Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 12

Species:

Leishmania donovani

UniProt:

A0A3S5H7V1_LEIDO

TriTrypDb:

LdBPK_332590.1 , LdCL_330033000 , LDHU3_33.3690

Length:

1051

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1013	1017	PF00656	0.700
CLV_C14_Caspase3-7	184	188	PF00656	0.493
CLV_C14_Caspase3-7	200	204	PF00656	0.581
CLV_C14_Caspase3-7	465	469	PF00656	0.630
CLV_C14_Caspase3-7	489	493	PF00656	0.770
CLV_C14_Caspase3-7	660	664	PF00656	0.565
CLV_C14_Caspase3-7	683	687	PF00656	0.520
CLV_C14_Caspase3-7	988	992	PF00656	0.642
CLV_NRD_NRD_1	21	23	PF00675	0.440
CLV_NRD_NRD_1	215	217	PF00675	0.611
CLV_NRD_NRD_1	42	44	PF00675	0.649
CLV_NRD_NRD_1	52	54	PF00675	0.605
CLV_NRD_NRD_1	557	559	PF00675	0.529
CLV_NRD_NRD_1	589	591	PF00675	0.509
CLV_NRD_NRD_1	613	615	PF00675	0.458
CLV_NRD_NRD_1	764	766	PF00675	0.559
CLV_NRD_NRD_1	791	793	PF00675	0.424
CLV_PCSK_KEX2_1	112	114	PF00082	0.562
CLV_PCSK_KEX2_1	21	23	PF00082	0.440
CLV_PCSK_KEX2_1	214	216	PF00082	0.621
CLV_PCSK_KEX2_1	420	422	PF00082	0.649
CLV_PCSK_KEX2_1	52	54	PF00082	0.658
CLV_PCSK_KEX2_1	589	591	PF00082	0.509
CLV_PCSK_KEX2_1	764	766	PF00082	0.559
CLV_PCSK_KEX2_1	791	793	PF00082	0.424
CLV_PCSK_KEX2_1	857	859	PF00082	0.410
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.570
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.649
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.410
CLV_PCSK_SKI1_1	151	155	PF00082	0.472
CLV_PCSK_SKI1_1	289	293	PF00082	0.681
CLV_PCSK_SKI1_1	37	41	PF00082	0.594
CLV_PCSK_SKI1_1	599	603	PF00082	0.555
CLV_PCSK_SKI1_1	615	619	PF00082	0.577
CLV_PCSK_SKI1_1	667	671	PF00082	0.430
CLV_PCSK_SKI1_1	791	795	PF00082	0.440
CLV_PCSK_SKI1_1	803	807	PF00082	0.518
CLV_PCSK_SKI1_1	870	874	PF00082	0.469
DEG_APCC_DBOX_1	213	221	PF00400	0.541
DEG_APCC_DBOX_1	42	50	PF00400	0.679
DEG_APCC_DBOX_1	790	798	PF00400	0.394
DOC_CKS1_1	240	245	PF01111	0.463
DOC_CYCLIN_RxL_1	283	297	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	703	709	PF00134	0.523
DOC_MAPK_DCC_7	225	233	PF00069	0.640
DOC_MAPK_DCC_7	43	51	PF00069	0.560
DOC_MAPK_DCC_7	840	848	PF00069	0.570
DOC_MAPK_gen_1	366	374	PF00069	0.466
DOC_MAPK_gen_1	791	797	PF00069	0.448
DOC_MAPK_gen_1	857	863	PF00069	0.449
DOC_MAPK_MEF2A_6	225	233	PF00069	0.640
DOC_MAPK_MEF2A_6	53	62	PF00069	0.497
DOC_MAPK_MEF2A_6	840	848	PF00069	0.602
DOC_PP1_RVXF_1	287	294	PF00149	0.646
DOC_PP2B_LxvP_1	309	312	PF13499	0.674
DOC_PP2B_PxIxI_1	228	234	PF00149	0.625
DOC_PP2B_PxIxI_1	314	320	PF00149	0.651
DOC_PP4_FxxP_1	445	448	PF00568	0.613
DOC_PP4_FxxP_1	972	975	PF00568	0.446
DOC_PP4_MxPP_1	848	851	PF00568	0.482
DOC_USP7_MATH_1	1041	1045	PF00917	0.677
DOC_USP7_MATH_1	197	201	PF00917	0.387
DOC_USP7_MATH_1	235	239	PF00917	0.502
DOC_USP7_MATH_1	275	279	PF00917	0.599
DOC_USP7_MATH_1	448	452	PF00917	0.650
DOC_USP7_MATH_1	507	511	PF00917	0.728
DOC_USP7_MATH_1	640	644	PF00917	0.544
DOC_USP7_MATH_1	692	696	PF00917	0.494
DOC_USP7_MATH_1	739	743	PF00917	0.557
DOC_USP7_MATH_1	760	764	PF00917	0.683
DOC_USP7_MATH_1	771	775	PF00917	0.434
DOC_USP7_MATH_1	776	780	PF00917	0.400
DOC_USP7_MATH_1	935	939	PF00917	0.653
DOC_USP7_UBL2_3	40	44	PF12436	0.574
DOC_WW_Pin1_4	1037	1042	PF00397	0.673
DOC_WW_Pin1_4	116	121	PF00397	0.486
DOC_WW_Pin1_4	239	244	PF00397	0.469
DOC_WW_Pin1_4	523	528	PF00397	0.692
DOC_WW_Pin1_4	62	67	PF00397	0.531
DOC_WW_Pin1_4	641	646	PF00397	0.554
DOC_WW_Pin1_4	754	759	PF00397	0.529
DOC_WW_Pin1_4	927	932	PF00397	0.642
DOC_WW_Pin1_4	939	944	PF00397	0.491
DOC_WW_Pin1_4	971	976	PF00397	0.455
LIG_14-3-3_CanoR_1	1028	1036	PF00244	0.688
LIG_14-3-3_CanoR_1	151	161	PF00244	0.461
LIG_14-3-3_CanoR_1	21	25	PF00244	0.475
LIG_14-3-3_CanoR_1	215	221	PF00244	0.601
LIG_14-3-3_CanoR_1	52	56	PF00244	0.620
LIG_14-3-3_CanoR_1	573	582	PF00244	0.422
LIG_14-3-3_CanoR_1	812	820	PF00244	0.412
LIG_14-3-3_CanoR_1	964	973	PF00244	0.517
LIG_14-3-3_CanoR_1	983	988	PF00244	0.609
LIG_Actin_WH2_2	7	23	PF00022	0.503
LIG_APCC_ABBA_1	430	435	PF00400	0.546
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BIR_III_2	775	779	PF00653	0.607
LIG_BIR_III_4	468	472	PF00653	0.640
LIG_BRCT_BRCA1_1	220	224	PF00533	0.649
LIG_BRCT_BRCA1_1	985	989	PF00533	0.525
LIG_Clathr_ClatBox_1	797	801	PF01394	0.521
LIG_CtBP_PxDLS_1	48	52	PF00389	0.528
LIG_CtBP_PxDLS_1	645	649	PF00389	0.439
LIG_deltaCOP1_diTrp_1	138	148	PF00928	0.431
LIG_DLG_GKlike_1	680	688	PF00625	0.453
LIG_EH1_1	581	589	PF00400	0.342
LIG_FHA_1	1028	1034	PF00498	0.626
LIG_FHA_1	264	270	PF00498	0.484
LIG_FHA_1	314	320	PF00498	0.613
LIG_FHA_1	427	433	PF00498	0.539
LIG_FHA_1	5	11	PF00498	0.525
LIG_FHA_1	57	63	PF00498	0.515
LIG_FHA_1	671	677	PF00498	0.555
LIG_FHA_1	712	718	PF00498	0.760
LIG_FHA_1	832	838	PF00498	0.489
LIG_FHA_1	871	877	PF00498	0.579
LIG_FHA_1	920	926	PF00498	0.558
LIG_FHA_2	1011	1017	PF00498	0.684
LIG_FHA_2	180	186	PF00498	0.445
LIG_FHA_2	240	246	PF00498	0.482
LIG_FHA_2	536	542	PF00498	0.568
LIG_FHA_2	601	607	PF00498	0.440
LIG_FHA_2	69	75	PF00498	0.527
LIG_FHA_2	904	910	PF00498	0.483
LIG_FHA_2	914	920	PF00498	0.436
LIG_LIR_Apic_2	237	243	PF02991	0.462
LIG_LIR_Apic_2	443	448	PF02991	0.584
LIG_LIR_Apic_2	79	83	PF02991	0.586
LIG_LIR_Gen_1	400	408	PF02991	0.458
LIG_LIR_Gen_1	663	672	PF02991	0.494
LIG_LIR_Nem_3	105	110	PF02991	0.433
LIG_LIR_Nem_3	400	405	PF02991	0.457
LIG_LIR_Nem_3	425	430	PF02991	0.524
LIG_LIR_Nem_3	431	436	PF02991	0.555
LIG_LIR_Nem_3	663	668	PF02991	0.493
LIG_LIR_Nem_3	874	880	PF02991	0.587
LIG_MAD2	667	675	PF02301	0.564
LIG_NRP_CendR_1	1050	1051	PF00754	0.693
LIG_PCNA_yPIPBox_3	337	350	PF02747	0.588
LIG_PTAP_UEV_1	500	505	PF05743	0.577
LIG_PTB_Apo_2	541	548	PF02174	0.509
LIG_PTB_Phospho_1	541	547	PF10480	0.510
LIG_SH2_CRK	375	379	PF00017	0.440
LIG_SH2_CRK	547	551	PF00017	0.500
LIG_SH2_CRK	582	586	PF00017	0.541
LIG_SH2_CRK	665	669	PF00017	0.485
LIG_SH2_CRK	751	755	PF00017	0.485
LIG_SH2_NCK_1	136	140	PF00017	0.528
LIG_SH2_PTP2	80	83	PF00017	0.585
LIG_SH2_SRC	136	139	PF00017	0.529
LIG_SH2_SRC	729	732	PF00017	0.373
LIG_SH2_SRC	80	83	PF00017	0.585
LIG_SH2_SRC	880	883	PF00017	0.460
LIG_SH2_STAP1	136	140	PF00017	0.410
LIG_SH2_STAP1	399	403	PF00017	0.424
LIG_SH2_STAP1	547	551	PF00017	0.500
LIG_SH2_STAP1	665	669	PF00017	0.408
LIG_SH2_STAP1	877	881	PF00017	0.572
LIG_SH2_STAT3	247	250	PF00017	0.608
LIG_SH2_STAT5	170	173	PF00017	0.595
LIG_SH2_STAT5	240	243	PF00017	0.481
LIG_SH2_STAT5	28	31	PF00017	0.585
LIG_SH2_STAT5	302	305	PF00017	0.661
LIG_SH2_STAT5	729	732	PF00017	0.373
LIG_SH2_STAT5	80	83	PF00017	0.585
LIG_SH2_STAT5	826	829	PF00017	0.530
LIG_SH3_1	80	86	PF00018	0.578
LIG_SH3_3	309	315	PF00018	0.673
LIG_SH3_3	39	45	PF00018	0.682
LIG_SH3_3	498	504	PF00018	0.679
LIG_SH3_3	52	58	PF00018	0.488
LIG_SH3_3	521	527	PF00018	0.772
LIG_SH3_3	63	69	PF00018	0.551
LIG_SH3_3	653	659	PF00018	0.435
LIG_SH3_3	669	675	PF00018	0.448
LIG_SH3_3	78	84	PF00018	0.597
LIG_Sin3_3	546	553	PF02671	0.421
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.516
LIG_SUMO_SIM_anti_2	814	820	PF11976	0.343
LIG_SUMO_SIM_par_1	265	271	PF11976	0.591
LIG_TRAF2_1	182	185	PF00917	0.510
LIG_TRAF2_1	242	245	PF00917	0.495
LIG_TRAF2_1	335	338	PF00917	0.434
LIG_TRAF2_1	534	537	PF00917	0.549
LIG_TRAF2_1	603	606	PF00917	0.427
LIG_TRAF2_2	45	50	PF00917	0.560
LIG_UBA3_1	339	345	PF00899	0.521
LIG_UBA3_1	414	420	PF00899	0.611
LIG_UBA3_1	797	803	PF00899	0.476
LIG_WW_1	77	80	PF00397	0.588
MOD_CDK_SPK_2	927	932	PF00069	0.626
MOD_CDK_SPxxK_3	239	246	PF00069	0.463
MOD_CDK_SPxxK_3	971	978	PF00069	0.454
MOD_CK1_1	1004	1010	PF00069	0.723
MOD_CK1_1	310	316	PF00069	0.709
MOD_CK1_1	380	386	PF00069	0.464
MOD_CK1_1	419	425	PF00069	0.568
MOD_CK1_1	475	481	PF00069	0.644
MOD_CK1_1	493	499	PF00069	0.703
MOD_CK1_1	526	532	PF00069	0.623
MOD_CK1_1	644	650	PF00069	0.529
MOD_CK1_1	695	701	PF00069	0.531
MOD_CK1_1	814	820	PF00069	0.544
MOD_CK1_1	927	933	PF00069	0.489
MOD_CK2_1	179	185	PF00069	0.514
MOD_CK2_1	239	245	PF00069	0.492
MOD_CK2_1	279	285	PF00069	0.703
MOD_CK2_1	357	363	PF00069	0.704
MOD_CK2_1	535	541	PF00069	0.517
MOD_CK2_1	600	606	PF00069	0.506
MOD_CK2_1	68	74	PF00069	0.513
MOD_CK2_1	913	919	PF00069	0.429
MOD_CK2_1	982	988	PF00069	0.600
MOD_Cter_Amidation	612	615	PF01082	0.493
MOD_GlcNHglycan	1043	1046	PF01048	0.674
MOD_GlcNHglycan	121	124	PF01048	0.507
MOD_GlcNHglycan	273	276	PF01048	0.676
MOD_GlcNHglycan	277	280	PF01048	0.657
MOD_GlcNHglycan	285	288	PF01048	0.571
MOD_GlcNHglycan	358	362	PF01048	0.720
MOD_GlcNHglycan	421	424	PF01048	0.659
MOD_GlcNHglycan	488	491	PF01048	0.698
MOD_GlcNHglycan	492	495	PF01048	0.716
MOD_GlcNHglycan	501	504	PF01048	0.562
MOD_GlcNHglycan	532	535	PF01048	0.515
MOD_GlcNHglycan	695	698	PF01048	0.525
MOD_GlcNHglycan	707	710	PF01048	0.632
MOD_GlcNHglycan	722	725	PF01048	0.625
MOD_GlcNHglycan	741	744	PF01048	0.308
MOD_GlcNHglycan	926	929	PF01048	0.586
MOD_GSK3_1	1006	1013	PF00069	0.772
MOD_GSK3_1	1023	1030	PF00069	0.618
MOD_GSK3_1	1035	1042	PF00069	0.657
MOD_GSK3_1	112	119	PF00069	0.463
MOD_GSK3_1	152	159	PF00069	0.461
MOD_GSK3_1	175	182	PF00069	0.504
MOD_GSK3_1	197	204	PF00069	0.569
MOD_GSK3_1	227	234	PF00069	0.607
MOD_GSK3_1	235	242	PF00069	0.470
MOD_GSK3_1	271	278	PF00069	0.580
MOD_GSK3_1	279	286	PF00069	0.613
MOD_GSK3_1	303	310	PF00069	0.735
MOD_GSK3_1	319	326	PF00069	0.437
MOD_GSK3_1	422	429	PF00069	0.541
MOD_GSK3_1	482	489	PF00069	0.655
MOD_GSK3_1	526	533	PF00069	0.643
MOD_GSK3_1	58	65	PF00069	0.524
MOD_GSK3_1	616	623	PF00069	0.478
MOD_GSK3_1	640	647	PF00069	0.598
MOD_GSK3_1	735	742	PF00069	0.544
MOD_GSK3_1	899	906	PF00069	0.549
MOD_GSK3_1	935	942	PF00069	0.579
MOD_GSK3_1	948	955	PF00069	0.684
MOD_GSK3_1	997	1004	PF00069	0.678
MOD_N-GLC_1	1001	1006	PF02516	0.629
MOD_N-GLC_1	253	258	PF02516	0.478
MOD_N-GLC_1	263	268	PF02516	0.474
MOD_N-GLC_1	389	394	PF02516	0.406
MOD_N-GLC_1	832	837	PF02516	0.520
MOD_N-GLC_1	884	889	PF02516	0.361
MOD_N-GLC_1	935	940	PF02516	0.524
MOD_N-GLC_1	964	969	PF02516	0.515
MOD_NEK2_1	121	126	PF00069	0.581
MOD_NEK2_1	154	159	PF00069	0.464
MOD_NEK2_1	20	25	PF00069	0.474
MOD_NEK2_1	263	268	PF00069	0.485
MOD_NEK2_1	292	297	PF00069	0.697
MOD_NEK2_1	357	362	PF00069	0.708
MOD_NEK2_1	621	626	PF00069	0.462
MOD_NEK2_1	910	915	PF00069	0.599
MOD_NEK2_2	235	240	PF00069	0.651
MOD_NEK2_2	428	433	PF00069	0.523
MOD_PIKK_1	1004	1010	PF00454	0.772
MOD_PIKK_1	121	127	PF00454	0.577
MOD_PIKK_1	128	134	PF00454	0.459
MOD_PIKK_1	292	298	PF00454	0.661
MOD_PIKK_1	4	10	PF00454	0.538
MOD_PK_1	216	222	PF00069	0.551
MOD_PK_1	952	958	PF00069	0.615
MOD_PKA_1	112	118	PF00069	0.508
MOD_PKA_2	1027	1033	PF00069	0.625
MOD_PKA_2	112	118	PF00069	0.577
MOD_PKA_2	20	26	PF00069	0.481
MOD_PKA_2	51	57	PF00069	0.642
MOD_PKA_2	557	563	PF00069	0.597
MOD_PKA_2	811	817	PF00069	0.396
MOD_PKA_2	963	969	PF00069	0.619
MOD_PKA_2	982	988	PF00069	0.572
MOD_PKB_1	214	222	PF00069	0.549
MOD_Plk_1	141	147	PF00069	0.422
MOD_Plk_1	263	269	PF00069	0.479
MOD_Plk_1	380	386	PF00069	0.464
MOD_Plk_1	389	395	PF00069	0.455
MOD_Plk_1	571	577	PF00069	0.451
MOD_Plk_1	814	820	PF00069	0.536
MOD_Plk_1	832	838	PF00069	0.409
MOD_Plk_1	884	890	PF00069	0.360
MOD_Plk_1	964	970	PF00069	0.511
MOD_Plk_2-3	919	925	PF00069	0.426
MOD_Plk_4	1007	1013	PF00069	0.779
MOD_Plk_4	197	203	PF00069	0.466
MOD_Plk_4	263	269	PF00069	0.479
MOD_Plk_4	380	386	PF00069	0.501
MOD_Plk_4	398	404	PF00069	0.316
MOD_Plk_4	428	434	PF00069	0.538
MOD_Plk_4	448	454	PF00069	0.440
MOD_Plk_4	58	64	PF00069	0.654
MOD_Plk_4	644	650	PF00069	0.587
MOD_Plk_4	680	686	PF00069	0.515
MOD_Plk_4	76	82	PF00069	0.530
MOD_Plk_4	814	820	PF00069	0.510
MOD_Plk_4	833	839	PF00069	0.481
MOD_Plk_4	913	919	PF00069	0.546
MOD_ProDKin_1	1037	1043	PF00069	0.674
MOD_ProDKin_1	116	122	PF00069	0.478
MOD_ProDKin_1	239	245	PF00069	0.467
MOD_ProDKin_1	523	529	PF00069	0.692
MOD_ProDKin_1	62	68	PF00069	0.527
MOD_ProDKin_1	641	647	PF00069	0.546
MOD_ProDKin_1	754	760	PF00069	0.531
MOD_ProDKin_1	927	933	PF00069	0.641
MOD_ProDKin_1	939	945	PF00069	0.493
MOD_ProDKin_1	971	977	PF00069	0.450
MOD_SUMO_rev_2	238	248	PF00179	0.490
MOD_SUMO_rev_2	26	34	PF00179	0.700
MOD_SUMO_rev_2	799	805	PF00179	0.486
MOD_SUMO_rev_2	919	927	PF00179	0.514
TRG_DiLeu_BaEn_1	257	262	PF01217	0.475
TRG_DiLeu_BaEn_1	801	806	PF01217	0.431
TRG_DiLeu_BaLyEn_6	972	977	PF01217	0.438
TRG_ENDOCYTIC_2	136	139	PF00928	0.411
TRG_ENDOCYTIC_2	150	153	PF00928	0.461
TRG_ENDOCYTIC_2	249	252	PF00928	0.479
TRG_ENDOCYTIC_2	375	378	PF00928	0.436
TRG_ENDOCYTIC_2	547	550	PF00928	0.379
TRG_ENDOCYTIC_2	582	585	PF00928	0.541
TRG_ENDOCYTIC_2	665	668	PF00928	0.489
TRG_ENDOCYTIC_2	826	829	PF00928	0.594
TRG_ER_diArg_1	20	22	PF00400	0.436
TRG_ER_diArg_1	214	216	PF00400	0.535
TRG_ER_diArg_1	456	459	PF00400	0.686
TRG_ER_diArg_1	51	53	PF00400	0.582
TRG_ER_diArg_1	588	590	PF00400	0.481
TRG_ER_diArg_1	764	766	PF00400	0.559
TRG_ER_diArg_1	791	793	PF00400	0.405
TRG_NES_CRM1_1	257	271	PF08389	0.535
TRG_NES_CRM1_1	381	394	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	978	982	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9F7	Leptomonas seymouri	56%	100%
A4HLV7	Leishmania braziliensis	71%	99%
E9AHR4	Leishmania infantum	100%	100%
E9B485	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3U1	Leishmania major	93%	100%