LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H7T4_LEIDO
TriTrypDb:
LdBPK_323860.1 , LdCL_320044600 , LDHU3_32.4990
Length:
135

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7T4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7T4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 132 134 PF00675 0.694
CLV_NRD_NRD_1 6 8 PF00675 0.557
CLV_NRD_NRD_1 65 67 PF00675 0.552
CLV_PCSK_FUR_1 130 134 PF00082 0.691
CLV_PCSK_KEX2_1 132 134 PF00082 0.698
CLV_PCSK_KEX2_1 6 8 PF00082 0.470
CLV_PCSK_SKI1_1 12 16 PF00082 0.492
CLV_PCSK_SKI1_1 67 71 PF00082 0.466
DOC_CYCLIN_yCln2_LP_2 53 59 PF00134 0.659
DOC_MAPK_gen_1 123 131 PF00069 0.617
DOC_MAPK_gen_1 44 53 PF00069 0.571
DOC_MAPK_MEF2A_6 44 53 PF00069 0.563
DOC_MAPK_NFAT4_5 46 54 PF00069 0.639
DOC_MAPK_RevD_3 24 38 PF00069 0.564
DOC_PP1_RVXF_1 65 72 PF00149 0.504
DOC_PP1_RVXF_1 79 86 PF00149 0.450
DOC_USP7_UBL2_3 105 109 PF12436 0.595
DOC_USP7_UBL2_3 119 123 PF12436 0.704
DOC_USP7_UBL2_3 44 48 PF12436 0.572
DOC_WW_Pin1_4 52 57 PF00397 0.579
DOC_WW_Pin1_4 94 99 PF00397 0.467
LIG_FHA_2 106 112 PF00498 0.754
LIG_LIR_Nem_3 58 63 PF02991 0.528
LIG_SH3_3 19 25 PF00018 0.521
MOD_CK2_1 105 111 PF00069 0.715
MOD_GlcNHglycan 90 93 PF01048 0.507
MOD_GSK3_1 26 33 PF00069 0.613
MOD_GSK3_1 88 95 PF00069 0.479
MOD_NEK2_1 36 41 PF00069 0.571
MOD_PKA_1 12 18 PF00069 0.555
MOD_ProDKin_1 52 58 PF00069 0.575
MOD_ProDKin_1 94 100 PF00069 0.472
MOD_SUMO_rev_2 64 69 PF00179 0.552
TRG_ENDOCYTIC_2 60 63 PF00928 0.533
TRG_ER_diArg_1 129 132 PF00400 0.752
TRG_ER_diArg_1 6 9 PF00400 0.453
TRG_NLS_MonoExtC_3 36 41 PF00514 0.597
TRG_NLS_MonoExtN_4 9 15 PF00514 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HXE6 Leptomonas seymouri 74% 100%
A0A0S4IS54 Bodo saltans 67% 84%
A0A1X0NSL1 Trypanosomatidae 68% 100%
A0A422P317 Trypanosoma rangeli 68% 100%
A4HL08 Leishmania braziliensis 81% 100%
A4I8I9 Leishmania infantum 99% 100%
D0AAM8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
E9B3E9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q4Q1 Leishmania major 90% 100%
V5DME8 Trypanosoma cruzi 67% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS