Miro-like protein/Ras family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7S9_LEIDO

TriTrypDb:

LdBPK_323240.1 , LdCL_320038400 , LDHU3_32.4100

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7S9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	770	774	PF00656	0.742
CLV_NRD_NRD_1	267	269	PF00675	0.563
CLV_NRD_NRD_1	340	342	PF00675	0.521
CLV_NRD_NRD_1	444	446	PF00675	0.523
CLV_NRD_NRD_1	467	469	PF00675	0.532
CLV_NRD_NRD_1	63	65	PF00675	0.373
CLV_NRD_NRD_1	668	670	PF00675	0.456
CLV_NRD_NRD_1	79	81	PF00675	0.343
CLV_NRD_NRD_1	813	815	PF00675	0.536
CLV_PCSK_FUR_1	811	815	PF00082	0.560
CLV_PCSK_KEX2_1	267	269	PF00082	0.563
CLV_PCSK_KEX2_1	339	341	PF00082	0.470
CLV_PCSK_KEX2_1	467	469	PF00082	0.501
CLV_PCSK_KEX2_1	63	65	PF00082	0.394
CLV_PCSK_KEX2_1	668	670	PF00082	0.456
CLV_PCSK_KEX2_1	811	813	PF00082	0.538
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.487
CLV_PCSK_SKI1_1	107	111	PF00082	0.434
CLV_PCSK_SKI1_1	13	17	PF00082	0.583
CLV_PCSK_SKI1_1	139	143	PF00082	0.349
CLV_PCSK_SKI1_1	183	187	PF00082	0.343
CLV_PCSK_SKI1_1	327	331	PF00082	0.395
CLV_PCSK_SKI1_1	455	459	PF00082	0.453
CLV_PCSK_SKI1_1	573	577	PF00082	0.501
CLV_PCSK_SKI1_1	65	69	PF00082	0.364
CLV_PCSK_SKI1_1	813	817	PF00082	0.562
DEG_APCC_DBOX_1	449	457	PF00400	0.387
DEG_APCC_DBOX_1	610	618	PF00400	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.792
DEG_ODPH_VHL_1	541	554	PF01847	0.414
DEG_SPOP_SBC_1	239	243	PF00917	0.767
DEG_SPOP_SBC_1	24	28	PF00917	0.729
DEG_SPOP_SBC_1	248	252	PF00917	0.530
DEG_SPOP_SBC_1	96	100	PF00917	0.343
DOC_CKS1_1	416	421	PF01111	0.504
DOC_CKS1_1	532	537	PF01111	0.520
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.371
DOC_MAPK_DCC_7	46	56	PF00069	0.648
DOC_MAPK_gen_1	339	346	PF00069	0.484
DOC_MAPK_gen_1	539	546	PF00069	0.399
DOC_MAPK_gen_1	548	556	PF00069	0.393
DOC_MAPK_gen_1	570	580	PF00069	0.501
DOC_MAPK_gen_1	609	616	PF00069	0.441
DOC_MAPK_gen_1	63	69	PF00069	0.345
DOC_MAPK_MEF2A_6	339	348	PF00069	0.475
DOC_MAPK_MEF2A_6	548	556	PF00069	0.494
DOC_PP1_RVXF_1	453	459	PF00149	0.395
DOC_PP1_RVXF_1	51	57	PF00149	0.615
DOC_PP1_RVXF_1	551	557	PF00149	0.391
DOC_PP2B_LxvP_1	233	236	PF13499	0.635
DOC_PP2B_LxvP_1	716	719	PF13499	0.611
DOC_PP2B_LxvP_1	749	752	PF13499	0.482
DOC_PP4_FxxP_1	458	461	PF00568	0.411
DOC_USP7_MATH_1	237	241	PF00917	0.774
DOC_USP7_MATH_1	249	253	PF00917	0.490
DOC_USP7_MATH_2	490	496	PF00917	0.513
DOC_USP7_UBL2_3	208	212	PF12436	0.438
DOC_WW_Pin1_4	226	231	PF00397	0.578
DOC_WW_Pin1_4	415	420	PF00397	0.489
DOC_WW_Pin1_4	531	536	PF00397	0.420
DOC_WW_Pin1_4	754	759	PF00397	0.568
DOC_WW_Pin1_4	818	823	PF00397	0.725
LIG_14-3-3_CanoR_1	349	356	PF00244	0.465
LIG_14-3-3_CanoR_1	373	379	PF00244	0.348
LIG_14-3-3_CanoR_1	404	410	PF00244	0.478
LIG_14-3-3_CanoR_1	573	579	PF00244	0.471
LIG_14-3-3_CanoR_1	668	672	PF00244	0.435
LIG_14-3-3_CanoR_1	720	726	PF00244	0.544
LIG_14-3-3_CanoR_1	97	104	PF00244	0.428
LIG_APCC_ABBA_1	623	628	PF00400	0.371
LIG_APCC_ABBAyCdc20_2	622	628	PF00400	0.371
LIG_BIR_III_4	778	782	PF00653	0.606
LIG_BRCT_BRCA1_1	494	498	PF00533	0.543
LIG_BRCT_BRCA1_1	84	88	PF00533	0.403
LIG_deltaCOP1_diTrp_1	561	567	PF00928	0.396
LIG_EH1_1	341	349	PF00400	0.477
LIG_FHA_1	131	137	PF00498	0.348
LIG_FHA_1	278	284	PF00498	0.433
LIG_FHA_1	722	728	PF00498	0.567
LIG_FHA_1	775	781	PF00498	0.706
LIG_FHA_1	97	103	PF00498	0.343
LIG_FHA_2	187	193	PF00498	0.331
LIG_FHA_2	780	786	PF00498	0.575
LIG_LIR_Apic_2	522	527	PF02991	0.401
LIG_LIR_Gen_1	140	150	PF02991	0.343
LIG_LIR_Gen_1	351	360	PF02991	0.484
LIG_LIR_Gen_1	377	384	PF02991	0.348
LIG_LIR_Gen_1	411	420	PF02991	0.464
LIG_LIR_Gen_1	495	506	PF02991	0.503
LIG_LIR_Gen_1	555	563	PF02991	0.399
LIG_LIR_Nem_3	140	145	PF02991	0.343
LIG_LIR_Nem_3	174	179	PF02991	0.340
LIG_LIR_Nem_3	377	381	PF02991	0.347
LIG_LIR_Nem_3	411	415	PF02991	0.430
LIG_LIR_Nem_3	495	501	PF02991	0.492
LIG_LIR_Nem_3	555	559	PF02991	0.382
LIG_LIR_Nem_3	561	567	PF02991	0.362
LIG_LIR_Nem_3	662	666	PF02991	0.358
LIG_MYND_1	527	531	PF01753	0.408
LIG_NRBOX	304	310	PF00104	0.400
LIG_NRBOX	655	661	PF00104	0.486
LIG_PCNA_yPIPBox_3	13	24	PF02747	0.559
LIG_PCNA_yPIPBox_3	566	575	PF02747	0.437
LIG_Pex14_1	378	382	PF04695	0.362
LIG_Pex14_2	142	146	PF04695	0.343
LIG_REV1ctd_RIR_1	86	93	PF16727	0.401
LIG_SH2_CRK	663	667	PF00017	0.372
LIG_SH2_CRK	753	757	PF00017	0.566
LIG_SH2_SRC	525	528	PF00017	0.520
LIG_SH2_SRC	581	584	PF00017	0.593
LIG_SH2_SRC	71	74	PF00017	0.399
LIG_SH2_SRC	786	789	PF00017	0.448
LIG_SH2_STAP1	265	269	PF00017	0.570
LIG_SH2_STAP1	387	391	PF00017	0.464
LIG_SH2_STAP1	412	416	PF00017	0.439
LIG_SH2_STAT3	14	17	PF00017	0.627
LIG_SH2_STAT5	134	137	PF00017	0.443
LIG_SH2_STAT5	14	17	PF00017	0.527
LIG_SH2_STAT5	304	307	PF00017	0.474
LIG_SH2_STAT5	382	385	PF00017	0.370
LIG_SH2_STAT5	431	434	PF00017	0.507
LIG_SH2_STAT5	448	451	PF00017	0.513
LIG_SH2_STAT5	525	528	PF00017	0.388
LIG_SH2_STAT5	748	751	PF00017	0.432
LIG_SH2_STAT5	786	789	PF00017	0.504
LIG_SH3_3	393	399	PF00018	0.437
LIG_SH3_3	503	509	PF00018	0.527
LIG_SH3_3	577	583	PF00018	0.527
LIG_SH3_3	669	675	PF00018	0.426
LIG_SUMO_SIM_par_1	183	189	PF11976	0.443
LIG_SUMO_SIM_par_1	489	497	PF11976	0.474
LIG_SUMO_SIM_par_1	722	728	PF11976	0.567
LIG_TRAF2_1	124	127	PF00917	0.368
LIG_TRAF2_1	364	367	PF00917	0.500
LIG_TRAF2_1	603	606	PF00917	0.505
LIG_TRAF2_1	759	762	PF00917	0.685
LIG_TRFH_1	556	560	PF08558	0.368
LIG_TYR_ITIM	69	74	PF00017	0.399
LIG_UBA3_1	141	147	PF00899	0.343
LIG_UBA3_1	301	310	PF00899	0.475
LIG_UBA3_1	331	339	PF00899	0.461
LIG_WRC_WIRS_1	213	218	PF05994	0.441
MOD_CDC14_SPxK_1	757	760	PF00782	0.665
MOD_CDK_SPxK_1	754	760	PF00069	0.621
MOD_CK1_1	128	134	PF00069	0.399
MOD_CK1_1	224	230	PF00069	0.546
MOD_CK1_1	240	246	PF00069	0.666
MOD_CK1_1	26	32	PF00069	0.735
MOD_CK1_1	277	283	PF00069	0.432
MOD_CK1_1	408	414	PF00069	0.501
MOD_CK1_1	634	640	PF00069	0.423
MOD_CK1_1	642	648	PF00069	0.437
MOD_CK1_1	690	696	PF00069	0.539
MOD_CK1_1	738	744	PF00069	0.516
MOD_CK1_1	774	780	PF00069	0.760
MOD_CK2_1	146	152	PF00069	0.343
MOD_CK2_1	361	367	PF00069	0.417
MOD_CK2_1	431	437	PF00069	0.501
MOD_CK2_1	779	785	PF00069	0.573
MOD_CK2_1	89	95	PF00069	0.390
MOD_CK2_1	97	103	PF00069	0.301
MOD_GlcNHglycan	148	151	PF01048	0.352
MOD_GlcNHglycan	157	160	PF01048	0.312
MOD_GlcNHglycan	293	296	PF01048	0.417
MOD_GlcNHglycan	298	301	PF01048	0.372
MOD_GlcNHglycan	636	639	PF01048	0.495
MOD_GlcNHglycan	710	713	PF01048	0.544
MOD_GlcNHglycan	99	102	PF01048	0.405
MOD_GSK3_1	130	137	PF00069	0.335
MOD_GSK3_1	2	9	PF00069	0.695
MOD_GSK3_1	224	231	PF00069	0.525
MOD_GSK3_1	23	30	PF00069	0.660
MOD_GSK3_1	515	522	PF00069	0.525
MOD_GSK3_1	634	641	PF00069	0.481
MOD_GSK3_1	688	695	PF00069	0.521
MOD_GSK3_1	767	774	PF00069	0.761
MOD_N-GLC_1	224	229	PF02516	0.572
MOD_N-GLC_1	639	644	PF02516	0.484
MOD_NEK2_1	155	160	PF00069	0.343
MOD_NEK2_1	186	191	PF00069	0.343
MOD_NEK2_1	238	243	PF00069	0.775
MOD_NEK2_1	274	279	PF00069	0.384
MOD_NEK2_1	405	410	PF00069	0.393
MOD_NEK2_1	574	579	PF00069	0.364
MOD_NEK2_1	721	726	PF00069	0.472
MOD_NEK2_1	735	740	PF00069	0.347
MOD_NEK2_1	798	803	PF00069	0.525
MOD_NEK2_1	89	94	PF00069	0.428
MOD_NEK2_2	75	80	PF00069	0.343
MOD_OFUCOSY	736	742	PF10250	0.507
MOD_PIKK_1	515	521	PF00454	0.578
MOD_PIKK_1	719	725	PF00454	0.560
MOD_PK_1	760	766	PF00069	0.784
MOD_PKA_2	348	354	PF00069	0.458
MOD_PKA_2	610	616	PF00069	0.476
MOD_PKA_2	642	648	PF00069	0.522
MOD_PKA_2	667	673	PF00069	0.461
MOD_PKA_2	719	725	PF00069	0.491
MOD_PKA_2	774	780	PF00069	0.592
MOD_PKA_2	96	102	PF00069	0.373
MOD_Plk_1	105	111	PF00069	0.480
MOD_Plk_1	137	143	PF00069	0.343
MOD_Plk_1	760	766	PF00069	0.727
MOD_Plk_2-3	492	498	PF00069	0.536
MOD_Plk_2-3	767	773	PF00069	0.760
MOD_Plk_4	130	136	PF00069	0.368
MOD_Plk_4	405	411	PF00069	0.511
MOD_Plk_4	576	582	PF00069	0.490
MOD_Plk_4	610	616	PF00069	0.476
MOD_Plk_4	631	637	PF00069	0.479
MOD_Plk_4	721	727	PF00069	0.460
MOD_ProDKin_1	226	232	PF00069	0.592
MOD_ProDKin_1	415	421	PF00069	0.495
MOD_ProDKin_1	531	537	PF00069	0.421
MOD_ProDKin_1	754	760	PF00069	0.584
MOD_ProDKin_1	818	824	PF00069	0.728
TRG_DiLeu_BaEn_1	483	488	PF01217	0.483
TRG_DiLeu_BaEn_1	728	733	PF01217	0.415
TRG_DiLeu_BaEn_2	137	143	PF01217	0.443
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.504
TRG_DiLeu_LyEn_5	390	395	PF01217	0.412
TRG_ENDOCYTIC_2	412	415	PF00928	0.436
TRG_ENDOCYTIC_2	663	666	PF00928	0.365
TRG_ENDOCYTIC_2	71	74	PF00928	0.399
TRG_ENDOCYTIC_2	748	751	PF00928	0.432
TRG_ER_diArg_1	267	269	PF00400	0.579
TRG_ER_diArg_1	466	468	PF00400	0.478
TRG_ER_diArg_1	52	55	PF00400	0.551
TRG_ER_diArg_1	550	553	PF00400	0.460
TRG_ER_diArg_1	598	601	PF00400	0.556
TRG_ER_diArg_1	811	814	PF00400	0.561
TRG_NLS_MonoExtC_3	338	343	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	814	818	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9V2	Leptomonas seymouri	78%	82%
A0A1X0NT83	Trypanosomatidae	51%	82%
A0A422NYM8	Trypanosoma rangeli	47%	84%
A4HKV0	Leishmania braziliensis	89%	100%
A4I8C9	Leishmania infantum	100%	100%
E9B388	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q4W7	Leishmania major	97%	100%
V5DM76	Trypanosoma cruzi	47%	94%