Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7V8_LEIDO

TriTrypDb:

LdBPK_340420.1 , LdCL_340009300 , LDHU3_34.0590

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S5H7V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7V8

PDB structure(s): 7ane_b

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	8
GO:0006518	peptide metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009059	macromolecule biosynthetic process	4	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	8
GO:0043043	peptide biosynthetic process	5	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003735	structural constituent of ribosome	2	8
GO:0005198	structural molecule activity	1	8
GO:0005488	binding	1	8
GO:0019843	rRNA binding	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.466
CLV_NRD_NRD_1	36	38	PF00675	0.446
CLV_PCSK_SKI1_1	63	67	PF00082	0.431
DOC_MAPK_gen_1	81	91	PF00069	0.443
DOC_MAPK_MEF2A_6	63	71	PF00069	0.386
DOC_MAPK_MEF2A_6	84	93	PF00069	0.436
DOC_PP1_SILK_1	42	47	PF00149	0.542
DOC_USP7_MATH_1	131	135	PF00917	0.453
LIG_14-3-3_CanoR_1	15	25	PF00244	0.440
LIG_14-3-3_CanoR_1	63	68	PF00244	0.416
LIG_deltaCOP1_diTrp_1	142	148	PF00928	0.449
LIG_eIF4E_1	30	36	PF01652	0.440
LIG_FHA_1	64	70	PF00498	0.427
LIG_FHA_1	90	96	PF00498	0.513
LIG_FHA_2	119	125	PF00498	0.440
LIG_LIR_Gen_1	118	127	PF02991	0.447
LIG_LIR_Gen_1	136	143	PF02991	0.449
LIG_LIR_Nem_3	118	123	PF02991	0.465
LIG_LIR_Nem_3	136	141	PF02991	0.446
LIG_LIR_Nem_3	142	148	PF02991	0.449
LIG_LIR_Nem_3	151	156	PF02991	0.445
LIG_LIR_Nem_3	60	64	PF02991	0.407
LIG_SH2_CRK	4	8	PF00017	0.383
LIG_SH2_PTP2	64	67	PF00017	0.429
LIG_SH2_STAP1	17	21	PF00017	0.562
LIG_SH2_STAP1	4	8	PF00017	0.363
LIG_SH2_STAP1	61	65	PF00017	0.396
LIG_SH2_STAT3	17	20	PF00017	0.537
LIG_SH2_STAT5	114	117	PF00017	0.478
LIG_SH2_STAT5	156	159	PF00017	0.553
LIG_SH2_STAT5	17	20	PF00017	0.537
LIG_SH2_STAT5	64	67	PF00017	0.405
LIG_SH3_3	6	12	PF00018	0.378
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.411
LIG_TYR_ITIM	2	7	PF00017	0.404
LIG_WRC_WIRS_1	117	122	PF05994	0.438
MOD_CK2_1	118	124	PF00069	0.441
MOD_GlcNHglycan	133	136	PF01048	0.452
MOD_N-GLC_1	89	94	PF02516	0.560
MOD_NEK2_1	148	153	PF00069	0.435
MOD_PIKK_1	16	22	PF00454	0.464
MOD_PKA_1	15	21	PF00069	0.450
MOD_PKA_1	37	43	PF00069	0.456
MOD_PKA_2	151	157	PF00069	0.440
MOD_PKA_2	99	105	PF00069	0.634
MOD_PKB_1	13	21	PF00069	0.431
MOD_Plk_1	54	60	PF00069	0.544
MOD_Plk_1	89	95	PF00069	0.569
MOD_Plk_4	2	8	PF00069	0.423
TRG_ENDOCYTIC_2	114	117	PF00928	0.478
TRG_ENDOCYTIC_2	138	141	PF00928	0.446
TRG_ENDOCYTIC_2	4	7	PF00928	0.366
TRG_ENDOCYTIC_2	48	51	PF00928	0.457
TRG_ENDOCYTIC_2	64	67	PF00928	0.386
TRG_ER_diArg_1	12	15	PF00400	0.437
TRG_ER_diArg_1	150	153	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A8	Leptomonas seymouri	91%	100%
A0A0S4KFM8	Bodo saltans	62%	100%
A0A1X0P9F3	Trypanosomatidae	74%	99%
A0A3R7MKN1	Trypanosoma rangeli	79%	100%
A4HAF4	Leishmania braziliensis	95%	100%
A4I9L0	Leishmania infantum	99%	100%
D0A1X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	99%
E9B4K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q3G8	Leishmania major	99%	100%