Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7U8_LEIDO

TriTrypDb:

LdBPK_332140.1 , LdCL_330028300 , LDHU3_33.3100

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H7U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.660
CLV_C14_Caspase3-7	250	254	PF00656	0.654
CLV_C14_Caspase3-7	507	511	PF00656	0.546
CLV_NRD_NRD_1	142	144	PF00675	0.481
CLV_NRD_NRD_1	231	233	PF00675	0.564
CLV_NRD_NRD_1	235	237	PF00675	0.551
CLV_NRD_NRD_1	331	333	PF00675	0.511
CLV_NRD_NRD_1	423	425	PF00675	0.754
CLV_NRD_NRD_1	480	482	PF00675	0.435
CLV_NRD_NRD_1	520	522	PF00675	0.392
CLV_PCSK_FUR_1	232	236	PF00082	0.537
CLV_PCSK_KEX2_1	142	144	PF00082	0.510
CLV_PCSK_KEX2_1	231	233	PF00082	0.564
CLV_PCSK_KEX2_1	234	236	PF00082	0.562
CLV_PCSK_KEX2_1	331	333	PF00082	0.511
CLV_PCSK_KEX2_1	423	425	PF00082	0.754
CLV_PCSK_KEX2_1	480	482	PF00082	0.435
CLV_PCSK_KEX2_1	520	522	PF00082	0.392
CLV_PCSK_KEX2_1	614	616	PF00082	0.452
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.452
CLV_PCSK_PC7_1	231	237	PF00082	0.528
CLV_PCSK_SKI1_1	142	146	PF00082	0.522
CLV_PCSK_SKI1_1	453	457	PF00082	0.489
CLV_PCSK_SKI1_1	575	579	PF00082	0.399
DEG_APCC_DBOX_1	479	487	PF00400	0.654
DEG_APCC_DBOX_1	574	582	PF00400	0.399
DEG_SPOP_SBC_1	252	256	PF00917	0.700
DEG_SPOP_SBC_1	34	38	PF00917	0.683
DOC_CKS1_1	661	666	PF01111	0.706
DOC_CKS1_1	69	74	PF01111	0.727
DOC_CYCLIN_RxL_1	447	457	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.660
DOC_CYCLIN_yCln2_LP_2	688	691	PF00134	0.732
DOC_MAPK_gen_1	520	528	PF00069	0.602
DOC_MAPK_gen_1	572	581	PF00069	0.542
DOC_MAPK_MEF2A_6	575	583	PF00069	0.392
DOC_PP1_RVXF_1	398	405	PF00149	0.287
DOC_PP2B_LxvP_1	299	302	PF13499	0.751
DOC_PP2B_LxvP_1	43	46	PF13499	0.731
DOC_PP2B_LxvP_1	681	684	PF13499	0.726
DOC_PP2B_LxvP_1	688	691	PF13499	0.685
DOC_PP2B_LxvP_1	705	708	PF13499	0.619
DOC_PP4_FxxP_1	69	72	PF00568	0.730
DOC_USP7_MATH_1	111	115	PF00917	0.694
DOC_USP7_MATH_1	137	141	PF00917	0.719
DOC_USP7_MATH_1	165	169	PF00917	0.728
DOC_USP7_MATH_1	196	200	PF00917	0.737
DOC_USP7_MATH_1	24	28	PF00917	0.779
DOC_USP7_MATH_1	272	276	PF00917	0.696
DOC_USP7_MATH_1	290	294	PF00917	0.678
DOC_USP7_MATH_1	34	38	PF00917	0.696
DOC_USP7_MATH_1	368	372	PF00917	0.720
DOC_USP7_MATH_1	414	418	PF00917	0.523
DOC_USP7_MATH_1	425	429	PF00917	0.450
DOC_USP7_MATH_1	512	516	PF00917	0.585
DOC_USP7_MATH_1	533	537	PF00917	0.568
DOC_USP7_MATH_1	697	701	PF00917	0.694
DOC_USP7_MATH_1	80	84	PF00917	0.771
DOC_USP7_MATH_2	53	59	PF00917	0.646
DOC_USP7_UBL2_3	369	373	PF12436	0.677
DOC_WW_Pin1_4	115	120	PF00397	0.812
DOC_WW_Pin1_4	129	134	PF00397	0.722
DOC_WW_Pin1_4	153	158	PF00397	0.697
DOC_WW_Pin1_4	199	204	PF00397	0.696
DOC_WW_Pin1_4	213	218	PF00397	0.657
DOC_WW_Pin1_4	234	239	PF00397	0.710
DOC_WW_Pin1_4	297	302	PF00397	0.717
DOC_WW_Pin1_4	37	42	PF00397	0.744
DOC_WW_Pin1_4	412	417	PF00397	0.541
DOC_WW_Pin1_4	644	649	PF00397	0.697
DOC_WW_Pin1_4	657	662	PF00397	0.629
DOC_WW_Pin1_4	68	73	PF00397	0.763
LIG_14-3-3_CanoR_1	142	151	PF00244	0.674
LIG_14-3-3_CanoR_1	331	338	PF00244	0.724
LIG_14-3-3_CanoR_1	348	357	PF00244	0.633
LIG_14-3-3_CanoR_1	381	389	PF00244	0.728
LIG_14-3-3_CanoR_1	392	402	PF00244	0.483
LIG_14-3-3_CanoR_1	409	416	PF00244	0.422
LIG_14-3-3_CanoR_1	424	430	PF00244	0.479
LIG_14-3-3_CanoR_1	453	462	PF00244	0.289
LIG_14-3-3_CanoR_1	554	560	PF00244	0.583
LIG_14-3-3_CanoR_1	644	648	PF00244	0.715
LIG_14-3-3_CanoR_1	673	679	PF00244	0.718
LIG_14-3-3_CanoR_1	90	98	PF00244	0.721
LIG_BRCT_BRCA1_1	287	291	PF00533	0.706
LIG_BRCT_BRCA1_1	385	389	PF00533	0.687
LIG_BRCT_BRCA1_1	496	500	PF00533	0.617
LIG_BRCT_BRCA1_1	543	547	PF00533	0.610
LIG_BRCT_BRCA1_1	569	573	PF00533	0.544
LIG_BRCT_BRCA1_1	646	650	PF00533	0.710
LIG_BRCT_BRCA1_1	92	96	PF00533	0.713
LIG_deltaCOP1_diTrp_1	494	500	PF00928	0.618
LIG_EH_1	281	285	PF12763	0.727
LIG_FHA_1	174	180	PF00498	0.730
LIG_FHA_1	254	260	PF00498	0.638
LIG_FHA_1	298	304	PF00498	0.721
LIG_FHA_1	341	347	PF00498	0.739
LIG_FHA_1	38	44	PF00498	0.726
LIG_FHA_1	425	431	PF00498	0.445
LIG_FHA_1	504	510	PF00498	0.615
LIG_FHA_1	580	586	PF00498	0.287
LIG_FHA_1	599	605	PF00498	0.387
LIG_FHA_1	90	96	PF00498	0.732
LIG_FHA_2	102	108	PF00498	0.722
LIG_LIR_Apic_2	401	407	PF02991	0.312
LIG_LIR_Gen_1	281	292	PF02991	0.662
LIG_LIR_Gen_1	494	502	PF02991	0.624
LIG_LIR_Gen_1	557	567	PF02991	0.625
LIG_LIR_Gen_1	574	585	PF02991	0.262
LIG_LIR_Gen_1	606	616	PF02991	0.588
LIG_LIR_Gen_1	97	106	PF02991	0.706
LIG_LIR_LC3C_4	702	707	PF02991	0.686
LIG_LIR_Nem_3	281	287	PF02991	0.663
LIG_LIR_Nem_3	449	455	PF02991	0.447
LIG_LIR_Nem_3	457	462	PF02991	0.319
LIG_LIR_Nem_3	494	499	PF02991	0.621
LIG_LIR_Nem_3	557	562	PF02991	0.625
LIG_LIR_Nem_3	574	580	PF02991	0.262
LIG_LIR_Nem_3	606	612	PF02991	0.583
LIG_LIR_Nem_3	677	681	PF02991	0.719
LIG_LIR_Nem_3	97	101	PF02991	0.726
LIG_MYND_1	297	301	PF01753	0.713
LIG_MYND_1	41	45	PF01753	0.696
LIG_Pex14_1	496	500	PF04695	0.617
LIG_Pex14_2	469	473	PF04695	0.332
LIG_Pex14_2	573	577	PF04695	0.262
LIG_SH2_CRK	502	506	PF00017	0.613
LIG_SH2_CRK	609	613	PF00017	0.677
LIG_SH2_CRK	70	74	PF00017	0.671
LIG_SH2_GRB2like	502	505	PF00017	0.615
LIG_SH2_NCK_1	172	176	PF00017	0.711
LIG_SH2_NCK_1	534	538	PF00017	0.625
LIG_SH2_NCK_1	70	74	PF00017	0.635
LIG_SH2_SRC	172	175	PF00017	0.709
LIG_SH2_SRC	502	505	PF00017	0.633
LIG_SH2_SRC	567	570	PF00017	0.601
LIG_SH2_STAT5	152	155	PF00017	0.701
LIG_SH2_STAT5	208	211	PF00017	0.690
LIG_SH2_STAT5	445	448	PF00017	0.440
LIG_SH2_STAT5	460	463	PF00017	0.296
LIG_SH2_STAT5	471	474	PF00017	0.289
LIG_SH2_STAT5	70	73	PF00017	0.682
LIG_SH3_3	211	217	PF00018	0.684
LIG_SH3_3	332	338	PF00018	0.742
LIG_SH3_3	362	368	PF00018	0.768
LIG_SH3_3	42	48	PF00018	0.727
LIG_SH3_3	433	439	PF00018	0.501
LIG_SH3_3	57	63	PF00018	0.717
LIG_SH3_3	658	664	PF00018	0.674
LIG_SH3_3	703	709	PF00018	0.722
LIG_Sin3_3	175	182	PF02671	0.661
LIG_SUMO_SIM_anti_2	253	262	PF11976	0.640
LIG_SUMO_SIM_anti_2	582	588	PF11976	0.287
LIG_SUMO_SIM_par_1	253	262	PF11976	0.640
LIG_SUMO_SIM_par_1	577	582	PF11976	0.363
LIG_TRAF2_1	361	364	PF00917	0.770
LIG_TYR_ITIM	607	612	PF00017	0.674
LIG_UBA3_1	441	447	PF00899	0.466
LIG_WRC_WIRS_1	556	561	PF05994	0.596
LIG_WRC_WIRS_1	675	680	PF05994	0.717
LIG_WRC_WIRS_1	95	100	PF05994	0.705
LIG_WW_1	149	152	PF00397	0.695
LIG_WW_2	60	63	PF00397	0.656
MOD_CDK_SPxxK_3	115	122	PF00069	0.731
MOD_CK1_1	199	205	PF00069	0.718
MOD_CK1_1	20	26	PF00069	0.806
MOD_CK1_1	207	213	PF00069	0.748
MOD_CK1_1	216	222	PF00069	0.667
MOD_CK1_1	225	231	PF00069	0.646
MOD_CK1_1	237	243	PF00069	0.692
MOD_CK1_1	295	301	PF00069	0.726
MOD_CK1_1	326	332	PF00069	0.742
MOD_CK1_1	37	43	PF00069	0.763
MOD_CK1_1	390	396	PF00069	0.528
MOD_CK1_1	428	434	PF00069	0.490
MOD_CK1_1	454	460	PF00069	0.324
MOD_CK1_1	488	494	PF00069	0.632
MOD_CK1_1	557	563	PF00069	0.612
MOD_CK1_1	588	594	PF00069	0.349
MOD_CK1_1	598	604	PF00069	0.252
MOD_CK1_1	659	665	PF00069	0.721
MOD_CK1_1	83	89	PF00069	0.794
MOD_CK1_1	97	103	PF00069	0.739
MOD_CK2_1	348	354	PF00069	0.741
MOD_CK2_1	358	364	PF00069	0.716
MOD_CK2_1	368	374	PF00069	0.649
MOD_CK2_1	488	494	PF00069	0.632
MOD_CK2_1	610	616	PF00069	0.681
MOD_CK2_1	97	103	PF00069	0.758
MOD_DYRK1A_RPxSP_1	644	648	PF00069	0.726
MOD_GlcNHglycan	139	142	PF01048	0.608
MOD_GlcNHglycan	145	148	PF01048	0.549
MOD_GlcNHglycan	18	22	PF01048	0.496
MOD_GlcNHglycan	26	29	PF01048	0.560
MOD_GlcNHglycan	278	281	PF01048	0.524
MOD_GlcNHglycan	332	335	PF01048	0.549
MOD_GlcNHglycan	350	353	PF01048	0.431
MOD_GlcNHglycan	385	388	PF01048	0.543
MOD_GlcNHglycan	392	395	PF01048	0.292
MOD_GlcNHglycan	430	433	PF01048	0.648
MOD_GlcNHglycan	456	459	PF01048	0.324
MOD_GlcNHglycan	506	509	PF01048	0.370
MOD_GlcNHglycan	522	525	PF01048	0.344
MOD_GlcNHglycan	535	538	PF01048	0.356
MOD_GlcNHglycan	57	60	PF01048	0.542
MOD_GlcNHglycan	684	687	PF01048	0.526
MOD_GlcNHglycan	701	704	PF01048	0.425
MOD_GSK3_1	111	118	PF00069	0.779
MOD_GSK3_1	152	159	PF00069	0.684
MOD_GSK3_1	20	27	PF00069	0.804
MOD_GSK3_1	272	279	PF00069	0.760
MOD_GSK3_1	286	293	PF00069	0.668
MOD_GSK3_1	319	326	PF00069	0.716
MOD_GSK3_1	33	40	PF00069	0.683
MOD_GSK3_1	336	343	PF00069	0.644
MOD_GSK3_1	369	376	PF00069	0.729
MOD_GSK3_1	383	390	PF00069	0.629
MOD_GSK3_1	408	415	PF00069	0.631
MOD_GSK3_1	424	431	PF00069	0.457
MOD_GSK3_1	447	454	PF00069	0.416
MOD_GSK3_1	520	527	PF00069	0.624
MOD_GSK3_1	529	536	PF00069	0.601
MOD_GSK3_1	557	564	PF00069	0.605
MOD_GSK3_1	567	574	PF00069	0.573
MOD_GSK3_1	581	588	PF00069	0.244
MOD_GSK3_1	636	643	PF00069	0.705
MOD_GSK3_1	656	663	PF00069	0.597
MOD_GSK3_1	90	97	PF00069	0.777
MOD_N-GLC_1	199	204	PF02516	0.434
MOD_N-GLC_1	272	277	PF02516	0.571
MOD_N-GLC_1	503	508	PF02516	0.408
MOD_N-GLC_1	529	534	PF02516	0.444
MOD_N-GLC_1	541	546	PF02516	0.339
MOD_NEK2_1	291	296	PF00069	0.677
MOD_NEK2_1	340	345	PF00069	0.683
MOD_NEK2_1	398	403	PF00069	0.312
MOD_NEK2_1	430	435	PF00069	0.481
MOD_NEK2_1	451	456	PF00069	0.403
MOD_NEK2_1	54	59	PF00069	0.774
MOD_NEK2_1	555	560	PF00069	0.593
MOD_NEK2_1	581	586	PF00069	0.399
MOD_NEK2_1	621	626	PF00069	0.703
MOD_NEK2_1	699	704	PF00069	0.740
MOD_OFUCOSY	593	599	PF10250	0.337
MOD_PIKK_1	272	278	PF00454	0.718
MOD_PIKK_1	314	320	PF00454	0.734
MOD_PIKK_1	373	379	PF00454	0.761
MOD_PIKK_1	387	393	PF00454	0.629
MOD_PIKK_1	414	420	PF00454	0.526
MOD_PIKK_1	548	554	PF00454	0.631
MOD_PIKK_1	557	563	PF00454	0.567
MOD_PKA_1	142	148	PF00069	0.705
MOD_PKA_1	423	429	PF00069	0.513
MOD_PKA_1	520	526	PF00069	0.598
MOD_PKA_2	142	148	PF00069	0.705
MOD_PKA_2	306	312	PF00069	0.724
MOD_PKA_2	330	336	PF00069	0.726
MOD_PKA_2	408	414	PF00069	0.612
MOD_PKA_2	423	429	PF00069	0.480
MOD_PKA_2	520	526	PF00069	0.598
MOD_PKA_2	571	577	PF00069	0.542
MOD_PKA_2	643	649	PF00069	0.729
MOD_PKA_2	80	86	PF00069	0.784
MOD_PKA_2	89	95	PF00069	0.694
MOD_Plk_1	173	179	PF00069	0.718
MOD_Plk_1	252	258	PF00069	0.700
MOD_Plk_1	322	328	PF00069	0.734
MOD_Plk_1	529	535	PF00069	0.647
MOD_Plk_4	204	210	PF00069	0.697
MOD_Plk_4	425	431	PF00069	0.463
MOD_Plk_4	447	453	PF00069	0.417
MOD_Plk_4	485	491	PF00069	0.661
MOD_Plk_4	581	587	PF00069	0.339
MOD_Plk_4	690	696	PF00069	0.696
MOD_ProDKin_1	115	121	PF00069	0.812
MOD_ProDKin_1	129	135	PF00069	0.723
MOD_ProDKin_1	153	159	PF00069	0.697
MOD_ProDKin_1	199	205	PF00069	0.694
MOD_ProDKin_1	213	219	PF00069	0.657
MOD_ProDKin_1	234	240	PF00069	0.709
MOD_ProDKin_1	297	303	PF00069	0.719
MOD_ProDKin_1	37	43	PF00069	0.747
MOD_ProDKin_1	412	418	PF00069	0.542
MOD_ProDKin_1	644	650	PF00069	0.698
MOD_ProDKin_1	657	663	PF00069	0.630
MOD_ProDKin_1	68	74	PF00069	0.762
MOD_SUMO_for_1	121	124	PF00179	0.698
MOD_SUMO_for_1	446	449	PF00179	0.409
TRG_DiLeu_BaEn_3	616	622	PF01217	0.590
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.703
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.547
TRG_ENDOCYTIC_2	459	462	PF00928	0.387
TRG_ENDOCYTIC_2	502	505	PF00928	0.633
TRG_ENDOCYTIC_2	609	612	PF00928	0.679
TRG_ER_diArg_1	142	144	PF00400	0.710
TRG_ER_diArg_1	231	234	PF00400	0.767
TRG_ER_diArg_1	423	425	PF00400	0.474
TRG_ER_diArg_1	479	481	PF00400	0.624
TRG_NES_CRM1_1	482	494	PF08389	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLR4	Leishmania braziliensis	50%	100%
A4I964	Leishmania infantum	99%	100%
E9B440	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3Y5	Leishmania major	83%	100%