Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7V0_LEIDO

TriTrypDb:

LdBPK_332460.1 , LdCL_330031600 , LDHU3_33.3520

Length:

1065

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.478
CLV_C14_Caspase3-7	523	527	PF00656	0.614
CLV_C14_Caspase3-7	950	954	PF00656	0.591
CLV_C14_Caspase3-7	957	961	PF00656	0.549
CLV_MEL_PAP_1	437	443	PF00089	0.554
CLV_NRD_NRD_1	130	132	PF00675	0.438
CLV_NRD_NRD_1	197	199	PF00675	0.492
CLV_NRD_NRD_1	207	209	PF00675	0.412
CLV_NRD_NRD_1	261	263	PF00675	0.535
CLV_NRD_NRD_1	514	516	PF00675	0.615
CLV_NRD_NRD_1	805	807	PF00675	0.672
CLV_NRD_NRD_1	887	889	PF00675	0.620
CLV_NRD_NRD_1	943	945	PF00675	0.556
CLV_NRD_NRD_1	974	976	PF00675	0.639
CLV_PCSK_KEX2_1	130	132	PF00082	0.438
CLV_PCSK_KEX2_1	197	199	PF00082	0.502
CLV_PCSK_KEX2_1	514	516	PF00082	0.615
CLV_PCSK_KEX2_1	778	780	PF00082	0.781
CLV_PCSK_KEX2_1	807	809	PF00082	0.637
CLV_PCSK_KEX2_1	887	889	PF00082	0.620
CLV_PCSK_KEX2_1	943	945	PF00082	0.557
CLV_PCSK_KEX2_1	974	976	PF00082	0.638
CLV_PCSK_PC1ET2_1	778	780	PF00082	0.550
CLV_PCSK_PC1ET2_1	807	809	PF00082	0.663
CLV_PCSK_SKI1_1	150	154	PF00082	0.551
CLV_PCSK_SKI1_1	308	312	PF00082	0.649
CLV_PCSK_SKI1_1	401	405	PF00082	0.566
CLV_PCSK_SKI1_1	431	435	PF00082	0.611
CLV_PCSK_SKI1_1	457	461	PF00082	0.535
CLV_PCSK_SKI1_1	700	704	PF00082	0.508
CLV_PCSK_SKI1_1	820	824	PF00082	0.545
CLV_Separin_Fungi	485	491	PF03568	0.602
DEG_APCC_DBOX_1	114	122	PF00400	0.518
DEG_APCC_DBOX_1	196	204	PF00400	0.482
DEG_APCC_DBOX_1	430	438	PF00400	0.559
DEG_SPOP_SBC_1	367	371	PF00917	0.577
DOC_ANK_TNKS_1	1053	1060	PF00023	0.618
DOC_CKS1_1	390	395	PF01111	0.591
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.705
DOC_MAPK_gen_1	428	438	PF00069	0.542
DOC_MAPK_gen_1	514	520	PF00069	0.612
DOC_MAPK_gen_1	71	81	PF00069	0.543
DOC_MAPK_gen_1	963	972	PF00069	0.545
DOC_MAPK_MEF2A_6	431	438	PF00069	0.606
DOC_MAPK_MEF2A_6	74	83	PF00069	0.604
DOC_PP1_RVXF_1	908	914	PF00149	0.591
DOC_PP1_SILK_1	700	705	PF00149	0.596
DOC_PP2B_LxvP_1	685	688	PF13499	0.496
DOC_PP2B_LxvP_1	79	82	PF13499	0.705
DOC_PP4_FxxP_1	361	364	PF00568	0.650
DOC_USP7_MATH_1	178	182	PF00917	0.574
DOC_USP7_MATH_1	277	281	PF00917	0.603
DOC_USP7_MATH_1	30	34	PF00917	0.674
DOC_USP7_MATH_1	439	443	PF00917	0.530
DOC_USP7_MATH_1	62	66	PF00917	0.671
DOC_USP7_MATH_1	72	76	PF00917	0.734
DOC_USP7_MATH_1	781	785	PF00917	0.602
DOC_USP7_MATH_1	795	799	PF00917	0.648
DOC_USP7_MATH_1	8	12	PF00917	0.674
DOC_USP7_MATH_1	845	849	PF00917	0.668
DOC_USP7_MATH_1	859	863	PF00917	0.627
DOC_USP7_MATH_1	889	893	PF00917	0.631
DOC_USP7_MATH_1	895	899	PF00917	0.556
DOC_USP7_MATH_1	96	100	PF00917	0.570
DOC_USP7_UBL2_3	1052	1056	PF12436	0.627
DOC_WW_Pin1_4	1031	1036	PF00397	0.630
DOC_WW_Pin1_4	35	40	PF00397	0.614
DOC_WW_Pin1_4	360	365	PF00397	0.674
DOC_WW_Pin1_4	389	394	PF00397	0.604
DOC_WW_Pin1_4	43	48	PF00397	0.592
DOC_WW_Pin1_4	50	55	PF00397	0.655
DOC_WW_Pin1_4	57	62	PF00397	0.747
DOC_WW_Pin1_4	683	688	PF00397	0.588
DOC_WW_Pin1_4	789	794	PF00397	0.711
DOC_WW_Pin1_4	836	841	PF00397	0.634
DOC_WW_Pin1_4	864	869	PF00397	0.664
DOC_WW_Pin1_4	870	875	PF00397	0.727
LIG_14-3-3_CanoR_1	145	153	PF00244	0.553
LIG_14-3-3_CanoR_1	208	212	PF00244	0.506
LIG_14-3-3_CanoR_1	219	225	PF00244	0.426
LIG_14-3-3_CanoR_1	230	238	PF00244	0.400
LIG_14-3-3_CanoR_1	366	376	PF00244	0.625
LIG_14-3-3_CanoR_1	440	448	PF00244	0.623
LIG_14-3-3_CanoR_1	514	519	PF00244	0.661
LIG_14-3-3_CanoR_1	581	590	PF00244	0.521
LIG_14-3-3_CanoR_1	634	642	PF00244	0.626
LIG_14-3-3_CanoR_1	71	81	PF00244	0.712
LIG_14-3-3_CanoR_1	722	731	PF00244	0.507
LIG_14-3-3_CanoR_1	752	761	PF00244	0.573
LIG_14-3-3_CanoR_1	806	815	PF00244	0.662
LIG_14-3-3_CanoR_1	887	896	PF00244	0.637
LIG_Actin_WH2_2	160	178	PF00022	0.387
LIG_Actin_WH2_2	193	210	PF00022	0.424
LIG_Actin_WH2_2	566	583	PF00022	0.608
LIG_Actin_WH2_2	873	889	PF00022	0.612
LIG_Actin_WH2_2	909	926	PF00022	0.525
LIG_BIR_III_4	409	413	PF00653	0.639
LIG_BRCT_BRCA1_1	322	326	PF00533	0.668
LIG_BRCT_BRCA1_1	357	361	PF00533	0.620
LIG_BRCT_BRCA1_1	797	801	PF00533	0.699
LIG_BRCT_BRCA1_1	847	851	PF00533	0.512
LIG_BRCT_BRCA1_2	322	328	PF00533	0.524
LIG_CaM_IQ_9	200	216	PF13499	0.466
LIG_Clathr_ClatBox_1	152	156	PF01394	0.398
LIG_FHA_1	17	23	PF00498	0.637
LIG_FHA_1	252	258	PF00498	0.480
LIG_FHA_1	290	296	PF00498	0.559
LIG_FHA_1	385	391	PF00498	0.733
LIG_FHA_1	398	404	PF00498	0.612
LIG_FHA_1	506	512	PF00498	0.630
LIG_FHA_1	520	526	PF00498	0.548
LIG_FHA_1	585	591	PF00498	0.527
LIG_FHA_1	592	598	PF00498	0.531
LIG_FHA_1	672	678	PF00498	0.637
LIG_FHA_1	680	686	PF00498	0.606
LIG_FHA_1	74	80	PF00498	0.726
LIG_FHA_1	852	858	PF00498	0.559
LIG_FHA_1	918	924	PF00498	0.626
LIG_FHA_1	96	102	PF00498	0.591
LIG_FHA_2	369	375	PF00498	0.654
LIG_FHA_2	586	592	PF00498	0.525
LIG_LIR_Apic_2	358	364	PF02991	0.590
LIG_LIR_Gen_1	442	453	PF02991	0.604
LIG_LIR_Gen_1	691	698	PF02991	0.542
LIG_LIR_Gen_1	719	727	PF02991	0.605
LIG_LIR_Nem_3	442	448	PF02991	0.602
LIG_LIR_Nem_3	691	695	PF02991	0.547
LIG_LIR_Nem_3	719	723	PF02991	0.600
LIG_LIR_Nem_3	84	88	PF02991	0.667
LIG_MLH1_MIPbox_1	322	326	PF16413	0.578
LIG_MYND_1	402	406	PF01753	0.651
LIG_MYND_1	86	90	PF01753	0.560
LIG_NRBOX	117	123	PF00104	0.489
LIG_PDZ_Class_2	1060	1065	PF00595	0.661
LIG_REV1ctd_RIR_1	323	332	PF16727	0.520
LIG_SH2_CRK	445	449	PF00017	0.577
LIG_SH2_CRK	720	724	PF00017	0.606
LIG_SH2_SRC	552	555	PF00017	0.625
LIG_SH2_STAP1	168	172	PF00017	0.476
LIG_SH2_STAP1	552	556	PF00017	0.627
LIG_SH2_STAP1	742	746	PF00017	0.599
LIG_SH2_STAT3	168	171	PF00017	0.476
LIG_SH2_STAT3	708	711	PF00017	0.465
LIG_SH2_STAT5	569	572	PF00017	0.668
LIG_SH2_STAT5	708	711	PF00017	0.465
LIG_SH2_STAT5	742	745	PF00017	0.602
LIG_SH2_STAT5	875	878	PF00017	0.608
LIG_SH2_STAT5	879	882	PF00017	0.611
LIG_SH3_2	1035	1040	PF14604	0.631
LIG_SH3_2	44	49	PF14604	0.580
LIG_SH3_3	1032	1038	PF00018	0.663
LIG_SH3_3	38	44	PF00018	0.587
LIG_SH3_3	399	405	PF00018	0.671
LIG_SH3_3	527	533	PF00018	0.599
LIG_SH3_3	787	793	PF00018	0.579
LIG_SH3_3	80	86	PF00018	0.581
LIG_SH3_3	877	883	PF00018	0.610
LIG_SUMO_SIM_anti_2	967	974	PF11976	0.561
LIG_SUMO_SIM_par_1	151	156	PF11976	0.544
LIG_TRAF2_1	919	922	PF00917	0.568
LIG_UBA3_1	152	157	PF00899	0.398
LIG_WW_3	746	750	PF00397	0.564
MOD_CDC14_SPxK_1	363	366	PF00782	0.627
MOD_CDC14_SPxK_1	46	49	PF00782	0.586
MOD_CDK_SPxK_1	360	366	PF00069	0.623
MOD_CDK_SPxK_1	43	49	PF00069	0.582
MOD_CDK_SPxxK_3	35	42	PF00069	0.597
MOD_CDK_SPxxK_3	57	64	PF00069	0.676
MOD_CK1_1	1043	1049	PF00069	0.686
MOD_CK1_1	11	17	PF00069	0.667
MOD_CK1_1	181	187	PF00069	0.541
MOD_CK1_1	280	286	PF00069	0.518
MOD_CK1_1	368	374	PF00069	0.770
MOD_CK1_1	384	390	PF00069	0.574
MOD_CK1_1	52	58	PF00069	0.693
MOD_CK1_1	579	585	PF00069	0.557
MOD_CK1_1	60	66	PF00069	0.722
MOD_CK1_1	75	81	PF00069	0.655
MOD_CK1_1	784	790	PF00069	0.621
MOD_CK1_1	796	802	PF00069	0.623
MOD_CK1_1	826	832	PF00069	0.635
MOD_CK1_1	867	873	PF00069	0.648
MOD_CK2_1	318	324	PF00069	0.515
MOD_CK2_1	368	374	PF00069	0.663
MOD_CK2_1	385	391	PF00069	0.563
MOD_CK2_1	585	591	PF00069	0.544
MOD_GlcNHglycan	1003	1006	PF01048	0.605
MOD_GlcNHglycan	1027	1030	PF01048	0.574
MOD_GlcNHglycan	1049	1052	PF01048	0.606
MOD_GlcNHglycan	138	141	PF01048	0.520
MOD_GlcNHglycan	179	183	PF01048	0.405
MOD_GlcNHglycan	231	234	PF01048	0.388
MOD_GlcNHglycan	357	360	PF01048	0.609
MOD_GlcNHglycan	381	384	PF01048	0.689
MOD_GlcNHglycan	406	409	PF01048	0.637
MOD_GlcNHglycan	55	58	PF01048	0.746
MOD_GlcNHglycan	67	70	PF01048	0.642
MOD_GlcNHglycan	712	715	PF01048	0.502
MOD_GlcNHglycan	755	758	PF01048	0.617
MOD_GlcNHglycan	765	768	PF01048	0.560
MOD_GlcNHglycan	782	786	PF01048	0.528
MOD_GlcNHglycan	801	804	PF01048	0.668
MOD_GlcNHglycan	825	828	PF01048	0.586
MOD_GlcNHglycan	851	854	PF01048	0.751
MOD_GlcNHglycan	861	864	PF01048	0.619
MOD_GlcNHglycan	897	900	PF01048	0.690
MOD_GlcNHglycan	905	908	PF01048	0.487
MOD_GlcNHglycan	997	1000	PF01048	0.592
MOD_GSK3_1	1027	1034	PF00069	0.635
MOD_GSK3_1	1043	1050	PF00069	0.687
MOD_GSK3_1	320	327	PF00069	0.642
MOD_GSK3_1	355	362	PF00069	0.553
MOD_GSK3_1	377	384	PF00069	0.768
MOD_GSK3_1	385	392	PF00069	0.621
MOD_GSK3_1	43	50	PF00069	0.828
MOD_GSK3_1	53	60	PF00069	0.674
MOD_GSK3_1	576	583	PF00069	0.564
MOD_GSK3_1	585	592	PF00069	0.493
MOD_GSK3_1	679	686	PF00069	0.726
MOD_GSK3_1	7	14	PF00069	0.711
MOD_GSK3_1	737	744	PF00069	0.670
MOD_GSK3_1	747	754	PF00069	0.593
MOD_GSK3_1	757	764	PF00069	0.520
MOD_GSK3_1	789	796	PF00069	0.679
MOD_GSK3_1	802	809	PF00069	0.573
MOD_GSK3_1	841	848	PF00069	0.678
MOD_GSK3_1	866	873	PF00069	0.654
MOD_GSK3_1	895	902	PF00069	0.709
MOD_N-GLC_1	384	389	PF02516	0.709
MOD_N-GLC_1	665	670	PF02516	0.663
MOD_N-GLC_1	864	869	PF02516	0.667
MOD_NEK2_1	13	18	PF00069	0.691
MOD_NEK2_1	365	370	PF00069	0.620
MOD_NEK2_1	379	384	PF00069	0.574
MOD_NEK2_1	476	481	PF00069	0.577
MOD_NEK2_1	580	585	PF00069	0.611
MOD_NEK2_1	593	598	PF00069	0.475
MOD_NEK2_1	665	670	PF00069	0.693
MOD_NEK2_1	679	684	PF00069	0.531
MOD_NEK2_1	730	735	PF00069	0.590
MOD_NEK2_1	753	758	PF00069	0.701
MOD_NEK2_1	823	828	PF00069	0.671
MOD_NEK2_1	851	856	PF00069	0.559
MOD_NEK2_2	757	762	PF00069	0.594
MOD_PIKK_1	162	168	PF00454	0.404
MOD_PIKK_1	280	286	PF00454	0.528
MOD_PIKK_1	392	398	PF00454	0.657
MOD_PIKK_1	476	482	PF00454	0.550
MOD_PIKK_1	505	511	PF00454	0.603
MOD_PIKK_1	747	753	PF00454	0.687
MOD_PIKK_1	8	14	PF00454	0.691
MOD_PIKK_1	867	873	PF00454	0.674
MOD_PIKK_1	917	923	PF00454	0.626
MOD_PK_1	514	520	PF00069	0.612
MOD_PKA_1	514	520	PF00069	0.612
MOD_PKA_1	806	812	PF00069	0.670
MOD_PKA_2	1043	1049	PF00069	0.652
MOD_PKA_2	207	213	PF00069	0.516
MOD_PKA_2	218	224	PF00069	0.391
MOD_PKA_2	229	235	PF00069	0.399
MOD_PKA_2	365	371	PF00069	0.618
MOD_PKA_2	417	423	PF00069	0.529
MOD_PKA_2	439	445	PF00069	0.616
MOD_PKA_2	513	519	PF00069	0.662
MOD_PKA_2	580	586	PF00069	0.614
MOD_PKA_2	671	677	PF00069	0.629
MOD_PKA_2	70	76	PF00069	0.709
MOD_PKA_2	751	757	PF00069	0.592
MOD_Plk_1	289	295	PF00069	0.575
MOD_Plk_1	565	571	PF00069	0.611
MOD_Plk_1	665	671	PF00069	0.651
MOD_Plk_4	1058	1064	PF00069	0.627
MOD_Plk_4	385	391	PF00069	0.618
MOD_Plk_4	507	513	PF00069	0.614
MOD_Plk_4	585	591	PF00069	0.535
MOD_Plk_4	637	643	PF00069	0.502
MOD_Plk_4	698	704	PF00069	0.557
MOD_Plk_4	712	718	PF00069	0.524
MOD_Plk_4	968	974	PF00069	0.590
MOD_ProDKin_1	1031	1037	PF00069	0.627
MOD_ProDKin_1	35	41	PF00069	0.615
MOD_ProDKin_1	360	366	PF00069	0.676
MOD_ProDKin_1	389	395	PF00069	0.604
MOD_ProDKin_1	43	49	PF00069	0.596
MOD_ProDKin_1	50	56	PF00069	0.656
MOD_ProDKin_1	57	63	PF00069	0.746
MOD_ProDKin_1	683	689	PF00069	0.586
MOD_ProDKin_1	789	795	PF00069	0.710
MOD_ProDKin_1	836	842	PF00069	0.631
MOD_ProDKin_1	864	870	PF00069	0.660
MOD_SUMO_for_1	245	248	PF00179	0.523
MOD_SUMO_for_1	459	462	PF00179	0.585
MOD_SUMO_rev_2	143	153	PF00179	0.533
MOD_SUMO_rev_2	309	317	PF00179	0.591
MOD_SUMO_rev_2	462	472	PF00179	0.565
TRG_DiLeu_BaEn_1	818	823	PF01217	0.613
TRG_DiLeu_BaEn_2	1031	1037	PF01217	0.578
TRG_DiLeu_BaEn_3	169	175	PF01217	0.457
TRG_DiLeu_BaLyEn_6	685	690	PF01217	0.582
TRG_ENDOCYTIC_2	445	448	PF00928	0.574
TRG_ENDOCYTIC_2	720	723	PF00928	0.604
TRG_ENDOCYTIC_2	772	775	PF00928	0.554
TRG_ENDOCYTIC_2	816	819	PF00928	0.563
TRG_ER_diArg_1	130	132	PF00400	0.481
TRG_ER_diArg_1	196	198	PF00400	0.533
TRG_ER_diArg_1	415	418	PF00400	0.584
TRG_ER_diArg_1	425	428	PF00400	0.509
TRG_ER_diArg_1	472	475	PF00400	0.544
TRG_ER_diArg_1	886	888	PF00400	0.612
TRG_ER_diArg_1	973	975	PF00400	0.625
TRG_NES_CRM1_1	112	127	PF08389	0.462
TRG_NES_CRM1_1	256	269	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	820	824	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD26	Leptomonas seymouri	28%	79%
A4HLU6	Leishmania braziliensis	59%	100%
E9AHQ1	Leishmania infantum	99%	100%
E9B472	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q3V4	Leishmania major	84%	100%