Flagellar attachment zone protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S5H7W0_LEIDO

TriTrypDb:

LdBPK_340700.1 , LdBPK_340710.1 , LdCL_340012650

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A0A3S5H7W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.398
CLV_C14_Caspase3-7	412	416	PF00656	0.592
CLV_NRD_NRD_1	122	124	PF00675	0.415
CLV_NRD_NRD_1	165	167	PF00675	0.384
CLV_NRD_NRD_1	93	95	PF00675	0.428
CLV_PCSK_FUR_1	397	401	PF00082	0.481
CLV_PCSK_FUR_1	533	537	PF00082	0.509
CLV_PCSK_KEX2_1	236	238	PF00082	0.463
CLV_PCSK_KEX2_1	306	308	PF00082	0.387
CLV_PCSK_KEX2_1	399	401	PF00082	0.490
CLV_PCSK_KEX2_1	535	537	PF00082	0.514
CLV_PCSK_KEX2_1	93	95	PF00082	0.428
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.463
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.387
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.490
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.514
CLV_PCSK_SKI1_1	123	127	PF00082	0.408
CLV_PCSK_SKI1_1	258	262	PF00082	0.379
CLV_PCSK_SKI1_1	307	311	PF00082	0.309
CLV_PCSK_SKI1_1	360	364	PF00082	0.407
CLV_PCSK_SKI1_1	38	42	PF00082	0.412
CLV_PCSK_SKI1_1	61	65	PF00082	0.408
CLV_PCSK_SKI1_1	752	756	PF00082	0.371
CLV_PCSK_SKI1_1	807	811	PF00082	0.435
DEG_APCC_DBOX_1	629	637	PF00400	0.376
DEG_APCC_DBOX_1	85	93	PF00400	0.397
DEG_APCC_KENBOX_2	745	749	PF00400	0.443
DEG_MDM2_SWIB_1	791	798	PF02201	0.474
DEG_Nend_Nbox_1	1	3	PF02207	0.514
DOC_MAPK_gen_1	109	116	PF00069	0.322
DOC_MAPK_gen_1	662	670	PF00069	0.433
DOC_MAPK_MEF2A_6	283	292	PF00069	0.504
DOC_PP1_RVXF_1	358	364	PF00149	0.327
DOC_USP7_MATH_1	425	429	PF00917	0.555
DOC_USP7_MATH_1	458	462	PF00917	0.558
DOC_USP7_MATH_1	542	546	PF00917	0.520
DOC_USP7_UBL2_3	109	113	PF12436	0.321
DOC_USP7_UBL2_3	199	203	PF12436	0.434
DOC_WW_Pin1_4	129	134	PF00397	0.409
DOC_WW_Pin1_4	206	211	PF00397	0.485
DOC_WW_Pin1_4	294	299	PF00397	0.379
DOC_WW_Pin1_4	427	432	PF00397	0.567
DOC_WW_Pin1_4	562	567	PF00397	0.564
LIG_14-3-3_CanoR_1	123	131	PF00244	0.417
LIG_14-3-3_CanoR_1	283	287	PF00244	0.406
LIG_14-3-3_CanoR_1	385	391	PF00244	0.444
LIG_14-3-3_CanoR_1	445	455	PF00244	0.539
LIG_14-3-3_CanoR_1	543	547	PF00244	0.530
LIG_14-3-3_CanoR_1	99	107	PF00244	0.336
LIG_Actin_WH2_2	110	125	PF00022	0.406
LIG_Actin_WH2_2	53	68	PF00022	0.341
LIG_BIR_III_4	415	419	PF00653	0.531
LIG_BIR_III_4	484	488	PF00653	0.408
LIG_CSK_EPIYA_1	470	474	PF00017	0.558
LIG_FHA_1	175	181	PF00498	0.310
LIG_FHA_1	269	275	PF00498	0.517
LIG_FHA_1	282	288	PF00498	0.328
LIG_FHA_1	347	353	PF00498	0.329
LIG_FHA_1	375	381	PF00498	0.360
LIG_FHA_1	42	48	PF00498	0.390
LIG_FHA_1	52	58	PF00498	0.392
LIG_FHA_1	578	584	PF00498	0.571
LIG_FHA_1	771	777	PF00498	0.539
LIG_FHA_1	782	788	PF00498	0.459
LIG_FHA_2	149	155	PF00498	0.393
LIG_FHA_2	309	315	PF00498	0.400
LIG_FHA_2	34	40	PF00498	0.366
LIG_FHA_2	353	359	PF00498	0.395
LIG_FHA_2	474	480	PF00498	0.513
LIG_FHA_2	595	601	PF00498	0.511
LIG_FHA_2	717	723	PF00498	0.358
LIG_Integrin_isoDGR_2	72	74	PF01839	0.401
LIG_LIR_Apic_2	164	168	PF02991	0.321
LIG_LIR_Gen_1	157	165	PF02991	0.380
LIG_LIR_Gen_1	42	47	PF02991	0.389
LIG_LIR_Gen_1	694	703	PF02991	0.440
LIG_LIR_Gen_1	767	776	PF02991	0.456
LIG_LIR_Gen_1	792	803	PF02991	0.434
LIG_LIR_Nem_3	157	161	PF02991	0.389
LIG_LIR_Nem_3	42	46	PF02991	0.399
LIG_LIR_Nem_3	658	664	PF02991	0.352
LIG_LIR_Nem_3	694	699	PF02991	0.445
LIG_LIR_Nem_3	767	771	PF02991	0.440
LIG_LIR_Nem_3	792	798	PF02991	0.443
LIG_LYPXL_SIV_4	224	232	PF13949	0.371
LIG_NRBOX	750	756	PF00104	0.371
LIG_PCNA_yPIPBox_3	746	755	PF02747	0.369
LIG_Pex14_2	791	795	PF04695	0.465
LIG_SH2_CRK	165	169	PF00017	0.409
LIG_SH2_CRK	21	25	PF00017	0.381
LIG_SH2_CRK	229	233	PF00017	0.408
LIG_SH2_CRK	43	47	PF00017	0.381
LIG_SH2_CRK	661	665	PF00017	0.362
LIG_SH2_SRC	23	26	PF00017	0.312
LIG_SH2_SRC	5	8	PF00017	0.484
LIG_SH2_STAP1	344	348	PF00017	0.410
LIG_SH2_STAP1	43	47	PF00017	0.381
LIG_SH2_STAP1	473	477	PF00017	0.530
LIG_SH2_STAP1	696	700	PF00017	0.446
LIG_SH2_STAT5	23	26	PF00017	0.312
LIG_SH2_STAT5	353	356	PF00017	0.326
LIG_SH2_STAT5	43	46	PF00017	0.282
LIG_SH2_STAT5	5	8	PF00017	0.484
LIG_SH2_STAT5	594	597	PF00017	0.448
LIG_SH3_3	285	291	PF00018	0.399
LIG_SH3_3	292	298	PF00018	0.354
LIG_SH3_3	579	585	PF00018	0.568
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.330
LIG_TRAF2_1	476	479	PF00917	0.421
LIG_TRAF2_1	597	600	PF00917	0.506
LIG_TYR_ITIM	19	24	PF00017	0.363
LIG_UBA3_1	81	88	PF00899	0.395
LIG_WRC_WIRS_1	278	283	PF05994	0.389
LIG_WRC_WIRS_1	768	773	PF05994	0.435
MOD_CDK_SPxxK_3	427	434	PF00069	0.557
MOD_CK1_1	186	192	PF00069	0.435
MOD_CK1_1	268	274	PF00069	0.603
MOD_CK1_1	423	429	PF00069	0.551
MOD_CK1_1	770	776	PF00069	0.454
MOD_CK2_1	148	154	PF00069	0.384
MOD_CK2_1	308	314	PF00069	0.399
MOD_CK2_1	33	39	PF00069	0.361
MOD_CK2_1	352	358	PF00069	0.394
MOD_CK2_1	386	392	PF00069	0.444
MOD_CK2_1	473	479	PF00069	0.521
MOD_CK2_1	594	600	PF00069	0.520
MOD_CK2_1	652	658	PF00069	0.428
MOD_CK2_1	716	722	PF00069	0.356
MOD_GlcNHglycan	185	188	PF01048	0.425
MOD_GlcNHglycan	292	295	PF01048	0.394
MOD_GlcNHglycan	369	372	PF01048	0.405
MOD_GlcNHglycan	422	425	PF01048	0.542
MOD_GlcNHglycan	440	443	PF01048	0.534
MOD_GlcNHglycan	558	561	PF01048	0.523
MOD_GSK3_1	186	193	PF00069	0.470
MOD_GSK3_1	26	33	PF00069	0.413
MOD_GSK3_1	264	271	PF00069	0.460
MOD_GSK3_1	277	284	PF00069	0.289
MOD_GSK3_1	286	293	PF00069	0.350
MOD_GSK3_1	419	426	PF00069	0.545
MOD_GSK3_1	781	788	PF00069	0.507
MOD_GSK3_1	88	95	PF00069	0.406
MOD_N-GLC_2	816	818	PF02516	0.462
MOD_NEK2_1	281	286	PF00069	0.610
MOD_NEK2_1	333	338	PF00069	0.430
MOD_NEK2_1	386	391	PF00069	0.442
MOD_PIKK_1	446	452	PF00454	0.620
MOD_PK_1	88	94	PF00069	0.403
MOD_PKA_1	123	129	PF00069	0.417
MOD_PKA_2	282	288	PF00069	0.398
MOD_PKA_2	444	450	PF00069	0.546
MOD_PKA_2	542	548	PF00069	0.530
MOD_PKA_2	785	791	PF00069	0.496
MOD_PKA_2	92	98	PF00069	0.417
MOD_Plk_1	41	47	PF00069	0.395
MOD_Plk_1	793	799	PF00069	0.383
MOD_Plk_2-3	652	658	PF00069	0.348
MOD_Plk_4	282	288	PF00069	0.603
MOD_Plk_4	767	773	PF00069	0.432
MOD_ProDKin_1	129	135	PF00069	0.399
MOD_ProDKin_1	206	212	PF00069	0.475
MOD_ProDKin_1	294	300	PF00069	0.389
MOD_ProDKin_1	427	433	PF00069	0.567
MOD_ProDKin_1	562	568	PF00069	0.565
MOD_SUMO_for_1	262	265	PF00179	0.407
MOD_SUMO_for_1	524	527	PF00179	0.485
MOD_SUMO_for_1	641	644	PF00179	0.353
MOD_SUMO_rev_2	193	200	PF00179	0.355
MOD_SUMO_rev_2	316	325	PF00179	0.411
MOD_SUMO_rev_2	478	482	PF00179	0.497
MOD_SUMO_rev_2	507	514	PF00179	0.461
TRG_DiLeu_BaEn_1	112	117	PF01217	0.322
TRG_DiLeu_BaEn_1	695	700	PF01217	0.444
TRG_DiLeu_BaEn_1	705	710	PF01217	0.379
TRG_ENDOCYTIC_2	21	24	PF00928	0.372
TRG_ENDOCYTIC_2	229	232	PF00928	0.402
TRG_ENDOCYTIC_2	43	46	PF00928	0.389
TRG_ENDOCYTIC_2	459	462	PF00928	0.499
TRG_ENDOCYTIC_2	661	664	PF00928	0.364
TRG_ENDOCYTIC_2	696	699	PF00928	0.447
TRG_ENDOCYTIC_2	768	771	PF00928	0.431
TRG_ENDOCYTIC_2	78	81	PF00928	0.411
TRG_ER_diArg_1	799	802	PF00400	0.455
TRG_ER_diArg_1	92	94	PF00400	0.413
TRG_NES_CRM1_1	495	510	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	752	756	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HAH8	Leishmania braziliensis	75%	99%