SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7T5_LEIDO

TriTrypDb:

LdBPK_324010.1 , LdCL_320046100 , LDHU3_32.5140

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7T5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.534
CLV_C14_Caspase3-7	585	589	PF00656	0.728
CLV_NRD_NRD_1	228	230	PF00675	0.609
CLV_NRD_NRD_1	25	27	PF00675	0.558
CLV_NRD_NRD_1	357	359	PF00675	0.517
CLV_NRD_NRD_1	392	394	PF00675	0.524
CLV_NRD_NRD_1	607	609	PF00675	0.776
CLV_NRD_NRD_1	670	672	PF00675	0.502
CLV_NRD_NRD_1	735	737	PF00675	0.763
CLV_PCSK_KEX2_1	218	220	PF00082	0.509
CLV_PCSK_KEX2_1	228	230	PF00082	0.532
CLV_PCSK_KEX2_1	356	358	PF00082	0.546
CLV_PCSK_KEX2_1	605	607	PF00082	0.662
CLV_PCSK_KEX2_1	670	672	PF00082	0.502
CLV_PCSK_KEX2_1	735	737	PF00082	0.733
CLV_PCSK_KEX2_1	87	89	PF00082	0.531
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.615
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.546
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.662
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.531
CLV_PCSK_SKI1_1	260	264	PF00082	0.636
CLV_PCSK_SKI1_1	379	383	PF00082	0.514
CLV_PCSK_SKI1_1	472	476	PF00082	0.452
CLV_PCSK_SKI1_1	523	527	PF00082	0.473
CLV_PCSK_SKI1_1	645	649	PF00082	0.459
CLV_PCSK_SKI1_1	670	674	PF00082	0.620
CLV_PCSK_SKI1_1	96	100	PF00082	0.509
DEG_COP1_1	429	438	PF00400	0.422
DEG_SCF_FBW7_1	862	868	PF00400	0.685
DEG_SPOP_SBC_1	170	174	PF00917	0.694
DOC_CKS1_1	690	695	PF01111	0.633
DOC_CKS1_1	862	867	PF01111	0.705
DOC_CYCLIN_RxL_1	104	112	PF00134	0.608
DOC_CYCLIN_RxL_1	212	223	PF00134	0.606
DOC_CYCLIN_RxL_1	323	334	PF00134	0.458
DOC_CYCLIN_yClb5_NLxxxL_5	107	115	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	628	634	PF00134	0.483
DOC_MAPK_gen_1	218	224	PF00069	0.595
DOC_MAPK_gen_1	23	31	PF00069	0.551
DOC_MAPK_gen_1	606	616	PF00069	0.599
DOC_MAPK_gen_1	670	677	PF00069	0.527
DOC_MAPK_gen_1	854	862	PF00069	0.629
DOC_MAPK_MEF2A_6	43	51	PF00069	0.498
DOC_MAPK_MEF2A_6	854	862	PF00069	0.719
DOC_MAPK_RevD_3	721	736	PF00069	0.647
DOC_PP2B_LxvP_1	111	114	PF13499	0.638
DOC_PP2B_LxvP_1	628	631	PF13499	0.500
DOC_PP2B_LxvP_1	675	678	PF13499	0.649
DOC_PP2B_LxvP_1	884	887	PF13499	0.587
DOC_USP7_MATH_1	164	168	PF00917	0.504
DOC_USP7_MATH_1	240	244	PF00917	0.538
DOC_USP7_MATH_1	486	490	PF00917	0.553
DOC_USP7_MATH_1	513	517	PF00917	0.678
DOC_USP7_MATH_1	62	66	PF00917	0.554
DOC_USP7_MATH_1	759	763	PF00917	0.676
DOC_USP7_MATH_1	865	869	PF00917	0.687
DOC_USP7_UBL2_3	23	27	PF12436	0.569
DOC_USP7_UBL2_3	378	382	PF12436	0.485
DOC_USP7_UBL2_3	876	880	PF12436	0.599
DOC_WW_Pin1_4	2	7	PF00397	0.635
DOC_WW_Pin1_4	600	605	PF00397	0.745
DOC_WW_Pin1_4	689	694	PF00397	0.575
DOC_WW_Pin1_4	824	829	PF00397	0.630
DOC_WW_Pin1_4	861	866	PF00397	0.622
LIG_14-3-3_CanoR_1	163	169	PF00244	0.694
LIG_14-3-3_CanoR_1	219	225	PF00244	0.658
LIG_14-3-3_CanoR_1	627	631	PF00244	0.488
LIG_14-3-3_CanoR_1	670	678	PF00244	0.623
LIG_14-3-3_CanoR_1	726	732	PF00244	0.590
LIG_14-3-3_CanoR_1	854	859	PF00244	0.654
LIG_BIR_III_2	103	107	PF00653	0.608
LIG_BRCT_BRCA1_1	515	519	PF00533	0.574
LIG_CSK_EPIYA_1	295	299	PF00017	0.587
LIG_DLG_GKlike_1	854	862	PF00625	0.492
LIG_FHA_1	190	196	PF00498	0.675
LIG_FHA_1	411	417	PF00498	0.489
LIG_FHA_1	486	492	PF00498	0.519
LIG_FHA_1	546	552	PF00498	0.571
LIG_FHA_1	595	601	PF00498	0.750
LIG_FHA_1	620	626	PF00498	0.461
LIG_FHA_1	830	836	PF00498	0.509
LIG_FHA_2	370	376	PF00498	0.542
LIG_FHA_2	403	409	PF00498	0.439
LIG_FHA_2	576	582	PF00498	0.654
LIG_FHA_2	771	777	PF00498	0.450
LIG_FHA_2	801	807	PF00498	0.495
LIG_FHA_2	844	850	PF00498	0.586
LIG_LIR_Apic_2	139	145	PF02991	0.459
LIG_LIR_Gen_1	295	305	PF02991	0.483
LIG_LIR_Gen_1	429	438	PF02991	0.511
LIG_LIR_Gen_1	643	652	PF02991	0.614
LIG_LIR_Gen_1	691	702	PF02991	0.448
LIG_LIR_LC3C_4	762	767	PF02991	0.570
LIG_LIR_Nem_3	295	301	PF02991	0.577
LIG_LIR_Nem_3	422	428	PF02991	0.484
LIG_LIR_Nem_3	437	442	PF02991	0.452
LIG_LIR_Nem_3	443	449	PF02991	0.451
LIG_LIR_Nem_3	643	649	PF02991	0.603
LIG_LIR_Nem_3	691	697	PF02991	0.464
LIG_NRBOX	366	372	PF00104	0.515
LIG_NRP_CendR_1	915	916	PF00754	0.554
LIG_Pex14_1	151	155	PF04695	0.561
LIG_SH2_CRK	298	302	PF00017	0.491
LIG_SH2_CRK	305	309	PF00017	0.487
LIG_SH2_CRK	694	698	PF00017	0.548
LIG_SH2_CRK	838	842	PF00017	0.516
LIG_SH2_CRK	95	99	PF00017	0.512
LIG_SH2_PTP2	646	649	PF00017	0.611
LIG_SH2_STAT3	531	534	PF00017	0.523
LIG_SH2_STAT5	100	103	PF00017	0.404
LIG_SH2_STAT5	184	187	PF00017	0.651
LIG_SH2_STAT5	531	534	PF00017	0.411
LIG_SH2_STAT5	646	649	PF00017	0.589
LIG_SH2_STAT5	772	775	PF00017	0.394
LIG_SH2_STAT5	910	913	PF00017	0.546
LIG_SH3_3	188	194	PF00018	0.583
LIG_SH3_3	463	469	PF00018	0.537
LIG_SH3_3	646	652	PF00018	0.481
LIG_SH3_3	653	659	PF00018	0.470
LIG_SH3_3	684	690	PF00018	0.582
LIG_SH3_3	696	702	PF00018	0.369
LIG_SH3_3	750	756	PF00018	0.704
LIG_SH3_3	763	769	PF00018	0.381
LIG_SH3_3	859	865	PF00018	0.671
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.533
LIG_SUMO_SIM_anti_2	762	768	PF11976	0.422
LIG_SUMO_SIM_par_1	495	500	PF11976	0.627
LIG_SUMO_SIM_par_1	553	558	PF11976	0.481
LIG_TRAF2_1	117	120	PF00917	0.595
LIG_TRAF2_1	542	545	PF00917	0.611
LIG_TRAF2_1	804	807	PF00917	0.622
LIG_TYR_ITSM	690	697	PF00017	0.571
LIG_UBA3_1	286	291	PF00899	0.581
LIG_WRC_WIRS_1	435	440	PF05994	0.501
LIG_WRC_WIRS_1	446	451	PF05994	0.396
MOD_CDK_SPK_2	600	605	PF00069	0.727
MOD_CDK_SPxK_1	600	606	PF00069	0.746
MOD_CDK_SPxxK_3	600	607	PF00069	0.745
MOD_CK1_1	243	249	PF00069	0.617
MOD_CK1_1	319	325	PF00069	0.517
MOD_CK1_1	489	495	PF00069	0.602
MOD_CK1_1	575	581	PF00069	0.686
MOD_CK1_1	594	600	PF00069	0.753
MOD_CK1_1	676	682	PF00069	0.635
MOD_CK1_1	861	867	PF00069	0.476
MOD_CK2_1	331	337	PF00069	0.391
MOD_CK2_1	369	375	PF00069	0.542
MOD_CK2_1	402	408	PF00069	0.557
MOD_CK2_1	614	620	PF00069	0.568
MOD_CK2_1	647	653	PF00069	0.566
MOD_CK2_1	776	782	PF00069	0.638
MOD_CK2_1	800	806	PF00069	0.490
MOD_CK2_1	843	849	PF00069	0.457
MOD_GlcNHglycan	111	114	PF01048	0.678
MOD_GlcNHglycan	469	472	PF01048	0.629
MOD_GlcNHglycan	515	518	PF01048	0.545
MOD_GlcNHglycan	560	563	PF01048	0.537
MOD_GlcNHglycan	588	591	PF01048	0.754
MOD_GlcNHglycan	593	596	PF01048	0.756
MOD_GlcNHglycan	64	67	PF01048	0.517
MOD_GlcNHglycan	649	652	PF01048	0.592
MOD_GlcNHglycan	761	764	PF01048	0.570
MOD_GSK3_1	164	171	PF00069	0.572
MOD_GSK3_1	369	376	PF00069	0.511
MOD_GSK3_1	485	492	PF00069	0.511
MOD_GSK3_1	596	603	PF00069	0.739
MOD_GSK3_1	755	762	PF00069	0.710
MOD_GSK3_1	854	861	PF00069	0.605
MOD_N-GLC_1	109	114	PF02516	0.692
MOD_N-GLC_1	489	494	PF02516	0.598
MOD_N-GLC_1	600	605	PF02516	0.745
MOD_N-GLC_1	614	619	PF02516	0.398
MOD_NEK2_1	109	114	PF00069	0.681
MOD_NEK2_1	195	200	PF00069	0.552
MOD_NEK2_1	220	225	PF00069	0.627
MOD_NEK2_1	245	250	PF00069	0.635
MOD_NEK2_1	331	336	PF00069	0.385
MOD_NEK2_1	385	390	PF00069	0.554
MOD_NEK2_1	497	502	PF00069	0.619
MOD_NEK2_1	770	775	PF00069	0.391
MOD_NEK2_1	858	863	PF00069	0.526
MOD_NEK2_2	234	239	PF00069	0.658
MOD_NEK2_2	910	915	PF00069	0.610
MOD_PIKK_1	171	177	PF00454	0.678
MOD_PIKK_1	373	379	PF00454	0.599
MOD_PIKK_1	489	495	PF00454	0.580
MOD_PKA_1	670	676	PF00069	0.530
MOD_PKA_2	572	578	PF00069	0.578
MOD_PKA_2	626	632	PF00069	0.466
MOD_PKA_2	670	676	PF00069	0.613
MOD_PKA_2	725	731	PF00069	0.625
MOD_Plk_1	240	246	PF00069	0.610
MOD_Plk_1	614	620	PF00069	0.504
MOD_Plk_1	673	679	PF00069	0.663
MOD_Plk_1	858	864	PF00069	0.666
MOD_Plk_2-3	776	782	PF00069	0.638
MOD_Plk_4	184	190	PF00069	0.516
MOD_Plk_4	220	226	PF00069	0.580
MOD_Plk_4	434	440	PF00069	0.520
MOD_Plk_4	445	451	PF00069	0.380
MOD_Plk_4	692	698	PF00069	0.498
MOD_Plk_4	888	894	PF00069	0.660
MOD_ProDKin_1	2	8	PF00069	0.625
MOD_ProDKin_1	600	606	PF00069	0.746
MOD_ProDKin_1	689	695	PF00069	0.568
MOD_ProDKin_1	824	830	PF00069	0.627
MOD_ProDKin_1	861	867	PF00069	0.616
MOD_SUMO_for_1	157	160	PF00179	0.526
MOD_SUMO_for_1	381	384	PF00179	0.515
TRG_DiLeu_BaEn_1	461	466	PF01217	0.432
TRG_DiLeu_BaEn_1	72	77	PF01217	0.369
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.361
TRG_ENDOCYTIC_2	152	155	PF00928	0.568
TRG_ENDOCYTIC_2	298	301	PF00928	0.435
TRG_ENDOCYTIC_2	305	308	PF00928	0.427
TRG_ENDOCYTIC_2	446	449	PF00928	0.437
TRG_ENDOCYTIC_2	646	649	PF00928	0.597
TRG_ENDOCYTIC_2	694	697	PF00928	0.546
TRG_ENDOCYTIC_2	95	98	PF00928	0.426
TRG_ER_diArg_1	228	230	PF00400	0.609
TRG_ER_diArg_1	362	365	PF00400	0.573
TRG_ER_diArg_1	606	608	PF00400	0.656
TRG_ER_diArg_1	669	671	PF00400	0.495
TRG_ER_diArg_1	914	916	PF00400	0.539
TRG_NES_CRM1_1	125	139	PF08389	0.563
TRG_NES_CRM1_1	545	558	PF08389	0.543
TRG_NES_CRM1_1	666	680	PF08389	0.598
TRG_NLS_MonoCore_2	604	609	PF00514	0.680
TRG_NLS_MonoExtC_3	377	382	PF00514	0.555
TRG_NLS_MonoExtC_3	604	610	PF00514	0.634
TRG_NLS_MonoExtN_4	378	383	PF00514	0.598
TRG_NLS_MonoExtN_4	604	609	PF00514	0.715
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P499	Leptomonas seymouri	66%	94%
A0A1X0NSE3	Trypanosomatidae	44%	98%
A0A3R7L0F4	Trypanosoma rangeli	43%	97%
A4HL23	Leishmania braziliensis	84%	100%
A4I8K4	Leishmania infantum	100%	100%
D0AAL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	97%
E9B3G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q4N6	Leishmania major	95%	100%
V5BMI7	Trypanosoma cruzi	43%	96%