Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7T7_LEIDO

TriTrypDb:

LdBPK_330200.1 , LdCL_330006900 , LDHU3_33.0220

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S5H7T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.659
CLV_C14_Caspase3-7	290	294	PF00656	0.599
CLV_C14_Caspase3-7	635	639	PF00656	0.702
CLV_NRD_NRD_1	2	4	PF00675	0.473
CLV_NRD_NRD_1	256	258	PF00675	0.468
CLV_NRD_NRD_1	373	375	PF00675	0.638
CLV_NRD_NRD_1	402	404	PF00675	0.534
CLV_NRD_NRD_1	46	48	PF00675	0.431
CLV_NRD_NRD_1	465	467	PF00675	0.543
CLV_NRD_NRD_1	69	71	PF00675	0.473
CLV_NRD_NRD_1	73	75	PF00675	0.457
CLV_PCSK_KEX2_1	2	4	PF00082	0.473
CLV_PCSK_KEX2_1	256	258	PF00082	0.468
CLV_PCSK_KEX2_1	313	315	PF00082	0.582
CLV_PCSK_KEX2_1	328	330	PF00082	0.343
CLV_PCSK_KEX2_1	373	375	PF00082	0.638
CLV_PCSK_KEX2_1	401	403	PF00082	0.571
CLV_PCSK_KEX2_1	46	48	PF00082	0.431
CLV_PCSK_KEX2_1	465	467	PF00082	0.567
CLV_PCSK_KEX2_1	69	71	PF00082	0.473
CLV_PCSK_KEX2_1	73	75	PF00082	0.457
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.616
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.377
CLV_PCSK_PC7_1	309	315	PF00082	0.548
CLV_PCSK_PC7_1	69	75	PF00082	0.466
CLV_PCSK_SKI1_1	202	206	PF00082	0.536
CLV_PCSK_SKI1_1	256	260	PF00082	0.506
CLV_PCSK_SKI1_1	287	291	PF00082	0.452
CLV_PCSK_SKI1_1	314	318	PF00082	0.466
CLV_PCSK_SKI1_1	393	397	PF00082	0.643
CLV_PCSK_SKI1_1	637	641	PF00082	0.604
CLV_PCSK_SKI1_1	98	102	PF00082	0.428
DEG_APCC_DBOX_1	201	209	PF00400	0.475
DEG_Nend_UBRbox_1	1	4	PF02207	0.483
DEG_SPOP_SBC_1	628	632	PF00917	0.702
DOC_AGCK_PIF_3	676	679	PF00069	0.687
DOC_CKS1_1	439	444	PF01111	0.733
DOC_CKS1_1	610	615	PF01111	0.662
DOC_CYCLIN_RxL_1	614	626	PF00134	0.621
DOC_MAPK_gen_1	116	125	PF00069	0.471
DOC_MAPK_gen_1	152	161	PF00069	0.548
DOC_MAPK_gen_1	426	434	PF00069	0.454
DOC_MAPK_JIP1_4	549	555	PF00069	0.530
DOC_MAPK_MEF2A_6	152	161	PF00069	0.524
DOC_MAPK_MEF2A_6	393	400	PF00069	0.661
DOC_MAPK_MEF2A_6	552	561	PF00069	0.524
DOC_MAPK_NFAT4_5	393	401	PF00069	0.564
DOC_MIT_MIM_1	574	583	PF04212	0.524
DOC_PP2B_PxIxI_1	556	562	PF00149	0.562
DOC_PP4_FxxP_1	79	82	PF00568	0.438
DOC_USP7_MATH_1	178	182	PF00917	0.614
DOC_USP7_MATH_1	30	34	PF00917	0.457
DOC_USP7_MATH_1	391	395	PF00917	0.643
DOC_USP7_MATH_1	420	424	PF00917	0.399
DOC_USP7_MATH_1	477	481	PF00917	0.505
DOC_USP7_MATH_1	500	504	PF00917	0.571
DOC_USP7_MATH_1	505	509	PF00917	0.588
DOC_USP7_MATH_1	602	606	PF00917	0.677
DOC_USP7_MATH_1	628	632	PF00917	0.660
DOC_WW_Pin1_4	383	388	PF00397	0.694
DOC_WW_Pin1_4	410	415	PF00397	0.532
DOC_WW_Pin1_4	438	443	PF00397	0.651
DOC_WW_Pin1_4	466	471	PF00397	0.646
DOC_WW_Pin1_4	526	531	PF00397	0.681
DOC_WW_Pin1_4	609	614	PF00397	0.669
DOC_WW_Pin1_4	638	643	PF00397	0.733
DOC_WW_Pin1_4	73	78	PF00397	0.446
LIG_14-3-3_CanoR_1	104	110	PF00244	0.469
LIG_14-3-3_CanoR_1	256	261	PF00244	0.436
LIG_14-3-3_CanoR_1	353	361	PF00244	0.692
LIG_14-3-3_CanoR_1	374	382	PF00244	0.667
LIG_14-3-3_CanoR_1	465	470	PF00244	0.575
LIG_14-3-3_CanoR_1	487	497	PF00244	0.554
LIG_14-3-3_CanoR_1	579	584	PF00244	0.503
LIG_14-3-3_CanoR_1	646	656	PF00244	0.752
LIG_BRCT_BRCA1_1	489	493	PF00533	0.513
LIG_BRCT_BRCA1_1	75	79	PF00533	0.440
LIG_DLG_GKlike_1	127	134	PF00625	0.562
LIG_DLG_GKlike_1	579	587	PF00625	0.614
LIG_eIF4E_1	167	173	PF01652	0.622
LIG_FHA_1	207	213	PF00498	0.563
LIG_FHA_1	438	444	PF00498	0.729
LIG_FHA_1	466	472	PF00498	0.607
LIG_FHA_1	490	496	PF00498	0.497
LIG_FHA_1	505	511	PF00498	0.465
LIG_FHA_1	556	562	PF00498	0.547
LIG_FHA_1	604	610	PF00498	0.634
LIG_FHA_1	613	619	PF00498	0.668
LIG_FHA_1	660	666	PF00498	0.655
LIG_FHA_2	236	242	PF00498	0.603
LIG_FHA_2	288	294	PF00498	0.544
LIG_FHA_2	631	637	PF00498	0.722
LIG_HP1_1	201	205	PF01393	0.563
LIG_LIR_Apic_2	607	613	PF02991	0.645
LIG_LIR_Apic_2	76	82	PF02991	0.435
LIG_LIR_Gen_1	259	266	PF02991	0.542
LIG_LIR_Gen_1	490	500	PF02991	0.527
LIG_LIR_Gen_1	50	60	PF02991	0.466
LIG_LIR_Gen_1	574	583	PF02991	0.482
LIG_LIR_Gen_1	673	679	PF02991	0.617
LIG_LIR_Nem_3	165	170	PF02991	0.591
LIG_LIR_Nem_3	231	237	PF02991	0.481
LIG_LIR_Nem_3	259	264	PF02991	0.545
LIG_LIR_Nem_3	490	496	PF02991	0.533
LIG_LIR_Nem_3	50	56	PF02991	0.459
LIG_LIR_Nem_3	574	578	PF02991	0.481
LIG_LIR_Nem_3	581	587	PF02991	0.511
LIG_LIR_Nem_3	59	64	PF02991	0.484
LIG_LIR_Nem_3	673	679	PF02991	0.614
LIG_PDZ_Class_1	674	679	PF00595	0.619
LIG_Pex14_2	75	79	PF04695	0.490
LIG_Pex14_2	97	101	PF04695	0.421
LIG_REV1ctd_RIR_1	98	108	PF16727	0.445
LIG_SH2_CRK	170	174	PF00017	0.580
LIG_SH2_CRK	364	368	PF00017	0.666
LIG_SH2_NCK_1	170	174	PF00017	0.624
LIG_SH2_NCK_1	427	431	PF00017	0.472
LIG_SH2_STAP1	121	125	PF00017	0.472
LIG_SH2_STAT3	174	177	PF00017	0.705
LIG_SH2_STAT5	167	170	PF00017	0.531
LIG_SH3_3	143	149	PF00018	0.704
LIG_SH3_3	195	201	PF00018	0.516
LIG_SH3_3	384	390	PF00018	0.771
LIG_SH3_3	594	600	PF00018	0.490
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.471
LIG_SUMO_SIM_anti_2	490	498	PF11976	0.587
LIG_SUMO_SIM_par_1	490	498	PF11976	0.442
LIG_TYR_ITIM	168	173	PF00017	0.571
LIG_WRC_WIRS_1	81	86	PF05994	0.483
MOD_CDC14_SPxK_1	529	532	PF00782	0.676
MOD_CDK_SPK_2	609	614	PF00069	0.438
MOD_CDK_SPxK_1	526	532	PF00069	0.657
MOD_CK1_1	108	114	PF00069	0.480
MOD_CK1_1	368	374	PF00069	0.650
MOD_CK1_1	383	389	PF00069	0.719
MOD_CK1_1	450	456	PF00069	0.672
MOD_CK1_1	59	65	PF00069	0.431
MOD_CK1_1	630	636	PF00069	0.682
MOD_CK1_1	87	93	PF00069	0.397
MOD_CK2_1	235	241	PF00069	0.545
MOD_CK2_1	285	291	PF00069	0.508
MOD_CK2_1	495	501	PF00069	0.533
MOD_Cter_Amidation	311	314	PF01082	0.637
MOD_Cter_Amidation	326	329	PF01082	0.379
MOD_GlcNHglycan	164	167	PF01048	0.525
MOD_GlcNHglycan	23	26	PF01048	0.456
MOD_GlcNHglycan	367	370	PF01048	0.696
MOD_GlcNHglycan	377	380	PF01048	0.679
MOD_GlcNHglycan	447	450	PF01048	0.719
MOD_GlcNHglycan	452	455	PF01048	0.637
MOD_GlcNHglycan	479	482	PF01048	0.662
MOD_GlcNHglycan	49	52	PF01048	0.413
MOD_GlcNHglycan	501	505	PF01048	0.587
MOD_GlcNHglycan	625	628	PF01048	0.738
MOD_GlcNHglycan	675	679	PF01048	0.632
MOD_GlcNHglycan	89	92	PF01048	0.392
MOD_GSK3_1	104	111	PF00069	0.470
MOD_GSK3_1	30	37	PF00069	0.458
MOD_GSK3_1	443	450	PF00069	0.679
MOD_GSK3_1	500	507	PF00069	0.459
MOD_GSK3_1	623	630	PF00069	0.656
MOD_GSK3_1	638	645	PF00069	0.609
MOD_GSK3_1	73	80	PF00069	0.444
MOD_N-GLC_1	206	211	PF02516	0.557
MOD_NEK2_1	489	494	PF00069	0.608
MOD_NEK2_1	563	568	PF00069	0.559
MOD_NEK2_1	621	626	PF00069	0.750
MOD_NEK2_1	644	649	PF00069	0.657
MOD_NEK2_1	84	89	PF00069	0.462
MOD_PIKK_1	178	184	PF00454	0.625
MOD_PIKK_1	443	449	PF00454	0.705
MOD_PIKK_1	648	654	PF00454	0.772
MOD_PKA_1	256	262	PF00069	0.431
MOD_PKA_1	465	471	PF00069	0.629
MOD_PKA_2	256	262	PF00069	0.431
MOD_PKA_2	352	358	PF00069	0.648
MOD_PKA_2	465	471	PF00069	0.575
MOD_PKA_2	477	483	PF00069	0.565
MOD_PKA_2	578	584	PF00069	0.436
MOD_PKB_1	102	110	PF00069	0.463
MOD_PKB_1	485	493	PF00069	0.612
MOD_Plk_1	59	65	PF00069	0.431
MOD_Plk_4	235	241	PF00069	0.523
MOD_Plk_4	256	262	PF00069	0.431
MOD_Plk_4	391	397	PF00069	0.758
MOD_Plk_4	420	426	PF00069	0.555
MOD_Plk_4	452	458	PF00069	0.693
MOD_Plk_4	489	495	PF00069	0.602
MOD_Plk_4	566	572	PF00069	0.482
MOD_Plk_4	579	585	PF00069	0.520
MOD_Plk_4	604	610	PF00069	0.647
MOD_ProDKin_1	383	389	PF00069	0.695
MOD_ProDKin_1	410	416	PF00069	0.526
MOD_ProDKin_1	438	444	PF00069	0.650
MOD_ProDKin_1	466	472	PF00069	0.647
MOD_ProDKin_1	526	532	PF00069	0.686
MOD_ProDKin_1	609	615	PF00069	0.662
MOD_ProDKin_1	638	644	PF00069	0.733
MOD_ProDKin_1	73	79	PF00069	0.446
MOD_SUMO_rev_2	271	281	PF00179	0.472
MOD_SUMO_rev_2	324	330	PF00179	0.604
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.525
TRG_ENDOCYTIC_2	170	173	PF00928	0.550
TRG_ER_diArg_1	1	3	PF00400	0.502
TRG_ER_diArg_1	101	104	PF00400	0.444
TRG_ER_diArg_1	199	202	PF00400	0.624
TRG_ER_diArg_1	255	257	PF00400	0.513
TRG_ER_diArg_1	372	374	PF00400	0.643
TRG_ER_diArg_1	400	403	PF00400	0.722
TRG_ER_diArg_1	73	75	PF00400	0.461
TRG_NES_CRM1_1	488	502	PF08389	0.603
TRG_NLS_MonoExtC_3	69	74	PF00514	0.467
TRG_NLS_MonoExtN_4	69	74	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z6	Leptomonas seymouri	36%	100%
A0A3R7MER9	Trypanosoma rangeli	23%	100%
A4HL56	Leishmania braziliensis	70%	100%
A4I8N5	Leishmania infantum	100%	100%
E9B3J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4K4	Leishmania major	89%	100%
V5AVX1	Trypanosoma cruzi	23%	100%