMO_rev_2 208 213 PF00179 0.389
MOD_SUMO_rev_2 31 36 PF00179 0.506
MOD_SUMO_rev_2 59 64 PF00179 0.620
TRG_DiLeu_BaEn_4 128 134 PF01217 0.644
TRG_NLS_MonoExtC_3 143 148 PF00514 0.667
TRG_NLS_MonoExtN_4 143 148 PF00514 0.744

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4W7 Leptomonas seymouri 61% 100%
A0A0N1HZF7 Leptomonas seymouri 78% 100%
A0A0S4JC29 Bodo saltans 56% 100%
A0A0S4JK70 Bodo saltans 68% 98%
A0A1X0P9D3 Trypanosomatidae 57% 100%
A0A1X0PA37 Trypanosomatidae 70% 100%
A0A3Q8IVV7 Leishmania donovani 64% 91%
A0A3R7MFZ8 Trypanosoma rangeli 56% 100%
A0A422N8N9 Trypanosoma rangeli 71% 100%
A4HAJ1 Leishmania braziliensis 81% 100%
A4HAJ3 Leishmania braziliensis 81% 100%
A4HAJ7 Leishmania braziliensis 81% 100%
A4HP03 Leishmania braziliensis 61% 90%
A4I9P1 Leishmania infantum 100% 100%
A4IDB2 Leishmania infantum 64% 91%
C9ZN03 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 71%
D0A2X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9ASR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 90%
E9B4Q3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B4Q5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
O70251 Mus musculus 40% 100%
O74173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
O96827 Drosophila melanogaster 37% 100%
P12262 Artemia salina 36% 100%
P24534 Homo sapiens 39% 100%
P29545 Oryza sativa subsp. japonica 36% 100%
P29546 Triticum aestivum 34% 100%
P30151 Xenopus laevis 41% 100%
P34460 Caenorhabditis elegans 38% 100%
P34826 Oryctolagus cuniculus 40% 100%
P34827 Trypanosoma cruzi 66% 100%
P57776 Mus musculus 46% 85%
P93447 Spuriopimpinella brachycarpa 37% 100%
Q40682 Oryza sativa subsp. japonica 36% 100%
Q4Q3C1 Leishmania major 95% 99%
Q5E983 Bos taurus 40% 100%
Q66NE2 Leishmania major 62% 89%
Q68FR9 Rattus norvegicus 45% 85%
Q69BZ7 Penicillium citrinum 31% 100%
Q6DET9 Xenopus tropicalis 36% 100%
Q84WM9 Arabidopsis thaliana 37% 100%
Q9GRF8 Dictyostelium discoideum 37% 100%
Q9SI20 Arabidopsis thaliana 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS