Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7V7_LEIDO

TriTrypDb:

LdBPK_340270.1 , LdCL_340007800 , LDHU3_34.0410

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.655
CLV_C14_Caspase3-7	308	312	PF00656	0.716
CLV_NRD_NRD_1	137	139	PF00675	0.568
CLV_NRD_NRD_1	173	175	PF00675	0.457
CLV_NRD_NRD_1	301	303	PF00675	0.729
CLV_NRD_NRD_1	366	368	PF00675	0.584
CLV_NRD_NRD_1	38	40	PF00675	0.782
CLV_PCSK_KEX2_1	141	143	PF00082	0.593
CLV_PCSK_KEX2_1	173	175	PF00082	0.494
CLV_PCSK_KEX2_1	211	213	PF00082	0.694
CLV_PCSK_KEX2_1	301	303	PF00082	0.713
CLV_PCSK_KEX2_1	316	318	PF00082	0.471
CLV_PCSK_KEX2_1	366	368	PF00082	0.565
CLV_PCSK_KEX2_1	38	40	PF00082	0.762
CLV_PCSK_KEX2_1	54	56	PF00082	0.454
CLV_PCSK_KEX2_1	72	74	PF00082	0.547
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.580
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.694
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.662
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.559
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.547
CLV_PCSK_SKI1_1	138	142	PF00082	0.618
CLV_PCSK_SKI1_1	81	85	PF00082	0.719
CLV_Separin_Metazoa	150	154	PF03568	0.553
DEG_SPOP_SBC_1	125	129	PF00917	0.578
DOC_CKS1_1	101	106	PF01111	0.700
DOC_CKS1_1	108	113	PF01111	0.734
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.638
DOC_USP7_MATH_1	231	235	PF00917	0.521
DOC_USP7_MATH_1	249	253	PF00917	0.580
DOC_USP7_MATH_1	324	328	PF00917	0.687
DOC_USP7_MATH_2	2	8	PF00917	0.765
DOC_WW_Pin1_4	10	15	PF00397	0.704
DOC_WW_Pin1_4	100	105	PF00397	0.662
DOC_WW_Pin1_4	107	112	PF00397	0.656
DOC_WW_Pin1_4	197	202	PF00397	0.647
DOC_WW_Pin1_4	244	249	PF00397	0.730
DOC_WW_Pin1_4	276	281	PF00397	0.670
LIG_14-3-3_CanoR_1	15	24	PF00244	0.747
LIG_14-3-3_CanoR_1	242	248	PF00244	0.734
LIG_14-3-3_CanoR_1	325	333	PF00244	0.636
LIG_14-3-3_CanoR_1	349	356	PF00244	0.559
LIG_BRCT_BRCA1_1	126	130	PF00533	0.532
LIG_Clathr_ClatBox_1	295	299	PF01394	0.744
LIG_CtBP_PxDLS_1	345	349	PF00389	0.620
LIG_eIF4E_1	290	296	PF01652	0.743
LIG_EVH1_1	277	281	PF00568	0.595
LIG_FHA_1	198	204	PF00498	0.735
LIG_FHA_1	231	237	PF00498	0.656
LIG_FHA_1	267	273	PF00498	0.561
LIG_LIR_Apic_2	99	104	PF02991	0.665
LIG_LIR_Gen_1	161	168	PF02991	0.576
LIG_LIR_Nem_3	161	165	PF02991	0.544
LIG_LIR_Nem_3	99	105	PF02991	0.666
LIG_RPA_C_Fungi	314	326	PF08784	0.605
LIG_SH2_CRK	102	106	PF00017	0.702
LIG_SH2_CRK	162	166	PF00017	0.581
LIG_SH2_CRK	290	294	PF00017	0.702
LIG_SH2_NCK_1	162	166	PF00017	0.572
LIG_SH2_NCK_1	290	294	PF00017	0.743
LIG_SH2_SRC	180	183	PF00017	0.669
LIG_SH2_STAP1	147	151	PF00017	0.566
LIG_SH2_STAP1	267	271	PF00017	0.775
LIG_SH2_STAT5	102	105	PF00017	0.739
LIG_SH2_STAT5	96	99	PF00017	0.659
LIG_SH3_2	111	116	PF14604	0.691
LIG_SH3_3	108	114	PF00018	0.685
LIG_SH3_3	275	281	PF00018	0.603
LIG_SH3_3	340	346	PF00018	0.596
LIG_SH3_3	82	88	PF00018	0.690
LIG_SH3_CIN85_PxpxPR_1	111	116	PF14604	0.779
LIG_SH3_CIN85_PxpxPR_1	339	344	PF14604	0.654
LIG_TRAF2_1	176	179	PF00917	0.581
LIG_TRAF2_1	326	329	PF00917	0.755
LIG_WW_3	113	117	PF00397	0.727
LIG_WW_3	222	226	PF00397	0.706
MOD_CDK_SPK_2	10	15	PF00069	0.655
MOD_CDK_SPxxK_3	100	107	PF00069	0.700
MOD_CDK_SPxxK_3	109	116	PF00069	0.737
MOD_CK1_1	163	169	PF00069	0.601
MOD_CK1_1	376	382	PF00069	0.684
MOD_CK2_1	244	250	PF00069	0.680
MOD_Cter_Amidation	36	39	PF01082	0.662
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.678
MOD_GlcNHglycan	272	275	PF01048	0.777
MOD_GlcNHglycan	29	32	PF01048	0.790
MOD_GlcNHglycan	321	324	PF01048	0.618
MOD_GlcNHglycan	6	9	PF01048	0.734
MOD_GSK3_1	10	17	PF00069	0.638
MOD_GSK3_1	160	167	PF00069	0.626
MOD_GSK3_1	244	251	PF00069	0.783
MOD_GSK3_1	266	273	PF00069	0.710
MOD_GSK3_1	373	380	PF00069	0.586
MOD_GSK3_1	77	84	PF00069	0.686
MOD_GSK3_1	96	103	PF00069	0.635
MOD_N-GLC_1	47	52	PF02516	0.629
MOD_NEK2_2	249	254	PF00069	0.726
MOD_PIKK_1	15	21	PF00454	0.554
MOD_PIKK_1	225	231	PF00454	0.671
MOD_PIKK_1	324	330	PF00454	0.714
MOD_PKA_2	115	121	PF00069	0.770
MOD_PKA_2	14	20	PF00069	0.704
MOD_PKA_2	243	249	PF00069	0.695
MOD_PKA_2	324	330	PF00069	0.716
MOD_PKA_2	365	371	PF00069	0.586
MOD_PKB_1	317	325	PF00069	0.684
MOD_Plk_1	160	166	PF00069	0.572
MOD_Plk_1	249	255	PF00069	0.730
MOD_Plk_1	267	273	PF00069	0.706
MOD_Plk_4	160	166	PF00069	0.546
MOD_Plk_4	291	297	PF00069	0.743
MOD_Plk_4	96	102	PF00069	0.720
MOD_ProDKin_1	10	16	PF00069	0.704
MOD_ProDKin_1	100	106	PF00069	0.665
MOD_ProDKin_1	107	113	PF00069	0.654
MOD_ProDKin_1	197	203	PF00069	0.646
MOD_ProDKin_1	244	250	PF00069	0.733
MOD_ProDKin_1	276	282	PF00069	0.665
MOD_SUMO_for_1	140	143	PF00179	0.619
MOD_SUMO_rev_2	163	172	PF00179	0.558
MOD_SUMO_rev_2	51	56	PF00179	0.701
TRG_DiLeu_BaEn_2	328	334	PF01217	0.761
TRG_ENDOCYTIC_2	102	105	PF00928	0.674
TRG_ENDOCYTIC_2	162	165	PF00928	0.535
TRG_ER_diArg_1	173	175	PF00400	0.494
TRG_ER_diArg_1	255	258	PF00400	0.725
TRG_ER_diArg_1	301	304	PF00400	0.734
TRG_NLS_Bipartite_1	301	320	PF00514	0.722
TRG_NLS_MonoExtC_3	137	142	PF00514	0.610
TRG_NLS_MonoExtN_4	136	142	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK05	Leptomonas seymouri	60%	92%
A0A1X0P9W7	Trypanosomatidae	37%	100%
A0A3R7K419	Trypanosoma rangeli	35%	98%
A4HAE3	Leishmania braziliensis	82%	100%
A4I9J5	Leishmania infantum	100%	100%
E9B4J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q3I3	Leishmania major	95%	100%
V5B266	Trypanosoma cruzi	32%	100%