Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7V3_LEIDO

TriTrypDb:

LdBPK_332900.1 , LdCL_330036100 , LDHU3_33.4050

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.734
CLV_C14_Caspase3-7	590	594	PF00656	0.705
CLV_C14_Caspase3-7	599	603	PF00656	0.587
CLV_NRD_NRD_1	428	430	PF00675	0.662
CLV_NRD_NRD_1	695	697	PF00675	0.547
CLV_NRD_NRD_1	698	700	PF00675	0.521
CLV_NRD_NRD_1	726	728	PF00675	0.623
CLV_NRD_NRD_1	743	745	PF00675	0.385
CLV_NRD_NRD_1	836	838	PF00675	0.627
CLV_NRD_NRD_1	900	902	PF00675	0.637
CLV_PCSK_FUR_1	693	697	PF00082	0.476
CLV_PCSK_KEX2_1	450	452	PF00082	0.664
CLV_PCSK_KEX2_1	695	697	PF00082	0.477
CLV_PCSK_KEX2_1	698	700	PF00082	0.462
CLV_PCSK_KEX2_1	726	728	PF00082	0.623
CLV_PCSK_KEX2_1	743	745	PF00082	0.385
CLV_PCSK_KEX2_1	900	902	PF00082	0.637
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.627
CLV_PCSK_SKI1_1	330	334	PF00082	0.602
CLV_PCSK_SKI1_1	487	491	PF00082	0.659
CLV_PCSK_SKI1_1	519	523	PF00082	0.725
CLV_PCSK_SKI1_1	623	627	PF00082	0.732
CLV_PCSK_SKI1_1	665	669	PF00082	0.555
CLV_PCSK_SKI1_1	672	676	PF00082	0.545
CLV_PCSK_SKI1_1	698	702	PF00082	0.548
CLV_PCSK_SKI1_1	714	718	PF00082	0.469
CLV_PCSK_SKI1_1	743	747	PF00082	0.444
CLV_PCSK_SKI1_1	78	82	PF00082	0.540
CLV_PCSK_SKI1_1	789	793	PF00082	0.499
CLV_PCSK_SKI1_1	816	820	PF00082	0.580
DEG_APCC_DBOX_1	742	750	PF00400	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.544
DEG_SCF_TRCP1_1	151	156	PF00400	0.640
DEG_SCF_TRCP1_1	219	224	PF00400	0.732
DEG_SPOP_SBC_1	403	407	PF00917	0.669
DEG_SPOP_SBC_1	82	86	PF00917	0.602
DOC_CYCLIN_RxL_1	327	336	PF00134	0.602
DOC_CYCLIN_RxL_1	513	526	PF00134	0.650
DOC_CYCLIN_RxL_1	72	85	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	663	669	PF00134	0.484
DOC_MAPK_gen_1	618	627	PF00069	0.595
DOC_MAPK_gen_1	726	732	PF00069	0.498
DOC_MAPK_MEF2A_6	163	171	PF00069	0.612
DOC_PP1_RVXF_1	76	82	PF00149	0.541
DOC_PP2B_LxvP_1	391	394	PF13499	0.582
DOC_PP2B_LxvP_1	625	628	PF13499	0.580
DOC_PP4_FxxP_1	171	174	PF00568	0.608
DOC_USP7_MATH_1	25	29	PF00917	0.558
DOC_USP7_MATH_1	346	350	PF00917	0.682
DOC_USP7_MATH_1	38	42	PF00917	0.544
DOC_USP7_MATH_1	404	408	PF00917	0.700
DOC_USP7_MATH_1	491	495	PF00917	0.570
DOC_USP7_MATH_1	594	598	PF00917	0.784
DOC_USP7_MATH_1	600	604	PF00917	0.673
DOC_USP7_MATH_1	777	781	PF00917	0.643
DOC_USP7_MATH_2	366	372	PF00917	0.683
DOC_USP7_UBL2_3	614	618	PF12436	0.621
DOC_WW_Pin1_4	116	121	PF00397	0.698
DOC_WW_Pin1_4	130	135	PF00397	0.571
DOC_WW_Pin1_4	163	168	PF00397	0.684
DOC_WW_Pin1_4	205	210	PF00397	0.658
DOC_WW_Pin1_4	219	224	PF00397	0.671
DOC_WW_Pin1_4	276	281	PF00397	0.713
DOC_WW_Pin1_4	318	323	PF00397	0.761
DOC_WW_Pin1_4	359	364	PF00397	0.671
DOC_WW_Pin1_4	455	460	PF00397	0.675
DOC_WW_Pin1_4	463	468	PF00397	0.698
DOC_WW_Pin1_4	487	492	PF00397	0.583
DOC_WW_Pin1_4	892	897	PF00397	0.646
DOC_WW_Pin1_4	94	99	PF00397	0.681
LIG_14-3-3_CanoR_1	103	111	PF00244	0.716
LIG_14-3-3_CanoR_1	11	17	PF00244	0.541
LIG_14-3-3_CanoR_1	20	25	PF00244	0.519
LIG_14-3-3_CanoR_1	233	239	PF00244	0.642
LIG_14-3-3_CanoR_1	429	435	PF00244	0.720
LIG_14-3-3_CanoR_1	546	550	PF00244	0.556
LIG_14-3-3_CanoR_1	672	677	PF00244	0.663
LIG_14-3-3_CanoR_1	683	689	PF00244	0.444
LIG_Actin_WH2_2	682	700	PF00022	0.513
LIG_Actin_WH2_2	851	867	PF00022	0.518
LIG_BRCT_BRCA1_1	167	171	PF00533	0.612
LIG_BRCT_BRCA1_1	406	410	PF00533	0.607
LIG_BRCT_BRCA1_1	453	457	PF00533	0.630
LIG_BRCT_BRCA1_1	49	53	PF00533	0.556
LIG_FHA_1	286	292	PF00498	0.698
LIG_FHA_1	302	308	PF00498	0.695
LIG_FHA_1	334	340	PF00498	0.673
LIG_FHA_1	386	392	PF00498	0.576
LIG_FHA_1	456	462	PF00498	0.587
LIG_FHA_1	583	589	PF00498	0.714
LIG_FHA_1	676	682	PF00498	0.642
LIG_FHA_1	731	737	PF00498	0.520
LIG_FHA_1	755	761	PF00498	0.476
LIG_FHA_2	189	195	PF00498	0.655
LIG_FHA_2	356	362	PF00498	0.824
LIG_FHA_2	651	657	PF00498	0.555
LIG_FHA_2	819	825	PF00498	0.691
LIG_HCF-1_HBM_1	739	742	PF13415	0.556
LIG_LIR_Apic_2	168	174	PF02991	0.610
LIG_LIR_Gen_1	341	351	PF02991	0.598
LIG_LIR_Gen_1	506	512	PF02991	0.661
LIG_LIR_Gen_1	792	800	PF02991	0.524
LIG_LIR_Nem_3	108	114	PF02991	0.628
LIG_LIR_Nem_3	341	347	PF02991	0.596
LIG_LIR_Nem_3	50	56	PF02991	0.566
LIG_LIR_Nem_3	506	510	PF02991	0.669
LIG_LIR_Nem_3	753	759	PF02991	0.604
LIG_LIR_Nem_3	792	797	PF02991	0.524
LIG_MAD2	242	250	PF02301	0.764
LIG_MYND_1	280	284	PF01753	0.691
LIG_MYND_1	390	394	PF01753	0.616
LIG_PCNA_yPIPBox_3	722	736	PF02747	0.483
LIG_PCNA_yPIPBox_3	880	891	PF02747	0.574
LIG_PDZ_Class_2	905	910	PF00595	0.661
LIG_Pex14_1	541	545	PF04695	0.670
LIG_Pex14_2	684	688	PF04695	0.578
LIG_Pex14_2	771	775	PF04695	0.604
LIG_SH2_GRB2like	6	9	PF00017	0.534
LIG_SH2_STAP1	6	10	PF00017	0.534
LIG_SH2_STAP1	669	673	PF00017	0.667
LIG_SH2_STAP1	750	754	PF00017	0.483
LIG_SH3_2	228	233	PF14604	0.686
LIG_SH3_3	171	177	PF00018	0.603
LIG_SH3_3	222	228	PF00018	0.689
LIG_SH3_3	274	280	PF00018	0.673
LIG_SH3_3	292	298	PF00018	0.683
LIG_SH3_3	316	322	PF00018	0.774
LIG_SH3_3	342	348	PF00018	0.618
LIG_SH3_3	360	366	PF00018	0.586
LIG_SH3_3	461	467	PF00018	0.738
LIG_SH3_3	625	631	PF00018	0.750
LIG_SH3_3	76	82	PF00018	0.559
LIG_SUMO_SIM_anti_2	179	186	PF11976	0.624
LIG_SUMO_SIM_anti_2	399	409	PF11976	0.666
LIG_SUMO_SIM_anti_2	757	763	PF11976	0.460
LIG_SUMO_SIM_par_1	672	678	PF11976	0.657
LIG_TRAF2_1	191	194	PF00917	0.594
LIG_TRAF2_1	512	515	PF00917	0.602
LIG_TRAF2_1	809	812	PF00917	0.534
LIG_WW_2	280	283	PF00397	0.696
MOD_CDK_SPK_2	205	210	PF00069	0.658
MOD_CK1_1	105	111	PF00069	0.628
MOD_CK1_1	115	121	PF00069	0.564
MOD_CK1_1	18	24	PF00069	0.556
MOD_CK1_1	208	214	PF00069	0.634
MOD_CK1_1	268	274	PF00069	0.764
MOD_CK1_1	338	344	PF00069	0.652
MOD_CK1_1	405	411	PF00069	0.797
MOD_CK1_1	568	574	PF00069	0.746
MOD_CK2_1	188	194	PF00069	0.597
MOD_CK2_1	210	216	PF00069	0.642
MOD_CK2_1	355	361	PF00069	0.799
MOD_CK2_1	409	415	PF00069	0.676
MOD_CK2_1	806	812	PF00069	0.529
MOD_CK2_1	818	824	PF00069	0.688
MOD_CK2_1	860	866	PF00069	0.642
MOD_CK2_1	903	909	PF00069	0.665
MOD_CK2_1	94	100	PF00069	0.702
MOD_Cter_Amidation	620	623	PF01082	0.629
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.610
MOD_GlcNHglycan	12	15	PF01048	0.550
MOD_GlcNHglycan	140	143	PF01048	0.675
MOD_GlcNHglycan	151	154	PF01048	0.645
MOD_GlcNHglycan	155	158	PF01048	0.683
MOD_GlcNHglycan	212	215	PF01048	0.753
MOD_GlcNHglycan	219	222	PF01048	0.706
MOD_GlcNHglycan	267	270	PF01048	0.765
MOD_GlcNHglycan	27	30	PF01048	0.535
MOD_GlcNHglycan	34	37	PF01048	0.571
MOD_GlcNHglycan	370	373	PF01048	0.706
MOD_GlcNHglycan	395	398	PF01048	0.683
MOD_GlcNHglycan	415	420	PF01048	0.717
MOD_GlcNHglycan	436	439	PF01048	0.712
MOD_GlcNHglycan	453	456	PF01048	0.587
MOD_GlcNHglycan	480	483	PF01048	0.737
MOD_GlcNHglycan	49	52	PF01048	0.516
MOD_GlcNHglycan	493	496	PF01048	0.565
MOD_GlcNHglycan	550	553	PF01048	0.704
MOD_GlcNHglycan	570	573	PF01048	0.731
MOD_GlcNHglycan	602	605	PF01048	0.651
MOD_GlcNHglycan	808	811	PF01048	0.523
MOD_GlcNHglycan	892	895	PF01048	0.617
MOD_GSK3_1	102	109	PF00069	0.623
MOD_GSK3_1	112	119	PF00069	0.600
MOD_GSK3_1	149	156	PF00069	0.774
MOD_GSK3_1	16	23	PF00069	0.526
MOD_GSK3_1	179	186	PF00069	0.661
MOD_GSK3_1	217	224	PF00069	0.760
MOD_GSK3_1	25	32	PF00069	0.508
MOD_GSK3_1	263	270	PF00069	0.793
MOD_GSK3_1	272	279	PF00069	0.675
MOD_GSK3_1	318	325	PF00069	0.753
MOD_GSK3_1	333	340	PF00069	0.519
MOD_GSK3_1	355	362	PF00069	0.783
MOD_GSK3_1	38	45	PF00069	0.557
MOD_GSK3_1	402	409	PF00069	0.756
MOD_GSK3_1	430	437	PF00069	0.719
MOD_GSK3_1	451	458	PF00069	0.593
MOD_GSK3_1	483	490	PF00069	0.718
MOD_GSK3_1	567	574	PF00069	0.724
MOD_GSK3_1	582	589	PF00069	0.543
MOD_GSK3_1	594	601	PF00069	0.602
MOD_GSK3_1	6	13	PF00069	0.548
MOD_GSK3_1	684	691	PF00069	0.428
MOD_GSK3_1	886	893	PF00069	0.592
MOD_N-GLC_1	42	47	PF02516	0.560
MOD_N-GLC_1	451	456	PF02516	0.668
MOD_NEK2_1	12	17	PF00069	0.547
MOD_NEK2_1	234	239	PF00069	0.669
MOD_NEK2_1	24	29	PF00069	0.531
MOD_NEK2_1	333	338	PF00069	0.606
MOD_NEK2_1	434	439	PF00069	0.665
MOD_NEK2_1	565	570	PF00069	0.688
MOD_NEK2_1	642	647	PF00069	0.694
MOD_NEK2_1	684	689	PF00069	0.572
MOD_NEK2_1	701	706	PF00069	0.394
MOD_NEK2_1	717	722	PF00069	0.473
MOD_NEK2_1	730	735	PF00069	0.440
MOD_PIKK_1	176	182	PF00454	0.609
MOD_PIKK_1	183	189	PF00454	0.596
MOD_PIKK_1	272	278	PF00454	0.707
MOD_PIKK_1	322	328	PF00454	0.678
MOD_PIKK_1	361	367	PF00454	0.631
MOD_PIKK_1	409	415	PF00454	0.702
MOD_PK_1	886	892	PF00069	0.557
MOD_PKA_2	10	16	PF00069	0.543
MOD_PKA_2	102	108	PF00069	0.707
MOD_PKA_2	138	144	PF00069	0.625
MOD_PKA_2	188	194	PF00069	0.731
MOD_PKA_2	38	44	PF00069	0.568
MOD_PKA_2	503	509	PF00069	0.631
MOD_PKA_2	545	551	PF00069	0.701
MOD_PKA_2	804	810	PF00069	0.496
MOD_Plk_2-3	650	656	PF00069	0.628
MOD_Plk_4	165	171	PF00069	0.645
MOD_Plk_4	179	185	PF00069	0.546
MOD_Plk_4	430	436	PF00069	0.622
MOD_Plk_4	503	509	PF00069	0.642
MOD_Plk_4	582	588	PF00069	0.735
MOD_Plk_4	642	648	PF00069	0.632
MOD_Plk_4	789	795	PF00069	0.552
MOD_Plk_4	886	892	PF00069	0.667
MOD_ProDKin_1	116	122	PF00069	0.700
MOD_ProDKin_1	130	136	PF00069	0.571
MOD_ProDKin_1	163	169	PF00069	0.685
MOD_ProDKin_1	205	211	PF00069	0.659
MOD_ProDKin_1	219	225	PF00069	0.670
MOD_ProDKin_1	276	282	PF00069	0.713
MOD_ProDKin_1	318	324	PF00069	0.762
MOD_ProDKin_1	359	365	PF00069	0.672
MOD_ProDKin_1	455	461	PF00069	0.675
MOD_ProDKin_1	463	469	PF00069	0.700
MOD_ProDKin_1	487	493	PF00069	0.582
MOD_ProDKin_1	892	898	PF00069	0.647
MOD_ProDKin_1	94	100	PF00069	0.684
MOD_SUMO_for_1	667	670	PF00179	0.533
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.580
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.641
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.669
TRG_ER_diArg_1	693	696	PF00400	0.479
TRG_ER_diArg_1	697	699	PF00400	0.478
TRG_ER_diArg_1	726	728	PF00400	0.564
TRG_ER_diArg_1	742	744	PF00400	0.348
TRG_ER_diArg_1	781	784	PF00400	0.656
TRG_ER_diArg_1	899	901	PF00400	0.638
TRG_NLS_MonoExtC_3	836	842	PF00514	0.509
TRG_NLS_MonoExtN_4	834	841	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLY7	Leishmania braziliensis	51%	100%
A4I9B6	Leishmania infantum	100%	100%
E9B4B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q3Q9	Leishmania major	79%	98%