Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7T3_LEIDO

TriTrypDb:

LdBPK_323850.1 , LdCL_320044500 , LDHU3_32.4980

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.624
CLV_C14_Caspase3-7	379	383	PF00656	0.558
CLV_C14_Caspase3-7	66	70	PF00656	0.798
CLV_NRD_NRD_1	172	174	PF00675	0.502
CLV_NRD_NRD_1	250	252	PF00675	0.518
CLV_NRD_NRD_1	523	525	PF00675	0.443
CLV_NRD_NRD_1	527	529	PF00675	0.387
CLV_NRD_NRD_1	641	643	PF00675	0.521
CLV_NRD_NRD_1	712	714	PF00675	0.588
CLV_PCSK_KEX2_1	172	174	PF00082	0.595
CLV_PCSK_KEX2_1	250	252	PF00082	0.558
CLV_PCSK_KEX2_1	527	529	PF00082	0.412
CLV_PCSK_SKI1_1	124	128	PF00082	0.604
CLV_PCSK_SKI1_1	165	169	PF00082	0.521
CLV_PCSK_SKI1_1	251	255	PF00082	0.418
CLV_PCSK_SKI1_1	290	294	PF00082	0.583
CLV_PCSK_SKI1_1	439	443	PF00082	0.619
CLV_PCSK_SKI1_1	444	448	PF00082	0.677
CLV_PCSK_SKI1_1	503	507	PF00082	0.434
CLV_PCSK_SKI1_1	519	523	PF00082	0.388
CLV_PCSK_SKI1_1	527	531	PF00082	0.412
CLV_PCSK_SKI1_1	599	603	PF00082	0.501
CLV_PCSK_SKI1_1	680	684	PF00082	0.590
CLV_PCSK_SKI1_1	699	703	PF00082	0.335
CLV_Separin_Metazoa	559	563	PF03568	0.642
DEG_APCC_DBOX_1	25	33	PF00400	0.565
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SCF_FBW7_1	529	536	PF00400	0.495
DEG_SPOP_SBC_1	581	585	PF00917	0.613
DOC_AGCK_PIF_3	724	727	PF00069	0.639
DOC_CYCLIN_yCln2_LP_2	659	665	PF00134	0.487
DOC_MAPK_gen_1	38	45	PF00069	0.557
DOC_MAPK_gen_1	524	531	PF00069	0.418
DOC_MAPK_MEF2A_6	38	45	PF00069	0.580
DOC_MAPK_MEF2A_6	562	570	PF00069	0.703
DOC_PP1_RVXF_1	248	255	PF00149	0.414
DOC_PP1_RVXF_1	525	532	PF00149	0.398
DOC_PP1_RVXF_1	641	648	PF00149	0.628
DOC_PP4_FxxP_1	45	48	PF00568	0.661
DOC_USP7_MATH_1	236	240	PF00917	0.553
DOC_USP7_MATH_1	282	286	PF00917	0.668
DOC_USP7_MATH_1	326	330	PF00917	0.724
DOC_USP7_MATH_1	345	349	PF00917	0.659
DOC_USP7_MATH_1	465	469	PF00917	0.650
DOC_USP7_MATH_1	533	537	PF00917	0.544
DOC_USP7_MATH_1	58	62	PF00917	0.686
DOC_USP7_MATH_2	337	343	PF00917	0.624
DOC_USP7_UBL2_3	293	297	PF12436	0.516
DOC_USP7_UBL2_3	599	603	PF12436	0.417
DOC_USP7_UBL2_3	673	677	PF12436	0.508
DOC_USP7_UBL2_3	680	684	PF12436	0.452
DOC_WW_Pin1_4	27	32	PF00397	0.595
DOC_WW_Pin1_4	415	420	PF00397	0.571
DOC_WW_Pin1_4	44	49	PF00397	0.431
DOC_WW_Pin1_4	529	534	PF00397	0.523
DOC_WW_Pin1_4	577	582	PF00397	0.523
LIG_14-3-3_CanoR_1	16	25	PF00244	0.615
LIG_14-3-3_CanoR_1	688	696	PF00244	0.467
LIG_Actin_WH2_2	390	408	PF00022	0.577
LIG_BIR_III_4	166	170	PF00653	0.433
LIG_BRCT_BRCA1_1	131	135	PF00533	0.570
LIG_EVH1_2	41	45	PF00568	0.647
LIG_FHA_1	121	127	PF00498	0.621
LIG_FHA_1	178	184	PF00498	0.393
LIG_FHA_1	225	231	PF00498	0.501
LIG_FHA_1	535	541	PF00498	0.459
LIG_FHA_1	596	602	PF00498	0.482
LIG_FHA_2	289	295	PF00498	0.440
LIG_FHA_2	64	70	PF00498	0.673
LIG_FHA_2	81	87	PF00498	0.697
LIG_Integrin_RGD_1	203	205	PF01839	0.590
LIG_LIR_Apic_2	44	48	PF02991	0.629
LIG_LIR_Apic_2	52	56	PF02991	0.724
LIG_LIR_Apic_2	635	641	PF02991	0.506
LIG_LIR_Gen_1	393	398	PF02991	0.456
LIG_LIR_Gen_1	445	455	PF02991	0.728
LIG_LIR_Gen_1	484	493	PF02991	0.482
LIG_LIR_Nem_3	393	397	PF02991	0.438
LIG_LIR_Nem_3	445	450	PF02991	0.720
LIG_LIR_Nem_3	721	727	PF02991	0.495
LIG_MYND_3	283	287	PF01753	0.587
LIG_PCNA_yPIPBox_3	361	370	PF02747	0.431
LIG_PDZ_Class_2	722	727	PF00595	0.624
LIG_Pex14_2	306	310	PF04695	0.662
LIG_SH2_CRK	365	369	PF00017	0.368
LIG_SH2_STAP1	267	271	PF00017	0.516
LIG_SH2_STAP1	421	425	PF00017	0.487
LIG_SH2_STAP1	708	712	PF00017	0.481
LIG_SH2_STAT3	259	262	PF00017	0.503
LIG_SH2_STAT3	421	424	PF00017	0.379
LIG_SH2_STAT5	142	145	PF00017	0.538
LIG_SH2_STAT5	387	390	PF00017	0.408
LIG_SH2_STAT5	504	507	PF00017	0.412
LIG_SH2_STAT5	516	519	PF00017	0.453
LIG_SH3_3	116	122	PF00018	0.596
LIG_SH3_3	413	419	PF00018	0.454
LIG_SH3_3	557	563	PF00018	0.601
LIG_SH3_3	575	581	PF00018	0.484
LIG_SH3_3	642	648	PF00018	0.627
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.497
LIG_SUMO_SIM_par_1	269	276	PF11976	0.599
LIG_SUMO_SIM_par_1	543	548	PF11976	0.486
LIG_SUMO_SIM_par_1	95	101	PF11976	0.443
LIG_TRAF2_1	223	226	PF00917	0.731
LIG_TRAF2_1	285	288	PF00917	0.587
LIG_TRAF2_1	337	340	PF00917	0.633
LIG_TYR_ITIM	363	368	PF00017	0.457
MOD_CDK_SPK_2	415	420	PF00069	0.548
MOD_CK1_1	209	215	PF00069	0.712
MOD_CK1_1	329	335	PF00069	0.720
MOD_CK1_1	484	490	PF00069	0.549
MOD_CK1_1	580	586	PF00069	0.493
MOD_CK1_1	650	656	PF00069	0.486
MOD_CK1_1	68	74	PF00069	0.739
MOD_CK1_1	687	693	PF00069	0.606
MOD_CK1_1	75	81	PF00069	0.505
MOD_CK2_1	282	288	PF00069	0.589
MOD_CK2_1	483	489	PF00069	0.480
MOD_CK2_1	68	74	PF00069	0.711
MOD_CK2_1	80	86	PF00069	0.648
MOD_Cter_Amidation	525	528	PF01082	0.449
MOD_GlcNHglycan	110	113	PF01048	0.556
MOD_GlcNHglycan	18	21	PF01048	0.588
MOD_GlcNHglycan	187	190	PF01048	0.453
MOD_GlcNHglycan	192	195	PF01048	0.372
MOD_GlcNHglycan	238	241	PF01048	0.609
MOD_GlcNHglycan	259	262	PF01048	0.606
MOD_GlcNHglycan	320	323	PF01048	0.760
MOD_GlcNHglycan	331	334	PF01048	0.667
MOD_GlcNHglycan	347	350	PF01048	0.700
MOD_GlcNHglycan	371	374	PF01048	0.475
MOD_GlcNHglycan	389	392	PF01048	0.547
MOD_GlcNHglycan	74	77	PF01048	0.638
MOD_GSK3_1	108	115	PF00069	0.608
MOD_GSK3_1	205	212	PF00069	0.709
MOD_GSK3_1	236	243	PF00069	0.480
MOD_GSK3_1	426	433	PF00069	0.453
MOD_GSK3_1	529	536	PF00069	0.495
MOD_GSK3_1	577	584	PF00069	0.505
MOD_GSK3_1	64	71	PF00069	0.715
MOD_GSK3_1	98	105	PF00069	0.500
MOD_NEK2_1	129	134	PF00069	0.617
MOD_NEK2_1	185	190	PF00069	0.413
MOD_NEK2_1	442	447	PF00069	0.545
MOD_NEK2_1	483	488	PF00069	0.431
MOD_NEK2_1	534	539	PF00069	0.481
MOD_NEK2_1	582	587	PF00069	0.597
MOD_PIKK_1	102	108	PF00454	0.536
MOD_PIKK_1	241	247	PF00454	0.614
MOD_PIKK_1	326	332	PF00454	0.617
MOD_PKA_2	108	114	PF00069	0.602
MOD_PKA_2	129	135	PF00069	0.578
MOD_PKA_2	369	375	PF00069	0.427
MOD_PKA_2	687	693	PF00069	0.493
MOD_PKA_2	72	78	PF00069	0.662
MOD_Plk_1	224	230	PF00069	0.519
MOD_Plk_1	442	448	PF00069	0.567
MOD_Plk_1	97	103	PF00069	0.501
MOD_Plk_2-3	288	294	PF00069	0.441
MOD_Plk_4	478	484	PF00069	0.487
MOD_Plk_4	582	588	PF00069	0.589
MOD_Plk_4	661	667	PF00069	0.486
MOD_Plk_4	720	726	PF00069	0.561
MOD_ProDKin_1	27	33	PF00069	0.592
MOD_ProDKin_1	415	421	PF00069	0.567
MOD_ProDKin_1	44	50	PF00069	0.432
MOD_ProDKin_1	529	535	PF00069	0.533
MOD_ProDKin_1	577	583	PF00069	0.516
MOD_SUMO_for_1	706	709	PF00179	0.470
MOD_SUMO_rev_2	161	170	PF00179	0.529
MOD_SUMO_rev_2	436	441	PF00179	0.600
MOD_SUMO_rev_2	592	601	PF00179	0.489
TRG_DiLeu_BaEn_2	620	626	PF01217	0.636
TRG_DiLeu_BaEn_3	225	231	PF01217	0.363
TRG_DiLeu_LyEn_5	437	442	PF01217	0.547
TRG_ENDOCYTIC_2	142	145	PF00928	0.528
TRG_ENDOCYTIC_2	365	368	PF00928	0.365
TRG_ER_diArg_1	171	173	PF00400	0.600
TRG_ER_diArg_1	25	28	PF00400	0.518
TRG_ER_diArg_1	250	252	PF00400	0.558
TRG_ER_diArg_1	37	40	PF00400	0.532
TRG_ER_diArg_1	527	529	PF00400	0.412
TRG_NLS_MonoExtC_3	523	528	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P501	Leptomonas seymouri	63%	86%
A0A0S4JJK2	Bodo saltans	33%	89%
A0A1X0NRY5	Trypanosomatidae	42%	99%
A4HL07	Leishmania braziliensis	81%	100%
A4I8I8	Leishmania infantum	100%	100%
D0AAM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9B3E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4Q4Q2	Leishmania major	95%	100%
V5BLC8	Trypanosoma cruzi	41%	98%